Yr Athro Robert Powell

Athro Clinigol Anrhydeddus, Medicine

h.w.r.powell@abertawe.ac.uk

Dolenni Ymchwil

Trosolwg

Mae'r Athro Powell yn Niwrolegydd Ymgynghorol ac yn athro clinigol er anrhydedd yn Ysgol Feddygaeth Prifysgol Abertawe. Mae'n ymarfer yn glinigol fel niwrolegydd ym Mwrdd Iechyd Prifysgol Bae Abertawe (SBUHB) ac mae ganddo ddiddordebau is-arbenigedd mewn epilepsi a niwroleg cwsg.

Mae ef wedi cynnal ymchwil i'r defnydd o dechnegau niwroddelweddu uwch mewn cleifion sy'n cael llawdriniaeth epilepsi ac mae ei ddiddordebau ymchwil parhaus yn cynnwys defnyddio data a gesglir yn rheolaidd ar gyfer ymchwil niwroleg glinigol. Ei nod yw ymgorffori ymchwil yn ei arferion clinigol safonol, gan recriwtio cleifion o glinigau niwroleg SBUHB ym Miofanc Niwroleg Abertawe.

Mae'n gyd-ymchwilydd ac yn aelod gweithredol o Fiofanc Niwroleg Abertawe, yn gyd-ymchwilydd y prosiectau Geneteg Epilepsi Teuluol, yn aelod o grŵp niwroleg SAIL, ac yn gydweithredwr ar nifer o gonsortia geneteg epilepsi rhyngwladol. Bu'n brif ymchwilydd yn SBUHB ar gyfer nifer o astudiaethau aml-sefydliad y Sefydliad Cenedlaethol ar gyfer Ymchwil Iechyd a threialon cyffuriau masnachol.

Mae Rob yn aelod o gyngor cangen y DU o'r International League Against Epilepsy, ac yn ddiweddar mae ef wedi bod yn aelod o Grŵp Cynghori ar Epilepsi Cymdeithas Niwrolegwyr Prydain (ABN). Mae'n aelod o Bwyllgor Addysg yr ABN, ac mae'n gadeirydd y Pwyllgor Hyfforddiant Arbenigol ar gyfer Niwroleg yng Nghymru.

Meysydd Arbenigedd

Epilepsi
Niwroleg cwsg
Treialon clinigol

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Arweinydd Wythnos (wythnos epilepsi), cwrs Meddygaeth i Raddedigion Prifysgol Abertawe
Darlithydd ac ysgrifennwr cwestiynau ar gyfer y modiwl niwrowyddorau (PM 276), y cwrs israddedig mewn Gwyddorau Meddygol Cymhwysol, 2018 i'r presennol
Darlithydd ar raglen Cydymaith Meddygol Prifysgol Abertawe, 2017 i'r presennol

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Powell, R., Elwes, R., Hamandi, K., & Mullatti, N. (2018). Cingulate gyrus epilepsy. Practical Neurology, 18(6), 447-454.
https://doi.org/10.1136/practneurol-2017-001812, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60625
Stevelink, R., Luykx, J., Lin, B., Leu, C., Lal, D., Smith, A., Schijven, D., Carpay, J., Rademaker, K., Baldez, R., Devinsky, O., Braun, K., Jansen, F., Smit, D., Koeleman, B., Abou‐Khalil, B., Auce, P., Avbersek, A., Bahlo, M...., & Collaborative), . (2021). Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations. Epilepsia, 62(7), 1518-1527.
https://doi.org/10.1111/epi.16922, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60623
Niestroj, L., Perez-Palma, E., Howrigan, D., Zhou, Y., Cheng, F., Saarentaus, E., Nürnberg, P., Stevelink, R., Daly, M., Palotie, A., Lal, D., Feng, Y., Howrigan, D., Abbott, L., Tashman, K., Cerrato, F., Lal, D., Churchhouse, C., Gupta, N...., & Collaborative), . (2020). Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17 458 subjects. Brain, 143(7), 2106-2118.
https://doi.org/10.1093/brain/awaa171, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60622
Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J., Sills, G., Tudur-Smith, C., Plumpton, C., Hughes, D., Williamson, P., Baker, G., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R., Smith, P...., & Powell, R. (2021). The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. The Lancet, 397(10282), 1363-1374.
https://doi.org/10.1016/s0140-6736(21)00247-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60621
Motelow, J., Povysil, G., Dhindsa, R., Stanley, K., Allen, A., Feng, Y., Howrigan, D., Abbott, L., Tashman, K., Cerrato, F., Cusick, C., Singh, T., Heyne, H., Byrnes, A., Churchhouse, C., Watts, N., Solomonson, M., Lal, D., Gupta, N...., & Goldstein, D. (2021). Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals. The American Journal of Human Genetics, 108(6), 965-982.
https://doi.org/10.1016/j.ajhg.2021.04.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60620
Powell, R., Feng, Y., Howrigan, D., Abbott, L., Tashman, K., Cerrato, F., Singh, T., Heyne, H., Byrnes, A., Churchhouse, C., Watts, N., Solomonson, M., Lal, D., Heinzen, E., Dhindsa, R., Stanley, K., Cavalleri, G., Hakonarson, H., Helbig, I...., & Pickrell, O. (2019). Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals. The American Journal of Human Genetics, 105(2), 267-282.
https://doi.org/10.1016/j.ajhg.2019.05.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51398
Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J., Sills, G., Tudur-Smith, C., Plumpton, C., Hughes, D., Williamson, P., Baker, G., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R., Smith, P...., & Powell, R. (2021). The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. The Lancet, 397(10282), 1375-1386.
https://doi.org/10.1016/s0140-6736(21)00246-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60619
Fonferko-Shadrach, B., Lacey, A., White, C., Powell, H., Sawhney, I., Lyons, R., Smith, P., Kerr, M., Rees, M., Pickrell, W., Pickrell, O., & Powell, R. (2017). Validating epilepsy diagnoses in routinely collected data. Seizure, 52, 195-198.
https://doi.org/10.1016/j.seizure.2017.10.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38279
Daniels, H., Lacey, A., Akbari, A., Powell, R., & Pickrell, O. (2019). Epilepsy Mortality in Wales: 2005-2017. In International Journal of Population Data ScienceSwansea University.
https://doi.org/10.23889/ijpds.v4i3.1277, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53657
Miah, L., Strafford, H., Fonferko-Shadrach, B., Hollinghurst, J., Sawhney, I., Hadjikoutis, S., Rees, M., Powell, R., Lacey, A., & Pickrell, O. (2021). Incidence, Prevalence, and Health Care Outcomes in Idiopathic Intracranial Hypertension. Neurology, 96(8), e1251-e1261.
https://doi.org/10.1212/wnl.0000000000011463, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56133
Lee‐Lane, E., Torabi, F., Lacey, A., Fonferko-Shadrach, B., Harris, D., Akbari, A., Lyons, R., Rees, M., Sawhney, I., Halcox, J., Powell, R., & Pickrell, O. (2021). Epilepsy, antiepileptic drugs, and the risk of major cardiovascular events. Epilepsia, 62(7), 1604-1616.
https://doi.org/10.1111/epi.16930, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56988
Daniels, H., Lacey, A., Mikadze, D., Akbari, A., Fonferko-Shadrach, B., Hollinghurst, J., Lyons, R., Rees, M., Sawhney, I., Powell, R., Kerr, M., & Pickrell, O. (2022). Epilepsy mortality in Wales during COVID-19. Seizure - European Journal of Epilepsy, 94, 39-42.
https://doi.org/10.1016/j.seizure.2021.11.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58860
Wynford-Thomas, R., Powell, R., & Powell, R. (2017). Navigating the Island of Reil: how to understand the insular cortex. Practical Neurology, 17(2), 122-126.
https://doi.org/10.1136/practneurol-2016-001493, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39153
Hirst, C., Willis, M., Hussain, H., Powell, R., & Powell, R. (2015). Acute myeloid leucaemia presenting as a rapidly progressive polyradiculoneuropathy. BMJ Case Reports, 2015(nov17 2), bcr2015209556-bcr2015209556.
https://doi.org/10.1136/bcr-2015-209556, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39157
Caeyenberghs, K., Powell, H., Thomas, R., Brindley, L., Church, C., Evans, J., Muthukumaraswamy, S., Jones, D., Hamandi, K., & Powell, R. (2015). Hyperconnectivity in juvenile myoclonic epilepsy: A network analysis. NeuroImage: Clinical, 7, 98-104.
https://doi.org/10.1016/j.nicl.2014.11.018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39160
Powell, R., Hughes, T., & Powell, R. (2014). A chamber of secrets The neurology of the thalamus: lessons from acute stroke. Practical Neurology, 14(6), 440-445.
https://doi.org/10.1136/practneurol-2014-000852, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39154
Bonelli, S., Thompson, P., Yogarajah, M., Powell, R., Samson, R., McEvoy, A., Symms, M., Koepp, M., & Duncan, J. (2013). Memory reorganization following anterior temporal lobe resection: a longitudinal functional MRI study. Brain, 136(6), 1889-1900.
https://doi.org/10.1093/brain/awt105, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39175
Ali, K., Amin, R., Yoganathan, K., Powell, R., & Powell, R. (2013). Rapidly progressive cerebellar ataxia in West Wales. Case Reports, 2013(nov21 1), bcr2013201619-bcr2013201619.
https://doi.org/10.1136/bcr-2013-201619, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39158
Bonelli, S., Thompson, P., Yogarajah, M., Vollmar, C., Powell, R., Symms, M., McEvoy, A., Micallef, C., Koepp, M., & Duncan, J. (2012). Imaging language networks before and after anterior temporal lobe resection: Results of a longitudinal fMRI study. Epilepsia, 53(4), 639-650.
https://doi.org/10.1111/j.1528-1167.2012.03433.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39176
Powell, R., McLauchlan, D., & Powell, R. (2012). Acute symptomatic seizures. Practical Neurology, 12(3), 154-165.
https://doi.org/10.1136/practneurol-2012-000244, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39155
Bonelli, S., Powell, R., Thompson, P., Yogarajah, M., Focke, N., Stretton, J., Vollmar, C., Symms, M., Price, C., Duncan, J., Koepp, M., & Powell, R. (2011). Hippocampal activation correlates with visual confrontation naming: fMRI findings in controls and patients with temporal lobe epilepsy. Epilepsy Research, 95(3), 246-254.
https://doi.org/10.1016/j.eplepsyres.2011.04.007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39156
Bonelli, S., Powell, R., Yogarajah, M., Samson, R., Symms, M., Thompson, P., Koepp, M., Duncan, J., & Powell, R. (2010). Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection. Brain, 133(4), 1186-1199.
https://doi.org/10.1093/brain/awq006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39178
Bonelli, S., Powell, R., Yogarajah, M., Thompson, P., Symms, M., Koepp, M., & Duncan, J. (2009). Preoperative amygdala fMRI in temporal lobe epilepsy. Epilepsia, 50(2), 217-227.
https://doi.org/10.1111/j.1528-1167.2008.01739.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39179
Yogarajah, M., Powell, H., Heaney, D., Smith, S., Duncan, J., Sisodiya, S., & Powell, R. (2009). Long term monitoring in refractory epilepsy: the Gowers Unit experience. Journal of Neurology, Neurosurgery & Psychiatry, 80(3), 305-310.
https://doi.org/10.1136/jnnp.2008.144634, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39161
Yogarajah, M., Powell, H., Parker, G., Alexander, D., Thompson, P., Symms, M., Boulby, P., Wheeler-Kingshott, C., Barker, G., Koepp, M., Duncan, J., & Powell, R. (2008). Tractography of the parahippocampal gyrus and material specific memory impairment in unilateral temporal lobe epilepsy. NeuroImage, 40(4), 1755-1764.
https://doi.org/10.1016/j.neuroimage.2007.12.046, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39162
Hamandi, K., Powell, H., Laufs, H., Symms, M., Barker, G., Parker, G., Lemieux, L., Duncan, J., & Powell, R. (2008). Combined EEG-fMRI and tractography to visualise propagation of epileptic activity. Journal of Neurology, Neurosurgery & Psychiatry, 79(5), 594-597.
https://doi.org/10.1136/jnnp.2007.125401, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39163
Powell, H., Parker, G., Alexander, D., Symms, M., Boulby, P., Barker, G., Thompson, P., Koepp, M., Duncan, J., & Powell, R. (2008). Imaging language pathways predicts postoperative naming deficits. Journal of Neurology, Neurosurgery & Psychiatry, 79(3), 327-330.
https://doi.org/10.1136/jnnp.2007.126078, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39164
Powell, R. (2008). Examining the Nervous System. The Foundation Years, 4(4), 164-166.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39230
Powell, H., Richardson, M., Symms, M., Boulby, P., Thompson, P., Duncan, J., Koepp, M., & Powell, R. (2007). Preoperative fMRI predicts memory decline following anterior temporal lobe resection. Journal of Neurology, Neurosurgery & Psychiatry, 79(6), 686-693.
https://doi.org/10.1136/jnnp.2007.115139, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39165
Powell, H., Richardson, M., Symms, M., Boulby, P., Thompson, P., Duncan, J., Koepp, M., & Powell, R. (2007). Reorganization of Verbal and Nonverbal Memory in Temporal Lobe Epilepsy Due to Unilateral Hippocampal Sclerosis. Epilepsia, 48(8), 1512-1525.
https://doi.org/10.1111/j.1528-1167.2007.01053.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39166
Powell, H., Parker, G., Alexander, D., Symms, M., Boulby, P., Wheeler-Kingshott, C., Barker, G., Koepp, M., Duncan, J., & Powell, R. (2007). Abnormalities of language networks in temporal lobe epilepsy. NeuroImage, 36(1), 209-221.
https://doi.org/10.1016/j.neuroimage.2007.02.028, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39167
Powell, H., Parker, G., Alexander, D., Symms, M., Boulby, P., Wheeler-Kingshott, C., Barker, G., Noppeney, U., Koepp, M., Duncan, J., & Powell, R. (2006). Hemispheric asymmetries in language-related pathways: A combined functional MRI and tractography study. NeuroImage, 32(1), 388-399.
https://doi.org/10.1016/j.neuroimage.2006.03.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39168
Koepp, M., Hamandi, K., Symms, M., & Powell, R. (2006). Imaging structural and functional connectivity of the human thalamus. Future Neurology, 1, 153-157.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39231
Powell, R. (2005). Functional magnetic resonance imaging for assessment of language and memory in clinical practice.. Current Opinion in Neurology, 18(2), 161-166.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39174
Powell, H., Parker, G., Alexander, D., Symms, M., Boulby, P., Wheeler-Kingshott, C., Barker, G., Koepp, M., Duncan, J., & Powell, R. (2005). MR tractography predicts visual field defects following temporal lobe resection. Neurology, 65(4), 596-599.
https://doi.org/10.1212/01.wnl.0000172858.20354.73, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39169
Powell, H., Koepp, M., Symms, M., Boulby, P., Salek-Haddadi, A., Thompson, P., Duncan, J., Richardson, M., & Powell, R. (2005). Material-specific lateralization of memory encoding in the medial temporal lobe: Blocked versus event-related design. NeuroImage, 27(1), 231-239.
https://doi.org/10.1016/j.neuroimage.2005.04.033, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39170
Robert Powell, H., J. Koepp, M., Richardson, M., Symms, M., Thompson, P., Duncan, J., & Powell, R. (2004). The Application of Functional MRI of Memory in Temporal Lobe Epilepsy: A Clinical Review. Epilepsia, 45(7), 855-863.
https://doi.org/10.1111/j.0013-9580.2004.41603.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39171
Powell, H., Guye, M., Parker, G., Symms, M., Boulby, P., Koepp, M., Barker, G., Duncan, J., & Powell, R. (2004). Noninvasive in vivo demonstration of the connections of the human parahippocampal gyrus. NeuroImage, 22(2), 740-747.
https://doi.org/10.1016/j.neuroimage.2004.01.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39172
Powell, R. (2004). Advances in imaging technology in epilepsy. Progress in Neurology and Psychiatry, 8, 11-13.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39229
Powell, R. (2003). Epilepsy and perisylvian polymicrogyria in a patient with Kabuki syndrome. Developmental Medicine and Child Neurology, 45(12), 841-843.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39173
Hamandi, K. & Powell, R. (2010). Diffusion MRI in Epilepsy. Diffusion MRI: Theory, Methods, and Applications -587). Oxford University Press
https://doi.org/10.1093/med/9780195369779.003.0035, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39227
Strafford, H., Lacey, A., Hollinghurst, J., Akbari, A., Watkins, A., Paterson, J., Jennings, D., Lyons, R., Powell, R., Kerr, M., Chin, R., & Pickrell, O. (2023). COVID-19 vaccination uptake in people with epilepsy in wales. Seizure, 108, 49-52.
https://doi.org/10.1016/j.seizure.2023.04.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63099
http://dx.doi.org/10.1016/j.seizure.2023.04.006
Strafford, H., Hollinghurst, J., Lacey, A., Akbari, A., Watkins, A., Paterson, J., Jennings, D., Lyons, R., Powell, R., Kerr, M., Chin, R., & Pickrell, O. (2024). Epilepsy and the risk of COVID-19-related hospitalization and death: A population study. Epilepsia, 0
https://doi.org/10.1111/epi.17910, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65804
Strafford, H., Hollinghurst, J., Lacey, A., Akbari, A., Watkins, A., Paterson, J., Jennings, D., Lyons, R., Powell, R., Kerr, M., Chin, R., & Pickrell, O. (2024). Health care utilization and mortality for people with epilepsy during COVID‐19: A population study. Epilepsia, 0
https://doi.org/10.1111/epi.17920, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65805

Holl Ymchwil

Erthyglau Cylchgronau

Strafford, H., Hollinghurst, J., Lacey, A., Akbari, A., Watkins, A., Paterson, J., Jennings, D., Lyons, R., Powell, R., Kerr, M., Chin, R., & Pickrell, O. (2024). Epilepsy and the risk of COVID-19-related hospitalization and death: A population study. Epilepsia, 0
https://doi.org/10.1111/epi.17910, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65804
Strafford, H., Hollinghurst, J., Lacey, A., Akbari, A., Watkins, A., Paterson, J., Jennings, D., Lyons, R., Powell, R., Kerr, M., Chin, R., & Pickrell, O. (2024). Health care utilization and mortality for people with epilepsy during COVID‐19: A population study. Epilepsia, 0
https://doi.org/10.1111/epi.17920, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65805
Strafford, H., Lacey, A., Hollinghurst, J., Akbari, A., Watkins, A., Paterson, J., Jennings, D., Lyons, R., Powell, R., Kerr, M., Chin, R., & Pickrell, O. (2023). COVID-19 vaccination uptake in people with epilepsy in wales. Seizure, 108, 49-52.
https://doi.org/10.1016/j.seizure.2023.04.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63099
http://dx.doi.org/10.1016/j.seizure.2023.04.006
Daniels, H., Lacey, A., Mikadze, D., Akbari, A., Fonferko-Shadrach, B., Hollinghurst, J., Lyons, R., Rees, M., Sawhney, I., Powell, R., Kerr, M., & Pickrell, O. (2022). Epilepsy mortality in Wales during COVID-19. Seizure - European Journal of Epilepsy, 94, 39-42.
https://doi.org/10.1016/j.seizure.2021.11.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58860
Stevelink, R., Luykx, J., Lin, B., Leu, C., Lal, D., Smith, A., Schijven, D., Carpay, J., Rademaker, K., Baldez, R., Devinsky, O., Braun, K., Jansen, F., Smit, D., Koeleman, B., Abou‐Khalil, B., Auce, P., Avbersek, A., Bahlo, M...., & Collaborative), . (2021). Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations. Epilepsia, 62(7), 1518-1527.
https://doi.org/10.1111/epi.16922, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60623
Lee‐Lane, E., Torabi, F., Lacey, A., Fonferko-Shadrach, B., Harris, D., Akbari, A., Lyons, R., Rees, M., Sawhney, I., Halcox, J., Powell, R., & Pickrell, O. (2021). Epilepsy, antiepileptic drugs, and the risk of major cardiovascular events. Epilepsia, 62(7), 1604-1616.
https://doi.org/10.1111/epi.16930, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56988
Motelow, J., Povysil, G., Dhindsa, R., Stanley, K., Allen, A., Feng, Y., Howrigan, D., Abbott, L., Tashman, K., Cerrato, F., Cusick, C., Singh, T., Heyne, H., Byrnes, A., Churchhouse, C., Watts, N., Solomonson, M., Lal, D., Gupta, N...., & Goldstein, D. (2021). Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals. The American Journal of Human Genetics, 108(6), 965-982.
https://doi.org/10.1016/j.ajhg.2021.04.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60620
Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J., Sills, G., Tudur-Smith, C., Plumpton, C., Hughes, D., Williamson, P., Baker, G., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R., Smith, P...., & Powell, R. (2021). The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. The Lancet, 397(10282), 1363-1374.
https://doi.org/10.1016/s0140-6736(21)00247-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60621
Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J., Sills, G., Tudur-Smith, C., Plumpton, C., Hughes, D., Williamson, P., Baker, G., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R., Smith, P...., & Powell, R. (2021). The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. The Lancet, 397(10282), 1375-1386.
https://doi.org/10.1016/s0140-6736(21)00246-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60619
Miah, L., Strafford, H., Fonferko-Shadrach, B., Hollinghurst, J., Sawhney, I., Hadjikoutis, S., Rees, M., Powell, R., Lacey, A., & Pickrell, O. (2021). Incidence, Prevalence, and Health Care Outcomes in Idiopathic Intracranial Hypertension. Neurology, 96(8), e1251-e1261.
https://doi.org/10.1212/wnl.0000000000011463, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56133
Niestroj, L., Perez-Palma, E., Howrigan, D., Zhou, Y., Cheng, F., Saarentaus, E., Nürnberg, P., Stevelink, R., Daly, M., Palotie, A., Lal, D., Feng, Y., Howrigan, D., Abbott, L., Tashman, K., Cerrato, F., Lal, D., Churchhouse, C., Gupta, N...., & Collaborative), . (2020). Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17 458 subjects. Brain, 143(7), 2106-2118.
https://doi.org/10.1093/brain/awaa171, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60622
Powell, R., Feng, Y., Howrigan, D., Abbott, L., Tashman, K., Cerrato, F., Singh, T., Heyne, H., Byrnes, A., Churchhouse, C., Watts, N., Solomonson, M., Lal, D., Heinzen, E., Dhindsa, R., Stanley, K., Cavalleri, G., Hakonarson, H., Helbig, I...., & Pickrell, O. (2019). Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals. The American Journal of Human Genetics, 105(2), 267-282.
https://doi.org/10.1016/j.ajhg.2019.05.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51398
Powell, R., Elwes, R., Hamandi, K., & Mullatti, N. (2018). Cingulate gyrus epilepsy. Practical Neurology, 18(6), 447-454.
https://doi.org/10.1136/practneurol-2017-001812, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60625
Wynford-Thomas, R., Powell, R., & Powell, R. (2017). Navigating the Island of Reil: how to understand the insular cortex. Practical Neurology, 17(2), 122-126.
https://doi.org/10.1136/practneurol-2016-001493, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39153
Fonferko-Shadrach, B., Lacey, A., White, C., Powell, H., Sawhney, I., Lyons, R., Smith, P., Kerr, M., Rees, M., Pickrell, W., Pickrell, O., & Powell, R. (2017). Validating epilepsy diagnoses in routinely collected data. Seizure, 52, 195-198.
https://doi.org/10.1016/j.seizure.2017.10.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38279
Hirst, C., Willis, M., Hussain, H., Powell, R., & Powell, R. (2015). Acute myeloid leucaemia presenting as a rapidly progressive polyradiculoneuropathy. BMJ Case Reports, 2015(nov17 2), bcr2015209556-bcr2015209556.
https://doi.org/10.1136/bcr-2015-209556, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39157
Caeyenberghs, K., Powell, H., Thomas, R., Brindley, L., Church, C., Evans, J., Muthukumaraswamy, S., Jones, D., Hamandi, K., & Powell, R. (2015). Hyperconnectivity in juvenile myoclonic epilepsy: A network analysis. NeuroImage: Clinical, 7, 98-104.
https://doi.org/10.1016/j.nicl.2014.11.018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39160
Powell, R., Hughes, T., & Powell, R. (2014). A chamber of secrets The neurology of the thalamus: lessons from acute stroke. Practical Neurology, 14(6), 440-445.
https://doi.org/10.1136/practneurol-2014-000852, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39154
Bonelli, S., Thompson, P., Yogarajah, M., Powell, R., Samson, R., McEvoy, A., Symms, M., Koepp, M., & Duncan, J. (2013). Memory reorganization following anterior temporal lobe resection: a longitudinal functional MRI study. Brain, 136(6), 1889-1900.
https://doi.org/10.1093/brain/awt105, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39175
Ali, K., Amin, R., Yoganathan, K., Powell, R., & Powell, R. (2013). Rapidly progressive cerebellar ataxia in West Wales. Case Reports, 2013(nov21 1), bcr2013201619-bcr2013201619.
https://doi.org/10.1136/bcr-2013-201619, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39158
Bonelli, S., Thompson, P., Yogarajah, M., Vollmar, C., Powell, R., Symms, M., McEvoy, A., Micallef, C., Koepp, M., & Duncan, J. (2012). Imaging language networks before and after anterior temporal lobe resection: Results of a longitudinal fMRI study. Epilepsia, 53(4), 639-650.
https://doi.org/10.1111/j.1528-1167.2012.03433.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39176
Powell, R., McLauchlan, D., & Powell, R. (2012). Acute symptomatic seizures. Practical Neurology, 12(3), 154-165.
https://doi.org/10.1136/practneurol-2012-000244, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39155
Bonelli, S., Powell, R., Thompson, P., Yogarajah, M., Focke, N., Stretton, J., Vollmar, C., Symms, M., Price, C., Duncan, J., Koepp, M., & Powell, R. (2011). Hippocampal activation correlates with visual confrontation naming: fMRI findings in controls and patients with temporal lobe epilepsy. Epilepsy Research, 95(3), 246-254.
https://doi.org/10.1016/j.eplepsyres.2011.04.007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39156
Bonelli, S., Powell, R., Yogarajah, M., Samson, R., Symms, M., Thompson, P., Koepp, M., Duncan, J., & Powell, R. (2010). Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection. Brain, 133(4), 1186-1199.
https://doi.org/10.1093/brain/awq006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39178
Bonelli, S., Powell, R., Yogarajah, M., Thompson, P., Symms, M., Koepp, M., & Duncan, J. (2009). Preoperative amygdala fMRI in temporal lobe epilepsy. Epilepsia, 50(2), 217-227.
https://doi.org/10.1111/j.1528-1167.2008.01739.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39179
Yogarajah, M., Powell, H., Heaney, D., Smith, S., Duncan, J., Sisodiya, S., & Powell, R. (2009). Long term monitoring in refractory epilepsy: the Gowers Unit experience. Journal of Neurology, Neurosurgery & Psychiatry, 80(3), 305-310.
https://doi.org/10.1136/jnnp.2008.144634, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39161
Yogarajah, M., Powell, H., Parker, G., Alexander, D., Thompson, P., Symms, M., Boulby, P., Wheeler-Kingshott, C., Barker, G., Koepp, M., Duncan, J., & Powell, R. (2008). Tractography of the parahippocampal gyrus and material specific memory impairment in unilateral temporal lobe epilepsy. NeuroImage, 40(4), 1755-1764.
https://doi.org/10.1016/j.neuroimage.2007.12.046, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39162
Hamandi, K., Powell, H., Laufs, H., Symms, M., Barker, G., Parker, G., Lemieux, L., Duncan, J., & Powell, R. (2008). Combined EEG-fMRI and tractography to visualise propagation of epileptic activity. Journal of Neurology, Neurosurgery & Psychiatry, 79(5), 594-597.
https://doi.org/10.1136/jnnp.2007.125401, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39163
Powell, H., Parker, G., Alexander, D., Symms, M., Boulby, P., Barker, G., Thompson, P., Koepp, M., Duncan, J., & Powell, R. (2008). Imaging language pathways predicts postoperative naming deficits. Journal of Neurology, Neurosurgery & Psychiatry, 79(3), 327-330.
https://doi.org/10.1136/jnnp.2007.126078, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39164
Powell, R. (2008). Examining the Nervous System. The Foundation Years, 4(4), 164-166.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39230
Powell, H., Richardson, M., Symms, M., Boulby, P., Thompson, P., Duncan, J., Koepp, M., & Powell, R. (2007). Preoperative fMRI predicts memory decline following anterior temporal lobe resection. Journal of Neurology, Neurosurgery & Psychiatry, 79(6), 686-693.
https://doi.org/10.1136/jnnp.2007.115139, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39165
Powell, H., Richardson, M., Symms, M., Boulby, P., Thompson, P., Duncan, J., Koepp, M., & Powell, R. (2007). Reorganization of Verbal and Nonverbal Memory in Temporal Lobe Epilepsy Due to Unilateral Hippocampal Sclerosis. Epilepsia, 48(8), 1512-1525.
https://doi.org/10.1111/j.1528-1167.2007.01053.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39166
Powell, H., Parker, G., Alexander, D., Symms, M., Boulby, P., Wheeler-Kingshott, C., Barker, G., Koepp, M., Duncan, J., & Powell, R. (2007). Abnormalities of language networks in temporal lobe epilepsy. NeuroImage, 36(1), 209-221.
https://doi.org/10.1016/j.neuroimage.2007.02.028, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39167
Powell, H., Parker, G., Alexander, D., Symms, M., Boulby, P., Wheeler-Kingshott, C., Barker, G., Noppeney, U., Koepp, M., Duncan, J., & Powell, R. (2006). Hemispheric asymmetries in language-related pathways: A combined functional MRI and tractography study. NeuroImage, 32(1), 388-399.
https://doi.org/10.1016/j.neuroimage.2006.03.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39168
Koepp, M., Hamandi, K., Symms, M., & Powell, R. (2006). Imaging structural and functional connectivity of the human thalamus. Future Neurology, 1, 153-157.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39231
Powell, R. (2005). Functional magnetic resonance imaging for assessment of language and memory in clinical practice.. Current Opinion in Neurology, 18(2), 161-166.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39174
Powell, H., Parker, G., Alexander, D., Symms, M., Boulby, P., Wheeler-Kingshott, C., Barker, G., Koepp, M., Duncan, J., & Powell, R. (2005). MR tractography predicts visual field defects following temporal lobe resection. Neurology, 65(4), 596-599.
https://doi.org/10.1212/01.wnl.0000172858.20354.73, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39169
Powell, H., Koepp, M., Symms, M., Boulby, P., Salek-Haddadi, A., Thompson, P., Duncan, J., Richardson, M., & Powell, R. (2005). Material-specific lateralization of memory encoding in the medial temporal lobe: Blocked versus event-related design. NeuroImage, 27(1), 231-239.
https://doi.org/10.1016/j.neuroimage.2005.04.033, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39170
Robert Powell, H., J. Koepp, M., Richardson, M., Symms, M., Thompson, P., Duncan, J., & Powell, R. (2004). The Application of Functional MRI of Memory in Temporal Lobe Epilepsy: A Clinical Review. Epilepsia, 45(7), 855-863.
https://doi.org/10.1111/j.0013-9580.2004.41603.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39171
Powell, H., Guye, M., Parker, G., Symms, M., Boulby, P., Koepp, M., Barker, G., Duncan, J., & Powell, R. (2004). Noninvasive in vivo demonstration of the connections of the human parahippocampal gyrus. NeuroImage, 22(2), 740-747.
https://doi.org/10.1016/j.neuroimage.2004.01.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39172
Powell, R. (2004). Advances in imaging technology in epilepsy. Progress in Neurology and Psychiatry, 8, 11-13.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39229
Powell, R. (2003). Epilepsy and perisylvian polymicrogyria in a patient with Kabuki syndrome. Developmental Medicine and Child Neurology, 45(12), 841-843.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39173

Penodau Llyfrau

Hamandi, K. & Powell, R. (2010). Diffusion MRI in Epilepsy. Diffusion MRI: Theory, Methods, and Applications -587). Oxford University Press
https://doi.org/10.1093/med/9780195369779.003.0035, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39227

Cyfraniadau Cynadleddau

Daniels, H., Lacey, A., Akbari, A., Powell, R., & Pickrell, O. (2019). Epilepsy Mortality in Wales: 2005-2017. In International Journal of Population Data ScienceSwansea University.
https://doi.org/10.23889/ijpds.v4i3.1277, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53657

Modiwlau a Addysgir

PM-276 Neuroanatomy and neurology

Building on `An introduction to Neuroscience¿ this module will combine fundamental neuroscience with clinical neurology to provide a comprehensive understanding of the nervous system in health and disease.