Dr Ilyas Khan

Athro Cyswllt, Biomedical Sciences

+44 (0) 1792 602588

i.m.khan@abertawe.ac.uk

Siaradwr Cymraeg Sylfaenol

Swyddfa Weinyddol - 010
Llawr Gwaelod
Y Sefydliad Gwyddor Bywyd 2
Campws Singleton

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

https://orcid.org/0000-0002-3886-1987

ResearchGate

Trosolwg

Mae grŵp ymchwil Dr Khan yn gweithio i wneud gwahaniaeth pendant i bobl sy'n dioddef o glefydau'r cymalau fel osteoarthritis. Mae eu gwaith yn amrywio o ran cwmpas o ddeall rôl bôn-gelloedd yn natblygiad a chlefydau cartilag cymalog a meinweoedd cartilagaidd eraill a geir yn y trwyn, y glust a'r tracea, i beirianneg meinweoedd cartilag newydd ar gyfer trwsio ac adfywio diffygion cartilag. Mae llawer o'r astudiaethau hyn yn cael eu cynnal gan grŵp gwych o israddedigion, myfyrwyr gradd Meistr a PhD ôl-raddedig ac ymchwilwyr sy'n fyfyrwyr meddygol.

Mae myfyrwyr sy'n ymuno â'r labordy yn cael cyfleoedd i ymweld a gweithio nid yn unig yn y cyfleusterau o'r radd flaenaf yn y Ganolfan Nanoiechyd, ond hefyd gyda'n cydweithwyr yn y DU, Ewrop a ledled y byd.

Un o'r agweddau pwysicaf ar y gwaith yw trosi ein datblygiadau a'n llwyddiannau sydd ar flaen y gad yn y fyd-eang i'r clinig ac er mwyn gwneud hyn rydym wrthi'n gweithio gyda'n cydweithwyr yn y GIG i gyflymu'r broses hon.

Meysydd Arbenigedd

Bioleg cartilag
Bôn-gelloedd a chelloedd epiliol
Peirianneg meinweoedd
Crawniad meinweoedd
Matrics allgellol

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Mae Dr Khan yn addysgu (gyda Dr Wendy Francis) modiwl mewn Meddygaeth Adfywiol a Pheirianneg Meinweoedd i israddedigion gwyddorau biolegol. Addysgir cwrs mwy datblygedig mewn Meddygaeth Adfywiol i fyfyrwyr sydd wedi cofrestru ar gwrs lefel Meistr Nanofeddygaeth.

Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Bauza, G., Pasto, A., Mcculloch, P., Lintner, D., Brozovich, A., Niclot, F., Khan, I., Francis, L., Tasciotti, E., & Taraballi, F. (2020). Improving the immunosuppressive potential of articular chondroprogenitors in a three-dimensional culture setting. Scientific Reports, 10(1)
https://doi.org/10.1038/s41598-020-73188-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55672
Levato, R., Webb, W., Otto, I., Mensinga, A., Zhang, Y., Rijen, M., Weeren, R., Khan, I., & Malda, J. (2017). The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells. Acta Biomaterialia, 61
https://doi.org/10.1016/j.actbio.2017.08.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34875
Alzyoud, J., Khan, I., & Rees, S. (2017). In vitro studies to evaluate the effect of varying culture conditions and IPL fluencies on tenocyte activities. Lasers in Medical Science, 32(7), 1561-1570.
https://doi.org/10.1007/s10103-017-2279-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35062
Bissardon, C., Proux, O., Bureau, S., Suess, E., Winkel, L., Conlan, S., Francis, L., Khan, I., Charlet, L., Hazemann, J., & Bohic, S. (2019). Sub-ppm level high energy resolution fluorescence detected X-ray absorption spectroscopy of selenium in articular cartilage. The Analyst, 144(11), 3488-3493.
https://doi.org/10.1039/c9an00207c, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49778
http://dx.doi.org/10.1039/c9an00207c
Morgan, B., Bauza-Mayol, G., Gardner, O., ZHANG, Y., Levato, R., Archer, C., Weeren, R., Malda, J., Conlan, S., Francis, L., & Khan, I. (2020). Bone Morphogenetic Protein-9 Is a Potent Chondrogenic and Morphogenic Factor for Articular Cartilage Chondroprogenitors. Stem Cells and Development, 29(14)
https://doi.org/10.1089/scd.2019.0209, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54205
Prasopthum, A., Deng, Z., Khan, I., Yin, Z., Guo, B., & Yang, J. (2020). Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells. Biomaterials Science, 8(15), 4287-4298.
https://doi.org/10.1039/d0bm00621a, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54499
Singh, R., Alzyoud, J., Trickett, R., Thomas, P., Theobald, P., & Khan, I. (2018). Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance. The Journal of Hand Surgery (Asian-Pacific Volume), 23(04), 463-468.
https://doi.org/10.1142/S2424835518500431, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49768
Otto, I., Levato, R., Webb, W., Khan, I., Breugem, C., Malda, J., & Khan, I. (2018). Progenitor cells in auricular cartilage demonstrate cartilage-forming capacity in 3D hydrogel culture. European Cells and Materials, 35, 132-150.
https://doi.org/10.22203/eCM.v035a10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41044
Ahmad, F., Soe, S., White, N., Johnston, R., Khan, I., Liao, J., Jones, M., Prabhu, R., Maconochie, I., Theobald, P., Johnston, R., & Khan, I. (2018). Region-Specific Microstructure in the Neonatal Ventricles of a Porcine Model. Annals of Biomedical Engineering
https://doi.org/10.1007/s10439-018-2089-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41043
Fellows, C., Williams, R., Davies, I., Gohil, K., Baird, D., Fairclough, J., Rooney, P., Archer, C., & Khan, I. (2017). Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence. Scientific Reports, 7(1), 41421
https://doi.org/10.1038/srep41421, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31768
Fellows, C., Matta, C., Zakany, R., Khan, I., & Mobasheri, A. (2016). Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair. Frontiers in Genetics, 7
https://doi.org/10.3389/fgene.2016.00213, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31769
Zhang, Y., Morgan, B., Smith, R., Fellows, C., Thornton, C., Snow, M., Francis, L., & Khan, I. (2017). Platelet-rich plasma induces post-natal maturation of immature articular cartilage and correlates with LOXL1 activation. Scientific Reports, 7(1)
https://doi.org/10.1038/s41598-017-02297-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33950
Khan, I., Francis, L., Theobald, P., Perni, S., Young, R., Prokopovich, P., Conlan, R., Archer, C., & Conlan, S. (2013). In vitro growth factor-induced bio engineering of mature articular cartilage. Biomaterials, 34(5), 1478-1487.
https://doi.org/10.1016/j.biomaterials.2012.09.076, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13945

Holl Ymchwil

Erthyglau Cylchgronau

Bauza, G., Pasto, A., Mcculloch, P., Lintner, D., Brozovich, A., Niclot, F., Khan, I., Francis, L., Tasciotti, E., & Taraballi, F. (2020). Improving the immunosuppressive potential of articular chondroprogenitors in a three-dimensional culture setting. Scientific Reports, 10(1)
https://doi.org/10.1038/s41598-020-73188-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55672
Prasopthum, A., Deng, Z., Khan, I., Yin, Z., Guo, B., & Yang, J. (2020). Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells. Biomaterials Science, 8(15), 4287-4298.
https://doi.org/10.1039/d0bm00621a, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54499
Morgan, B., Bauza-Mayol, G., Gardner, O., ZHANG, Y., Levato, R., Archer, C., Weeren, R., Malda, J., Conlan, S., Francis, L., & Khan, I. (2020). Bone Morphogenetic Protein-9 Is a Potent Chondrogenic and Morphogenic Factor for Articular Cartilage Chondroprogenitors. Stem Cells and Development, 29(14)
https://doi.org/10.1089/scd.2019.0209, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54205
Bissardon, C., Proux, O., Bureau, S., Suess, E., Winkel, L., Conlan, S., Francis, L., Khan, I., Charlet, L., Hazemann, J., & Bohic, S. (2019). Sub-ppm level high energy resolution fluorescence detected X-ray absorption spectroscopy of selenium in articular cartilage. The Analyst, 144(11), 3488-3493.
https://doi.org/10.1039/c9an00207c, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49778
http://dx.doi.org/10.1039/c9an00207c
Singh, R., Alzyoud, J., Trickett, R., Thomas, P., Theobald, P., & Khan, I. (2018). Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance. The Journal of Hand Surgery (Asian-Pacific Volume), 23(04), 463-468.
https://doi.org/10.1142/S2424835518500431, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49768
Ahmad, F., Soe, S., White, N., Johnston, R., Khan, I., Liao, J., Jones, M., Prabhu, R., Maconochie, I., Theobald, P., Johnston, R., & Khan, I. (2018). Region-Specific Microstructure in the Neonatal Ventricles of a Porcine Model. Annals of Biomedical Engineering
https://doi.org/10.1007/s10439-018-2089-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41043
Otto, I., Levato, R., Webb, W., Khan, I., Breugem, C., Malda, J., & Khan, I. (2018). Progenitor cells in auricular cartilage demonstrate cartilage-forming capacity in 3D hydrogel culture. European Cells and Materials, 35, 132-150.
https://doi.org/10.22203/eCM.v035a10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41044
Levato, R., Webb, W., Otto, I., Mensinga, A., Zhang, Y., Rijen, M., Weeren, R., Khan, I., & Malda, J. (2017). The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells. Acta Biomaterialia, 61
https://doi.org/10.1016/j.actbio.2017.08.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34875
Zhang, Y., Morgan, B., Smith, R., Fellows, C., Thornton, C., Snow, M., Francis, L., & Khan, I. (2017). Platelet-rich plasma induces post-natal maturation of immature articular cartilage and correlates with LOXL1 activation. Scientific Reports, 7(1)
https://doi.org/10.1038/s41598-017-02297-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33950
Alzyoud, J., Khan, I., & Rees, S. (2017). In vitro studies to evaluate the effect of varying culture conditions and IPL fluencies on tenocyte activities. Lasers in Medical Science, 32(7), 1561-1570.
https://doi.org/10.1007/s10103-017-2279-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35062
Fellows, C., Williams, R., Davies, I., Gohil, K., Baird, D., Fairclough, J., Rooney, P., Archer, C., & Khan, I. (2017). Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence. Scientific Reports, 7(1), 41421
https://doi.org/10.1038/srep41421, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31768
Fellows, C., Matta, C., Zakany, R., Khan, I., & Mobasheri, A. (2016). Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair. Frontiers in Genetics, 7
https://doi.org/10.3389/fgene.2016.00213, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31769
Khan, I., Francis, L., Theobald, P., Perni, S., Young, R., Prokopovich, P., Conlan, R., Archer, C., & Conlan, S. (2013). In vitro growth factor-induced bio engineering of mature articular cartilage. Biomaterials, 34(5), 1478-1487.
https://doi.org/10.1016/j.biomaterials.2012.09.076, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13945

Goruchwyliaeth

Development of synthetic bone allografts using tissue engineering and decellularisation. (cyfredol)

MSc

Goruchwyliwr arall: Dr Zhidao Xia
An investigation into BMP9-induced postnatal maturation of articular cartilage (dyfarnwyd 2024)

MSc

Goruchwyliwr arall: Prof Lewis Francis

Modiwlau a Addysgir

PM-130 Fundamental Research Skills

This module is designed to develop the skills required for students of biochemistry and genetics degree programmes. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.
PM-132 Eukaryotic Cell Biology

This module will provide students with a broad introduction to fundamental concepts in Eukaryotic cell biology, such as investigating the origins of the cell, the structure or eukaryotic cells, the different types of specialised cells, and cells which help prevent disease. There will be a general focus on human cells throughout the module with some references to other organisms when needed. Students will gain practical experience in identification and differentiation of cells from different human and animal species.
PM-132C Bioleg Celloedd Ewcaryotig

Bydd y modiwl hwn yn darparu cyflwyniad bras i gysyniadau sylfaenol ym maes bioleg celloedd Ewcaryotig, gan ymchwilio i darddiad y gell, strwythur y gell a chelloedd arbenigol a chelloedd mewn clefyd. Bydd ffocws cyffredinol ar gelloedd dynol drwy gydol y modiwl, gan gyfeirio at organebau eraill yn ôl yr angen. Bydd myfyrwyr yn cael profiad ymarferol o nodi celloedd, gwahaniaethu rhwng gwahanol gelloedd dynol a rhywogaethau o anifeiliaid.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-358 Tissue Engineering and Regenerative Medicine

This module will provide students with a firm understanding of the principles of Regenerative Medicine that extend from cellular to tissue and organ repair and regeneration. This module will focus on the practical aspects of revolutionary technologies, generated through research, that have the potential to significantly improve how we treat injury, illness and disease.
PMBM02 Introduction to Biomedical Science Practice in Health Care

The role of Biomedical Science in the delivery and provision of Health Care will be explored and critically evaluated within this module. This module is designed to provide you with the fundamental and principal concepts of Health Care, specifically to support the role of Biomedical Science. It will provide learning activities based around the general themes of Biomedical Science in Health Care, Anatomy and Pathology, Patient Experience, Pharmacology and Professionalism.
PMEM104 Reconstructive and Regenerative Medicine

This module will explore the opportunity, trends and developments in innovation in the Life Science Sector in relation to Reconstructive and Regenerative Medicine. Students will be introduced to the strategic approach for developing partnerships and leading innovation in reconstructive and regenerative medicine.
PMNM01 Regenerative Medicine

Regenerative Medicine is the design and application of cell and drug therapies incorporating nanotechnology and nanoscience in order to repair, replace and regenerate human cells, tissues or organs. This module provides the foundation for understanding how tissues can be returned to normal function by first exploring the fascinating anatomy and physiology of cells, tissues, organs and organ systems. The module builds upon the latter knowledge through teaching the core concepts of stem cell biology, including the isolation, characterisation and application of embryonic stem cells, induced pluripotential stem cells and adult stem cells. The potential of tissue engineering will be explored through a thorough understanding of how tissues are biofabricated in vitro ¿ building on concepts such as the structure and organisation of tissues as well as stem cell biology. The vast potential of stem cells for research and clinical use will be explored from the perspective of their interface with nanotechnology genetic (CRISPR) and tissue engineering, which together, have had a profound influence in the delivery of `smarter¿ therapies.
PMRM00 Introduction to the practice of Medical Physicists & Clinical Engineers in Health Care

Provides a broad-based overview of the Medical Physics & Clinical Engineering discipline.
PMZM12 Regenerative Medicine

Regenerative medicine is the application of nanotechnology and nanoscience in the process of replacing or regenerating human cells, tissues or organs to restore or establish normal function. This module will explore the basic concepts in stem cell biology, critically review the endogenous repair mechanisms, describe the basic concepts and principles of tissue engineering and relate this knowledge to it application and use within the clinical context.

Grantiau a Phrosiectau Allweddol

Cynhyrchu gwaith atgyweirio cadarn a gwydn ar ddiffygion cartilag gan ddefnyddio bôn-gelloedd oedolion â meinwe penodol – dull systematig, therapiwtig. 2014 - 2020

Mewn cydweithrediad ag Ysgol Feddygaeth Utrecht, Yr Iseldiroedd. , £1,300,000

Hanes Gyrfa

PhD, Coleg Imperial, Llundain, DU

1996 - 2000

Rolau Eraill

Aelod o'r Panel Adolygu Rhyngwladol , eCM Journal

2012 - Presennol

Dr Ilyas Khan

Rhif ffôn

Cyfeiriad ebost

Welsh language proficiency

Dolenni Ymchwil

Trosolwg

Meysydd Arbenigedd

Uchafbwyntiau Gyrfa

Uchafbwyntiau Ymchwil

Holl Ymchwil

Development of synthetic bone allografts using tissue engineering and decellularisation. (cyfredol)

An investigation into BMP9-induced postnatal maturation of articular cartilage (dyfarnwyd 2024)

PM-130 Fundamental Research Skills

PM-132 Eukaryotic Cell Biology

PM-132C Bioleg Celloedd Ewcaryotig

PM-344 Capstone Project

PM-358 Tissue Engineering and Regenerative Medicine

PMBM02 Introduction to Biomedical Science Practice in Health Care

PMEM104 Reconstructive and Regenerative Medicine

PMNM01 Regenerative Medicine

PMRM00 Introduction to the practice of Medical Physicists & Clinical Engineers in Health Care

PMZM12 Regenerative Medicine

PhD, Coleg Imperial, Llundain, DU

Aelod o'r Panel Adolygu Rhyngwladol , eCM Journal