Yr Athro Shareen Doak

Uchafbwyntiau Ymchwil

1. Braakhuis, H., Gremmer, E., Bannuscher, A., Drasler, B., Keshavan, S., Rothen-Rutishauser, B., Birk, B., Verlohner, A., Landsiedel, R., Meldrum, K., Doak, S., Clift, M., Erdem, J., Foss, O., Zienolddiny-Narui, S., Serchi, T., Moschini, E., Weber, P., Burla, S...., & Vandebriel, R. (2023). Transferability and reproducibility of exposed air-liquid interface co-culture lung models. NanoImpact, 31, 100466

   https://doi.org/10.1016/j.impact.2023.100466, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63446

   http://dx.doi.org/10.1016/j.impact.2023.100466
2. Doak, S., Andreoli, C., Burgum, M., Chaudhry, Q., Bleeker, E., Bossa, C., Domenech, J., Drobne, D., Fessard, V., Jeliazkova, N., Longhin, E., Rundén-Pran, E., Stepnik, M., Yamani, N., Catalán, J., & Dusinska, M. (2023). Current status and future challenges of genotoxicity OECD test guidelines (TGs) for nanomaterials: a workshop report. Mutagenesis

   https://doi.org/10.1093/mutage/gead017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63542

   http://dx.doi.org/10.1093/mutage/gead017
3. Jovic, T., Nicholson, T., Arora, H., Nelson, K., Doak, S., & Whitaker, I. (2023). A comparative analysis of pulp-derived nanocelluloses for 3D bioprinting facial cartilages. Carbohydrate Polymers, 321, 121261

   https://doi.org/10.1016/j.carbpol.2023.121261, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64062

   http://dx.doi.org/10.1016/j.carbpol.2023.121261
4. Stannard, L., Doherty, A., Chapman, K., Doak, S., Jenkins, G., & Stannard, L. (2024). Multi-endpoint analysis of cadmium chloride-induced genotoxicity shows role for reactive oxygen species and p53 activation in DNA damage induction, cell cycle irregularities, and cell size aberrations. Mutagenesis, 39(1), 13-23.

   https://doi.org/10.1093/mutage/gead025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64199

   http://dx.doi.org/10.1093/mutage/gead025
5. Coskun, E., Singh, N., Scanlan, L., Jaruga, P., Doak, S., Dizdaroglu, M., & Nelson, B. (2022). Inhibition of human APE1 and MTH1 DNA repair proteins by dextran-coated γ-Fe₂O₃ ultrasmall superparamagnetic iron oxide nanoparticles. Nanomedicine, 17(26), 2011-2021.

   https://doi.org/10.2217/nnm-2022-0204, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62772

   http://dx.doi.org/10.2217/nnm-2022-0204
6. Amaral Duarte De Moura, J., Meldrum, K., Doak, S., & Clift, M. (2023). Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook. Seminars in Cell & Developmental Biology, 147, 70-82.

   https://doi.org/10.1016/j.semcdb.2022.12.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62217

   http://dx.doi.org/10.1016/j.semcdb.2022.12.006
7. Bannuscher, A., Schmid, O., Drasler, B., Rohrbasser, A., Braakhuis, H., Meldrum, K., Zwart, E., Gremmer, E., Birk, B., Rissel, M., Landsiedel, R., Moschini, E., Evans, S., Kumar, P., Orak, S., Doryab, A., Erdem, J., Serchi, T., Vandebriel, R...., & Rothen-Rutishauser, B. (2022). An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials. NanoImpact, 28, 100439

   https://doi.org/10.1016/j.impact.2022.100439, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62077
8. Meldrum, K., Amaral Duarte De Moura, J., Doak, S., & Clift, M. (2022). Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro. Nanomaterials, 12(19), 3431

   https://doi.org/10.3390/nano12193431, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61384
9. Evans, S., Lawrence, R., Ilett, M., Burgum, M., Meldrum, K., Hondow, N., Jenkins, G., Clift, M., & Doak, S. (2022). Industrial-relevant TiO2 types do not promote cytotoxicity in the A549 or TK6 cell lines regardless of cell specific interaction. Toxicology in Vitro, 83, 105415

   https://doi.org/10.1016/j.tiv.2022.105415, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60312
10. Llewellyn, S., Kermanizadeh, A., Ude, V., Jacobsen, N., Conway, G., Shah, U., Niemeijer, M., Moné, M., Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G., & Doak, S. (2022). Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in Vitro, 85, 105473

    https://doi.org/10.1016/j.tiv.2022.105473, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61191
11. Evans, S., Jenkins, G., Doak, S., & Clift, M. (2019). Cellular Defense Mechanisms Following Nanomaterial Exposure: A Focus on Oxidative Stress and Cytotoxicity. Biological Responses to Nanoscale Particles (pp. 243-254). Springer International Publishing

    https://doi.org/10.1007/978-3-030-12461-8_10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50127
12. Doak, S., Clift, M., Costa, A., Delmaar, C., Gosens, I., Halappanavar, S., Kelly, S., Pejinenburg, W., Rothen‐Rutishauser, B., Schins, R., Stone, V., Tran, L., Vijver, M., Vogel, U., Wohlleben, W., & Cassee, F. (2022). The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability—A PATROLS Perspective on New Approach Methodologies. Small, 18(17), 2200231

    https://doi.org/10.1002/smll.202200231, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59702
13. Groff, K., Evans, S., Doak, S., Pfuhler, S., Corvi, R., Saunders, S., & Stoddart, G. (2021). In vitro and integrated in vivo strategies to reduce animal use in genotoxicity testing. Mutagenesis, 36(6), 389-400.

    https://doi.org/10.1093/mutage/geab035, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58118
14. Verdon, R., Stone, V., Murphy, F., Christopher, E., Johnston, H., Doak, S., Vogel, U., Haase, A., & Kermanizadeh, A. (2022). The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment. Particle and Fibre Toxicology, 19(1)

    https://doi.org/10.1186/s12989-022-00476-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59989
15. Evans, S., Vecchiarelli, P., Clift, M., Doak, S., & Lead, J. (2021). Overview of Nanotoxicology in Humans and the Environment; Developments, Challenges and Impacts. Nanotoxicology in Humans and the Environment (pp. 1-40). Springer International Publishing

    https://doi.org/10.1007/978-3-030-79808-6_1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59028
16. Llewellyn, S., Parak, W., Hühn, J., Burgum, M., Evans, S., Chapman, K., Jenkins, G., Doak, S., & Clift, M. (2022). Deducing the cellular mechanisms associated with the potential genotoxic impact of gold and silver engineered nanoparticles upon different lung epithelial cell lines in vitro. Nanotoxicology, 16(1), 52-72.

    https://doi.org/10.1080/17435390.2022.2030823, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59210
17. Meldrum, K., Evans, S., Vogel, U., Tran, L., Doak, S., & Clift, M. (2022). The influence of exposure approaches to in vitro lung epithelial barrier models to assess engineered nanomaterial hazard. Nanotoxicology, 16(1), 114-134.

    https://doi.org/10.1080/17435390.2022.2051627, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59667
18. Kah, M., Johnston, L., Kookana, R., Bruce, W., Haase, A., Ritz, V., Dinglasan, J., Doak, S., Garelick, H., & Gubala, V. (2021). Comprehensive framework for human health risk assessment of nanopesticides. Nature Nanotechnology, 16(9), 955-964.

    https://doi.org/10.1038/s41565-021-00964-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57882
19. Isigonis, P., Afantitis, A., Antunes, D., Bartonova, A., Beitollahi, A., Bohmer, N., Bouman, E., Chaudhry, Q., Cimpan, M., Cimpan, E., Doak, S., Dupin, D., Fedrigo, D., Fessard, V., Gromelski, M., Gutleb, A., Halappanavar, S., Hoet, P., Jeliazkova, N...., & Dusinska, M. (2020). Risk Governance of Emerging Technologies Demonstrated in Terms of its Applicability to Nanomaterials. Small, 16(36), 2003303

    https://doi.org/10.1002/smll.202003303, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57432
20. Llewellyn, S., Conway, G., Zanoni, I., Jørgensen, A., Shah, U., Seleci, D., Keller, J., Kim, J., Wohlleben, W., Jensen, K., Costa, A., Jenkins, G., Clift, M., & Doak, S. (2021). Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver. Journal of Nanobiotechnology, 19(1)

    https://doi.org/10.1186/s12951-021-00938-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57237
21. Llewellyn, S., Kämpfer, A., Keller, J., Vilsmeier, K., Büttner, V., Seleci, D., Schins, R., Doak, S., & Wohlleben, W. (2021). Simulating Nanomaterial Transformation in Cascaded Biological Compartments to Enhance the Physiological Relevance of In Vitro Dosing Regimes: Optional or Required?. Small, 17(15), 2004630

    https://doi.org/10.1002/smll.202004630, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56095
22. Thomson, E., Jessop, Z., Naderi, N., Griffin, M., Dobbs, T., Ibrahim, A., Evans, S., Burnell, S., Doak, S., & Whitaker, I. (2016). Adipose regeneration and implications for breast reconstruction: update and the future. Gland Surgery, 5(2), 227-241.

    https://doi.org/10.3978/j.issn.2227-684X.2016.01.01, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56657

    https://gs.amegroups.com/article/view/9095
23. Barosova, H., Meldrum, K., Karakocak, B., Balog, S., Doak, S., Petri-Fink, A., Clift, M., & Rothen-Rutishauser, B. (2021). Inter-laboratory variability of A549 epithelial cells grown under submerged and air-liquid interface conditions. Toxicology in Vitro, 75, 105178

    https://doi.org/10.1016/j.tiv.2021.105178, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56826
24. Clift, M. & Doak, S. (2021). Advanced In Vitro Models for Replacement of Animal Experiments. Small, 17(15), 2101474

    https://doi.org/10.1002/smll.202101474, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56827
25. Llewellyn, S., Niemeijer, M., Nymark, P., Moné, M., Water, B., Conway, G., Jenkins, G., & Doak, S. (2021). In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment. Small, 17(15), 2006055

    https://doi.org/10.1002/smll.202006055, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56073
26. Burgum, M., Clift, M., Evans, S., Hondow, N., Tarat, A., Jenkins, G., & Doak, S. (2021). Few-layer graphene induces both primary and secondary genotoxicity in epithelial barrier models in vitro. Journal of Nanobiotechnology, 19(1)

    https://doi.org/10.1186/s12951-021-00769-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56078
27. Conway, G., Shah, U., Llewellyn, S., Cervena, T., Evans, S., Al-Ali, A., Jenkins, G., Clift, M., & Doak, S. (2020). Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations. Mutagenesis, 35(4), 319-329.

    https://doi.org/10.1093/mutage/geaa018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54991
28. Chapman, K., Wilde, E., Chapman, F., Verma, J., Shah, U., Stannard, L., Seager, A., Tonkin, J., Brown, R., Doherty, A., Johnson, G., Doak, S., & Jenkins, G. (2021). Multiple-endpoint in vitro carcinogenicity test in human cell line TK6 distinguishes carcinogens from non-carcinogens and highlights mechanisms of action. Archives of Toxicology, 95(1), 321-336.

    https://doi.org/10.1007/s00204-020-02902-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55186
29. Shah, U., Verma, J., Chapman, K., Wilde, E., Tonkin, J., Brown, R., Johnson, G., Doak, S., & Jenkins, G. (2020). Detection of urethane-induced genotoxicity in vitro using metabolically competent human 2D and 3D spheroid culture models. Mutagenesis, 35(6), 445-452.

    https://doi.org/10.1093/mutage/geaa029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55770
30. Dural, E., Shah, U., Pritchard, D., Chapman, K., Doak, S., Jenkins, G., & Jenkins, G. (2020). The effect of chronic dosing and p53 status on the genotoxicity of pro-oxidant chemicals in vitro. Mutagenesis, 35(6), 479-489.

    https://doi.org/10.1093/mutage/geaa024, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55854
31. Walker, K., Doak, S., Dunstan, P., Dunstan, P., & Doak, S. (2011). Mechanisms of cell–cell adhesion identified by immunofluorescent labelling with quantum dots: A scanning near-field optical microscopy approach. Ultramicroscopy, 111(8), 1200-1205.

    https://doi.org/10.1016/j.ultramic.2011.01.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1118
32. Doak, S., Jenkins, G., Parry, E., Griffiths, A., Shah, V., Baxter, J., Parry, J., Jenkins, G., Doak, S., & Baxter, J. (2003). Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma. British Journal of Cancer, 89(9), 1729-1735.

    https://doi.org/10.1038/sj.bjc.6601323, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1363
33. Doak, S., Jenkins, G., & Doak, S. (2003). Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus. Gut, 52(5), 623-628.

    https://doi.org/10.1136/gut.52.5.623, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1388
34. Baylis, R., BAYLIS, R., DOAK, S., PARRY, J., DUNSTAN, P., Dunstan, P., & Doak, S. (2006). Chromosome morphology after long-term storage investigated by scanning near-field optical microscopy. Journal of Microscopy, 221(3), 177-182.

    https://doi.org/10.1111/j.1365-2818.2006.01561.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1549
35. Walker, K., Morgan, C., Doak, S., & Dunstan, P. (2012). Quantum Dots for Multiplexed Detection and Characterisation of Prostate Cancer Cells Using a Scanning Near-Field Optical Microscope. PLoS ONE, 7(2), e31592

    https://doi.org/10.1371/journal.pone.0031592, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa7294
36. Manshian, B., Jenkins, G., Williams, P., Wright, C., Barron, A., Brown, A., Hondow, N., Dunstan, P., Rickman, R., Brady, K., Doak, S., & Wright, C. (2013). Single-walled carbon nanotubes: differential genotoxic potential associated with physico-chemical properties. Nanotoxicology, 7(2), 144-156.

    https://doi.org/10.3109/17435390.2011.647928, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa7295
37. Johnson, G., Jenkins, G., Thomas, A., & Doak, S. (2010). Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 702(2), 189-192.

    https://doi.org/10.1016/j.mrgentox.2009.07.014, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9258
38. Jenkins, G., Zaïr, Z., Johnson, G., & Doak, S. (2010). Genotoxic thresholds, DNA repair, and susceptibility in human populations. Toxicology, 278(3), 305-310.

    https://doi.org/10.1016/j.tox.2009.11.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9893
39. Zair, Z., Jenkins, G., Doak, S., Singh, R., Brown, K., Johnson, G., Jenkins, G., Doak, S., & Johnson, G. (2011). N-Methylpurine DNA Glycosylase Plays a Pivotal Role in the Threshold Response of Ethyl Methanesulfonate-Induced Chromosome Damage. Toxicological Sciences, 119(2), 346-358.

    https://doi.org/10.1093/toxsci/kfq341, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10158
40. Seager, A., Shah, U., Mikhail, J., Nelson, B., Marquis, B., Doak, S., Johnson, G., Griffiths, S., Carmichael, P., Scott, S., Scott, A., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., & Mikhail, J. (2012). Pro-oxidant Induced DNA Damage in Human Lymphoblastoid Cells: Homeostatic Mechanisms of Genotoxic Tolerance. Toxicological Sciences, 128(2), 387-397.

    https://doi.org/10.1093/toxsci/kfs152, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10909

    http://toxsci.oxfordjournals.org/content/early/2012/04/26/toxsci.kfs152.abstract
41. Thomas, A., Jenkins, G., Kaina, B., Bodger, O., Tomaszowski, K., Lewis, P., Doak, S., Johnson, G., Jenkins, G., Lewis, P., Doak, S., Bodger, O., & Johnson, G. (2013). Influence of DNA Repair on Nonlinear Dose-Responses for Mutation. Toxicological Sciences, 132(1), 87-95.

    https://doi.org/10.1093/toxsci/kfs341, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13715
42. Jenkins, G., Doak, S., & Bruesehafer, K. (2014). Chromosome Breakage Induced by the Genotoxic Agents Mitomycin C and Cytosine arabinoside. Toxicological Sciences, 140(1), 94-102.

    https://doi.org/10.1093/toxsci/kfu058, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18150
43. Jenkins, G., Doak, S., & Chapman, K. (2014). Automation and validation of micronucleus detection in the 3D EpiDerm human reconstructed skin. Mutagenesis, 29(3), 165-175.

    https://doi.org/10.1093/mutage/geu011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18153
44. Whiteland, H., Lewis, P., Doak, S., & Morgan, C. (2014). A role for STEAP2 in prostate cancer progression. Clinical & Experimental Metastasis, 1-12.

    https://doi.org/10.1007/s10585-014-9679-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18791
45. Johnson, G., Slob, W., Doak, S., Fellows, M., Gollapudi, B., Heflich, R., Rees, B., Soeteman-Hernández, L., Verma, J., Wills, J., Jenkins, G., & White, P. (2015). New approaches to advance the use of genetic toxicology analyses for human health risk assessment. Toxicology Research, 4(3), 667-676.

    https://doi.org/10.1039/C4TX00118D, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19282

    http://pubs.rsc.org/en/content/articlelanding/2014/tx/c4tx00118d#!divAbstract
46. Tehrani, Z., Burwell, G., Azmi, M., Castaing, A., Rickman, R., Almarashi, J., Dunstan, P., Beigi, A., Doak, S., & Guy, O. (2014). Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker. 2D Materials, 1(2), 025004

    https://doi.org/10.1088/2053-1583/1/2/025004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19735
47. Azmi, M., Tehrani, Z., Lewis, R., Walker, K., Jones, D., Daniels, D., Doak, S., & Guy, O. (2014). Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker. Biosensors and Bioelectronics, 52, 216-224.

    https://doi.org/10.1016/j.bios.2013.08.030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19740
48. Seager, A., Shah, U., Brusehafer, K., Wills, J., Manshian, B., Chapman, K., Thomas, A., Scott, A., Doherty, A., Doak, S., Johnson, G., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., Bruesehafer, K., Shah, U., & Chapman, K. (2014). Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells. Mutagenesis, 29(3), 155-164.

    https://doi.org/10.1093/mutage/geu008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17804
49. Doak, S., Jenkins, G., Johnson, G., Quick, E., Parry, E., Parry, J., Jenkins, G., Doak, S., & Johnson, G. (2007). Mechanistic Influences for Mutation Induction Curves after Exposure to DNA-Reactive Carcinogens. Cancer Research, 67(8), 3904-3911.

    https://doi.org/10.1158/0008-5472.CAN-06-4061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17856
50. Chapman, K., Doak, S., Jenkins, G., Jenkins, G., Doak, S., & Chapman, K. (2015). Acute Dosing and p53-Deficiency Promote Cellular Sensitivity to DNA Methylating Agents. Toxicological Sciences, 144(2), 357-365.

    https://doi.org/10.1093/toxsci/kfv004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20121
51. Brüsehafer, K., Manshian, B., Doherty, A., Zaïr, Z., Johnson, G., Doak, S., Jenkins, G., & Bruesehafer, K. (2016). The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency. Mutagenesis, 31(2), 171-180.

    https://doi.org/10.1093/mutage/gev069, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23828
52. Wills, J., Johnson, G., Doak, S., Soeteman-Hernández, L., Slob, W., & White, P. (2016). Empirical analysis of BMD metrics in genetic toxicology part I:in vitroanalyses to provide robust potency rankings and support MOA determinations. Mutagenesis, 31(3), 255-263.

    https://doi.org/10.1093/mutage/gev085, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25190
53. Al-Himdani, S., Jessop, Z., Al-Sabah, A., Combellack, E., Ibrahim, A., Doak, S., Hart, A., Archer, C., Thornton, C., & Whitaker, I. (2017). Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice. Frontiers in Surgery, 4, article 4

    https://doi.org/10.3389/fsurg.2017.00004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31747

    http://journal.frontiersin.org/article/10.3389/fsurg.2017.00004/full
54. Pfuhler, S., Benthem, J., Curren, R., Doak, S., Dusinska, M., Hayashi, M., Heflich, R., Kidd, D., Kirkland, D., Luan, Y., Ouedraogo, G., Reisinger, K., Sofuni, T., Acker, F., Yang, Y., & Corvi, R. (2020). Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT). Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 850-851, 503135

    https://doi.org/10.1016/j.mrgentox.2020.503135, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53559
55. Burgum, M., Clift, M., Evans, S., Hondow, N., Miller, M., Bustamante-Lopez, S., Williams, A., Tarat, A., Jenkins, G., & Doak, S. (2021). In Vitro Primary‐Indirect Genotoxicity in Bronchial Epithelial Cells Promoted by Industrially Relevant Few‐Layer Graphene. Small, 17(15), 2002551

    https://doi.org/10.1002/smll.202002551, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54412
56. Llewellyn, S., Conway, G., Shah, U., Evans, S., Jenkins, G., Clift, M., & Doak, S. (2020). Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure. Journal of Visualized Experiments(160)

    https://doi.org/10.3791/61141, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54416
57. Cronin, J., Jones, N., Thornton, C., Jenkins, G., Doak, S., & Clift, M. (2020). Nanomaterials and Innate Immunity: A Perspective of the Current Status in Nanosafety. Chemical Research in Toxicology, 33(5), 1061-1073.

    https://doi.org/10.1021/acs.chemrestox.0c00051, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54417

    http://dx.doi.org/10.1021/acs.chemrestox.0c00051
58. Nelson, B., Minelli, C., Doak, S., & Roesslein, M. (2020). Emerging Standards and Analytical Science for Nanoenabled Medical Products. Annual Review of Analytical Chemistry, 13(1), 431-452.

    https://doi.org/10.1146/annurev-anchem-091619-102216, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54480
59. Chapman, F., Sparham, C., Hastie, C., Sanders, D., Egmond, R., Chapman, K., Doak, S., Scott, A., & Jenkins, G. (2020). Comparison of passive-dosed and solvent spiked exposures of pro-carcinogen, benzo[a]pyrene, to human lymphoblastoid cell line, MCL-5. Toxicology in Vitro, 67, 104905

    https://doi.org/10.1016/j.tiv.2020.104905, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54540
60. Nelson, B., Wright, C., Ibuki, Y., Moreno-Villanueva, M., Karlsson, H., Hendriks, G., Sims, C., Singh, N., & Doak, S. (2017). Emerging metrology for high-throughput nanomaterial genotoxicology. Mutagenesis, 32(1), 215-232.

    https://doi.org/10.1093/mutage/gew037, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54572
61. Ede, J., Lobaskin, V., Vogel, U., Lynch, I., Halappanavar, S., Doak, S., Roberts, M., & Shatkin, J. (2020). Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials. Nanomaterials, 10(6), 1229

    https://doi.org/10.3390/nano10061229, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54573
62. Clift, M., Jenkins, G., & Doak, S. (2020). An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health. Small, 16(36), 2002002

    https://doi.org/10.1002/smll.202002002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54913
63. Morgan, C., Lewis, P., Hopkins, L., Burnell, S., Kynaston, H., & Doak, S. (2015). Increased expression of ARF GTPases in prostate cancer tissue. SpringerPlus, 4(1)

    https://doi.org/10.1186/s40064-015-1136-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34906
64. Burden, N., Aschberger, K., Chaudhry, Q., Clift, M., Fowler, P., Johnston, H., Landsiedel, R., Rowland, J., Stone, V., & Doak, S. (2017). Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities?. Regulatory Toxicology and Pharmacology, 91, 257-266.

    https://doi.org/10.1016/j.yrtph.2017.10.021, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36250
65. Morgan, C., Swithenbank, L., Whiteland, H., & Doak, S. (2018). Increased ARF6 activation correlates with HGF stimulation in non-invasive prostate cancer cells. Journal of Cancer Metastasis and Treatment, 4(8), 46

    https://doi.org/10.20517/2394-4722.2018.19, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43606
66. Bodger, O., Burnell, S., Spencer-Harty, S., Howarth, S., Bodger, O., Kynaston, H., Morgan, C., & Doak, S. (2019). Utilisation of the STEAP protein family in a diagnostic setting may provide a more comprehensive prognosis of prostate cancer. PLOS ONE, 14(8), e0220456

    https://doi.org/10.1371/journal.pone.0220456, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51465
67. Evans, S., Gollapudi, B., Moore, M., & Doak, S. (2019). Horizon scanning for novel and emerging in vitro mammalian cell mutagenicity test systems. Mutation Research/Genetic Toxicology and Environmental Mutagenesis

    https://doi.org/10.1016/j.mrgentox.2019.02.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49201
68. Evans, S., Clift, M., Singh, N., Wills, J., Hondow, N., Wilkinson, T., Burgum, M., Brown, A., Jenkins, G., & Doak, S. (2019). In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials. Particle and Fibre Toxicology, 16(1)

    https://doi.org/10.1186/s12989-019-0291-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48861
69. Burnell, S., Spencer-Harty, S., Howarth, S., Bodger, O., Kynaston, H., Morgan, C., & Doak, S. (2018). STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells. Scientific Reports, 8(1)

    https://doi.org/10.1038/s41598-018-24655-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39502
70. Wills, J., Summers, H., Hondow, N., Sooresh, A., Meissner, K., White, P., Rees, P., Brown, A., & Doak, S. (2017). Characterizing Nanoparticles in Biological Matrices: Tipping Points in Agglomeration State and Cellular Delivery In Vitro. ACS Nano, 11(12), 11986-12000.

    https://doi.org/10.1021/acsnano.7b03708, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36707

    http://dx.doi.org/10.1021/acsnano.7b03708
71. Chapman, K., Hoffmann, G., Doak, S., & Jenkins, G. (2017). Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N -methyl- N -nitrosourea. Mutation Research/Genetic Toxicology and Environmental Mutagenesis

    https://doi.org/10.1016/j.mrgentox.2017.05.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33260
72. Joris, F., Valdepérez, D., Pelaz, B., Wang, T., Doak, S., Manshian, B., Soenen, S., Parak, W., De Smedt, S., & Raemdonck, K. (2017). Choose your cell model wisely: The in vitro nanoneurotoxicity of differentially coated iron oxide nanoparticles for neural cell labeling. Acta Biomaterialia

    https://doi.org/10.1016/j.actbio.2017.03.053, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33262
73. Wills, J., Hondow, N., Thomas, A., Chapman, K., Fish, D., Maffeis, T., Penny, M., Brown, R., Jenkins, G., Brown, A., White, P., & Doak, S. (2016). Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™). Particle and Fibre Toxicology, 13(1)

    https://doi.org/10.1186/s12989-016-0161-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29852
74. Peynshaert, K., Soenen, S., Manshian, B., Doak, S., Braeckmans, K., Smedt, S., & Remaut, K. (2016). Coating of Quantum Dots strongly defines their effect on lysosomal health and autophagy. Acta Biomaterialia, 48

    https://doi.org/10.1016/j.actbio.2016.10.022, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30608
75. Doak, S. (2016). Opinion of the Scientific Committee on consumer safety (SCCS) - Opinion on the use of 2,2′-methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) (nano) – S79 – In cosmetic products. Regulatory Toxicology and Pharmacology, 76, 215-216.

    https://doi.org/10.1016/j.yrtph.2016.01.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26473
76. Al-Ali, A., Singh, N., Manshian, B., Wilkinson, T., Wills, J., Jenkins, G., Doak, S., & Wilkinson, T. (2015). Quantum dot induced cellular perturbations involving varying toxicity pathways. Toxicol. Res.

    https://doi.org/10.1039/C4TX00175C, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20114
77. Manshian, B., Soenen, S., Al-Ali, A., Brown, A., Hondow, N., Wills, J., Jenkins, G., Doak, S., Jenkins, G., & Doak, S. (2015). Cell Type-Dependent Changes in CdSe/ZnS Quantum Dot Uptake and Toxic Endpoints. Toxicological Sciences

    https://doi.org/10.1093/toxsci/kfv002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20117
78. Manshian, B., Soenen, S., Brown, A., Hondow, N., Wills, J., Jenkins, G., Doak, S., Jenkins, G., & Doak, S. (2015). Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries. Mutagenesis, gev061

    https://doi.org/10.1093/mutage/gev061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26170

    http://europepmc.org/abstract/med/26275419
79. Soenen+José-Maria, S. & Doak, S. (2014). The effect of nanoparticle degradation on poly(methacrylic acid)-coated quantum dot toxicity: The importance of particle functionality assessment in toxicology. Acta Biomaterialia, 10(2), 732-741.

    https://doi.org/10.1016/j.actbio.2013.09.041, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17886
80. Soenen+Lynn, S. & Doak, S. (2014). Unraveling the effects of siRNA carrier systems on cell physiology: a multiparametric approach demonstrated on dextran nanogels. Nanomedicine, 9(1), 61-76.

    https://doi.org/10.2217/nnm.12.208, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17888
81. Pfuhler+Rosalie, S. & Doak, S. (2013). Genotoxicity of nanomaterials: Refining strategies and tests for hazard identification. Environmental and Molecular Mutagenesis, 54(4), 229-239.

    https://doi.org/10.1002/em.21770, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17889
82. Soenen+Bella, S. & Doak, S. (2013). Fluorescent non-porous silica nanoparticles for long-term cell monitoring: Cytotoxicity and particle functionality. Acta Biomaterialia, 9(11), 9183-9193.

    https://doi.org/10.1016/j.actbio.2013.04.026, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17887
83. Morgan, C., Jenkins, S., Kynaston, H., & Doak, S. (2013). The Role of Adhesion Molecules as Biomarkers for the Aggressive Prostate Cancer Phenotype. PLoS ONE, 8(12), e81666

    https://doi.org/10.1371/journal.pone.0081666, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16740
84. Whiteland, H., Spencer-Harty, S., Thomas, D., Davies, C., Morgan, C., Kynaston, H., Bose, P., Fenn, N., Lewis, P., Bodger, O., Jenkins, S., & Doak, S. (2013). Putative prognostic epithelial-to-mesenchymal transition biomarkers for aggressive prostate cancer. Experimental and Molecular Pathology, 95(2), 220-226.

    https://doi.org/10.1016/j.yexmp.2013.07.010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16741
85. Soenen, S., Manshian, B., Montenegro, J., Amin, F., Meermann, B., Thiron, T., Cornelissen, M., Vanhaecke, F., Doak, S., Parak, W., Smedt, S., & Braeckmans, K. (2012). Cytotoxic Effects of Gold Nanoparticles: A Multiparametric Study. ACS Nano, 6(7), 5767

    https://doi.org/10.1021/nn301714n, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11792
86. Doak, S., Manshian, B., Jenkins, G., Singh, N., Jenkins, G., & Doak, S. (2012). In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 745(1-2), 104

    https://doi.org/10.1016/j.mrgentox.2011.09.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10472
87. Doak, S., Manshian, B., Jenkins, G., & Doak, S. (2012). In vitro genotoxicity testing strategy for nanomaterials and the adptation of curent OECD guidelines.. Mutation Research - Gen tox, 745(1-2), 104-11.

    https://doi.org/10.1016/j.mrgentox.2011.09.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10081
88. Doak, S., Liu, Y., & Chen, C. (2012). Genotoxicity and Cancer. Adverse Effects of Engineered Nanomaterials (pp. 243Elsevier

    https://doi.org/10.1016/B978-0-12-386940-1.00014-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10476
89. Singh, N., Jenkins, G., Nelson, B., Marquis, B., Maffeis, T., Brown, A., Williams, P., Wright, C., Doak, S., & Wright, C. (2012). The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles. Biomaterials, 33(1), 163

    https://doi.org/10.1016/j.biomaterials.2011.09.087, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14121
90. Guy, O., Burwell, G., Tehrani, Z., Castaing, A., Walker, K., Doak, S., & Doak, S. (2012). Graphene Nano-Biosensors for Detection of Cancer Risk. Materials Science Forum, 711, 246-252.

    https://doi.org/10.4028/www.scientific.net/MSF.711.246, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10471
91. Hondow, N., Harrington, J., Brydson, R., Doak, S., Singh, N., Manshian, B., & Brown, A. (2011). STEM mode in the SEM: A practical tool for nanotoxicology. Nanotoxicology, 5(2), 215

    https://doi.org/10.3109/17435390.2010.535622, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9846
92. Griffiths, S., Singh, N., Jenkins, G., Wright, C., Jenkins, G., Williams, P., Doak, S., & Orbaek White, A. (2011). Dextran coated ultrafine superparamagnetic iron oxide nanoparticles: compatibility with common fluorometric and colorimetric dyes.. Analytical Chemistry, 83(10), 3778-3785.

    https://doi.org/10.1021/ac200103x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10082
93. Jenkins, G., Johnson, G., Parry, J., & Doak, S. (2011). Genotoxic Thresholds. Genotoxic Impurities (pp. 169John Wiley & Sons, Ltd

    https://doi.org/10.1002/9780470929377.ch7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10474
94. Doak, S. & Zaïr, Z. (2011). Real-Time Reverse-Transcription Polymerase Chain Reaction: Technical Considerations for Gene Expression Analysis. , 817, 251-270.

    https://doi.org/10.1007/978-1-61779-421-6_13, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10475
95. Singh, N., Manshian, B., Jenkins, G., Griffiths, S., Williams, P., Maffeis, T., Wright, C., Doak, S., & Wright, C. (2009). NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials. Biomaterials, 30(23-24), 3891-3914.

    https://doi.org/10.1016/j.biomaterials.2009.04.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10709
96. Doak, S., Griffiths, S., Manshian, B., Singh, N., Williams, P., Brown, A., Jenkins, G., Jenkins, G., Williams, P., & Doak, S. (2009). Confounding experimental considerations in nanogenotoxicology. Mutagenesis, 24(4), 285

    https://doi.org/10.1093/mutage/gep010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9847
97. Doak, S., Brusehafer, K., Dudley, E., Jenkins, G., Dudley, E., Doak, S., Johnson, G., & Bruesehafer, K. (2008). No-observed effect levels are associated with up-regulation of MGMT following MMS Exposure. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS ??, 648(1-2), 9-14.

    https://doi.org/10.1016/j.mrfmmm.2008.09.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10127
98. Doak, S., Rogers, D., Jones, B., Wright, C., Doak, S., & Francis, L. (2008). High resolution imaging using a novel atomic force microscope and confocal laser scanning microscope hybrid instrument: essential sample preparation aspects. Histochemistry & cell biology, 130(5), 909-916.

    https://doi.org/10.1007/s00418-008-0489-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10128
99. Doak, S., Jenkins, S., Hurle, R., Varma, M., Hawizy, A., Kynaston, H., & Parry, J. (2007). Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer. Cancer Genetics and Cytogenetics, 176(2), 161-165.

    https://doi.org/10.1016/j.cancergencyto.2007.03.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16739

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