Yr Athro William Griffiths

Athro mewn Sbectrometreg Màs, Biomedical Sciences

+44 (0) 1792 295562

w.j.griffiths@abertawe.ac.uk

Siaradwr Cymraeg Sylfaenol

303
Trydydd Llawr - Neuroscience
Y Sefydliad Gwyddor Bywyd 1
Campws Singleton

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

https://orcid.org/0000-0002-4129-6616

ResearchGate

ResearcherID

Scopus

Trosolwg

Yr Athro William J Griffiths (WJG) mewn cyfuniad â'r Athro Yuqin Wang sy'n arwain Grŵp Ymchwil Oxysterol Prifysgol Abertawe. Ffocws ymchwil y grŵp yw astudio biosynthesis colesterol a metaboledd a sut mae'n amrywio o ran iechyd a chlefydau, yn enwedig clefyd niwroddirywiol. Mae'r grŵp yn defnyddio ac yn datblygu dulliau sbectrometreg màs datblygedig i gyflawni'r nod hwn.

Derbyniodd WJG ei BSc a'i PhD mewn Cemeg o Goleg Prifysgol, Caerdydd, ar y pryd yn rhan o Brifysgol Cymru. Cafodd ei hyfforddi mewn sbectrometreg màs biofeddygol yn Sefydliad Karolinska yn Stockholm ac enillodd gymhwyster addysgu Prifysgol ohono. Mae WJG wedi dal swyddi academaidd ym Mhrifysgol India'r Gorllewin, Kingston Jamaica; Sefydliad Karolinska; a'r Ysgol Fferylliaeth, Prifysgol Llundain. Symudodd WJG i Abertawe yn 2007 i gymryd Cadeirydd Sbectrometreg Torfol yn yr Ysgol Feddygol.

Mae diddordebau ymchwil WJG mewn lipidomeg, biosynthesis asid bustl a biocemeg lipid, yn enwedig mewn perthynas â chlefyd niwroddirywiol a'r system imiwnedd. Mae gan WJG fwy na 250 o gyhoeddiadau gyda mwy na 7,000 o ddyfyniadau. Mae WJG wedi golygu dau lyfr. Mae WJG yn eistedd ar fwrdd golygyddol y Journal of Lipid Reseach ac o Clinical Mass Spectrometry. Mae WJG yn aelod o'r pwyllgor enwi Mapiau Lipid Rhyngwladol.

Chwaraeodd WJG undeb rygbi rhyngwladol i Jamaica yn ystod ei gyfnod ym Mhrifysgol India'r Gorllewin.

Meysydd Arbenigedd

Metaboledd colesterol
Oxysterols
Asidau bustl
Gwallau metaboledd colesterol
Sbectrometreg torfol
Delweddu sbectrometreg màs
Lipidomeg
Clefyd niwroddirywiol

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Mae WJG yn dysgu myfyrwyr israddedig ac ôl-raddedig ym meysydd biocemeg lipid a sbectrometreg màs biofeddygol. WJG yw cynrychiolydd Abertawe i grŵp rheoli Partneriaeth Hyfforddiant Doethurol Biowyddorau De Orllewin Lloegr a ariennir gan BBSRC.

Ymchwil Prif Wobrau Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Ahmed, H., Wang, Y., Griffiths, W., Levey, A., Pikuleva, I., Liang, S., & Haider, A. (2024). Brain cholesterol and Alzheimer’s disease: challenges and opportunities in probe and drug development. Brain, 0
https://doi.org/10.1093/brain/awae028, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65566
Latorre-Leal, M., Rodriguez-Rodriguez, P., Franchini, L., Nikolidakis, O., Daniilidou, M., Delac, L., Varshney, M., Arroyo-García, L., Eroli, F., Winblad, B., Blennow, K., Zetterberg, H., Kivipelto, M., Pacciarini, M., Wang, Y., Griffiths, W., Björkhem, I., Matton, A., Nalvarte, I...., & Maioli, S. (2024). CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice. Science Advances, 10(4)
https://doi.org/10.1126/sciadv.adj1354, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65333
Hennegan, J., Bryant, A., Griffiths, L., Trigano, M., Bartley, O., Bartlett, J., Minahan, C., Oliveira, W., Yutuc, E., Ntikas, S., Bartsocas, C., Markouri, M., Antoniadou, E., Laina, I., Howell, O., Li, M., Wang, Y., Griffiths, W., Lane, E...., & Theofilopoulos, S. (2024). Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development. iScience, 27(1), 108670
https://doi.org/10.1016/j.isci.2023.108670, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65068
Griffiths, W., Yutuc, E., Ali Asgari, M., & Wang, Y. (2023). Role of Bile Acid Pathway Intermediates in Pathology of CTX
https://doi.org/10.5281/zenodo.10050199, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64910
Conroy, M., Andrews, R., Andrews, S., Cockayne, L., Dennis, E., Fahy, E., Gaud, C., Griffiths, W., Jukes, G., Kolchin, M., Mendivelso, K., Lopez-Clavijo, A., Ready, C., Subramaniam, S., & O’Donnell, V. (2023). LIPID MAPS: update to databases and tools for the lipidomics community. Nucleic Acids Research
https://doi.org/10.1093/nar/gkad896, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64901
http://dx.doi.org/10.1093/nar/gkad896
Griffiths, W., Yutuc, E., & Wang, Y. (2023). Mass Spectrometry Imaging of Cholesterol and Oxysterols. Implication of Oxysterols and Phytosterols in Aging and Human Diseases (pp. 73-87). Springer International Publishing
https://doi.org/10.1007/978-3-031-43883-7_5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64898
Daniilidou, M., Eroli, F., Alanko, V., Goikolea, J., Latorre-Leal, M., Rodriguez-Rodriguez, P., Griffiths, W., Wang, Y., Pacciarini, M., Brinkmalm, A., Zetterberg, H., Blennow, K., Rosenberg, A., Bogdanovic, N., Winblad, B., Kivipelto, M., Ibghi, D., Cedazo-Minguez, A., Maioli, S., & Matton, A. (2023). Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities. Brain Communications, 5(5)
https://doi.org/10.1093/braincomms/fcad228, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63624
http://dx.doi.org/10.1093/braincomms/fcad228
Dickson, A., Yutuc, E., Thornton, C., Dunford, J., Oppermann, U., Wang, Y., & Griffiths, W. (2023). HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta. Open Biology, 13(5)
https://doi.org/10.1098/rsob.220313, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61629
http://dx.doi.org/10.1098/rsob.220313
Dickson, A., Yutuc, E., Thornton, C., Wang, Y., & Griffiths, W. (2022). Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry. Frontiers in Endocrinology, 13
https://doi.org/10.3389/fendo.2022.1031013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61630
Haider, A., Zhao, C., Wang, L., Xiao, Z., Rong, J., Xia, X., Chen, Z., Pfister, S., Mast, N., Yutuc, E., Chen, J., Li, Y., Shao, T., Warnock, G., Dawoud, A., Connors, T., Oakley, D., Wei, H., Wang, J...., & Liang, S. (2022). Assessment of cholesterol homeostasis in the living human brain. Science Translational Medicine, 14(665)
https://doi.org/10.1126/scitranslmed.adc9967, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61471
McDonald, J., Ejsing, C., Kopczynski, D., Holčapek, M., Aoki, J., Arita, M., Arita, M., Baker, E., Bertrand-Michel, J., Bowden, J., Brügger, B., Ellis, S., Fedorova, M., Griffiths, W., Han, X., Hartler, J., Hoffmann, N., Koelmel, J., Köfeler, H...., & Ekroos, K. (2022). Introducing the Lipidomics Minimal Reporting Checklist. Nature Metabolism, 4(9), 1086-1088.
https://doi.org/10.1038/s42255-022-00628-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60824
Ghzaiel, I., Sassi, K., Zarrouk, A., Ghosh, S., Dias, I., Nury, T., Ksila, M., Essadek, S., Joutey, M., Brahmi, F., Mihoubi, W., Rup-Jacques, S., Samadi, M., Rezig, L., Meziane, S., Ghrairi, T., Masmoudi-Kouki, O., Hammami, S., Nasser, B...., & Lizard, G. (2022). Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications. Redox Experimental Medicine, 2022(1), R40-R56.
https://doi.org/10.1530/rem-22-0005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60624
Saud, Z., Tyrrell, V., Zaragkoulias, A., Protty, M., Statkute, E., Rubina, A., Bentley, K., White, D., Rodrigues, P., Murphy, R., Köfeler, H., Griffiths, W., Alvarez-Jarreta, J., Brown, R., Newcombe, R., Heyman, J., Pritchard, M., Mcleod, R., Arya, A...., & Stanton, R. (2022). The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research, 63(6), 100208
https://doi.org/10.1016/j.jlr.2022.100208, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60471
Griffiths, W. & Wang, Y. (2021). Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development. Frontiers in Physiology, 12
https://doi.org/10.3389/fphys.2021.723224, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57898
Griffiths, W. & Wang, Y. (2022). Cholesterol metabolism: from lipidomics to immunology. Journal of Lipid Research, 63(2), 100165
https://doi.org/10.1016/j.jlr.2021.100165, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59064
Angelini, R., Yutuc, E., Wyatt, M., Newton, J., Yusuf, F., Griffiths, L., Cooze, B., Assad, D., Frache, G., Rao, W., Allen, L., Korade, Z., Nguyen, T., Rathnayake, R., Cologna, S., Howell, O., Clench, M., Wang, Y., & Griffiths, W. (2020). Visualising Cholesterol in Brain by On-Tissue Derivatisation and Quantitative Mass Spectrometry Imaging. bioRxiv
https://doi.org/10.1101/2020.11.06.369447, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60125
Horlock, A., Ormsby, T., Owens, S., Horlock, A., Davies, D., Griffiths, W., Wang, Y., Cronin, J., Bromfield, J., & Sheldon, M. (2021). Oxysterols protect bovine endometrial cells against pore‐forming toxins from pathogenic bacteria. The FASEB Journal, 35(10), 1-21.
https://doi.org/10.1096/fj.202100036r, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57632
Köfeler, H., Eichmann, T., Ahrends, R., Bowden, J., Danne-Rasche, N., Dennis, E., Fedorova, M., Griffiths, W., Han, X., Hartler, J., Holčapek, M., Jirásko, R., Koelmel, J., Ejsing, C., Liebisch, G., Ni, Z., O’Donnell, V., Quehenberger, O., Schwudke, D...., & Ekroos, K. (2021). Quality control requirements for the correct annotation of lipidomics data. Nature Communications, 12(1)
https://doi.org/10.1038/s41467-021-24984-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57631
Höflinger, P., Hauser, S., Yutuc, E., Hengel, H., Griffiths, L., Radelfahr, F., Howell, O., Wang, Y., Connor, S., Duell, P., DeBarber, A., Martus, P., Lütjohann, D., Griffiths, W., & Schöls, L. (2021). Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis. Journal of Lipid Research, 62, 100078
https://doi.org/10.1016/j.jlr.2021.100078, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56747
Griffiths, W., Abdel-Khalik, J., Moore, S., Wijeyekoon, R., Crick, P., Yutuc, E., Farrell, K., Breen, D., Williams-Gray, C., Theofilopoulos, S., Arenas, E., Trupp, M., Barker, R., & Wang, Y. (2021). The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features. Frontiers in Aging Neuroscience, 13, 685594
https://doi.org/10.3389/fnagi.2021.685594, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57043
Griffiths, W. (n.d.) Profiling the Lipidome requires quality control
https://doi.org/10.5281/zenodo.4672232, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56656
Angelini, R., Yutuc, E., Wyatt, M., Newton, J., YUSUF, F., Griffiths, L., Cooze, B., Assad, D., Frache, G., Rao, W., Allen, L., Korade, Z., Nguyen, T., Rathnayake, R., Cologna, S., Howell, O., Clench, M., Wang, Y., & Griffiths, W. (2021). Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging. Analytical Chemistry, 93(11), 4932-4943.
https://doi.org/10.1021/acs.analchem.0c05399, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56326
http://dx.doi.org/10.1021/acs.analchem.0c05399
Yutuc, E., Dickson, A., Pacciarini, M., Griffiths, L., Baker, P., Connell, L., Öhman, A., Forsgren, L., Trupp, M., Vilarinho, S., Khalil, Y., Clayton, P., Sari, S., Dalgic, B., Höflinger, P., Schöls, L., Griffiths, W., & Wang, Y. (2021). Deep mining of oxysterols and cholestenoic acids in human plasma and cerebrospinal fluid: Quantification using isotope dilution mass spectrometry. Analytica Chimica Acta, 1154, 338259
https://doi.org/10.1016/j.aca.2021.338259, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56163
Wang, Y., Yutuc, E., & Griffiths, W. (2021). Cholesterol metabolism pathways – are the intermediates more important than the products?. The FEBS Journal, 288(12), 3727-3745.
https://doi.org/10.1111/febs.15727, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56158
Hajeyah, A., Griffiths, W., Wang, Y., Finch, A., & O’Donnell, V. (2020). The Biosynthesis of Enzymatically Oxidized Lipids. Frontiers in Endocrinology, 11
https://doi.org/10.3389/fendo.2020.591819, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55699
Abdel-Khalik, J., Hearn, T., Dickson, A., Crick, P., Yutuc, E., Austin-Muttitt, K., Bigger, B., Morris, A., Shackleton, C., Clayton, P., Iida, T., Sircar, R., Rohatgi, R., Marschall, H., Sjövall, J., Björkhem, I., Mullins, J., Griffiths, W., & Wang, Y. (2021). Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates. The Journal of Steroid Biochemistry and Molecular Biology, 206, 105794
https://doi.org/10.1016/j.jsbmb.2020.105794, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55690
Zang, R., Case, J., Yutuc, E., Ma, X., Shen, S., Castro, M., Liu, Z., Zeng, Q., Zhao, H., Son, J., Rothlauf, P., Kreutzberger, A., Hou, G., Zhang, H., Bose, S., Wang, X., Vahey, M., Mani, K., Griffiths, W...., & Ding, S. (2020). Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Proceedings of the National Academy of Sciences, 117(50), 32105-32113.
https://doi.org/10.1073/pnas.2012197117, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55583
Wang, Y., Yutuc, E., & Griffiths, W. (2020). Standardizing and increasing the utility of lipidomics: a look to the next decade. Expert Review of Proteomics, 17(10), 699-717.
https://doi.org/10.1080/14789450.2020.1847086, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55597
Baloni, P., Funk, C., Yan, J., Yurkovich, J., Kueider-Paisley, A., Nho, K., Heinken, A., Jia, W., Mahmoudiandehkordi, S., Louie, G., Saykin, A., Arnold, M., Kastenmüller, G., Griffiths, W., Thiele, I., Kaddurah-Daouk, R., Price, N., Kaddurah-Daouk, R., Kueider-Paisley, A...., & Moreno, H. (2020). Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease. Cell Reports Medicine, 1(8), 100138
https://doi.org/10.1016/j.xcrm.2020.100138, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55544
Liebisch, G., Fahy, E., Aoki, J., Dennis, E., Durand, T., Ejsing, C., Fedorova, M., Feussner, I., Griffiths, W., Köfeler, H., Merrill, A., Murphy, R., O’Donnell, V., Oskolkova, O., Subramaniam, S., Wakelam, M., & Spener, F. (2020). Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures. Journal of Lipid Research, 61(12), 1539-1555.
https://doi.org/10.1194/jlr.s120001025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55457
Ogundare, M., Theofilopoulos, S., Lockhart, A., Hall, L., Arenas, E., Sjövall, J., Brenton, A., Wang, Y., Griffiths, W., Brenton, A., & Gregory, S. (2009). Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain?. Journal of Biological Chemistry, 285(7), 4666-4679.
https://doi.org/10.1074/jbc.M109.086678, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9808
Wang, Y., Muneton, S., Sjövall, J., Jovanovic, J., & Griffiths, W. (2008). The Effect of 24S-Hydroxycholesterol on Cholesterol Homeostasis in Neurons: Quantitative Changes to the Cortical Neuron Proteome. Journal of Proteome Research, 7(4), 1606-1614.
https://doi.org/10.1021/pr7006076, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10007
Griffiths, W., Hornshaw, M., Woffendin, G., Baker, S., Lockhart, A., Heidelberger, S., Gustafsson, M., Sjövall, J., & Wang, Y. (2008). Discovering Oxysterols in Plasma: A Window on the Metabolome. Journal of Proteome Research, 7(8), 3602-3612.
https://doi.org/10.1021/pr8001639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10200
Wang, Y., Sousa, K., Bodin, K., Griffiths, W., & Wang, Y. (2009). Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Molecular BioSystems, 5, 529-41.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10201
Karu, K., Hornshaw, M., Woffendin, G., Bodin, K., Hamberg, M., Alvelius, G., Sjovall, J., Turton, J., Wang, Y., Griffiths, W., Griffiths, W., & Wang, Y. (2007). Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. The Journal of Lipid Research, 48(4), 976-987.
https://doi.org/10.1194/jlr.M600497-JLR200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1359
Wang, Y., Hornshaw, M., Alvelius, G., Bodin, K., Liu, S., Sjövall, J., & Griffiths, W. (2006). Matrix-Assisted Laser Desorption/Ionization High-Energy Collision-Induced Dissociation of Steroids: Analysis of Oxysterols in Rat Brain. Analytical Chemistry, 78(1), 164-173.
https://doi.org/10.1021/ac051461b, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1360
Griffiths, W., Wang, Y., Alvelius, G., Liu, S., Bodin, K., & Sjövall, J. (2006). Analysis of oxysterols by electrospray tandem mass spectrometry. Journal of the American Society for Mass Spectrometry, 17(3), 341-362.
https://doi.org/10.1016/j.jasms.2005.10.012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1361
Wang, Y. & Griffiths, W. (2008). Capillary liquid chromatography combined with tandem mass spectrometry for the study of neurosteroids and oxysterols in brain. Neurochemistry International, 52(4-5), 506-521.
https://doi.org/10.1016/j.neuint.2007.07.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19142
Robertson, K., Hsieh, W., Forster, T., Blanc, M., Lu, H., Crick, P., Yutuc, E., Watterson, S., Martin, K., Griffiths, S., Enright, A., Yamamoto, M., Pradeepa, M., Lennox, K., Behlke, M., Talbot, S., Haas, J., Dölken, L., Griffiths, W...., & Ghazal, P. (2016). An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway. PLOS Biology, 14(3), e1002364
https://doi.org/10.1371/journal.pbio.1002364, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27043
Kurowska-Stolarska, M., Hasoo, M., Welsh, D., Stewart, L., McIntyre, D., Morton, B., Johnstone, S., Miller, A., Asquith, D., Millar, N., Millar, A., Feghali-Bostwick, C., Hirani, N., Crick, P., Wang, Y., Griffiths, W., McInnes, I., & McSharry, C. (2017). The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis. Journal of Allergy and Clinical Immunology, 139(6), 1946-1956.
https://doi.org/10.1016/j.jaci.2016.09.021, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30968
Theofilopoulos, S., Wang, Y., Kitambi, S., Sacchetti, P., Sousa, K., Bodin, K., Kirk, J., Saltó, C., Gustafsson, M., Toledo, E., Karu, K., Gustafsson, J., Steffensen, K., Ernfors, P., Sjövall, J., Griffiths, W., & Arenas, E. (2013). Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nature Chemical Biology, 9(2), 126-133.
https://doi.org/10.1038/nchembio.1156, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34740
http://dx.doi.org/10.1038/nchembio.1156
Theofilopoulos, S., Griffiths, W., Crick, P., Yang, S., Meljon, A., Ogundare, M., Kitambi, S., Lockhart, A., Tuschl, K., Clayton, P., Morris, A., Martinez, A., Reddy, M., Martinuzzi, A., Bassi, M., Honda, A., Mizuochi, T., Kimura, A., Nittono, H...., & Wang, Y. (2014). Cholestenoic acids regulate motor neuron survival via liver X receptors. Journal of Clinical Investigation, 124(11), 4829-4842.
https://doi.org/10.1172/jci68506, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34741
http://dx.doi.org/10.1172/jci68506
Theofilopoulos, S., Oliveira, W., Yang, S., Yutuc, E., Saeed, A., Abdel-Khalik, J., Ullgren, A., Cedazo-Minguez, A., Björkhem, I., Wang, Y., Griffiths, W., & Arenas, E. (2019). 24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo. Journal of Biological Chemistry, 294(11), 4169-4176.
https://doi.org/10.1074/jbc.ra118.005639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48277
http://dx.doi.org/10.1074/jbc.ra118.005639
Griffiths, W., Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Howell, O., & Wang, Y. (2018). Imaging Oxysterols in Mouse Brain by On-Tissue Derivatisation-Robotic Liquid Micro-Extraction Surface Analysis-Liquid Chromatography Mass Spectrometry
https://doi.org/10.1101/450973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48402
Meljon, A., Crick, P., Yutuc, E., Yau, J., Seckl, J., Theofilopoulos, S., Arenas, E., Wang, Y., & Griffiths, W. (2019). Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5. Biomolecules, 9(4), 149
https://doi.org/10.3390/biom9040149, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50029
Griffiths, W., Wang, Y., Brenton, A., Hall, L., Arenas, E., Lockhart, A., Theofilopoulos, S., Sjövall, J., & Ogundare, M. (2010). Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain?. Journal of Biological Chemistry, 285(7), 4666-4679.
https://doi.org/10.1074/jbc.m109.086678, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52579
http://dx.doi.org/10.1074/jbc.m109.086678
Griffiths, W., Arenas, E., Sjövall, J., Karu, K., Theofilopoulos, S., Hornshaw, M., Sacchetti, P., Bodin, K., Sousa, K., Woffendin, G., & Wang, Y. (2009). Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Molecular BioSystems, 5(5), 529
https://doi.org/10.1039/b819502a, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52580
http://dx.doi.org/10.1039/b819502a
Griffiths, W. & Wang, Y. (2020). Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites. Prostaglandins & Other Lipid Mediators, 147, 106381
https://doi.org/10.1016/j.prostaglandins.2019.106381, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52696
Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., & Griffiths, W. (2019). Imaging Sterols and Oxysterols in Mouse Brain Reveals Distinct Spatial Cholesterol Metabolism
https://doi.org/10.1101/450973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53208
Hudson, N., Reverter, A., Griffiths, W., Yutuc, E., Wang, Y., Jeanes, A., McWilliam, S., Pethick, D., & Greenwood, P. (2020). Gene expression identifies metabolic and functional differences between intramuscular and subcutaneous adipocytes in cattle. BMC Genomics, 21(1)
https://doi.org/10.1186/s12864-020-6505-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53490
Griffiths, W. & Wang, Y. (2020). Lipidomics Royal Society of Chemistry.
https://doi.org/10.1039/9781788013109, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53522
http://dx.doi.org/10.1039/9781788013109
Griffiths, W. & Wang, Y. (2020). CHAPTER 10. New Scans and Resources in Lipidomics. New Developments in Mass Spectrometry (pp. 263-282). Royal Society of Chemistry
https://doi.org/10.1039/9781788013109-00263, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53523
Wang, Y. & Griffiths, W. (2020). CHAPTER 6. Derivatisation for Direct Infusion– and Liquid Chromatography–Mass Spectrometry. New Developments in Mass Spectrometry (pp. 122-147). Royal Society of Chemistry
https://doi.org/10.1039/9781788013109-00122, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53524
Griffiths, W., Yutuc, E., Davies, D., Dickson, A., Angelini, R., Assad, D., Frache, G., & Wang, Y. (2020). CHAPTER 1. Lipidomics Basics. New Developments in Mass Spectrometry (pp. 1-24). Royal Society of Chemistry
https://doi.org/10.1039/9781788013109-00001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53525
Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., & Griffiths, W. (2020). Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism. Proceedings of the National Academy of Sciences, 117(11), 5749-5760.
https://doi.org/10.1073/pnas.1917421117, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53792
Wang, Y., Yutuc, E., & Griffiths, W. (2021). Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors. British Journal of Pharmacology, 178(16), 3176-3193.
https://doi.org/10.1111/bph.15191, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54644
Yutuc, E., Crick, P., Yutuc, E., Abdel-Khalik, J., Saeed, A., Betsholtz, C., Genove, G., Björkhem, I., Wang, Y., & Griffiths, W. (2019). Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse. The Journal of Steroid Biochemistry and Molecular Biology, 195, 105475
https://doi.org/10.1016/j.jsbmb.2019.105475, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51994
Griffiths, W. (2019). Lipidomics needs more standardization. Nature Metabolism
https://doi.org/10.1038/s42255-019-0094-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51034
Raselli, T., Hearn, T., Wyss, A., Atrott, K., Peter, A., Frey-Wagner, I., Spalinger, M., Maggio, E., Sailer, A., Schmitt, J., Schreiner, P., Moncsek, A., Mertens, J., Scharl, M., Griffiths, W., Bueter, M., Geier, A., Rogler, G., Wang, Y., & Misselwitz, B. (2019). Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis. Journal of Lipid Research, 60(7), 1270-1283.
https://doi.org/10.1194/jlr.M093229, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50635
Yutuc, E., Griffiths, W., Yutuc, E., Abdel-Khalik, J., Crick, P., Hearn, T., Dickson, A., Bigger, B., Wu, T., Goenka, A., Ghosh, A., Jones, S., Covey, D., Ory, D., & Wang, Y. (2019). Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders. Free Radical Biology and Medicine
https://doi.org/10.1016/j.freeradbiomed.2019.04.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50061
Lütjohann, D., Björkhem, I., Friedrichs, S., Kerksiek, A., Lövgren-Sandblom, A., Geilenkeuser, W., Ahrends, R., Andrade, I., Ansorena, D., Astiasarán, I., Baila-Rueda, L., Barriuso, B., Becker, S., Bretillon, L., Browne, R., Caccia, C., Ceglarek, U., Cenarro, A., Crick, P...., & Schött, H. (2019). First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods. The Journal of Steroid Biochemistry and Molecular Biology, 190, 115-125.
https://doi.org/10.1016/j.jsbmb.2019.03.025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49899
Griffiths, W. & Wang, Y. (2019). Oxysterol research: a brief review. Biochemical Society Transactions, 47(2), 517-526.
https://doi.org/10.1042/BST20180135, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49840
Yutuc, E., Abdel-Khalik, J., Crick, P., Yutuc, E., Wang, Y., & Griffiths, W. (2019). Developing an Enzyme-Assisted Derivatization Method for Analysis of C27 Bile Alcohols and Acids by Electrospray Ionization-Mass Spectrometry. Molecules, 24(3), 597
https://doi.org/10.3390/molecules24030597, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48910
Griffiths, W., Abdel-Khalik, J., Yutuc, E., Roman, G., Warner, M., Gustafsson, J., & Wang, Y. (2019). Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients. Free Radical Biology and Medicine, 134, 42-52.
https://doi.org/10.1016/j.freeradbiomed.2018.12.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48010
Griffiths, W., Crick, P., Meljon, A., Theofilopoulos, S., Abdel-Khalik, J., Yutuc, E., Parker, J., Kelly, D., Kelly, S., Arenas, E., & Wang, Y. (2019). Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1864(2), 191-211.
https://doi.org/10.1016/j.bbalip.2018.11.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa46057
http://dx.doi.org/10.1016/j.bbalip.2018.11.006
Griffiths, W. & Wang, Y. (2019). Sterolomics in biology, biochemistry, medicine. TrAC Trends in Analytical Chemistry, 120, 115280
https://doi.org/10.1016/j.trac.2018.10.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45237
Lütjohann, D., Björkhem, I., Friedrichs, S., Kerksiek, A., Geilenkeuser, W., Lövgren-Sandblom, A., Ansorena, D., Astiasarán, I., Baila-Rueda, L., Barriuso, B., Bretillon, L., Browne, R., Caccia, C., Cenarro, A., Crick, P., Fauler, G., García-Llatas, G., Griffiths, W., Iuliano, L...., & Schött, H. (2018). International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods. Biochimie, 153, 26-32.
https://doi.org/10.1016/j.biochi.2018.07.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43215
Abdel-Khalik, J., Crick, P., Yutuc, E., DeBarber, A., Duell, P., Steiner, R., Laina, I., Wang, Y., & Griffiths, W. (2018). Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma. Biochimie
https://doi.org/10.1016/j.biochi.2018.06.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40916
Griffiths, W., Gilmore, I., Yutuc, E., Abdel-Khalik, J., Crick, P., Hearn, T., Dickson, A., Bigger, B., Wu, T., Goenka, A., Ghosh, A., Jones, S., & Wang, Y. (2018). Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation. Journal of Lipid Research, 59(6), 1058-1070.
https://doi.org/10.1194/jlr.d083246, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39367
Bezine, M., Maatoug, S., Ben Khalifa, R., Debbabi, M., Zarrouk, A., Wang, Y., Griffiths, W., Nury, T., Samadi, M., Vejux, A., de Sèze, J., Moreau, T., Kharrat, R., El Ayeb, M., & Lizard, G. (2018). Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0). Biochimie
https://doi.org/10.1016/j.biochi.2018.02.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38836
Griffiths, W. & Wang, Y. (2018). An update on oxysterol biochemistry: New discoveries in lipidomics. Biochemical and Biophysical Research Communications, 504(3), 617-622.
https://doi.org/10.1016/j.bbrc.2018.02.019, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38513
Wang, Y. & Griffiths, W. (2017). Unravelling new pathways of sterol metabolism. Current Opinion in Clinical Nutrition and Metabolic Care, 1
https://doi.org/10.1097/MCO.0000000000000442, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37645
Griffiths, W. & Wang, Y. (2017). Sterolomics: State of the Art, Developments, Limitations and Challenges. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
https://doi.org/10.1016/j.bbalip.2017.03.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32631
Rees, D., Crick, P., Jenkins, G., Wang, Y., Griffiths, W., Brown, T., & Al-Sarireh, B. (2017). Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease. The Journal of Steroid Biochemistry and Molecular Biology, 174, 290-295.
https://doi.org/10.1016/j.jsbmb.2017.10.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36199
Griffiths, W. (n.d.) Metabolomics, Metabonomics and Metabolite Profiling
https://doi.org/10.1039/9781847558107-fp005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49854
Griffiths, W. (n.d.) Metabolomics, Metabonomics and Metabolite Profiling
https://doi.org/10.1039/9781847558107-fp001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49853
Griffiths, W. (n.d.) Metabolomics, Metabonomics and Metabolite Profiling
https://doi.org/10.1039/9781847558107-fp006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49852
Marschall, H., Griffiths, W., Götze, U., Zhang, J., Wietholtz, H., Busch, N., Sjövall, J., & Matern, S. (1994). The major metabolites of ursodeoxycholic acid in human urine are conjugated withN-acetylglucosamine. Hepatology, 20(4), 845-853.
https://doi.org/10.1002/hep.1840200412, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49851
Griffiths, W., Zhang, J., & Sjövall, J. (1994). Charge-remote fragmentation of sulphated and glucuronidated bile acids and their 2-aminoethanesulphonic acid derivatives. Rapid Communications in Mass Spectrometry, 8(3), 227-236.
https://doi.org/10.1002/rcm.1290080302, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49850
Lindh, I., Griffiths, W., Bergman, T., & Sjövall, J. (1994). Charge-remote fragmentation of peptides derivatized with 4-aminonaphthalenesulphonic acid. Rapid Communications in Mass Spectrometry, 8(10), 797-803.
https://doi.org/10.1002/rcm.1290081002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49849
Griffiths, W., Lindh, I., Bergman, T., & Sjövall, J. (1995). Negative-ion electrospray mass spectra of peptides derivatized with 4-aminonaphthalenesulphonic acid. Rapid Communications in Mass Spectrometry, 9(8), 667-676.
https://doi.org/10.1002/rcm.1290090809, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49848
Yang, Y., Griffiths, W., Lindgren, J., Sjövall, J., & Griffiths, W. (1995). Liquid chromatography/mass spectrometry with collision-induced dissociation of arachidonic acid metabolites derivatized with aminobenzenesulphonic acid. Rapid Communications in Mass Spectrometry, 9(4), 289-299.
https://doi.org/10.1002/rcm.1290090407, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49847
Severs, J., Griffiths, W., Harris, F., Andrews, S., Parry, D., & Griffiths, W. (1996). Double ionization of the n-alkyl iodides C2H5I, C3H7I and C4H9I. Journal of the Chemical Society, Faraday Transactions, 92(18), 3293
https://doi.org/10.1039/ft9969203293, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49846
Jornvall, H., Griffiths, W., & Bergman, T. (2002). Encyclopedia of Molecular Biology
https://doi.org/10.1002/047120918x.emb1233, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49845
J��rnvall, H., Griffiths, W., & Bergman, T. (2002). Encyclopedia of Molecular Biology
https://doi.org/10.1002/047120918x.emb0353, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49844
Griffiths, W. (2007). Separation and identification of cholesterol metabolites in rat brain using LC-MSⁿ.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49843
Griffiths, W. (2010). Targeted Steroidomic Analysis by 'charge-tagging' and MS n.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49842
Griffiths, W., Hearn, T., Crick, P., Abdel-Khalik, J., Dickson, A., Yutuc, E., & Wang, Y. (2017). Charge-tagging liquid chromatography–mass spectrometry methodology targeting oxysterol diastereoisomers. Chemistry and Physics of Lipids, 207, 69-80.
https://doi.org/10.1016/j.chemphyslip.2017.04.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32978
Griffiths, W., Abdel-Khalik, J., Yutuc, E., Morgan, A., Gilmore, I., Hearn, T., & Wang, Y. (2017). Cholesterolomics: An update. Analytical Biochemistry
https://doi.org/10.1016/j.ab.2017.01.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31729
Abdel-Khalik, J., Yutuc, E., Crick, P., Gustafsson, J., Warner, M., Roman, G., Talbot, K., Gray, E., Griffiths, W., Turner, M., & Wang, Y. (2017). Defective cholesterol metabolism in amyotrophic lateral sclerosis. Journal of Lipid Research, jlr.P071639
https://doi.org/10.1194/jlr.P071639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30987

Holl Ymchwil

Erthyglau Cylchgronau

Ahmed, H., Wang, Y., Griffiths, W., Levey, A., Pikuleva, I., Liang, S., & Haider, A. (2024). Brain cholesterol and Alzheimer’s disease: challenges and opportunities in probe and drug development. Brain, 0
https://doi.org/10.1093/brain/awae028, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65566
Latorre-Leal, M., Rodriguez-Rodriguez, P., Franchini, L., Nikolidakis, O., Daniilidou, M., Delac, L., Varshney, M., Arroyo-García, L., Eroli, F., Winblad, B., Blennow, K., Zetterberg, H., Kivipelto, M., Pacciarini, M., Wang, Y., Griffiths, W., Björkhem, I., Matton, A., Nalvarte, I...., & Maioli, S. (2024). CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice. Science Advances, 10(4)
https://doi.org/10.1126/sciadv.adj1354, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65333
Hennegan, J., Bryant, A., Griffiths, L., Trigano, M., Bartley, O., Bartlett, J., Minahan, C., Oliveira, W., Yutuc, E., Ntikas, S., Bartsocas, C., Markouri, M., Antoniadou, E., Laina, I., Howell, O., Li, M., Wang, Y., Griffiths, W., Lane, E...., & Theofilopoulos, S. (2024). Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development. iScience, 27(1), 108670
https://doi.org/10.1016/j.isci.2023.108670, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65068
Conroy, M., Andrews, R., Andrews, S., Cockayne, L., Dennis, E., Fahy, E., Gaud, C., Griffiths, W., Jukes, G., Kolchin, M., Mendivelso, K., Lopez-Clavijo, A., Ready, C., Subramaniam, S., & O’Donnell, V. (2023). LIPID MAPS: update to databases and tools for the lipidomics community. Nucleic Acids Research
https://doi.org/10.1093/nar/gkad896, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64901
http://dx.doi.org/10.1093/nar/gkad896
Daniilidou, M., Eroli, F., Alanko, V., Goikolea, J., Latorre-Leal, M., Rodriguez-Rodriguez, P., Griffiths, W., Wang, Y., Pacciarini, M., Brinkmalm, A., Zetterberg, H., Blennow, K., Rosenberg, A., Bogdanovic, N., Winblad, B., Kivipelto, M., Ibghi, D., Cedazo-Minguez, A., Maioli, S., & Matton, A. (2023). Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities. Brain Communications, 5(5)
https://doi.org/10.1093/braincomms/fcad228, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63624
http://dx.doi.org/10.1093/braincomms/fcad228
Dickson, A., Yutuc, E., Thornton, C., Dunford, J., Oppermann, U., Wang, Y., & Griffiths, W. (2023). HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta. Open Biology, 13(5)
https://doi.org/10.1098/rsob.220313, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61629
http://dx.doi.org/10.1098/rsob.220313
Dickson, A., Yutuc, E., Thornton, C., Wang, Y., & Griffiths, W. (2022). Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry. Frontiers in Endocrinology, 13
https://doi.org/10.3389/fendo.2022.1031013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61630
Haider, A., Zhao, C., Wang, L., Xiao, Z., Rong, J., Xia, X., Chen, Z., Pfister, S., Mast, N., Yutuc, E., Chen, J., Li, Y., Shao, T., Warnock, G., Dawoud, A., Connors, T., Oakley, D., Wei, H., Wang, J...., & Liang, S. (2022). Assessment of cholesterol homeostasis in the living human brain. Science Translational Medicine, 14(665)
https://doi.org/10.1126/scitranslmed.adc9967, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61471
McDonald, J., Ejsing, C., Kopczynski, D., Holčapek, M., Aoki, J., Arita, M., Arita, M., Baker, E., Bertrand-Michel, J., Bowden, J., Brügger, B., Ellis, S., Fedorova, M., Griffiths, W., Han, X., Hartler, J., Hoffmann, N., Koelmel, J., Köfeler, H...., & Ekroos, K. (2022). Introducing the Lipidomics Minimal Reporting Checklist. Nature Metabolism, 4(9), 1086-1088.
https://doi.org/10.1038/s42255-022-00628-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60824
Ghzaiel, I., Sassi, K., Zarrouk, A., Ghosh, S., Dias, I., Nury, T., Ksila, M., Essadek, S., Joutey, M., Brahmi, F., Mihoubi, W., Rup-Jacques, S., Samadi, M., Rezig, L., Meziane, S., Ghrairi, T., Masmoudi-Kouki, O., Hammami, S., Nasser, B...., & Lizard, G. (2022). Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications. Redox Experimental Medicine, 2022(1), R40-R56.
https://doi.org/10.1530/rem-22-0005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60624
Saud, Z., Tyrrell, V., Zaragkoulias, A., Protty, M., Statkute, E., Rubina, A., Bentley, K., White, D., Rodrigues, P., Murphy, R., Köfeler, H., Griffiths, W., Alvarez-Jarreta, J., Brown, R., Newcombe, R., Heyman, J., Pritchard, M., Mcleod, R., Arya, A...., & Stanton, R. (2022). The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research, 63(6), 100208
https://doi.org/10.1016/j.jlr.2022.100208, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60471
Griffiths, W. & Wang, Y. (2022). Cholesterol metabolism: from lipidomics to immunology. Journal of Lipid Research, 63(2), 100165
https://doi.org/10.1016/j.jlr.2021.100165, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59064
Griffiths, W. & Wang, Y. (2021). Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development. Frontiers in Physiology, 12
https://doi.org/10.3389/fphys.2021.723224, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57898
Horlock, A., Ormsby, T., Owens, S., Horlock, A., Davies, D., Griffiths, W., Wang, Y., Cronin, J., Bromfield, J., & Sheldon, M. (2021). Oxysterols protect bovine endometrial cells against pore‐forming toxins from pathogenic bacteria. The FASEB Journal, 35(10), 1-21.
https://doi.org/10.1096/fj.202100036r, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57632
Griffiths, W., Abdel-Khalik, J., Moore, S., Wijeyekoon, R., Crick, P., Yutuc, E., Farrell, K., Breen, D., Williams-Gray, C., Theofilopoulos, S., Arenas, E., Trupp, M., Barker, R., & Wang, Y. (2021). The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features. Frontiers in Aging Neuroscience, 13, 685594
https://doi.org/10.3389/fnagi.2021.685594, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57043
Köfeler, H., Eichmann, T., Ahrends, R., Bowden, J., Danne-Rasche, N., Dennis, E., Fedorova, M., Griffiths, W., Han, X., Hartler, J., Holčapek, M., Jirásko, R., Koelmel, J., Ejsing, C., Liebisch, G., Ni, Z., O’Donnell, V., Quehenberger, O., Schwudke, D...., & Ekroos, K. (2021). Quality control requirements for the correct annotation of lipidomics data. Nature Communications, 12(1)
https://doi.org/10.1038/s41467-021-24984-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57631
Wang, Y., Yutuc, E., & Griffiths, W. (2021). Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors. British Journal of Pharmacology, 178(16), 3176-3193.
https://doi.org/10.1111/bph.15191, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54644
Wang, Y., Yutuc, E., & Griffiths, W. (2021). Cholesterol metabolism pathways – are the intermediates more important than the products?. The FEBS Journal, 288(12), 3727-3745.
https://doi.org/10.1111/febs.15727, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56158
Höflinger, P., Hauser, S., Yutuc, E., Hengel, H., Griffiths, L., Radelfahr, F., Howell, O., Wang, Y., Connor, S., Duell, P., DeBarber, A., Martus, P., Lütjohann, D., Griffiths, W., & Schöls, L. (2021). Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis. Journal of Lipid Research, 62, 100078
https://doi.org/10.1016/j.jlr.2021.100078, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56747
Yutuc, E., Dickson, A., Pacciarini, M., Griffiths, L., Baker, P., Connell, L., Öhman, A., Forsgren, L., Trupp, M., Vilarinho, S., Khalil, Y., Clayton, P., Sari, S., Dalgic, B., Höflinger, P., Schöls, L., Griffiths, W., & Wang, Y. (2021). Deep mining of oxysterols and cholestenoic acids in human plasma and cerebrospinal fluid: Quantification using isotope dilution mass spectrometry. Analytica Chimica Acta, 1154, 338259
https://doi.org/10.1016/j.aca.2021.338259, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56163
Angelini, R., Yutuc, E., Wyatt, M., Newton, J., YUSUF, F., Griffiths, L., Cooze, B., Assad, D., Frache, G., Rao, W., Allen, L., Korade, Z., Nguyen, T., Rathnayake, R., Cologna, S., Howell, O., Clench, M., Wang, Y., & Griffiths, W. (2021). Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging. Analytical Chemistry, 93(11), 4932-4943.
https://doi.org/10.1021/acs.analchem.0c05399, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56326
http://dx.doi.org/10.1021/acs.analchem.0c05399
Abdel-Khalik, J., Hearn, T., Dickson, A., Crick, P., Yutuc, E., Austin-Muttitt, K., Bigger, B., Morris, A., Shackleton, C., Clayton, P., Iida, T., Sircar, R., Rohatgi, R., Marschall, H., Sjövall, J., Björkhem, I., Mullins, J., Griffiths, W., & Wang, Y. (2021). Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates. The Journal of Steroid Biochemistry and Molecular Biology, 206, 105794
https://doi.org/10.1016/j.jsbmb.2020.105794, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55690
Zang, R., Case, J., Yutuc, E., Ma, X., Shen, S., Castro, M., Liu, Z., Zeng, Q., Zhao, H., Son, J., Rothlauf, P., Kreutzberger, A., Hou, G., Zhang, H., Bose, S., Wang, X., Vahey, M., Mani, K., Griffiths, W...., & Ding, S. (2020). Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Proceedings of the National Academy of Sciences, 117(50), 32105-32113.
https://doi.org/10.1073/pnas.2012197117, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55583
Wang, Y., Yutuc, E., & Griffiths, W. (2020). Standardizing and increasing the utility of lipidomics: a look to the next decade. Expert Review of Proteomics, 17(10), 699-717.
https://doi.org/10.1080/14789450.2020.1847086, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55597
Liebisch, G., Fahy, E., Aoki, J., Dennis, E., Durand, T., Ejsing, C., Fedorova, M., Feussner, I., Griffiths, W., Köfeler, H., Merrill, A., Murphy, R., O’Donnell, V., Oskolkova, O., Subramaniam, S., Wakelam, M., & Spener, F. (2020). Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures. Journal of Lipid Research, 61(12), 1539-1555.
https://doi.org/10.1194/jlr.s120001025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55457
Hudson, N., Reverter, A., Griffiths, W., Yutuc, E., Wang, Y., Jeanes, A., McWilliam, S., Pethick, D., & Greenwood, P. (2020). Gene expression identifies metabolic and functional differences between intramuscular and subcutaneous adipocytes in cattle. BMC Genomics, 21(1)
https://doi.org/10.1186/s12864-020-6505-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53490
Hajeyah, A., Griffiths, W., Wang, Y., Finch, A., & O’Donnell, V. (2020). The Biosynthesis of Enzymatically Oxidized Lipids. Frontiers in Endocrinology, 11
https://doi.org/10.3389/fendo.2020.591819, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55699
Baloni, P., Funk, C., Yan, J., Yurkovich, J., Kueider-Paisley, A., Nho, K., Heinken, A., Jia, W., Mahmoudiandehkordi, S., Louie, G., Saykin, A., Arnold, M., Kastenmüller, G., Griffiths, W., Thiele, I., Kaddurah-Daouk, R., Price, N., Kaddurah-Daouk, R., Kueider-Paisley, A...., & Moreno, H. (2020). Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease. Cell Reports Medicine, 1(8), 100138
https://doi.org/10.1016/j.xcrm.2020.100138, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55544
Angelini, R., Yutuc, E., Wyatt, M., Newton, J., Yusuf, F., Griffiths, L., Cooze, B., Assad, D., Frache, G., Rao, W., Allen, L., Korade, Z., Nguyen, T., Rathnayake, R., Cologna, S., Howell, O., Clench, M., Wang, Y., & Griffiths, W. (2020). Visualising Cholesterol in Brain by On-Tissue Derivatisation and Quantitative Mass Spectrometry Imaging. bioRxiv
https://doi.org/10.1101/2020.11.06.369447, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60125
Griffiths, W. & Wang, Y. (2020). Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites. Prostaglandins & Other Lipid Mediators, 147, 106381
https://doi.org/10.1016/j.prostaglandins.2019.106381, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52696
Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., & Griffiths, W. (2020). Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism. Proceedings of the National Academy of Sciences, 117(11), 5749-5760.
https://doi.org/10.1073/pnas.1917421117, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53792
Yutuc, E., Crick, P., Yutuc, E., Abdel-Khalik, J., Saeed, A., Betsholtz, C., Genove, G., Björkhem, I., Wang, Y., & Griffiths, W. (2019). Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse. The Journal of Steroid Biochemistry and Molecular Biology, 195, 105475
https://doi.org/10.1016/j.jsbmb.2019.105475, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51994
Griffiths, W. (2019). Lipidomics needs more standardization. Nature Metabolism
https://doi.org/10.1038/s42255-019-0094-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51034
Raselli, T., Hearn, T., Wyss, A., Atrott, K., Peter, A., Frey-Wagner, I., Spalinger, M., Maggio, E., Sailer, A., Schmitt, J., Schreiner, P., Moncsek, A., Mertens, J., Scharl, M., Griffiths, W., Bueter, M., Geier, A., Rogler, G., Wang, Y., & Misselwitz, B. (2019). Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis. Journal of Lipid Research, 60(7), 1270-1283.
https://doi.org/10.1194/jlr.M093229, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50635
Yutuc, E., Griffiths, W., Yutuc, E., Abdel-Khalik, J., Crick, P., Hearn, T., Dickson, A., Bigger, B., Wu, T., Goenka, A., Ghosh, A., Jones, S., Covey, D., Ory, D., & Wang, Y. (2019). Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders. Free Radical Biology and Medicine
https://doi.org/10.1016/j.freeradbiomed.2019.04.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50061
Griffiths, W. & Wang, Y. (2019). Oxysterol research: a brief review. Biochemical Society Transactions, 47(2), 517-526.
https://doi.org/10.1042/BST20180135, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49840
Griffiths, W. & Wang, Y. (2019). Sterolomics in biology, biochemistry, medicine. TrAC Trends in Analytical Chemistry, 120, 115280
https://doi.org/10.1016/j.trac.2018.10.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45237
Lütjohann, D., Björkhem, I., Friedrichs, S., Kerksiek, A., Lövgren-Sandblom, A., Geilenkeuser, W., Ahrends, R., Andrade, I., Ansorena, D., Astiasarán, I., Baila-Rueda, L., Barriuso, B., Becker, S., Bretillon, L., Browne, R., Caccia, C., Ceglarek, U., Cenarro, A., Crick, P...., & Schött, H. (2019). First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods. The Journal of Steroid Biochemistry and Molecular Biology, 190, 115-125.
https://doi.org/10.1016/j.jsbmb.2019.03.025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49899
Griffiths, W., Abdel-Khalik, J., Yutuc, E., Roman, G., Warner, M., Gustafsson, J., & Wang, Y. (2019). Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients. Free Radical Biology and Medicine, 134, 42-52.
https://doi.org/10.1016/j.freeradbiomed.2018.12.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48010
Meljon, A., Crick, P., Yutuc, E., Yau, J., Seckl, J., Theofilopoulos, S., Arenas, E., Wang, Y., & Griffiths, W. (2019). Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5. Biomolecules, 9(4), 149
https://doi.org/10.3390/biom9040149, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50029
Yutuc, E., Abdel-Khalik, J., Crick, P., Yutuc, E., Wang, Y., & Griffiths, W. (2019). Developing an Enzyme-Assisted Derivatization Method for Analysis of C27 Bile Alcohols and Acids by Electrospray Ionization-Mass Spectrometry. Molecules, 24(3), 597
https://doi.org/10.3390/molecules24030597, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48910
Theofilopoulos, S., Oliveira, W., Yang, S., Yutuc, E., Saeed, A., Abdel-Khalik, J., Ullgren, A., Cedazo-Minguez, A., Björkhem, I., Wang, Y., Griffiths, W., & Arenas, E. (2019). 24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo. Journal of Biological Chemistry, 294(11), 4169-4176.
https://doi.org/10.1074/jbc.ra118.005639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48277
http://dx.doi.org/10.1074/jbc.ra118.005639
Griffiths, W., Crick, P., Meljon, A., Theofilopoulos, S., Abdel-Khalik, J., Yutuc, E., Parker, J., Kelly, D., Kelly, S., Arenas, E., & Wang, Y. (2019). Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1864(2), 191-211.
https://doi.org/10.1016/j.bbalip.2018.11.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa46057
http://dx.doi.org/10.1016/j.bbalip.2018.11.006
Lütjohann, D., Björkhem, I., Friedrichs, S., Kerksiek, A., Geilenkeuser, W., Lövgren-Sandblom, A., Ansorena, D., Astiasarán, I., Baila-Rueda, L., Barriuso, B., Bretillon, L., Browne, R., Caccia, C., Cenarro, A., Crick, P., Fauler, G., García-Llatas, G., Griffiths, W., Iuliano, L...., & Schött, H. (2018). International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods. Biochimie, 153, 26-32.
https://doi.org/10.1016/j.biochi.2018.07.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43215
Abdel-Khalik, J., Crick, P., Yutuc, E., DeBarber, A., Duell, P., Steiner, R., Laina, I., Wang, Y., & Griffiths, W. (2018). Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma. Biochimie
https://doi.org/10.1016/j.biochi.2018.06.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40916
Bezine, M., Maatoug, S., Ben Khalifa, R., Debbabi, M., Zarrouk, A., Wang, Y., Griffiths, W., Nury, T., Samadi, M., Vejux, A., de Sèze, J., Moreau, T., Kharrat, R., El Ayeb, M., & Lizard, G. (2018). Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0). Biochimie
https://doi.org/10.1016/j.biochi.2018.02.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38836
Griffiths, W. & Wang, Y. (2018). An update on oxysterol biochemistry: New discoveries in lipidomics. Biochemical and Biophysical Research Communications, 504(3), 617-622.
https://doi.org/10.1016/j.bbrc.2018.02.019, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38513
Griffiths, W., Gilmore, I., Yutuc, E., Abdel-Khalik, J., Crick, P., Hearn, T., Dickson, A., Bigger, B., Wu, T., Goenka, A., Ghosh, A., Jones, S., & Wang, Y. (2018). Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation. Journal of Lipid Research, 59(6), 1058-1070.
https://doi.org/10.1194/jlr.d083246, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39367
Kurowska-Stolarska, M., Hasoo, M., Welsh, D., Stewart, L., McIntyre, D., Morton, B., Johnstone, S., Miller, A., Asquith, D., Millar, N., Millar, A., Feghali-Bostwick, C., Hirani, N., Crick, P., Wang, Y., Griffiths, W., McInnes, I., & McSharry, C. (2017). The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis. Journal of Allergy and Clinical Immunology, 139(6), 1946-1956.
https://doi.org/10.1016/j.jaci.2016.09.021, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30968
Wang, Y. & Griffiths, W. (2017). Unravelling new pathways of sterol metabolism. Current Opinion in Clinical Nutrition and Metabolic Care, 1
https://doi.org/10.1097/MCO.0000000000000442, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37645
Griffiths, W. & Wang, Y. (2017). Sterolomics: State of the Art, Developments, Limitations and Challenges. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
https://doi.org/10.1016/j.bbalip.2017.03.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32631
Griffiths, W., Hearn, T., Crick, P., Abdel-Khalik, J., Dickson, A., Yutuc, E., & Wang, Y. (2017). Charge-tagging liquid chromatography–mass spectrometry methodology targeting oxysterol diastereoisomers. Chemistry and Physics of Lipids, 207, 69-80.
https://doi.org/10.1016/j.chemphyslip.2017.04.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32978
Griffiths, W., Abdel-Khalik, J., Yutuc, E., Morgan, A., Gilmore, I., Hearn, T., & Wang, Y. (2017). Cholesterolomics: An update. Analytical Biochemistry
https://doi.org/10.1016/j.ab.2017.01.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31729
Rees, D., Crick, P., Jenkins, G., Wang, Y., Griffiths, W., Brown, T., & Al-Sarireh, B. (2017). Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease. The Journal of Steroid Biochemistry and Molecular Biology, 174, 290-295.
https://doi.org/10.1016/j.jsbmb.2017.10.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36199
Abdel-Khalik, J., Yutuc, E., Crick, P., Gustafsson, J., Warner, M., Roman, G., Talbot, K., Gray, E., Griffiths, W., Turner, M., & Wang, Y. (2017). Defective cholesterol metabolism in amyotrophic lateral sclerosis. Journal of Lipid Research, jlr.P071639
https://doi.org/10.1194/jlr.P071639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30987
Robertson, K., Hsieh, W., Forster, T., Blanc, M., Lu, H., Crick, P., Yutuc, E., Watterson, S., Martin, K., Griffiths, S., Enright, A., Yamamoto, M., Pradeepa, M., Lennox, K., Behlke, M., Talbot, S., Haas, J., Dölken, L., Griffiths, W...., & Ghazal, P. (2016). An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway. PLOS Biology, 14(3), e1002364
https://doi.org/10.1371/journal.pbio.1002364, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27043
Crick, P., Griffiths, W., Zhang, J., Beibel, M., Abdel-Khalik, J., Kuhle, J., Sailer, A., & Wang, Y. (2016). Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients. Molecular Neurobiology
https://doi.org/10.1007/s12035-016-0281-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31214
Griffiths, W., Abdel-Khalik, J., Crick, P., Ogundare, M., Shackleton, C., Tuschl, K., Kwok, M., Bigger, B., Morris, A., Honda, A., Xu, L., Porter, N., Björkhem, I., Clayton, P., & Wang, Y. (2016). Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients. The Journal of Steroid Biochemistry and Molecular Biology
https://doi.org/10.1016/j.jsbmb.2016.03.018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26789
Griffiths, W., Abdel-Khalik, J., Crick, P., Yutuc, E., & Wang, Y. (2016). New methods for analysis of oxysterols and related compounds by LC–MS. The Journal of Steroid Biochemistry and Molecular Biology, 162, 4-26.
https://doi.org/10.1016/j.jsbmb.2015.11.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25192
Griffiths, W., Abdel-Khalik, J., Hearn, T., Yutuc, E., Morgan, A., Wang, Y., Griffiths, W., Wang, Y., Morgan, A., & Yutuc, E. (2016). Current trends in oxysterol research. Biochemical Society Transactions, 44(2), 652-658.
https://doi.org/10.1042/BST20150255, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27117
Crick, P., Bentley, T., Wang, Y., & Griffiths, W. (2015). Revised sample preparation for the analysis of oxysterols by enzyme-assisted derivatisation for sterol analysis (EADSA). Analytical and Bioanalytical Chemistry, 407(17), 5235-5239.
https://doi.org/10.1007/s00216-015-8609-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22808
Crick, P., Beckers, L., Baes, M., Van Veldhoven, P., Wang, Y., & Griffiths, W. (2015). The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid. Steroids
https://doi.org/10.1016/j.steroids.2015.02.021, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20335
Iuliano, L., Crick, P., Zerbinati, C., Tritapepe, L., Abdel-Khalik, J., Poirot, M., Wang, Y., & Griffiths, W. (2015). Cholesterol metabolites exported from human brain. Steroids
https://doi.org/10.1016/j.steroids.2015.01.026, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20171
, ., Griffiths, W., & Wang, Y. (2014). Role of α-Methylacyl-CoA Racemase (Amacr) and peroxisomal Multifunctional Enzyme 1 (Mfe-1) in bile acid synthesis in mice. Biochemical Journal
https://doi.org/10.1042/BJ20130915, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17830
Saeed, A., Genove, G., Li, T., Luetjohann, D., Olin, M., Mast, N., Pikuleva, I., Crick, P., Wang, Y., Griffiths, W., Betsholtz, C., Bjorkhem, I., Griffiths, W., & Wang, Y. (2014). Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain. Journal of Biological Chemistry
https://doi.org/10.1074/jbc.M114.556159, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18147
Bjorkhem+U., I., Griffiths, W., & Wang, Y. (2014). On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO. The Journal of Lipid Research
https://doi.org/10.1194/jlr.P048603, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17919
, ., Griffiths, W., & Wang, Y. (2014). Liver disease in infancy caused by oxysterol 7α-hydroxylase deficiency: successful treatment with chenodeoxycholic acid. Journal of Inherited Metabolic Disease
https://doi.org/10.1007/s10545-014-9695-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17814
Crick, P., William Bentley, T., Abdel-Khalik, J., Matthews, I., Clayton, P., Morris, A., Bigger, B., Zerbinati, C., Tritapepe, L., Iuliano, L., Wang, Y., Griffiths, W., Griffiths, W., & Wang, Y. (2014). Quantitative Charge-Tags for Sterol and Oxysterol Analysis. Clinical Chemistry
https://doi.org/10.1373/clinchem.2014.231332, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19854
Griffiths, W., Jörnvall, H., & Griffiths, W. (2014). Oxysterols. Biochemical and Biophysical Research Communications, 446(3), 645-646.
https://doi.org/10.1016/j.bbrc.2014.04.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32520
http://www.scopus.com/inward/record.url?eid=2-s2.0-84898780214&partnerID=MN8TOARS
Wang, Y., Karu, K., Meljon, A., Turton, J., Yau, J., Seckl, J., Wang, Y., & Griffiths, W. (2014). 24S,25-Epoxycholesterol in mouse and rat brain. Biochemical and Biophysical Research Communications
https://doi.org/10.1016/j.bbrc.2014.05.012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17998
, ., Griffiths, W., & Wang, Y. (2014). Studies on the analysis of 25-hydroxyvitamin D3 by isotope-dilution liquid chromatography–tandem mass spectrometry using enzyme-assisted derivatisation. Biochemical and Biophysical Research Communications
https://doi.org/10.1016/j.bbrc.2014.01.088, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17818
, ., Griffiths, W., & Wang, Y. (2014). Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse. Biochemical and Biophysical Research Communications
https://doi.org/10.1016/j.bbrc.2014.01.153, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17817
, ., Griffiths, W., & Wang, Y. (2014). Evaluation of novel derivatisation reagents for the analysis of oxysterols. Biochemical and Biophysical Research Communications
https://doi.org/10.1016/j.bbrc.2014.01.173, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17816
, ., Griffiths, W., & Wang, Y. (2014). A new derivative for oxosteroid analysis by mass spectrometry. Biochemical and Biophysical Research Communications
https://doi.org/10.1016/j.bbrc.2014.01.190, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17815
Theofilopoulos, S., Griffiths, W., Crick, P., Yang, S., Meljon, A., Ogundare, M., Kitambi, S., Lockhart, A., Tuschl, K., Clayton, P., Morris, A., Martinez, A., Reddy, M., Martinuzzi, A., Bassi, M., Honda, A., Mizuochi, T., Kimura, A., Nittono, H...., & Wang, Y. (2014). Cholestenoic acids regulate motor neuron survival via liver X receptors. Journal of Clinical Investigation, 124(11), 4829-4842.
https://doi.org/10.1172/jci68506, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34741
http://dx.doi.org/10.1172/jci68506
Saini, R., Kataeva, O., Schmidt, A., Wang, Y., Meljon, A., Griffiths, W., & Knölker, H. (2013). Synthesis and biological activity of (24E)- and (24Z)-26-hydroxydesmosterol. Bioorganic & Medicinal Chemistry
https://doi.org/10.1016/j.bmc.2013.07.015, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15364
Mazein, A., Watterson, S., Hsieh, W., Griffiths, W., & Ghazal, P. (2013). A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. Biochemical Pharmacology
https://doi.org/10.1016/j.bcp.2013.03.021, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14862
Liebisch, G., Vizcaino, J., Kofeler, H., Trotzmuller, M., Griffiths, W., Schmitz, G., Spener, F., Wakelam, M., & Griffiths, W. (2013). Shorthand notation for lipid structures derived from mass spectrometry. The Journal of Lipid Research, 54(6)-1530.
https://doi.org/10.1194/jlr.M033506, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14864
Blanc, M., Hsieh, W., Robertson, K., Kropp, K., Forster, T., Shui, G., Lacaze, P., Watterson, S., Griffiths, S., Spann, N., Meljon, A., Talbot, S., Krishnan, K., Covey, D., Wenk, M., Craigon, M., Ruzsics, Z., Haas, J., Angulo, A...., & Griffiths, W. (2013). The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response. Immunity, 38(1), 106-118.
https://doi.org/10.1016/j.immuni.2012.11.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13836
Griffiths, W., Crick, P., & Wang, Y. (2013). Methods for oxysterol analysis: Past, present and future. Biochemical Pharmacology
https://doi.org/10.1016/j.bcp.2013.01.027, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14484
Meljon, A., Watson, G., Wang, Y., Shackleton, C., & Griffiths, W. (2013). Analysis by Liquid Chromatography - Mass Spectrometry of Sterols and Oxysterols in Brain of the Newborn Dhcr7Δ3-5/T93M Mouse: A Model of Smith-Lemli-Opitz Syndrome. Biochemical Pharmacology
https://doi.org/10.1016/j.bcp.2013.03.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14485
Theofilopoulos, S., Wang, Y., Kitambi, S., Sacchetti, P., Sousa, K., Bodin, K., Kirk, J., Saltó, C., Gustafsson, M., Toledo, E., Karu, K., Gustafsson, J., Steffensen, K., Ernfors, P., Sjövall, J., Griffiths, W., & Arenas, E. (2013). Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nature Chemical Biology, 9(2), 126-133.
https://doi.org/10.1038/nchembio.1156, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34740
http://dx.doi.org/10.1038/nchembio.1156
Griffiths, W., Crick, P., Wang, Y., Ogundare, M., Tuschl, K., Morris, A., Bigger, B., Clayton, P., & Wang, Y. (2012). Analytical strategies for characterization of oxysterol lipidomes: Liver X receptor ligands in plasma. Free Radical Biology and Medicine
https://doi.org/10.1016/j.freeradbiomed.2012.07.027, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12875
Chen, Y., Ogundare, M., Williams, C., Wang, Y., Wang, Y., Sewell, G., Smith, P., Rahman, F., O'Shea, N., Segal, A., & Griffiths, W. (2012). Shotgun cholanomics of ileal fluid. Biochimie
https://doi.org/10.1016/j.biochi.2012.09.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12882
Meljon, A., Theofilopoulos, S., Shackleton, C., Watson, G., Javitt, N., Knolker, H., Saini, R., Arenas, E., Wang, Y., Griffiths, W., Griffiths, W., Wang, Y., & Theofilopoulos, S. (2012). Analysis of bioactive oxysterols in newborn mouse brain by LC/MS. Journal of Lipid Research, 53(11), 2469-2483.
https://doi.org/10.1194/jlr.d028233, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12880
http://dx.doi.org/10.1194/jlr.d028233
Rai, D., Brunton, N., Koidis, A., Rawson, A., McLoughlin, P., & Griffiths, W. (2011). Characterisation of polyacetylenes isolated from carrot (Daucus carota) extracts by negative ion tandem mass spectrometry.. Rapid Commun Mass Spectrom., 25(15), 2231-9.
https://doi.org/10.1002/rcm.5103, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa5314
Mazein, A., Griffiths, W., Freeman, T., Ghazal, P., Mazein, A., Watterson, S., Gibbs, H., Hsieh, W., Abdullah, M., & Blanc, M. (2011). Regulation and feedback of cholesterol metabolism. Nature Precedings
https://doi.org/10.1038/npre.2011.6315.1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15365
Björkhem, I., Diczfalusy, U., Olsson, T., Russell, D., McDonald, J., Wang, Y., & Griffiths, W. (2011). Detecting oxysterols in the human circulation. Nature Immunology, 12(7), 577-577.
https://doi.org/10.1038/ni0711-577a, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10759
Karu, K., Turton, J., Wang, Y., & Griffiths, W. (2011). Nano-liquid chromatography–tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation. Chemistry and Physics of Lipids, 164(6), 411-424.
https://doi.org/10.1016/j.chemphyslip.2011.04.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10760
Brunnström, Å., Hamberg, M., Griffiths, W., Mannervik, B., & Claesson, H. (2011). Biosynthesis of 14,15-Hepoxilins in Human L1236 Hodgkin Lymphoma Cells and Eosinophils. Lipids, 46(1), 69-79.
https://doi.org/10.1007/s11745-010-3485-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10762
Griffiths, W., Wang, Y., Griffiths, W., & Wang, Y. (2011). Are 15-oxygenated sterols present in the human circulation?. The Journal of Lipid Research, 52(1), 4-5.
https://doi.org/10.1194/jlr.E012088, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10763
Griffiths, W., Ogundare, M., Williams, C., & Wang, Y. (2011). On the future of “omics”: lipidomics. Journal of Inherited Metabolic Disease, 34(3), 583-592.
https://doi.org/10.1007/s10545-010-9274-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10761
Griffiths, W. (2010). Targeted Steroidomic Analysis by 'charge-tagging' and MS n.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49842
Hornshaw, M., Griffiths, W., & Griffiths, W. (2010). Targeted Steroidomic Analysis by 'charge-tagging' and MS n. Bio Tech International, 22
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32521
http://www.scopus.com/inward/record.url?eid=2-s2.0-79953322430&partnerID=MN8TOARS
Brady, S., York, M., Scudamore, C., Williams, T., Griffiths, W., Turton, J., & Griffiths, W. (2010). Cardiac Troponin I in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat: Studies on Low Dose Levels and Routes of Administration. Toxicologic Pathology, 38(2), 287-291.
https://doi.org/10.1177/0192623309357948, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10939
Griffiths, W., Wang, Y., Brenton, A., Hall, L., Arenas, E., Lockhart, A., Theofilopoulos, S., Sjövall, J., & Ogundare, M. (2010). Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain?. Journal of Biological Chemistry, 285(7), 4666-4679.
https://doi.org/10.1074/jbc.m109.086678, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52579
http://dx.doi.org/10.1074/jbc.m109.086678
Wang, Y., Sousa, K., Bodin, K., Griffiths, W., & Wang, Y. (2009). Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Molecular BioSystems, 5, 529-41.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10201
Kim, C., Griffiths, W., Taylor, P., & Griffiths, W. (2009). Components derived fromPelargoniumstimulate macrophage killing ofMycobacteriumspecies. Journal of Applied Microbiology, 106(4), 1184-1193.
https://doi.org/10.1111/j.1365-2672.2008.04085.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32523
http://www.scopus.com/inward/record.url?eid=2-s2.0-62149093525&partnerID=MN8TOARS
Liere, P., Pianos, A., Eychenne, B., Cambourg, A., Bodin, K., Griffiths, W., Schumacher, M., Baulieu, E., Sjovall, J., & Griffiths, W. (2009). Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the key. The Journal of Lipid Research, 50(12), 2430-2444.
https://doi.org/10.1194/jlr.M900162-JLR200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10496
Griffiths, W. & Wang, Y. (2009). Sterol lipidomics in health and disease: Methodologies and applications. European Journal of Lipid Science and Technology, 111(1), 14-38.
https://doi.org/10.1002/ejlt.200800116, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10944
Seibert, C., Davidson, B., Fuller, B., Patterson, L., Griffiths, W., & Wang, Y. (2009). Multiple-Approaches to the Identification and Quantification of Cytochromes P450 in Human Liver Tissue by Mass Spectrometry. Journal of Proteome Research, 8(4), 1672-1681.
https://doi.org/10.1021/pr800795r, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10946
Ålander, J., Lengqvist, J., Holm, P., Svensson, R., Gerbaux, P., Heuvel, R., Hebert, H., Griffiths, W., Armstrong, R., & Morgenstern, R. (2009). Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione. Archives of Biochemistry and Biophysics, 487(1), 42-48.
https://doi.org/10.1016/j.abb.2009.04.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10949
Smyth, R., Lane, C., Ashiq, R., Turton, J., Clarke, C., Dare, T., York, M., Griffiths, W., & Munday, M. (2009). Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat. Cell Biology and Toxicology, 25(5), 499-512.
https://doi.org/10.1007/s10565-008-9104-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10952
Claesson, H., Griffiths, W., Brunnström, Å., Schain, F., Andersson, E., Feltenmark, S., Johnson, H., Porwit, A., Sjöberg, J., & Björkholm, M. (2009). Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo. FEBS Journal, 275(16), 4222-4234.
https://doi.org/10.1111/j.1742-4658.2008.06570.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10953
Ogundare, M., Theofilopoulos, S., Lockhart, A., Hall, L., Arenas, E., Sjövall, J., Brenton, A., Wang, Y., Griffiths, W., Brenton, A., & Gregory, S. (2009). Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain?. Journal of Biological Chemistry, 285(7), 4666-4679.
https://doi.org/10.1074/jbc.M109.086678, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9808
Griffiths, W., Arenas, E., Sjövall, J., Karu, K., Theofilopoulos, S., Hornshaw, M., Sacchetti, P., Bodin, K., Sousa, K., Woffendin, G., & Wang, Y. (2009). Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Molecular BioSystems, 5(5), 529
https://doi.org/10.1039/b819502a, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52580
http://dx.doi.org/10.1039/b819502a
Wang, Y., Muneton, S., Sjövall, J., Jovanovic, J., & Griffiths, W. (2008). The Effect of 24S-Hydroxycholesterol on Cholesterol Homeostasis in Neurons: Quantitative Changes to the Cortical Neuron Proteome. Journal of Proteome Research, 7(4), 1606-1614.
https://doi.org/10.1021/pr7006076, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10007
Griffiths, W., Hornshaw, M., Woffendin, G., Baker, S., Lockhart, A., Heidelberger, S., Gustafsson, M., Sjövall, J., & Wang, Y. (2008). Discovering Oxysterols in Plasma: A Window on the Metabolome. Journal of Proteome Research, 7(8), 3602-3612.
https://doi.org/10.1021/pr8001639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10200
Wang, Y. & Griffiths, W. (2008). Capillary liquid chromatography combined with tandem mass spectrometry for the study of neurosteroids and oxysterols in brain. Neurochemistry International, 52(4-5), 506-521.
https://doi.org/10.1016/j.neuint.2007.07.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19142
Ringqvist, E., Palm, J., Skarin, H., Hehl, A., Weiland, M., Davids, B., Reiner, D., Griffiths, W., Eckmann, L., Gillin, F., Svärd, S., & Griffiths, W. (2008). Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cells. Molecular and Biochemical Parasitology, 159(2), 85-91.
https://doi.org/10.1016/j.molbiopara.2008.02.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32527
http://www.scopus.com/inward/record.url?eid=2-s2.0-43049100037&partnerID=MN8TOARS
Schumacher, M., Liere, P., Akwa, Y., Rajkowski, K., Griffiths, W., Bodin, K., Sjövall, J., Baulieu, E., & Griffiths, W. (2008). Pregnenolone sulfate in the brain: A controversial neurosteroid. Neurochemistry International, 52(4-5), 522-540.
https://doi.org/10.1016/j.neuint.2007.08.022, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32526
http://www.scopus.com/inward/record.url?eid=2-s2.0-38349119532&partnerID=MN8TOARS
Narayanaswamy, M., Griffiths, W., Howard, P., Thurston, D., & Griffiths, W. (2008). An assay combining high-performance liquid chromatography and mass spectrometry to measure DNA interstrand cross-linking efficiency in oligonucleotides of varying sequences. Analytical Biochemistry, 374(1), 173-181.
https://doi.org/10.1016/j.ab.2007.11.018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32524
http://www.scopus.com/inward/record.url?eid=2-s2.0-38549119491&partnerID=MN8TOARS
Karu, K., Hornshaw, M., Woffendin, G., Bodin, K., Hamberg, M., Alvelius, G., Sjovall, J., Turton, J., Wang, Y., Griffiths, W., Griffiths, W., & Wang, Y. (2007). Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. The Journal of Lipid Research, 48(4), 976-987.
https://doi.org/10.1194/jlr.M600497-JLR200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1359
Griffiths, W. (2007). Separation and identification of cholesterol metabolites in rat brain using LC-MSⁿ.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49843
Griffiths, W., Milton, D., & Griffiths, W. (2007). Separation and identification of cholesterol metabolites in rat brain using LC-MSn. LC GC Europe, 20
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37604
http://www.scopus.com/inward/record.url?eid=2-s2.0-37349083526&partnerID=MN8TOARS
Griffiths, W., Karu, K., Hornshaw, M., Woffendin, G., Wang, Y., Griffiths, W., & Wang, Y. (2007). Metabolomics and metabolite profiling: past heroes and future developments. European Journal of Mass Spectrometry, 13(1), 45
https://doi.org/10.1255/ejms.850, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32533
http://www.scopus.com/inward/record.url?eid=2-s2.0-34250717475&partnerID=MN8TOARS
Wakefield, L., Cornish, V., Long, H., Griffiths, W., Sim, E., & Griffiths, W. (2007). Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism. Biochemical and Biophysical Research Communications, 364(3), 556-560.
https://doi.org/10.1016/j.bbrc.2007.10.026, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32531
http://www.scopus.com/inward/record.url?eid=2-s2.0-35649014879&partnerID=MN8TOARS
York, M., Scudamore, C., Brady, S., Chen, C., Wilson, S., Curtis, M., Evans, G., Griffiths, W., Whayman, M., Williams, T., Turton, J., & Griffiths, W. (2007). Characterization of Troponin Responses in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat. Toxicologic Pathology, 35(4), 606-617.
https://doi.org/10.1080/01926230701389316, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32530
http://www.scopus.com/inward/record.url?eid=2-s2.0-34548425249&partnerID=MN8TOARS
Wang, Y., Karu, K., Griffiths, W., Griffiths, W., & Wang, Y. (2007). Analysis of neurosterols and neurosteroids by mass spectrometry. Biochimie, 89(2), 182-191.
https://doi.org/10.1016/j.biochi.2006.10.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32529
http://www.scopus.com/inward/record.url?eid=2-s2.0-33846483721&partnerID=MN8TOARS
Lane, C., Wang, Y., Betts, R., Griffiths, W., Patterson, L., Griffiths, W., & Wang, Y. (2007). Comparative Cytochrome P450 Proteomics in the Livers of Immunodeficient Mice Using 18O Stable Isotope Labeling. Molecular & Cellular Proteomics, 6(6), 953-962.
https://doi.org/10.1074/mcp.M600296-MCP200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1379
Wang, Y., Hornshaw, M., Alvelius, G., Bodin, K., Liu, S., Sjövall, J., & Griffiths, W. (2006). Matrix-Assisted Laser Desorption/Ionization High-Energy Collision-Induced Dissociation of Steroids: Analysis of Oxysterols in Rat Brain. Analytical Chemistry, 78(1), 164-173.
https://doi.org/10.1021/ac051461b, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1360
Griffiths, W., Wang, Y., Alvelius, G., Liu, S., Bodin, K., & Sjövall, J. (2006). Analysis of oxysterols by electrospray tandem mass spectrometry. Journal of the American Society for Mass Spectrometry, 17(3), 341-362.
https://doi.org/10.1016/j.jasms.2005.10.012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1361
Wang, Y., Al-Gazzar, A., Seibert, C., Sharif, A., Lane, C., Griffiths, W., Griffiths, W., & Wang, Y. (2006). Proteomic analysis of cytochromes P450: a mass spectrometry approach. Biochemical Society Transactions, 34(6), 1246-1251.
https://doi.org/10.1042/BST0341246, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32539
http://www.scopus.com/inward/record.url?eid=2-s2.0-34248639064&partnerID=MN8TOARS
Rai, D., Landin, B., Alvelius, G., Griffiths, W., & Griffiths, W. (2006). Haemoglobin Södertälje (β118 Phe→Val): a new mutation in human haemoglobin identified by electrospray ionisation mass spectrometry. Rapid Communications in Mass Spectrometry, 20(22), 3481-3482.
https://doi.org/10.1002/rcm.2746, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32537
http://www.scopus.com/inward/record.url?eid=2-s2.0-33751072913&partnerID=MN8TOARS
Tjernberg, A., Markova, N., Griffiths, W., Hallén, D., & Griffiths, W. (2006). DMSO-Related Effects in Protein Characterization. Journal of Biomolecular Screening, 11(2), 131-137.
https://doi.org/10.1177/1087057105284218, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32536
http://www.scopus.com/inward/record.url?eid=2-s2.0-33644938893&partnerID=MN8TOARS
Khan, M., Wang, Y., Heidelberger, S., Alvelius, G., Liu, S., Sjövall, J., Griffiths, W., Griffiths, W., & Wang, Y. (2006). Analysis of derivatised steroids by matrix-assisted laser desorption/ionisation and post-source decay mass spectrometry. Steroids, 71(1), 42-53.
https://doi.org/10.1016/j.steroids.2005.08.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32534
http://www.scopus.com/inward/record.url?eid=2-s2.0-28544434661&partnerID=MN8TOARS
Griffiths, W. (2006). Why steroidomics in brain?. European Journal of Lipid Science and Technology, 108(9), 707-708.
https://doi.org/10.1002/ejlt.200600162, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10945
Tollin, M., Bergsson, G., Kai-Larsen, Y., Lengqvist, J., Sjövall, J., Griffiths, W., Skúladóttir, G., Haraldsson, Á., Jörnvall, H., Gudmundsson, G., Agerberth, B., & Griffiths, W. (2005). Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions. Cellular and Molecular Life Sciences, 62(19-20), 2390-2399.
https://doi.org/10.1007/s00018-005-5260-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32543
http://www.scopus.com/inward/record.url?eid=2-s2.0-27144556469&partnerID=MN8TOARS
Lengqvist, J., Mata De Urquiza, A., Perlmann, T., Sjövall, J., Griffiths, W., & Griffiths, W. (2005). Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRα. Journal of Mass Spectrometry, 40(11), 1448-1461.
https://doi.org/10.1002/jms.925, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32542
http://www.scopus.com/inward/record.url?eid=2-s2.0-27944479942&partnerID=MN8TOARS
Hosia, W., Griffiths, W., Johansson, J., & Griffiths, W. (2005). Hydrolysis of the amyloid ?-peptide (A?) 1-40 between Asp23-Val24 produces non-aggregating fragments. An electrospray mass spectrometric study. Journal of Mass Spectrometry, 40(2), 142-145.
https://doi.org/10.1002/jms.732, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32541
http://www.scopus.com/inward/record.url?eid=2-s2.0-14744275143&partnerID=MN8TOARS
Lengqvist, J., Alvélius, G., Jörnvall, H., Sjövall, J., Perlmann, T., Griffiths, W., & Griffiths, W. (2005). Electrospray mass spectrometry for the direct accurate mass measurement of ligands in complex with the retinoid X receptor α ligand binding domain. Journal of the American Society for Mass Spectrometry, 16(10), 1631-1640.
https://doi.org/10.1016/j.jasms.2005.06.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32540
http://www.scopus.com/inward/record.url?eid=2-s2.0-25144441148&partnerID=MN8TOARS
Wang, Y., Johansson, J., Agerberth, B., Jörnvall, H., Griffiths, W., & Griffiths, W. (2004). The antimicrobial peptide LL-37 binds to the human plasma protein apolipoprotein A-I [2]. Rapid Communications in Mass Spectrometry, 18
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37607
http://www.scopus.com/inward/record.url?eid=2-s2.0-1542319003&partnerID=MN8TOARS
Griffiths, W., Alvelius, G., Liu, S., Sjövall, J., & Griffiths, W. (2004). High-energy collision-induced dissociation of oxosteroids derivatised to Girard hydrazones. European Journal of Mass Spectrometry, 10
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37606
http://www.scopus.com/inward/record.url?eid=2-s2.0-1842610787&partnerID=MN8TOARS
Norberg, Å., Griffiths, W., Hjelmqvist, L., Jörnvall, H., Rökaeus, Å., & Griffiths, W. (2004). Identification of variant forms of the neuroendocrine peptide galanin. Rapid Communications in Mass Spectrometry, 18(14), 1583-1591.
https://doi.org/10.1002/rcm.1522, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32548
http://www.scopus.com/inward/record.url?eid=2-s2.0-3142712239&partnerID=MN8TOARS
Liere, P., Pianos, A., Eychenne, B., Cambourg, A., Liu, S., Griffiths, W., Schumacher, M., Sjövall, J., Baulieu, E., & Griffiths, W. (2004). Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain. The Journal of Lipid Research, 45(12), 2287-2302.
https://doi.org/10.1194/jlr.M400244-JLR200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32549
http://www.scopus.com/inward/record.url?eid=2-s2.0-10044255546&partnerID=MN8TOARS
Lane, C., Nisar, S., Griffiths, W., Fuller, B., Davidson, B., Hewes, J., Welham, K., Patterson, L., & Griffiths, W. (2004). Identification of cytochrome P450 enzymes in human colorectal metastases and the surrounding liver: a proteomic approach. European Journal of Cancer, 40(14), 2127-2134.
https://doi.org/10.1016/j.ejca.2004.04.029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32547
http://www.scopus.com/inward/record.url?eid=2-s2.0-4444325651&partnerID=MN8TOARS
Tjernberg, A., Carnö, S., Oliv, F., Benkestock, K., Edlund, P., Griffiths, W., Hallén, D., & Griffiths, W. (2004). Determination of Dissociation Constants for Protein−Ligand Complexes by Electrospray Ionization Mass Spectrometry. Analytical Chemistry, 76(15), 4325-4331.
https://doi.org/10.1021/ac0497914, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32546
http://www.scopus.com/inward/record.url?eid=2-s2.0-3543008337&partnerID=MN8TOARS
Rai, D., Green, B., Landin, B., Alvelius, G., Griffiths, W., & Griffiths, W. (2004). Accurate mass measurement and tandem mass spectrometry of intact globin chains identify the low proportion variant hemoglobin Lepore–Boston–Washington from the blood of a heterozygote. Journal of Mass Spectrometry, 39(3), 289-294.
https://doi.org/10.1002/jms.581, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32545
http://www.scopus.com/inward/record.url?eid=2-s2.0-1642363958&partnerID=MN8TOARS
Nisar, S., Lane, C., Wilderspin, A., Welham, K., Griffiths, W., Patterson, L., & Griffiths, W. (2004). A PROTEOMIC APPROACH TO THE IDENTIFICATION OF CYTOCHROME P450 ISOFORMS IN MALE AND FEMALE RAT LIVER BY NANOSCALE LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION-TANDEM MASS SPECTROMETRY. Drug Metabolism and Disposition, 32(4), 382-386.
https://doi.org/10.1124/dmd.32.4.382, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32544
http://www.scopus.com/inward/record.url?eid=2-s2.0-1842536853&partnerID=MN8TOARS
Lengqvist, J. & Griffiths, W. (2004). Observation of an Intact Noncovalent Homotrimer of Detergent-solubilized Rat Microsomal Glutathione Transferase-1 by Electrospray Mass Spectrometry. Journal of Biological Chemistry, 279(14), 13311-13316.
https://doi.org/10.1074/jbc.M310958200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1378
Lengqvist, J. & Griffiths, W. (2004). Polyunsaturated Fatty Acids Including Docosahexaenoic and Arachidonic Acid Bind to the Retinoid X Receptor Ligand-binding Domain. Molecular & Cellular Proteomics, 3(7), 692-703.
https://doi.org/10.1074/mcp.M400003-MCP200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1377
Juntti-Berggren, L. & Griffiths, W. (2004). Apolipoprotein CIII promotes Ca2+-dependent cell death in type 1 diabetes. Proceedings of the National Academy of Sciences, 101(27), 10090-10094.
https://doi.org/10.1073/pnas.0403551101, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1376
Griffiths, W. & Griffiths, W. (2003). Tandem mass spectrometry in the study of fatty acids, bile acids, and steroids.. Mass spectrometry reviews, 22
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37610
http://www.scopus.com/inward/record.url?eid=2-s2.0-0042766457&partnerID=MN8TOARS
Griffiths, W. & Griffiths, W. (2003). Tandem mass spectrometry in the study of fatty acids, bile acids, and steroids. Mass Spectrometry Reviews, 22
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37609
http://www.scopus.com/inward/record.url?eid=2-s2.0-0043207969&partnerID=MN8TOARS
Griffiths, W., Liu, S., Alvelius, G., Sjövall, J., & Griffiths, W. (2003). Derivatisation for the characterisation of neutral oxosteroids by electrospray and matrix-assisted laser desorption/ionisation tandem mass spectrometry: The Girard P derivative. Rapid Communications in Mass Spectrometry, 17
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37608
http://www.scopus.com/inward/record.url?eid=2-s2.0-0038035661&partnerID=MN8TOARS
Höög, J., Strömberg, P., Hedberg, J., Griffiths, W., & Griffiths, W. (2003). The mammalian alcohol dehydrogenases interact in several metabolic pathways. Chemico-Biological Interactions, 143-144, 175-181.
https://doi.org/10.1016/S0009-2797(02)00225-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32559
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037325510&partnerID=MN8TOARS
Hedberg, J., Griffiths, W., Nilsson, S., Höög, J., & Griffiths, W. (2003). Reduction of S-nitrosoglutathione by human alcohol dehydrogenase 3 is an irreversible reaction as analysed by electrospray mass spectrometry. European Journal of Biochemistry, 270(6), 1249-1256.
https://doi.org/10.1046/j.1432-1033.2003.03486.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32558
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037351726&partnerID=MN8TOARS
Liu, S., Griffiths, W., Sjövall, J., & Griffiths, W. (2003). On-Column Electrochemical Reactions Accompanying the Electrospray Process. Analytical Chemistry, 75(4), 1022-1030.
https://doi.org/10.1021/ac026066p, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32557
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037442877&partnerID=MN8TOARS
Liu, S., Sjövall, J., Griffiths, W., & Griffiths, W. (2003). Neurosteroids in Rat Brain: Extraction, Isolation, and Analysis by Nanoscale Liquid Chromatography−Electrospray Mass Spectrometry. Analytical Chemistry, 75(21), 5835-5846.
https://doi.org/10.1021/ac0346297, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32556
http://www.scopus.com/inward/record.url?eid=2-s2.0-0242354104&partnerID=MN8TOARS
Palm, J., Weiland, M., Griffiths, W., Ljungström, I., Svärd, S., & Griffiths, W. (2003). Identification of Immunoreactive Proteins during Acute Human Giardiasis. The Journal of Infectious Diseases, 187(12), 1849-1859.
https://doi.org/10.1086/375356, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32555
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037563766&partnerID=MN8TOARS
Abraham-Nordling, M., Gudmundsson, G., Grunewald, J., Agerberth, B., Griffiths, W., & Griffiths, W. (2003). Identification of a potent antibacterial factor isolated from bronchoalveolar lavage fluid: guanidine,N-[3-[(aminoiminomethyl)amino]propyl]-N-dodecyl-, a potential source of error in the analysis of antibacterial agents. Rapid Communications in Mass Spectrometry, 17(3), 183-191.
https://doi.org/10.1002/rcm.891, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32554
http://www.scopus.com/inward/record.url?eid=2-s2.0-12244296134&partnerID=MN8TOARS
Hjelmqvist, L., Norin, A., El-Ahmad, M., Griffiths, W., Jörnvall, H., & Griffiths, W. (2003). Distinct but parallel evolutionary patterns between alcohol and aldehyde dehydrogenases: addition of fish/human betaine aldehyde dehydrogenase divergence. Cellular and Molecular Life Sciences (CMLS), 60(9), 2009-2016.
https://doi.org/10.1007/s00018-003-3287-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32553
http://www.scopus.com/inward/record.url?eid=2-s2.0-0141526315&partnerID=MN8TOARS
Weiland, M., Palm, J., Griffiths, W., McCaffery, J., Svärd, S., & Griffiths, W. (2003). Characterisation of alpha-1 giardin: an immunodominant Giardia lamblia annexin with glycosaminoglycan-binding activity. International Journal for Parasitology, 33(12), 1341-1351.
https://doi.org/10.1016/S0020-7519(03)00201-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32552
http://www.scopus.com/inward/record.url?eid=2-s2.0-0141867659&partnerID=MN8TOARS
Liu, S., Griffiths, W., Sjövall, J., & Griffiths, W. (2003). Capillary Liquid Chromatography/Electrospray Mass Spectrometry for Analysis of Steroid Sulfates in Biological Samples. Analytical Chemistry, 75(4), 791-797.
https://doi.org/10.1021/ac0262154, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32551
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037442602&partnerID=MN8TOARS
Rai, D., Griffiths, W., Landin, B., Wild, B., Alvelius, G., Green, B., & Griffiths, W. (2003). Accurate Mass Measurement by Electrospray Ionization Quadrupole Mass Spectrometry: Detection of Variants Differing by <6 Da from Normal in Human Hemoglobin Heterozygotes. Analytical Chemistry, 75(9), 1978-1982.
https://doi.org/10.1021/ac026228h, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32550
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037509972&partnerID=MN8TOARS
Hosia, W., Johansson, J., Griffiths, W., & Griffiths, W. (2002). Hydrogen/deuterium exchange and aggregation of a polyvaline and a polyleucine alpha-helix investigated by matrix-assisted laser desorption ionization mass spectrometry.. Molecular & cellular proteomics : MCP, 1
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37614
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036690049&partnerID=MN8TOARS
Rai, D., Landin, B., Griffiths, W., Alvelius, G., & Griffiths, W. (2002). Identification of N-terminal acetylation in Hb Raleigh (?1Val?Ac-Ala) by electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 16(18), 1793-1796.
https://doi.org/10.1002/rcm.774, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32566
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036377492&partnerID=MN8TOARS
Rai, D., Landin, B., Alvelius, G., Griffiths, W., & Griffiths, W. (2002). Electrospray Tandem Mass Spectrometry of Intact β-Chain Hemoglobin Variants. Analytical Chemistry, 74(9), 2097-2102.
https://doi.org/10.1021/ac011068f, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32565
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036558179&partnerID=MN8TOARS
Lengqvist, J., Griffiths, W., Perlmann, T., Sjövall, J., & Griffiths, W. (2002). Detection of a receptor-ligand non-covalent complex using a triple quadrupole mass spectrometer. Rapid Communications in Mass Spectrometry, 16(20), 2003-2006.
https://doi.org/10.1002/rcm.811, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32564
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036388229&partnerID=MN8TOARS
Rai, D., Landin, B., Griffiths, W., Alvelius, G., Green, B., & Griffiths, W. (2002). Characterization of the elusive disulfide bridge forming human Hb variant: Hb Ta-Li β83 (EF7)Gly → Cys by electrospray mass spectrometry. Journal of the American Society for Mass Spectrometry, 13(2), 187-191.
https://doi.org/10.1016/S1044-0305(01)00349-X, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32563
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036099033&partnerID=MN8TOARS
Markovič, O., Cederlund, E., Griffiths, W., Lipka, T., Jörnvall, H., & Griffiths, W. (2002). Characterization of carrot pectin methylesterase. Cellular and Molecular Life Sciences (CMLS), 59(3), 513-518.
https://doi.org/10.1007/s00018-002-8442-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32562
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036210626&partnerID=MN8TOARS
Jerremalm, E., Videhult, P., Alvelius, G., Griffiths, W., Bergman, T., Eksborg, S., Ehrsson, H., & Griffiths, W. (2002). Alkaline Hydrolysis of Oxaliplatin—Isolation and Identification of the Oxalato Monodentate Intermediate. Journal of Pharmaceutical Sciences, 91(10), 2116-2121.
https://doi.org/10.1002/jps.10201, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32560
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036786474&partnerID=MN8TOARS
Wang, Y., Griffiths, W., Jörnvall, H., Agerberth, B., Johansson, J., Griffiths, W., & Wang, Y. (2002). Antibacterial peptides in stimulated human granulocytes. European Journal of Biochemistry, 269(2), 512-518.
https://doi.org/10.1046/j.0014-2956.2001.02675.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32561
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036164391&partnerID=MN8TOARS
Alvelius, G., Hjalmarson, O., Griffiths, W., Björkhem, I., Sjövall, J., & Griffiths, W. (2001). Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick disease, type C. Journal of Lipid Research, 42
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37621
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034759769&partnerID=MN8TOARS
Griffiths, W., Jonsson, A., & Griffiths, W. (2001). Gas-phase conformation can have an influence on peptide fragmentation. European Journal of Mass Spectrometry, 7
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37620
http://www.scopus.com/inward/record.url?eid=2-s2.0-0346977266&partnerID=MN8TOARS
Rai, D., Griffiths, W., Alvelius, G., Landin, B., & Griffiths, W. (2001). Electrospray mass spectrometry: An efficient method to detect silent hemoglobin variants causing erythrocytosis. Clinical Chemistry, 47
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37619
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034956021&partnerID=MN8TOARS
Griffiths, W., Jonsson, A., Liu, S., Rai, D., Wang, Y., & Griffiths, W. (2001). Electrospray and tandem mass spectrometry in biochemistry. Biochemical Journal, 355
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37618
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035340925&partnerID=MN8TOARS
Gustafsson, M., Griffiths, W., Furusjö, E., Johansson, J., & Griffiths, W. (2001). The palmitoyl groups of lung surfactant protein C reduce unfolding into a fibrillogenic intermediate. Journal of Molecular Biology, 310(4), 937-950.
https://doi.org/10.1006/jmbi.2001.4810, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32572
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035919776&partnerID=MN8TOARS
Stark, M., Danielsson, O., Griffiths, W., Jörnvall, H., Johansson, J., & Griffiths, W. (2001). Peptide repertoire of human cerebrospinal fluid: novel proteolytic fragments of neuroendocrine proteins. Journal of Chromatography B: Biomedical Sciences and Applications, 754(2), 357-367.
https://doi.org/10.1016/S0378-4347(00)00628-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32571
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035946722&partnerID=MN8TOARS
Zaltash, S., Griffiths, W., Beck, D., Duan, C., Weaver, T., Johansson, J., & Griffiths, W. (2001). Membrane Activity of (Cys48Ser) Lung Surfactant Protein B Increases with Dimerisation. Biological Chemistry, 382(6)
https://doi.org/10.1515/BC.2001.116, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32570
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034912495&partnerID=MN8TOARS
Jonsson, A., Bergman, T., Jrnvall, H., Griffiths, W., & Griffiths, W. (2001). Gln-Gly cleavage: a dominant dissociation site in the fragmentation of protonated peptides. Rapid Communications in Mass Spectrometry, 15(9), 713-720.
https://doi.org/10.1002/rcm.289, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32568
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035023888&partnerID=MN8TOARS
Jonsson, A., Bergman, T., Jörnvall, H., Griffiths, W., Bratt, P., Strömberg, N., & Griffiths, W. (2001). Gln-Gly cleavage: Correlation between collision-induced dissociation and biological degradation. Journal of the American Society for Mass Spectrometry, 12(3), 337-342.
https://doi.org/10.1016/S1044-0305(01)00210-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32569
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035561190&partnerID=MN8TOARS
Griffiths, W., Jonsson, A., & Griffiths, W. (2001). Gas phase conformation can have an influence on peptide fragmentation. PROTEOMICS, 1(8), 934-945.
https://doi.org/10.1002/1615-9861(200108)1:8<934::AID-PROT934>3.0.CO;2-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32567
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035434422&partnerID=MN8TOARS
Griffiths, W. & Griffiths, W. (2000). Nanospray mass spectrometry in protein and peptide chemistry.. EXS, 88
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37622
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033644703&partnerID=MN8TOARS
Yang, Y., Griffiths, W., Nordling, M., Nygren, J., Möller, L., Bergman, J., Liepinsh, E., Otting, G., Gustafsson, J., Rafter, J., Sjövall, J., & Griffiths, W. (2000). Ring Opening of Benzo[a]pyrene in the Germ-Free Rat Is a Novel Pathway for Formation of Potentially Genotoxic Metabolites†. Biochemistry, 39(50), 15585-15591.
https://doi.org/10.1021/bi001148y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32579
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034687666&partnerID=MN8TOARS
Li, T., Bratt, P., Jonsson, A., Ryberg, M., Johansson, I., Griffiths, W., Bergman, T., Stromberg, N., & Griffiths, W. (2000). Possible Release of an ArgGlyArgProGln Pentapeptide with Innate Immunity Properties from Acidic Proline-Rich Proteins by Proteolytic Activity in Commensal Streptococcus and Actinomyces Species. Infection and Immunity, 68(9), 5425-5429.
https://doi.org/10.1128/IAI.68.9.5425-5429.2000, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32578
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033855722&partnerID=MN8TOARS
Rai, D., Alvelius, G., Landin, B., Griffiths, W., & Griffiths, W. (2000). Electrospray tandem mass spectrometry in the rapid identification of ?-chain haemoglobin variants. Rapid Communications in Mass Spectrometry, 14(14), 1184-1194.
https://doi.org/10.1002/1097-0231(20000730)14:14<1184::AID-RCM7>3.0.CO;2-S, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32577
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033932279&partnerID=MN8TOARS
De Urquiza, A., Liu, S., Sjoberg, M., Zetterstrom, R., Griffiths, W., Sjovall, J., Perlmann, T., & Griffiths, W. (2000). Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain. Science, 290(5499), 2140-2144.
https://doi.org/10.1126/science.290.5499.2140, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32576
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034672081&partnerID=MN8TOARS
Lindh, I., Hjelmqvist, L., Bergman, T., Sjövall, J., Griffiths, W., & Griffiths, W. (2000). De novo sequencing of proteolytic peptides by a combination of C-terminal derivatization and nano-electrospray/ collision-induced dissociation mass spectrometry. Journal of the American Society for Mass Spectrometry, 11(8), 673-686.
https://doi.org/10.1016/S1044-0305(00)00138-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32575
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034483890&partnerID=MN8TOARS
Wang, Y., Johansson, J., Griffiths, W., Griffiths, W., & Wang, Y. (2000). Characterisation of variant forms of prophenin: mechanistic aspects of the fragmentation of proline-rich peptides. Rapid Communications in Mass Spectrometry, 14(23), 2182-2202.
https://doi.org/10.1002/1097-0231(20001215)14:23<2182::AID-RCM151>3.0.CO;2-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32574
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033658161&partnerID=MN8TOARS
Liu, S., Sjövall, J., Griffiths, W., & Griffiths, W. (2000). Analysis of oxosteroids by nano-electrospray mass spectrometry of their oximes. Rapid Communications in Mass Spectrometry, 14(6), 390-400.
https://doi.org/10.1002/(SICI)1097-0231(20000331)14:6<390::AID-RCM882>3.0.CO;2-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32573
http://www.scopus.com/inward/record.url?eid=2-s2.0-0342980228&partnerID=MN8TOARS
Griffiths, W., Liu, S., Yang, Y., Purdy, R., Sjövall, J., & Griffiths, W. (1999). Nano-electrospray tandem mass spectrometry for the analysis of neurosteroid sulphates. Rapid Communications in Mass Spectrometry, 13
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37623
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032764203&partnerID=MN8TOARS
Jonsson, A., Carlquist, M., Husman, B., Ljunggren, J., Jörnvall, H., Bergman, T., Griffiths, W., & Griffiths, W. (1999). Structural analysis of the thyroid hormone receptor ligand binding domain: studies using a quadrupole time-of-flight tandem mass spectrometer. Rapid Communications in Mass Spectrometry, 13(18), 1782-1791.
https://doi.org/10.1002/(SICI)1097-0231(19990930)13:18<1782::AID-RCM714>3.0.CO;2-W, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32583
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032856196&partnerID=MN8TOARS
Yang, Y., Griffiths, W., Midtvedt, T., Sjövall, J., Rafter, J., Gustafsson, J., & Griffiths, W. (1999). Characterization of Conjugated Metabolites of Benzo[a]pyrene in Germ-Free Rat Urine by Liquid Chromatography/Electrospray Tandem Mass Spectrometry. Chemical Research in Toxicology, 12(12), 1182-1189.
https://doi.org/10.1021/tx990101e, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32581
http://www.scopus.com/inward/record.url?eid=2-s2.0-0000158577&partnerID=MN8TOARS
Wang, Y., Griffiths, W., Curstedt, T., Johansson, J., Griffiths, W., & Wang, Y. (1999). Porcine pulmonary surfactant preparations contain the antibacterial peptide prophenin and a C-terminal 18-residue fragment thereof. FEBS Letters, 460(2), 257-262.
https://doi.org/10.1016/S0014-5793(99)01363-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32582
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032698902&partnerID=MN8TOARS
Catrina, S., Catrina, A., Sirzén, F., Griffiths, W., Bergman, T., Biberfeld, P., Coculescu, M., Mutt, V., & Griffiths, W. (1999). A cytotoxic, apoptotic, low -molecular weight factor from pineal gland. Life Sciences, 65(10), 1047-1057.
https://doi.org/10.1016/S0024-3205(99)00335-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32580
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033618545&partnerID=MN8TOARS
Nilsson, G., Gustafsson, M., Vandenbussche, G., Veldhuizen, E., Griffiths, W., Sjovall, J., Haagsman, H., Ruysschaert, J., Robertson, B., Curstedt, T., Johansson, J., & Griffiths, W. (1998). Synthetic peptide-containing surfactants. Evaluation of transmembrane versus amphipathic helices and surfactant protein C poly-valyl to poly-leucyl substitution. European Journal of Biochemistry, 255
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37625
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032125901&partnerID=MN8TOARS
Lindh, I., Sjövall, J., Bergman, T., Griffiths, W., & Griffiths, W. (1998). Negative-ion electrospray tandem mass spectrometry of peptides derivatized with 4-aminonaphthalenesulphonic acid. Journal of Mass Spectrometry, 33(10), 988-993.
https://doi.org/10.1002/(SICI)1096-9888(1998100)33:10<988::AID-JMS713>3.0.CO;2-S, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32589
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031740069&partnerID=MN8TOARS
Hamberg, M., Liepinsh, E., Otting, G., Griffiths, W., & Griffiths, W. (1998). Isolation and structure of a new galactolipid from oat seeds. Lipids, 33(4), 355-363.
https://doi.org/10.1007/s11745-998-0215-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32588
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031958209&partnerID=MN8TOARS
Wejde, J., Hjertman, M., Carlberg, M., Egestad, B., Griffiths, W., Sjövall, J., Larsson, O., & Griffiths, W. (1998). Dolichol-like lipids with stimulatory effect on DNA synthesis: Substrates for protein dolichylation?. Journal of Cellular Biochemistry, 71(4), 502-514.
https://doi.org/10.1002/(SICI)1097-4644(19981215)71:4<502::AID-JCB5>3.0.CO;2-P, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32587
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032534660&partnerID=MN8TOARS
Tornhamre, S., Sjölinder, M., Lindberg, Å., Ericsson, I., Näsman-Glaser, B., Griffiths, W., Lindgren, J., & Griffiths, W. (1998). Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity. European Journal of Biochemistry, 251(1-2), 227-235.
https://doi.org/10.1046/j.1432-1327.1998.2510227.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32586
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032517887&partnerID=MN8TOARS
Griffiths, W., Gustafsson, M., Yang, Y., Curstedt, T., Sjövall, J., Johansson, J., & Griffiths, W. (1998). Analysis of variant forms of porcine surfactant polypeptide-C by nano-electrospray mass spectrometry. Rapid Communications in Mass Spectrometry, 12(16), 1104-1114.
https://doi.org/10.1002/(SICI)1097-0231(19980831)12:16<1104::AID-RCM277>3.0.CO;2-L, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32585
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031820054&partnerID=MN8TOARS
Yang, Y., Rafter, J., Gustafsson, J., Sjövall, J., Griffiths, W., & Griffiths, W. (1998). Analysis of the major mercapturic acid pathway metabolites of benzo[a]pyrene found in rat urine by nano-electrospray mass spectrometry. Rapid Communications in Mass Spectrometry, 12(8), 465-471.
https://doi.org/10.1002/(SICI)1097-0231(19980430)12:8<465::AID-RCM180>3.0.CO;2-F, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32584
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031916298&partnerID=MN8TOARS
Yang, Y., Rafter, J., Gustafsson, J., Sjövall, J., Griffiths, W., & Griffiths, W. (1997). Letter: Differentiation of isomeric mercapturic acid pathway metabolites of benzo[a]pyrene. European Mass Spectrometry, 3
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37628
http://www.scopus.com/inward/record.url?eid=2-s2.0-0012699467&partnerID=MN8TOARS
Meng, L., Griffiths, W., Nazer, H., Yang, Y., Sjövall, J., & Griffiths, W. (1997). High levels of (24S)-24-hydroxycholesterol 3-sulfate, 24-glucuronide in the serum and urine of children with severe cholestatic liver disease. Journal of Lipid Research, 38
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37627
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030906963&partnerID=MN8TOARS
Lindh, I., Griffiths, W., Bergman, T., Sjövall, J., & Griffiths, W. (1997). Electrospray/collision-induced dissociation of derivatised peptides: Studies on a hybrid magnetic sector-orthogonal time-of-flight mass spectrometer. International Journal of Mass Spectrometry and Ion Processes, 164
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37626
http://www.scopus.com/inward/record.url?eid=2-s2.0-0002625405&partnerID=MN8TOARS
Zhang, J., Griffiths, W., Sjövall, J., & Griffiths, W. (1997). The synthesis of taurine-conjugated bile acids and bile acid sulfates labeled with 14C or 3H in the taurine moiety. Journal of Labelled Compounds and Radiopharmaceuticals, 39(2), 159-164.
https://doi.org/10.1002/(SICI)1099-1344(199702)39:2<159::AID-JLCR954>3.0.CO;2-W, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32593
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031023912&partnerID=MN8TOARS
Yang, Y., Griffiths, W., Sjövall, J., Gustafsson, J., Rafter, J., & Griffiths, W. (1997). Liquid chromatography-mass spectrometry with collision-induced dissociation of conjugated metabolites of benzol[a]pyrene. Journal of the American Society for Mass Spectrometry, 8(1), 50-61.
https://doi.org/10.1016/S1044-0305(96)00136-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32592
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031016601&partnerID=MN8TOARS
Hjertman, M., Wejde, J., Dricu, A., Carlberg, M., Griffiths, W., Sjövall, J., Larsson, O., & Griffiths, W. (1997). Evidence for protein dolichylation. FEBS Letters, 416(3), 235-238.
https://doi.org/10.1016/S0014-5793(97)01208-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32591
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030707602&partnerID=MN8TOARS
Yang, Y., Griffiths, W., Nazer, H., Sjövall, J., & Griffiths, W. (1997). Analysis of Bile Acids and Bile Alcohols in Urine by Capillary Column Liquid Chromatography-Mass Spectrometry using Fast Atom Bombardment or Electrospray Ionization and Collision-induced Dissociation. Biomedical Chromatography, 11(4), 240-255.
https://doi.org/10.1002/(SICI)1099-0801(199707)11:4<240::AID-BMC686>3.0.CO;2-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32590
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030853916&partnerID=MN8TOARS
Severs, J., Griffiths, W., Harris, F., Andrews, S., Parry, D., & Griffiths, W. (1996). Double ionization of the n-alkyl iodides C2H5I, C3H7I and C4H9I. Journal of the Chemical Society, Faraday Transactions, 92(18), 3293
https://doi.org/10.1039/ft9969203293, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49846
Meng, L., Griffiths, W., Sjövall, J., & Griffiths, W. (1996). The identification of novel steroid N-acetylglucosaminides in the urine of pregnant women. Journal of Steroid Biochemistry and Molecular Biology, 58
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37635
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030203363&partnerID=MN8TOARS
Griffiths, W., Yang, Y., Sjövall, J., Lindgren, J., & Griffiths, W. (1996). Electrospray/collision-induced dissociation mass spectrometry of mono-, di- and tri-hydroxylated lipoxygenase products, including leukotrienes of the B-series and lipoxins. Rapid Communications in Mass Spectrometry, 10
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37634
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029687682&partnerID=MN8TOARS
Griffiths, W., Yang, Y., Sjövall, J., Lindgren, J., & Griffiths, W. (1996). Electrospray tandem mass spectrometry of cysteinyl leukotrienes. Rapid Communications in Mass Spectrometry, 10
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37633
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029760907&partnerID=MN8TOARS
Severs, J., Griffiths, W., Harris, F., Andrews, S., Parry, D., & Griffiths, W. (1996). Double ionization of the n-alkyl iodides C2H5I, C3H7I and C4H9I. Journal of the Chemical Society - Faraday Transactions, 92
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37632
http://www.scopus.com/inward/record.url?eid=2-s2.0-33748826164&partnerID=MN8TOARS
Griffiths, W., Yang, Y., Lindgren, J., Sjövall, J., & Griffiths, W. (1996). Charge remote fragmentation of fatty acid anions in 400 eV collisions with xenon atoms. Rapid Communications in Mass Spectrometry, 10
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37631
http://www.scopus.com/inward/record.url?eid=2-s2.0-0002094136&partnerID=MN8TOARS
Griffiths, W., Hjertman, M., Lundsjö, A., Wejde, J., Sjövall, J., Larsson, O., & Griffiths, W. (1996). Analysis of dolichols and polyprenols and their derivatives by electron impact, fast atom bombardment and electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 10
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37630
http://www.scopus.com/inward/record.url?eid=2-s2.0-0000919489&partnerID=MN8TOARS
Griffiths, W., Brown, A., Reimendal, R., Yang, Y., Zhang, J., Sjövall, J., & Griffiths, W. (1996). A comparison of fast-atom bombardment and electrospray as methods of ionization in the study of sulphated- and sulphonated-lipids by tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 10
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37629
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029762192&partnerID=MN8TOARS
Griffiths, W., Langford, M., Harris, F., & Griffiths, W. (1996). A Reaction Window in Cross-sections for Double-electron-capture Reactions. Rapid Communications in Mass Spectrometry, 10(9), 997-1000.
https://doi.org/10.1002/(SICI)1097-0231(19960715)10:9<997::AID-RCM554>3.0.CO;2-A, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32594
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029761226&partnerID=MN8TOARS
Griffiths, W., Lindh, I., Bergman, T., & Sjövall, J. (1995). Negative-ion electrospray mass spectra of peptides derivatized with 4-aminonaphthalenesulphonic acid. Rapid Communications in Mass Spectrometry, 9(8), 667-676.
https://doi.org/10.1002/rcm.1290090809, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49848
Yang, Y., Griffiths, W., Lindgren, J., Sjövall, J., & Griffiths, W. (1995). Liquid chromatography/mass spectrometry with collision-induced dissociation of arachidonic acid metabolites derivatized with aminobenzenesulphonic acid. Rapid Communications in Mass Spectrometry, 9(4), 289-299.
https://doi.org/10.1002/rcm.1290090407, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49847
Griffiths, W., Lindh, I., Bergman, T., Sjovall, J., & Griffiths, W. (1995). Negative-ion electrospray mass spectra of peptides derivatized with 4-aminonaphthalenesulphonic acid. Rapid Communications in Mass Spectrometry, 9
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37638
http://www.scopus.com/inward/record.url?eid=2-s2.0-0028896136&partnerID=MN8TOARS
Yang, Y., Griffiths, W., Lindgren, J., Sjövall, J., & Griffiths, W. (1995). Liquid chromatography/mass spectrometry with collision-induced dissociation of arachidonic acid metabolites derivatized with aminobenzenesulphonic acid.. Rapid communications in mass spectrometry : RCM, 9
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37637
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029195760&partnerID=MN8TOARS
Gheorghe, M., Lindh, I., Griffiths, W., Sjovall, J., Bergman, T., & Griffiths, W. (1995). Analytical approaches to alcohol dehydrogenase structures. Advances in Experimental Medicine and Biology, 372
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37636
http://www.scopus.com/inward/record.url?eid=2-s2.0-0028997753&partnerID=MN8TOARS
Pettersson, T., Ernström, U., Griffiths, W., Sjövall, J., Bergman, T., Jörnval, H., & Griffiths, W. (1995). Lutein associated with a transthyretin indicates carotenoid derivation and novel multiplicity of transthyretin ligands. FEBS Letters, 365(1), 23-26.
https://doi.org/10.1016/0014-5793(95)00389-Q, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32595
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029031171&partnerID=MN8TOARS
Marschall, H., Griffiths, W., Götze, U., Zhang, J., Wietholtz, H., Busch, N., Sjövall, J., & Matern, S. (1994). The major metabolites of ursodeoxycholic acid in human urine are conjugated withN-acetylglucosamine. Hepatology, 20(4), 845-853.
https://doi.org/10.1002/hep.1840200412, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49851
Griffiths, W., Zhang, J., & Sjövall, J. (1994). Charge-remote fragmentation of sulphated and glucuronidated bile acids and their 2-aminoethanesulphonic acid derivatives. Rapid Communications in Mass Spectrometry, 8(3), 227-236.
https://doi.org/10.1002/rcm.1290080302, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49850
Lindh, I., Griffiths, W., Bergman, T., & Sjövall, J. (1994). Charge-remote fragmentation of peptides derivatized with 4-aminonaphthalenesulphonic acid. Rapid Communications in Mass Spectrometry, 8(10), 797-803.
https://doi.org/10.1002/rcm.1290081002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49849
Marschall, H., Griffiths, W., Götze, U., Zhang, J., Wietholtz, H., Busch, N., Sjövall, J., Matern, S., & Griffiths, W. (1994). The major metabolites of ursodeoxycholic acid in human urine are conjugated with N-acetylglucosamine. Hepatology, 20
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37642
http://www.scopus.com/inward/record.url?eid=2-s2.0-0028129397&partnerID=MN8TOARS
Marschall, H., Griffiths, W., Zhang, J., Wietholtz, H., Matern, H., Matern, S., Sjovall, J., & Griffiths, W. (1994). Positions of conjugation of bile acids with glucose and N- acetylglucosamine in vitro. Journal of Lipid Research, 35
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37641
http://www.scopus.com/inward/record.url?eid=2-s2.0-0027978472&partnerID=MN8TOARS
Severs, J., Harris, F., Griffiths, W., & Griffiths, W. (1994). Double-ionization energies to singlet and triplet electronic states of the acetaldehyde dication measured by double-charge-transfer spectroscopy. International Journal of Mass Spectrometry and Ion Processes, 139
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37640
http://www.scopus.com/inward/record.url?eid=2-s2.0-43949154301&partnerID=MN8TOARS
Lindh, I., Griffiths, W., Bergman, T., Sjovall, J., & Griffiths, W. (1994). Charge-remote fragmentation of peptides derivatized with 4-aminonaphthalenesulphonic acid. Rapid Communications in Mass Spectrometry, 8
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37639
http://www.scopus.com/inward/record.url?eid=2-s2.0-0028518981&partnerID=MN8TOARS
Griffiths, W., de Brito, A., Correia, N., Severs, J., Harris, F., & Griffiths, W. (1994). Triplet electronic states of the doubly charged ion of acetone: a combined theoretical and experimental study. International Journal of Mass Spectrometry and Ion Processes, 134(2-3), 197-201.
https://doi.org/10.1016/0168-1176(94)03983-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32596
http://www.scopus.com/inward/record.url?eid=2-s2.0-1442269576&partnerID=MN8TOARS
Zhang, J., Griffiths, W., Bergman, T., Sjovall, J., & Griffiths, W. (1993). Derivatization of bile acids with taurine for analysis by fast atom bombardment mass spectrometry with collision-induced fragmentation. Journal of Lipid Research, 34
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37643
http://www.scopus.com/inward/record.url?eid=2-s2.0-0027488862&partnerID=MN8TOARS
Griffiths, W., Andrews, S., Parry, D., Jackson, P., Rontree, J., Harris, F., & Griffiths, W. (1993). Measured and calculated double-ionization energies of the chlorofluoroethane molecules CF3CF2Cl, CF3CFCl2, CF3CCl3, CF2ClCF2Cl, CF2ClCFCl2, CF2ClCCl3, CFCl2CFCl2 and CFCl2CCl3. International Journal of Mass Spectrometry and Ion Processes, 124(3), 251-257.
https://doi.org/10.1016/0168-1176(93)80095-V, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32601
http://www.scopus.com/inward/record.url?eid=2-s2.0-28044433611&partnerID=MN8TOARS
Andrews, S., Parry, D., Jackson, P., Vairamani, M., Griffiths, W., Harris, F., & Griffiths, W. (1993). Electronic-state energies of the CH2I 2+ 2 , CHI 2+ 3 and CI 2+ 4 dications. Journal of the Chemical Society, Faraday Transactions, 89(16), 2945
https://doi.org/10.1039/FT9938902945, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32600
http://www.scopus.com/inward/record.url?eid=2-s2.0-0010821768&partnerID=MN8TOARS
Griffiths, W., Svensson, S., De Brito, A., Correia, N., Wannberg, B., Langford, M., Harris, F., Liegener, C., Ågren, H., & Griffiths, W. (1993). Doubly ionized states of hexafluorobenzene studied by high-resolution Auger electron and double-charge-transfer spectroscopies. J. Chem. Soc., Faraday Trans., 89(11), 1637-1643.
https://doi.org/10.1039/FT9938901637, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32599
http://www.scopus.com/inward/record.url?eid=2-s2.0-1242328965&partnerID=MN8TOARS
Griffiths, W., Svensson, S., Naves de Brito, A., Correia, N., Reid, C., Langford, M., Harris, F., Liegener, C., Ågren, H., & Griffiths, W. (1993). Doubly ionized states of carbon tetrafluoride. Chemical Physics, 173(1), 109-121.
https://doi.org/10.1016/0301-0104(93)80222-U, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32598
http://www.scopus.com/inward/record.url?eid=2-s2.0-21144465875&partnerID=MN8TOARS
Griffiths, W., Langford, M., Harris, F., & Griffiths, W. (1993). Double-ionization energies of fluorinated benzene molecules. Journal of the American Society for Mass Spectrometry, 4(6), 513-518.
https://doi.org/10.1016/1044-0305(93)80010-V, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32597
http://www.scopus.com/inward/record.url?eid=2-s2.0-0011687070&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1992). Triplet electronic states of the ethene dication. International Journal of Mass Spectrometry and Ion Processes, 122, 321-329.
https://doi.org/10.1016/0168-1176(92)87022-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32604
http://www.scopus.com/inward/record.url?eid=2-s2.0-44049111501&partnerID=MN8TOARS
Griffiths, W., Harris, F., Andrews, S., Parry, D., & Griffiths, W. (1992). Double-ionization energies of the chloroethane molecules CH3CH2Cl, CH3CHCl2, CH3CCl3, CH2ClCH2Cl, CH2ClCHCl2, CH2ClCCl3, CHCl2CHCl2, CHCl2CCl3 and CCl3CCl3. International Journal of Mass Spectrometry and Ion Processes, 112(1), 45-61.
https://doi.org/10.1016/0168-1176(92)87031-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32603
http://www.scopus.com/inward/record.url?eid=2-s2.0-1442269555&partnerID=MN8TOARS
Liegener, C., Naves De Brito, A., Agren, H., Correia, N., Griffiths, W., Svensson, S., Harris, F., & Griffiths, W. (1992). Auger and double-charge-transfer spectra of polyconjugated hydrocarbons: Butadiene, hexatriene, and polyacetylene. Physical Review B, 46(18), 11295-11309.
https://doi.org/10.1103/PhysRevB.46.11295, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32602
http://www.scopus.com/inward/record.url?eid=2-s2.0-21444456066&partnerID=MN8TOARS
Griffiths, W., Egestad, B., Sjövall, J., & Griffiths, W. (1991). Charge-remote fragmentation of taurine-conjugated bile acids.. Rapid communications in mass spectrometry : RCM, 5
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37644
http://www.scopus.com/inward/record.url?eid=2-s2.0-0026225570&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1991). The benzene dication: Energies of excited states determined by double-charge-transfer spectroscopy using OH+ and F+ projectile ions. Chemical Physics, 157(1-2), 299-304.
https://doi.org/10.1016/0301-0104(91)87153-M, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32607
http://www.scopus.com/inward/record.url?eid=2-s2.0-1242351511&partnerID=MN8TOARS
Griffiths, W., Correia, N., Keane, M., Naves De Brito, A., Svensson, S., Karlsson, L., & Griffiths, W. (1991). Doubly ionized states of N2O studied by photon-induced Auger electron and double charge transfer spectroscopies. Journal of Physics B: Atomic, Molecular and Optical Physics, 24(19), 4187-4201.
https://doi.org/10.1088/0953-4075/24/19/014, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32606
http://www.scopus.com/inward/record.url?eid=2-s2.0-0004475507&partnerID=MN8TOARS
Griffiths, W., Harris, F., Andrews, S., Parry, D., & Griffiths, W. (1991). Double ionization energies to form the C2H2+6 ion in triplet ground and electronically excited states. International Journal of Mass Spectrometry and Ion Processes, 110(1-2), 135-143.
https://doi.org/10.1016/0168-1176(91)80022-F, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32605
http://www.scopus.com/inward/record.url?eid=2-s2.0-44949275235&partnerID=MN8TOARS
Griffiths, W., Harris, F., Parry, D., & Griffiths, W. (1990). Electronically excited states of the CH3I2+ ion. Journal of the Chemical Society, Faraday Transactions, 86(16), 2801
https://doi.org/10.1039/FT9908602801, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32608
http://www.scopus.com/inward/record.url?eid=2-s2.0-33748813606&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1989). The energies of triplet states of CO2+2 and OCS2+ ions. An experimental investigation by double-charge-transfer spectroscopy. International Journal of Mass Spectrometry and Ion Processes, 87(3), 349-357.
https://doi.org/10.1016/0168-1176(89)80034-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32613
http://www.scopus.com/inward/record.url?eid=2-s2.0-0000101933&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1989). Double ionization energies of the fluoroethane molecules C2H5F, CH3CHF2, CH2FCHF2, CH3CF3, CHF2CF3 and C2F6 measured by double-charge-transfer spectroscopy. Journal of the Chemical Society, Faraday Transactions 2, 85(9), 1575
https://doi.org/10.1039/F29898501575, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32611
http://www.scopus.com/inward/record.url?eid=2-s2.0-37049079349&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1989). Experimental determination of the energies required to form CH3NH2+2 and CH3SH2+ ions from their neutral counterparts. International Journal of Mass Spectrometry and Ion Processes, 89(1), 125-131.
https://doi.org/10.1016/0168-1176(89)85037-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32612
http://www.scopus.com/inward/record.url?eid=2-s2.0-3743117642&partnerID=MN8TOARS
Griffiths, W., Mathur, D., Harris, F., & Griffiths, W. (1989). An experimental investigation of a reaction window in cross-sections for double-charge-transfer reactions. International Journal of Mass Spectrometry and Ion Processes, 87(1), R1-R6.
https://doi.org/10.1016/0168-1176(89)80013-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32610
http://www.scopus.com/inward/record.url?eid=2-s2.0-9544225799&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1989). Amended interpretation of the results obtained in an experimental investigation of the structure of the H3O− ion. International Journal of Mass Spectrometry and Ion Processes, 87(1), R25
https://doi.org/10.1016/0168-1176(89)80017-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32609
http://www.scopus.com/inward/record.url?eid=2-s2.0-45249126244&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1988). Single and double ionization energies of sulphur hexafluoride measured by double charge transfer spectroscopy. International Journal of Mass Spectrometry and Ion Processes, 85(2), 259-264.
https://doi.org/10.1016/0168-1176(88)83021-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32620
http://www.scopus.com/inward/record.url?eid=2-s2.0-0039336319&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1988). Single and double ionization energies of sulphur hexafluoride measured by double charge transfer spectroscopy. International Journal of Mass Spectrometry and Ion Processes, 85(2), 259-264.
https://doi.org/10.1016/0168-1176(88)83021-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32621
http://www.scopus.com/inward/record.url?eid=2-s2.0-0039336319&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1988). Experimental evidence for two different structures of the H3O− ion and two different structures of the H3O+ ion. International Journal of Mass Spectrometry and Ion Processes, 85(3), 339-355.
https://doi.org/10.1016/0168-1176(88)80047-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32618
http://www.scopus.com/inward/record.url?eid=2-s2.0-0042645949&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1988). Experimental evidence for two different structures of the H3O− ion and two different structures of the H3O+ ion. International Journal of Mass Spectrometry and Ion Processes, 85(3), 339-355.
https://doi.org/10.1016/0168-1176(88)80047-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32619
http://www.scopus.com/inward/record.url?eid=2-s2.0-0042645949&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1988). Double ionization energies of the chlorofluoromethanes CF3Cl, CF2Cl2 and CFCl3 determined using double-charge-transfer spectroscopy. International Journal of Mass Spectrometry and Ion Processes, 86, 341-350.
https://doi.org/10.1016/0168-1176(88)80076-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32616
http://www.scopus.com/inward/record.url?eid=2-s2.0-38249029262&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1988). Double ionization energies of the chlorofluoromethanes CF3Cl, CF2Cl2 and CFCl3 determined using double-charge-transfer spectroscopy. International Journal of Mass Spectrometry and Ion Processes, 86, 341-350.
https://doi.org/10.1016/0168-1176(88)80076-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32617
http://www.scopus.com/inward/record.url?eid=2-s2.0-38249029262&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1988). Double ionization energies of fluoromethanes measured using a double electron-capture technique. International Journal of Mass Spectrometry and Ion Processes, 85(1), 69-79.
https://doi.org/10.1016/0168-1176(88)83005-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32614
http://www.scopus.com/inward/record.url?eid=2-s2.0-0003113155&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1988). Double ionization energies of fluoromethanes measured using a double electron-capture technique. International Journal of Mass Spectrometry and Ion Processes, 85(1), 69-79.
https://doi.org/10.1016/0168-1176(88)83005-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32615
http://www.scopus.com/inward/record.url?eid=2-s2.0-0003113155&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1987). Ionization energies of CH3O• and CH3S• radicals measured by charge-inversion energy-loss spectrometry. Chemical Physics Letters, 142(1-2), 7-9.
https://doi.org/10.1016/0009-2614(87)87240-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32628
http://www.scopus.com/inward/record.url?eid=2-s2.0-45949114882&partnerID=MN8TOARS
Griffiths, W., Harris, F., Beynon, J., & Griffiths, W. (1987). Experimental evidence for the stability of the NH4., H3O., H3S., and H3. radicals by neutralization-reionization spectroscopy. International Journal of Mass Spectrometry and Ion Processes, 77(2-3), 233-239.
https://doi.org/10.1016/0168-1176(87)87010-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32626
http://www.scopus.com/inward/record.url?eid=2-s2.0-0001463599&partnerID=MN8TOARS
Griffiths, W., Harris, F., Beynon, J., & Griffiths, W. (1987). Experimental evidence for the stability of the NH4., H3O., H3S., and H3. radicals by neutralization-reionization spectroscopy. International Journal of Mass Spectrometry and Ion Processes, 77(2-3), 233-239.
https://doi.org/10.1016/0168-1176(87)87010-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32627
http://www.scopus.com/inward/record.url?eid=2-s2.0-0001463599&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1987). Energetics of charge-inversion reactions of H3O+ and H3O− ions. International Journal of Mass Spectrometry and Ion Processes, 77(2-3), R7-R12.
https://doi.org/10.1016/0168-1176(87)87013-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32624
http://www.scopus.com/inward/record.url?eid=2-s2.0-23544433282&partnerID=MN8TOARS
Griffiths, W., Harris, F., & Griffiths, W. (1987). Energetics of charge-inversion reactions of H3O+ and H3O− ions. International Journal of Mass Spectrometry and Ion Processes, 77(2-3), R7-R12.
https://doi.org/10.1016/0168-1176(87)87013-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32625
http://www.scopus.com/inward/record.url?eid=2-s2.0-23544433282&partnerID=MN8TOARS
Griffiths, W., Mathur, D., Harris, F., & Griffiths, W. (1987). Double ionisation energy of methane measured using a double electron capture technique. Journal of Physics B: Atomic and Molecular Physics, 20(15), L493-L497.
https://doi.org/10.1088/0022-3700/20/15/007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32622
http://www.scopus.com/inward/record.url?eid=2-s2.0-25344463196&partnerID=MN8TOARS
Griffiths, W., Mathur, D., Harris, F., & Griffiths, W. (1987). Double ionisation energy of methane measured using a double electron capture technique. Journal of Physics B: Atomic and Molecular Physics, 20(15), L493-L497.
https://doi.org/10.1088/0022-3700/20/15/007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32623
http://www.scopus.com/inward/record.url?eid=2-s2.0-25344463196&partnerID=MN8TOARS
Griffiths, W., Harris, F., Brenton, A., Beynon, J., & Griffiths, W. (1986). Experimental determination of the ionization energy of the CH5· radical. International Journal of Mass Spectrometry and Ion Processes, 74(2-3), 317-321.
https://doi.org/10.1016/0168-1176(86)85015-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32630
http://www.scopus.com/inward/record.url?eid=2-s2.0-41149168000&partnerID=MN8TOARS
Griffiths, W., Harris, F., Brenton, A., Beynon, J., & Griffiths, W. (1986). Experimental determination of the ionization energy of the CH5· radical. International Journal of Mass Spectrometry and Ion Processes, 74(2-3), 317-321.
https://doi.org/10.1016/0168-1176(86)85015-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32629
http://www.scopus.com/inward/record.url?eid=2-s2.0-41149168000&partnerID=MN8TOARS

Llyfrau Awdurol

Griffiths, W. & Wang, Y. (2020). Lipidomics Royal Society of Chemistry.
https://doi.org/10.1039/9781788013109, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53522
http://dx.doi.org/10.1039/9781788013109
Griffiths, W., Wang, Y., & Griffiths, W. (2014). Comprehensive Biomedical Physics. Chapter: Lipidomics in Metabolomics (1st ed.). Elsevier.
https://doi.org/10.1016/B978-0-444-53632-7.01113-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32519
http://www.scopus.com/inward/record.url?eid=2-s2.0-84943371635&partnerID=MN8TOARS
Dudley, E., Yousef, M., Wang, Y., Griffiths, W., & Griffiths, W. (2010). Targeted metabolomics and mass spectrometry
https://doi.org/10.1016/B978-0-12-381264-3.00002-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32522
http://www.scopus.com/inward/record.url?eid=2-s2.0-78649829438&partnerID=MN8TOARS
Wang, Y., Griffiths, W., & Griffiths, W. (2007). Steroids, sterols and the nervous system
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37605
http://www.scopus.com/inward/record.url?eid=2-s2.0-84871833055&partnerID=MN8TOARS
Wang, Y., Griffiths, W., & Griffiths, W. (2007). Mass spectrometry for metabolite identification
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37603
http://www.scopus.com/inward/record.url?eid=2-s2.0-84871846715&partnerID=MN8TOARS
Griffiths, W. & Griffiths, W. (1999). Tandem mass spectrometry of alcohol dehydrogenase and related biomolecules
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37624
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033282015&partnerID=MN8TOARS

Penodau Llyfrau

Griffiths, W., Yutuc, E., & Wang, Y. (2023). Mass Spectrometry Imaging of Cholesterol and Oxysterols. Implication of Oxysterols and Phytosterols in Aging and Human Diseases (pp. 73-87). Springer International Publishing
https://doi.org/10.1007/978-3-031-43883-7_5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64898
Griffiths, W. & Wang, Y. (2020). CHAPTER 10. New Scans and Resources in Lipidomics. New Developments in Mass Spectrometry (pp. 263-282). Royal Society of Chemistry
https://doi.org/10.1039/9781788013109-00263, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53523
Wang, Y. & Griffiths, W. (2020). CHAPTER 6. Derivatisation for Direct Infusion– and Liquid Chromatography–Mass Spectrometry. New Developments in Mass Spectrometry (pp. 122-147). Royal Society of Chemistry
https://doi.org/10.1039/9781788013109-00122, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53524
Griffiths, W., Yutuc, E., Davies, D., Dickson, A., Angelini, R., Assad, D., Frache, G., & Wang, Y. (2020). CHAPTER 1. Lipidomics Basics. New Developments in Mass Spectrometry (pp. 1-24). Royal Society of Chemistry
https://doi.org/10.1039/9781788013109-00001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53525
Griffiths, W. (2017). Liquid Chromatography-Mass Spectrometry of Sterols. Encyclopedia of Lipidomics Springer Science+Business Media B.V.
https://doi.org/10.1007/978-94-007-7864-1_79-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32968
Griffiths, W., Ogundare, M., Meljon, A., & Wang, Y. (2012). Mass Spectrometry for Steroid Analysis. Mass Spectrometry Handbook Wiley
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10781
Wang, Y., Meljon, A., Ogundare, M., & Griffiths, W. (2012). Development and application of novel analytical methods in lipidomics. Chemical Genomics and Proteomics, Second Edition Taylor & Francis Group
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10814
Kasal, A., Budesinsky, M., & Griffiths, W. (2010). Spectroscopic Methods of Steroid Analysis. Steroid Analysis Springer Science
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10941
Makin, H., Honour, J., Shackleton, C., & Griffiths, W. (2010). General Methods for the Extraction, Purification, and Measurement of Steroids by Chromatography and Mass Spectrometry. Steroid Analysis, Springer Science
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10942
Sjövall, J., Griffiths, W., Setchell, K., Mano, N., & Goto, J. (2010). Analysis of Bile Acids. Steroid Analysis,
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10943
Wang, Y. & Griffiths, W. (2007). Chapter 1. Mass Spectrometry for Metabolite Identification. Metabolomics, Metabonomics and Metabolite Profiling (pp. 1-43). Royal Society of Chemistry
https://doi.org/10.1039/9781847558107-00001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10985
Griffiths, W. & Wang, Y. (n.d.) Introduction and Overview of Lipidomic Strategies. Lipidomics (pp. 1-11). Humana Press
https://doi.org/10.1007/978-1-4939-6946-3_1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31986

Cyfraniadau Cynadleddau

Liu, S., Griffiths, W., Sjövall, J., & Griffiths, W. (2002). Steroid oxidation: On-column electrochemical reactions can accompany the electrospray process. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37617
http://www.scopus.com/inward/record.url?eid=2-s2.0-2442669373&partnerID=MN8TOARS
Wang, Y., Griffiths, W., & Griffiths, W. (2002). MS/MS of prophenin: Application of high resolution and accurate mass. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37616
http://www.scopus.com/inward/record.url?eid=2-s2.0-2442651859&partnerID=MN8TOARS
Lengqvist, J., Griffiths, W., Bergman, A., Sjövall, J., Perlmann, T., & Griffiths, W. (2002). Ligand binding to RXR α. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37615
http://www.scopus.com/inward/record.url?eid=2-s2.0-2442685699&partnerID=MN8TOARS
Rai, D., Landin, B., Alvelius, G., Griffiths, W., & Griffiths, W. (2002). Gel-elution: A method to enrich and isolate variant hemoglobins for electrospray mass spectrometry. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37613
http://www.scopus.com/inward/record.url?eid=2-s2.0-2442665469&partnerID=MN8TOARS
Griffiths, W., Alvelius, G., Liu, S., Sjövall, J., & Griffiths, W. (2002). Derivatives revisited: Analysis of neutral steroids by electrospray mass spectrometry. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37612
http://www.scopus.com/inward/record.url?eid=2-s2.0-2442708000&partnerID=MN8TOARS
Hosia, W., Griffiths, W., Johansson, J., & Griffiths, W. (2002). Aggregation and helical rigidity of similar peptides studied by H /D-exchange MALDI mass spectrometry. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37611
http://www.scopus.com/inward/record.url?eid=2-s2.0-2442676792&partnerID=MN8TOARS

Llyfrau wedi'u Golygu

Griffiths, W. (Ed.). (2008). Metabolomics, Metabonomics and Metabolite Profiling. Royal Society of Chemistry.
https://doi.org/10.1039/9781847558107, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10984

Cynnyrch Ymchwil Arall

Griffiths, W., Yutuc, E., Ali Asgari, M., & Wang, Y. (2023). Role of Bile Acid Pathway Intermediates in Pathology of CTX
https://doi.org/10.5281/zenodo.10050199, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64910
Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., & Griffiths, W. (2019). Imaging Sterols and Oxysterols in Mouse Brain Reveals Distinct Spatial Cholesterol Metabolism
https://doi.org/10.1101/450973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53208
Griffiths, W., Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Howell, O., & Wang, Y. (2018). Imaging Oxysterols in Mouse Brain by On-Tissue Derivatisation-Robotic Liquid Micro-Extraction Surface Analysis-Liquid Chromatography Mass Spectrometry
https://doi.org/10.1101/450973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48402
Griffiths, W. & Wang, Y. (2011). Analysis of oxysterol metabolomes
https://doi.org/10.1016/j.bbalip.2011.05.012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10758
Griffiths, W., Koal, T., Wang, Y., Kohl, M., Enot, D., Deigner, H., & Griffiths, W. (2010). Targeted Metabolomics for Biomarker Discovery
https://doi.org/10.1002/anie.200905579, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10764
Griffiths, W. & Sjövall, J. (2010). Analytical strategies for characterization of bile acid and oxysterol metabolomes
https://doi.org/10.1016/j.bbrc.2010.02.149, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10782
Griffiths, W., Sjovall, J., & Griffiths, W. (2010). Bile acids: analysis in biological fluids and tissues
https://doi.org/10.1194/jlr.R001941-JLR200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10783
Griffiths, W. & Wang, Y. (2009). Analysis of neurosterols by GC–MS and LC–MS/MS
https://doi.org/10.1016/j.jchromb.2009.05.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10947
Griffiths, W. & Wang, Y. (2009). Mass spectrometry: from proteomics to metabolomics and lipidomics
https://doi.org/10.1039/B618553N, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10948
Griffiths, W. & Wang, Y. (2009). The Importance of Steroidomics in the Study of Neurodegenerative Disease and Ageing
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10951
Wang, Y. & Griffiths, W. (2007). Modern Methods of Bile Acid Analysis by Mass Spectrometry: A View into the Metabolome
https://doi.org/10.2174/157341107780361709, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10957
Jornvall, H., Griffiths, W., & Bergman, T. (2002). Encyclopedia of Molecular Biology
https://doi.org/10.1002/047120918x.emb1233, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49845
J��rnvall, H., Griffiths, W., & Bergman, T. (2002). Encyclopedia of Molecular Biology
https://doi.org/10.1002/047120918x.emb0353, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49844
Griffiths, W. (n.d.) Profiling the Lipidome requires quality control
https://doi.org/10.5281/zenodo.4672232, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56656
Griffiths, W. (n.d.) Metabolomics, Metabonomics and Metabolite Profiling
https://doi.org/10.1039/9781847558107-fp005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49854
Griffiths, W. (n.d.) Metabolomics, Metabonomics and Metabolite Profiling
https://doi.org/10.1039/9781847558107-fp001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49853
Griffiths, W. (n.d.) Metabolomics, Metabonomics and Metabolite Profiling
https://doi.org/10.1039/9781847558107-fp006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49852

Goruchwyliaeth

Sterol Biomarker Discovery in Neurodegenerative Diseases (dyfarnwyd 2023)

PhD

Goruchwyliwr arall: Prof Michael Gravenor

Goruchwyliwr arall: Prof Yuqin Wang
Cholesterol Dysregulation in Multiple Sclerosis: Implications for Pathogenesis and Opportunities for Monitoring and Treating Progressive Disease (dyfarnwyd 2024)

PhD

Goruchwyliwr arall: Dr Owain Howell
The profiling and imaging of sterol molecules in the human brain (dyfarnwyd 2023)

PhD

Goruchwyliwr arall: Dr Owain Howell

Modiwlau a Addysgir

PM-278 Advanced Metabolism

The modules seeks to expand upon the first year metabolism module (PM-127) to encompass the metabolism of other biomolecules and further additions to central glycolysis and the TCA cycle. The module discusses the uptake and metabolism of carbohydrates other than glucose, the use of carbohydrates in the pentose phosphate and Entner-Douderoff pathways and disease implications. Fatty acid and cholesterol metabolism and transport systems are discussed, alongside clinical implications and modern therapeutic drugs that target these pathways. The pathways of amino acid synthesis and degradation in humans are described along with an introduction to the urea cycle.
PM-278C Metabolaeth Uwch

Nod y modiwl hwn yw ehangu ar fodiwl metabolaeth y flwyddyn gyntaf (PM-127) i gynnwys metabolaeth biofoleciwlau eraill ac ychwanegu mwy am glycolsis canolog a'r cylchred TCA. Mae'r modiwl yn trafod ymlifiad a metabolaeth carbohydradau ac eithrio glucos, y defnydd o garbohydradau yn y llwybrau ffosffad pentos ac Entner-Douderoff a¿r goblygiadau clefyd. Caiff metabolaeth asid brasterog a cholesterol a systemau cludo eu trafod, ynghyd â goblygiadau clinigol a chyffuriau therapiwtig modern sy'n targedu'r llwybrau hyn.Caiff llwybrau synthesis asidau amino a diraddiad mewn pobl eu disgrifio ynghyd â chyflwyniad i'r gylchred wrea.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-400 Advanced Research Project A

The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an extended period of time. The project will fall into one of the current medically-related research themes: Biomarkers and Genes; Microbes and Immunity; Devices and health informatics. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title. For example, a Genetics student could be assigned a project investigating gene function in an insect vector of a tropical disease, using the technique of RNA interference. The advanced research project is divided between 2 modules, PM-400 and PM-405.

Grantiau a Phrosiectau Allweddol

A 3-D Neurosterol Atlas of Mouse Brain 2020 - 2024

, with Professor Yuqin Wang , £553,879
Mass Spectrometry Based Lipidomics and Metabolomics to Drive Bioscience 2019 - 2020

, with Professor Yuqin Wang , £748,381
Lipid Biomarkers for Parkinson's Disease 2019 - 2021

, with Professor Yuqin Wang , 312,816 USD

Yr Athro William Griffiths

Rhif ffôn

Cyfeiriad ebost

Welsh language proficiency

Twitter Account

Dolenni Ymchwil

Trosolwg

Meysydd Arbenigedd

Uchafbwyntiau Gyrfa

Uchafbwyntiau Ymchwil

Holl Ymchwil

Sterol Biomarker Discovery in Neurodegenerative Diseases (dyfarnwyd 2023)

Cholesterol Dysregulation in Multiple Sclerosis: Implications for Pathogenesis and Opportunities for Monitoring and Treating Progressive Disease (dyfarnwyd 2024)

The profiling and imaging of sterol molecules in the human brain (dyfarnwyd 2023)

PM-278 Advanced Metabolism

PM-278C Metabolaeth Uwch

PM-344 Capstone Project

PM-400 Advanced Research Project A