Dr Spyridon Zisimopoulos

Athro Cyswllt, Biomedical Sciences

spyros.zissimopoulos@abertawe.ac.uk

Swyddfa Academaidd - 142
Llawr Cyntaf
Y Sefydliad Gwyddor Bywyd 1
Campws Singleton

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

https://orcid.org/0000-0001-5196-9450

ResearchGate

Trosolwg

Mae Spyros yn Uwch-gymrawd Ymchwil y British Heart Foundation ac yn Athro Cyswllt sydd wedi cael 20 mlynedd o brofiad o ymchwilio i'r broses o gyplysu cynhyrfu â chrebachu yn y galon, a gwaith calsiwm fel cyfrwng arwyddion. Enillodd Spyros BSc mewn Cemeg o Brifysgol Athens yng Ngwlad Groeg ac MSc mewn Biocemeg a Bioleg Foleciwlaidd o Goleg y Brenin Llundain. Dyfarnwyd PhD iddo gan Goleg Meddygaeth Prifysgol Cymru am nodweddu cymhlygyn sianelau rhyddhau calsiwm derbynyddion ryanodine (ryanodine receptor calcium release channel complex). Bu Spyros yn gweithio am sawl blwyddyn yn Sefydliad Ymchwil y Galon Cymru, Caerdydd, gydag ymchwilwyr o'r un meddylfryd (Tony Lai, Alan Williams, Chris George, Lowri Thomas) er mwyn ennill ac ehangu ei arbenigedd ym meysydd biowybodeg, bioleg foleciwlaidd, biocemeg, nodweddu sianelau unigol bioffisegol, fflworoleuedd a microsgopeg gydffocal. Cafodd gyrfa annibynnol Spyros ei sbarduno gan Gymrodoriaeth Ymchwil Ganolradd y BHF yn 2019 a'i hatgyfnerthu gan Uwch-gymrodoriaeth Ymchwil y BHF yn 2015. Mae ef wedi bod yn Ysgol Feddygaeth Abertawe ers 2017 ac fe'i penodwyd yn Athro Cyswllt yn 2020.

Mae prif ymchwil Spyros yn ymwneud â dadansoddi strwythur-gweithrediad sianelau rhyddhau calsiwm derbynyddion ryanodine a'i rôl mewn achosion o arhythmia a marwolaeth y galon. Mae ganddo uchelgais penodol i nodi cyffuriau newydd i atal achosion o arhythmia sy'n targedu gweithrediad derbynyddion ryanodine yn benodol ac yn ei sefydlogi.

Meysydd Arbenigedd

Calsiwm fel cyfrwng arwyddion
Cyplysu cynhyrfu â chrebachu yn y galon
Mecanweithiau moleciwlaidd clefydau
Rhyngweithiadau protein-protein
Gweithgarwch sianelau rhyddhau calsiwm

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Mae Spyros wedi goruchwylio sawl myfyriwr ymchwil ôl-raddedig ar lefel MSc a PhD. Mae ef hefyd yn cyfrannu'n weithredol at addysgu’r rhaglen BSc yn y Gwyddorau Meddygol Cymhwysol.

Ymchwil Prif Wobrau Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

ZHANG, Y., Rabesahala de Meritens, C., Beckmann, A., Lai, F., & Zisimopoulos, S. (2022). Defective ryanodine receptor N-terminus inter-subunit interaction is a common mechanism in neuromuscular and cardiac disorders. Frontiers in Physiology, 13
https://doi.org/10.3389/fphys.2022.1032132, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62166
Patel, S., Zisimopoulos, S., & Marchant, J. (2022). Endo-Lysosomal Two-Pore Channels and Their Protein Partners. Handbook of Experimental Pharmacology Springer Berlin Heidelberg
https://doi.org/10.1007/164_2022_601, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62165
Fowler, E. & Zisimopoulos, S. (2022). Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease. Biomolecules, 12(8), 1030
https://doi.org/10.3390/biom12081030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62164
Yin, L., Zahradnikova, A., Rizzetto, R., Boncompagni, S., Rabesahala de Meritens, C., ZHANG, Y., Joanne, P., Marqués-Sulé, E., Aguilar-Sánchez, Y., Fernández-Tenorio, M., Villejoubert, O., Li, L., Wang, Y., Mateo, P., Nicolas, V., Gerbaud, P., Lai, F., Perrier, R., Álvarez, J...., & Gómez, A. (2021). Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation. Circulation Research, 129(3), e35-e52.
https://doi.org/10.1161/circresaha.121.319094, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57636
http://dx.doi.org/10.1161/circresaha.121.319094
Seidel, M., Rabesahala de Meritens, C., Johnson, L., Parthimos, D., Bannister, M., Thomas, N., Ozekhome-Mike, E., Lai, F., & Zisimopoulos, S. (2021). Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function. Cardiovascular Research, 117(3), 780-791.
https://doi.org/10.1093/cvr/cvaa043, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53861
Stanczyk, P., Seidel, M., White, J., Viero, C., George, C., Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2018). Association of cardiac myosin-binding protein-C with the ryanodine receptor channel – putative retrograde regulation?. Journal of Cell Science, 131(15), jcs210443
https://doi.org/10.1242/jcs.210443, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41186
Handhle, A., Ormonde, C., Thomas, N., Bralesford, C., Williams, A., Lai, F., Zissimopoulos, S., Thomas, N., & Zisimopoulos, S. (2016). Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain. Journal of Cell Science, jcs.191643
https://doi.org/10.1242/jcs.191643, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35345
http://www.scopus.com/inward/record.url?eid=2-s2.0-84995529372&partnerID=MN8TOARS
Stanczyk, P., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2016). Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study. Journal of Visualized Experiments(113)
https://doi.org/10.3791/54271, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36630
Seidel, M., Thomas, N., Williams, A., Lai, F., Zissimopoulos, S., Thomas, N., Zisimopoulos, S., & Williams, A. (2015). Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors. Cardiovascular Research, 105(1), 118-128.
https://doi.org/10.1093/cvr/cvu240, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35341
http://www.scopus.com/inward/record.url?eid=2-s2.0-84929081932&partnerID=MN8TOARS
Domingo, D., Neco, P., Fernández-Pons, E., Zissimopoulos, S., Molina, P., Olagüe, J., Suárez-Mier, M., Lai, F., Gómez, A., Zorio, E., & Zisimopoulos, S. (2015). Non-ventricular, Clinical, and Functional Features of the RyR2R420Q Mutation Causing Catecholaminergic Polymorphic Ventricular Tachycardia. Revista Española de Cardiología (English Edition), 68(5), 398-407.
https://doi.org/10.1016/j.rec.2014.04.023, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36632
Seidel, M., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2015). Structural and functional interactions within ryanodine receptor. Biochemical Society Transactions, 43(3), 377-383.
https://doi.org/10.1042/BST20140292, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36631
Ljubojevic, S., Radulovic, S., Leitinger, G., Sedej, S., Sacherer, M., Holzer, M., Winkler, C., Pritz, E., Mittler, T., Schmidt, A., Sereinigg, M., Wakula, P., Zissimopoulos, S., Bisping, E., Post, H., Marsche, G., Bossuyt, J., Bers, D., Kockskamper, J...., & Zisimopoulos, S. (2014). Early Remodeling of Perinuclear Ca2+ Stores and Nucleoplasmic Ca2+ Signaling During the Development of Hypertrophy and Heart Failure. Circulation, 130(3), 244-255.
https://doi.org/10.1161/CIRCULATIONAHA.114.008927, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36634
Zissimopoulos, S., Marsh, J., Stannard, L., Seidel, M., Lai, F., & Zisimopoulos, S. (2014). N-terminus oligomerization is conserved in intracellular calcium release channels. Biochemical Journal, 459(2), 265-273.
https://doi.org/10.1042/BJ20131061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36635
Lam, A., Galione, A., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2013). Hax-1 identified as a two-pore channel (TPC)-binding protein. FEBS Letters, 587(23), 3782-3786.
https://doi.org/10.1016/j.febslet.2013.10.031, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36639
Zissimopoulos, S., Viero, C., Seidel, M., Cumbes, B., White, J., Cheung, I., Stewart, R., Jeyakumar, L., Fleischer, S., Mukherjee, S., Lowri Thomas, N., Williams, A., Anthony Lai, F., Cumbes, B., Thomas, N., Zisimopoulos, S., Mukherjee, S., & Williams, A. (2013). N-terminus oligomerization regulates the function of cardiac ryanodine receptors. Journal of Cell Science, 126(21), 5042-5051.
https://doi.org/10.1242/jcs.133538, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34390
http://www.scopus.com/inward/record.url?eid=2-s2.0-84887595981&partnerID=MN8TOARS
Zissimopoulos, S., Seifan, S., Maxwell, C., Williams, A., Lai, F., Zisimopoulos, S., & Williams, A. (2012). Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart. Journal of Cell Science, 125(7), 1759-1769.
https://doi.org/10.1242/jcs.098012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35915
Zissimopoulos, S., Thomas, N., Jamaluddin, W., Lai, F., Thomas, N., & Zisimopoulos, S. (2009). FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. Biochemical Journal, 419(2), 273-278.
https://doi.org/10.1042/BJ20082324, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35332
http://www.scopus.com/inward/record.url?eid=2-s2.0-64249111141&partnerID=MN8TOARS
Gomez, A., Rueda, A., Sainte-Marie, Y., Pereira, L., Zissimopoulos, S., Zhu, X., Schaub, R., Perrier, E., Perrier, R., Latouche, C., Richard, S., Picot, M., Jaisser, F., Lai, F., Valdivia, H., Benitah, J., & Zisimopoulos, S. (2009). Mineralocorticoid Modulation of Cardiac Ryanodine Receptor Activity Is Associated With Downregulation of FK506-Binding Proteins. Circulation, 119(16), 2179-2187.
https://doi.org/10.1161/CIRCULATIONAHA.108.805804, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36642
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2007). Ryanodine receptor structure, function and pathophysiology. Calcium - A Matter of Life or Death (pp. 287-342). Elsevier
https://doi.org/10.1016/S0167-7306(06)41012-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36654
http://www.sciencedirect.com/science/article/pii/S0167730606410127
Zissimopoulos, S., Docrat, N., Lai, F., & Zisimopoulos, S. (2007). Redox Sensitivity of the Ryanodine Receptor Interaction with FK506-binding Protein. Journal of Biological Chemistry, 282(10), 6976-6983.
https://doi.org/10.1074/jbc.M607590200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36644
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2006). Redox regulation of the ryanodine receptor/calcium release channel. Biochemical Society Transactions, 34(5), 919-921.
https://doi.org/10.1042/BST0340919, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36645
Liu, N. & Zisimopoulos, S. (2006). Arrhythmogenesis in Catecholaminergic Polymorphic Ventricular Tachycardia: Insights From a RyR2 R4496C Knock-In Mouse Model. Circulation Research, 99(3), 292-298.
https://doi.org/10.1161/01.RES.0000235869.50747.e1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36646
De Crescenzo, V., Fogarty, K., ZhuGe, R., Tuft, R., Lifshitz, L., Carmichael, J., Bellve, K., Baker, S., Zissimopoulos, S., Lai, F., Lemos, J., Walsh, J., & Zisimopoulos, S. (2006). Dihydropyridine Receptors and Type 1 Ryanodine Receptors Constitute the Molecular Machinery for Voltage-Induced Ca2+ Release in Nerve Terminals. Journal of Neuroscience, 26(29), 7565-7574.
https://doi.org/10.1523/JNEUROSCI.1512-06.2006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36647
Zisimopoulos, S., West, D., Williams, A., & Lai, F. (2006). Ryanodine receptor interaction with the SNARE-associated protein snapin. Journal of Cell Science, 119(11), 2386-2397.
https://doi.org/10.1242/jcs.02936, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35574
http://europepmc.org/abstract/med/16723744
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2005). Interaction of FKBP12.6 with the Cardiac Ryanodine Receptor C-terminal Domain. Journal of Biological Chemistry, 280(7), 5475-5485.
https://doi.org/10.1074/jbc.M412954200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36649
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2005). Central Domain of the Human Cardiac Muscle Ryanodine Receptor Does Not Mediate Interaction With FKBP12.6. Cell Biochemistry and Biophysics, 43(2), 203-220.
https://doi.org/10.1385/CBB:43:2:203, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36650
Blayney, L., Zissimopoulos, S., Ralph, E., Abbot, E., Matthews, L., Lai, F., & Zisimopoulos, S. (2004). Ryanodine Receptor Oligomeric Interaction. Journal of Biological Chemistry, 279(15), 14639-14648.
https://doi.org/10.1074/jbc.M308014200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36651
STEWART, R., ZISSIMOPOULOS, S., LAI, F., & Zisimopoulos, S. (2003). Oligomerization of the cardiac ryanodine receptor C-terminal tail. Biochemical Journal, 376(3), 795-799.
https://doi.org/10.1042/BJ20030597, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36652

Holl Ymchwil

Erthyglau Cylchgronau

ZHANG, Y., Rabesahala de Meritens, C., Beckmann, A., Lai, F., & Zisimopoulos, S. (2022). Defective ryanodine receptor N-terminus inter-subunit interaction is a common mechanism in neuromuscular and cardiac disorders. Frontiers in Physiology, 13
https://doi.org/10.3389/fphys.2022.1032132, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62166
Fowler, E. & Zisimopoulos, S. (2022). Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease. Biomolecules, 12(8), 1030
https://doi.org/10.3390/biom12081030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62164
Yin, L., Zahradnikova, A., Rizzetto, R., Boncompagni, S., Rabesahala de Meritens, C., ZHANG, Y., Joanne, P., Marqués-Sulé, E., Aguilar-Sánchez, Y., Fernández-Tenorio, M., Villejoubert, O., Li, L., Wang, Y., Mateo, P., Nicolas, V., Gerbaud, P., Lai, F., Perrier, R., Álvarez, J...., & Gómez, A. (2021). Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation. Circulation Research, 129(3), e35-e52.
https://doi.org/10.1161/circresaha.121.319094, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57636
http://dx.doi.org/10.1161/circresaha.121.319094
Seidel, M., Rabesahala de Meritens, C., Johnson, L., Parthimos, D., Bannister, M., Thomas, N., Ozekhome-Mike, E., Lai, F., & Zisimopoulos, S. (2021). Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function. Cardiovascular Research, 117(3), 780-791.
https://doi.org/10.1093/cvr/cvaa043, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53861
Stanczyk, P., Seidel, M., White, J., Viero, C., George, C., Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2018). Association of cardiac myosin-binding protein-C with the ryanodine receptor channel – putative retrograde regulation?. Journal of Cell Science, 131(15), jcs210443
https://doi.org/10.1242/jcs.210443, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41186
Handhle, A., Ormonde, C., Thomas, N., Bralesford, C., Williams, A., Lai, F., Zissimopoulos, S., Thomas, N., & Zisimopoulos, S. (2016). Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain. Journal of Cell Science, jcs.191643
https://doi.org/10.1242/jcs.191643, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35345
http://www.scopus.com/inward/record.url?eid=2-s2.0-84995529372&partnerID=MN8TOARS
Stanczyk, P., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2016). Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study. Journal of Visualized Experiments(113)
https://doi.org/10.3791/54271, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36630
Seidel, M., Thomas, N., Williams, A., Lai, F., Zissimopoulos, S., Thomas, N., Zisimopoulos, S., & Williams, A. (2015). Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors. Cardiovascular Research, 105(1), 118-128.
https://doi.org/10.1093/cvr/cvu240, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35341
http://www.scopus.com/inward/record.url?eid=2-s2.0-84929081932&partnerID=MN8TOARS
Domingo, D., Neco, P., Fernández-Pons, E., Zissimopoulos, S., Molina, P., Olagüe, J., Suárez-Mier, M., Lai, F., Gómez, A., Zorio, E., & Zisimopoulos, S. (2015). Non-ventricular, Clinical, and Functional Features of the RyR2R420Q Mutation Causing Catecholaminergic Polymorphic Ventricular Tachycardia. Revista Española de Cardiología (English Edition), 68(5), 398-407.
https://doi.org/10.1016/j.rec.2014.04.023, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36632
Seidel, M., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2015). Structural and functional interactions within ryanodine receptor. Biochemical Society Transactions, 43(3), 377-383.
https://doi.org/10.1042/BST20140292, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36631
Ljubojevic, S., Radulovic, S., Leitinger, G., Sedej, S., Sacherer, M., Holzer, M., Winkler, C., Pritz, E., Mittler, T., Schmidt, A., Sereinigg, M., Wakula, P., Zissimopoulos, S., Bisping, E., Post, H., Marsche, G., Bossuyt, J., Bers, D., Kockskamper, J...., & Zisimopoulos, S. (2014). Early Remodeling of Perinuclear Ca2+ Stores and Nucleoplasmic Ca2+ Signaling During the Development of Hypertrophy and Heart Failure. Circulation, 130(3), 244-255.
https://doi.org/10.1161/CIRCULATIONAHA.114.008927, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36634
Zissimopoulos, S., Marsh, J., Stannard, L., Seidel, M., Lai, F., & Zisimopoulos, S. (2014). N-terminus oligomerization is conserved in intracellular calcium release channels. Biochemical Journal, 459(2), 265-273.
https://doi.org/10.1042/BJ20131061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36635
Lam, A., Galione, A., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2013). Hax-1 identified as a two-pore channel (TPC)-binding protein. FEBS Letters, 587(23), 3782-3786.
https://doi.org/10.1016/j.febslet.2013.10.031, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36639
Zissimopoulos, S., Viero, C., Seidel, M., Cumbes, B., White, J., Cheung, I., Stewart, R., Jeyakumar, L., Fleischer, S., Mukherjee, S., Lowri Thomas, N., Williams, A., Anthony Lai, F., Cumbes, B., Thomas, N., Zisimopoulos, S., Mukherjee, S., & Williams, A. (2013). N-terminus oligomerization regulates the function of cardiac ryanodine receptors. Journal of Cell Science, 126(21), 5042-5051.
https://doi.org/10.1242/jcs.133538, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34390
http://www.scopus.com/inward/record.url?eid=2-s2.0-84887595981&partnerID=MN8TOARS
Zissimopoulos, S., Seifan, S., Maxwell, C., Williams, A., Lai, F., Zisimopoulos, S., & Williams, A. (2012). Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart. Journal of Cell Science, 125(7), 1759-1769.
https://doi.org/10.1242/jcs.098012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35915
Zissimopoulos, S., Thomas, N., Jamaluddin, W., Lai, F., Thomas, N., & Zisimopoulos, S. (2009). FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. Biochemical Journal, 419(2), 273-278.
https://doi.org/10.1042/BJ20082324, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35332
http://www.scopus.com/inward/record.url?eid=2-s2.0-64249111141&partnerID=MN8TOARS
Gomez, A., Rueda, A., Sainte-Marie, Y., Pereira, L., Zissimopoulos, S., Zhu, X., Schaub, R., Perrier, E., Perrier, R., Latouche, C., Richard, S., Picot, M., Jaisser, F., Lai, F., Valdivia, H., Benitah, J., & Zisimopoulos, S. (2009). Mineralocorticoid Modulation of Cardiac Ryanodine Receptor Activity Is Associated With Downregulation of FK506-Binding Proteins. Circulation, 119(16), 2179-2187.
https://doi.org/10.1161/CIRCULATIONAHA.108.805804, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36642
Zissimopoulos, S., Docrat, N., Lai, F., & Zisimopoulos, S. (2007). Redox Sensitivity of the Ryanodine Receptor Interaction with FK506-binding Protein. Journal of Biological Chemistry, 282(10), 6976-6983.
https://doi.org/10.1074/jbc.M607590200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36644
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2006). Redox regulation of the ryanodine receptor/calcium release channel. Biochemical Society Transactions, 34(5), 919-921.
https://doi.org/10.1042/BST0340919, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36645
Liu, N. & Zisimopoulos, S. (2006). Arrhythmogenesis in Catecholaminergic Polymorphic Ventricular Tachycardia: Insights From a RyR2 R4496C Knock-In Mouse Model. Circulation Research, 99(3), 292-298.
https://doi.org/10.1161/01.RES.0000235869.50747.e1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36646
De Crescenzo, V., Fogarty, K., ZhuGe, R., Tuft, R., Lifshitz, L., Carmichael, J., Bellve, K., Baker, S., Zissimopoulos, S., Lai, F., Lemos, J., Walsh, J., & Zisimopoulos, S. (2006). Dihydropyridine Receptors and Type 1 Ryanodine Receptors Constitute the Molecular Machinery for Voltage-Induced Ca2+ Release in Nerve Terminals. Journal of Neuroscience, 26(29), 7565-7574.
https://doi.org/10.1523/JNEUROSCI.1512-06.2006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36647
Zisimopoulos, S., West, D., Williams, A., & Lai, F. (2006). Ryanodine receptor interaction with the SNARE-associated protein snapin. Journal of Cell Science, 119(11), 2386-2397.
https://doi.org/10.1242/jcs.02936, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35574
http://europepmc.org/abstract/med/16723744
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2005). Interaction of FKBP12.6 with the Cardiac Ryanodine Receptor C-terminal Domain. Journal of Biological Chemistry, 280(7), 5475-5485.
https://doi.org/10.1074/jbc.M412954200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36649
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2005). Central Domain of the Human Cardiac Muscle Ryanodine Receptor Does Not Mediate Interaction With FKBP12.6. Cell Biochemistry and Biophysics, 43(2), 203-220.
https://doi.org/10.1385/CBB:43:2:203, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36650
Blayney, L., Zissimopoulos, S., Ralph, E., Abbot, E., Matthews, L., Lai, F., & Zisimopoulos, S. (2004). Ryanodine Receptor Oligomeric Interaction. Journal of Biological Chemistry, 279(15), 14639-14648.
https://doi.org/10.1074/jbc.M308014200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36651
STEWART, R., ZISSIMOPOULOS, S., LAI, F., & Zisimopoulos, S. (2003). Oligomerization of the cardiac ryanodine receptor C-terminal tail. Biochemical Journal, 376(3), 795-799.
https://doi.org/10.1042/BJ20030597, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36652

Penodau Llyfrau

Patel, S., Zisimopoulos, S., & Marchant, J. (2022). Endo-Lysosomal Two-Pore Channels and Their Protein Partners. Handbook of Experimental Pharmacology Springer Berlin Heidelberg
https://doi.org/10.1007/164_2022_601, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62165
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2007). Ryanodine receptor structure, function and pathophysiology. Calcium - A Matter of Life or Death (pp. 287-342). Elsevier
https://doi.org/10.1016/S0167-7306(06)41012-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36654
http://www.sciencedirect.com/science/article/pii/S0167730606410127

Modiwlau a Addysgir

PM-130 Fundamental Research Skills

This module is designed to develop the skills required for students of biochemistry and genetics degree programmes. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.
PM-266 The Cardiovascular System

Leading on from the first year Human Physiology Module (PM-154), the Cardiovascular Module will introduce and define the fundamental cellular mechanisms that regulate the physiology of healthy cardiovascular function. The Module will describe the processes that allow regular heartbeat and blood vessel function and how perturbations in the systems covered may lead to pathophysiological conditions. There will be an emphasis on experimental approaches used to study the cardiovascular mechanisms described.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-376 Advanced Research Topics in Biomedical Science

This module seeks to provide students with an understanding of a diverse array of research topics within the field of Biomedical science as representative of the diverse research activity at Swansea University. Topics will reflect the current research staff activity, but may include topics such as extracellular vesicles, lipidomics, cardiovascular research, cancer therapeutics and biomaterials research. Students will gain a background to each topic, an appreciation of the current methodologies utilised within each field and the current research developments within these.

Grantiau a Phrosiectau Allweddol

Drug-induced stabilisation of RyR2 to improve calcium handling and cardiac function in arrhythmogenic cardiac disease 2015 - 2020

Uwch-gymrodoriaeth Ymchwil , with gyda Dr Yadan Zhang, Ms Astrid Beckmann, Mr Jake Evans , £1,029,695

Dr Spyridon Zisimopoulos

Cyfeiriad ebost

Dolenni Ymchwil

Trosolwg

Meysydd Arbenigedd

Uchafbwyntiau Gyrfa

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Holl Ymchwil

Erthyglau Cylchgronau

Penodau Llyfrau

Modiwlau a Addysgir

PM-130 Fundamental Research Skills

PM-266 The Cardiovascular System

PM-344 Capstone Project

PM-376 Advanced Research Topics in Biomedical Science

Grantiau a Phrosiectau Allweddol

Drug-induced stabilisation of RyR2 to improve calcium handling and cardiac function in arrhythmogenic cardiac disease 2015 - 2020