Yr Athro Juan Mareque-Rivas

Athro, Chemistry

juan.mareque-rivas@abertawe.ac.uk

438
Trydydd Llawr
Adeilad Grove
Campws Singleton

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

https://orcid.org/0000-0002-7405-3338

ResearchGate

Trosolwg

Graddiodd yr Athro Mareque-Rivas o Brifysgol Strathclyde ac Universidade de Santiago de Compostela gyda graddau mewn Cemeg a Chemeg Gymhwysol, gan arbenigo mewn cemeg anorganig, ffisegol a fferyllol. Gwnaeth ei Ddoethuriaeth (1995-98) mewn cemeg uwchfoleciwlaidd ym Mhrifysgol Missouri-St Louis ac yna gwnaeth waith ymchwil ôl-ddoethurol yn MIT yn labordy Steve Lippard ym maes metelonewrogemeg (1998-2000). Sefydlodd ei grŵp ymchwil annibynnol yn yr EastChem School of Chemistry ym Mhrifysgol Caeredin (2000-11). Derbyniodd Swydd Athro Ymchwil Ikerbasque i ymuno â’r Centre for Cooperative Research in Biomaterials (CIG biomaGUNE) yn San Sebastian, a ffurfiwyd yn ddiweddar iawn, lle sefydlodd y Theranostic Nanomedicine Laboratory a lle’r oedd yn Arweinydd Grŵp ar ei gyfer. Wrth ddychwelyd i’r DU, cafodd ei benodi gan Brifysgol Aberdeen i gychwyn rhaglen Beirianneg Biofeddygol yn yr Ysgol Beirianneg. Yn ystod 2016-17, ymunodd â Phrifysgol Abertawe fel Athro Ymchwil, gan wasanaethu fel Cyd-Bennaeth yr Adran (2016-18) ac yn Bennaeth Ymchwil (2016-21) yn yr Adran Gemeg Newydd.

Meysydd Arbenigedd

Bioddeunyddau
Imiwnoleg Gemegol
Deunyddiau a Pholymerau
Cemeg Bioanorganig
Cemeg Uwchfoleciwlaidd
Cemeg Bioddynwaredol a Bioysbrydoledig
Brechlynau
Imiwnotherapi Canser
Delweddu Moleciwlaidd

Uchafbwyntiau Gyrfa

Ymchwil

Mae dulliau’r gwyddorau cemegol a deunyddiau yn darparu cyfleoedd sylweddol ym maes ymchwil feddygol. Ein prif ddiddordeb yw’r ffordd y gellir eu cymhwyso gyda’r nod o gael modiwleiddio imiwnedd wedi’i reoli er mwyn gwella gallu systemau imiwnedd i atal a thrin clefydau. Mae’r gwaith ymchwil amlddisgyblaethol wedi’i dargedu tuag at ddatblygu platfformau theranostig (therapi + diagnosis) ar gyfer clefydau heintus, awto-imiwn a chanser.

Datblygu moleciwlau a bioddeunyddiau imiwnofodylaidd. Mae ein strategaethau synthetig yn manteisio ar hunan-gydosodiad wedi’i gyfeirio a threfn er mwyn lleihau nifer y camau synthetig a sicrhau gweithredu effeithlon ar raddfa fwy ac addasu rhwydd wrth gynhyrchu gan ddefnyddio arferion gweithgynhyrchu da (GMP). Mae ymatebion cemoddewisol a chlymiad bio-orthogonol a dulliau cyfunedd sy’n benodol i’r safle yn cyflwyno biofoleciwlau i’r targed yn y modd gorau bosibl. Rydym yn creu dyfeisiau bioddeunydd y gellir eu mewnblannu er mwyn modiwleiddio’n lleol y system imiwnedd.

Astudiaethau ar y rhyngwyneb imiwnoleg cemeg-cemegol bio-anorganig. Rydym yn archwilio sut gall rhai strwythurau a swyddogaethau biolegol sylweddau biolegol anorganig (e.e. cemeg bioanorganig haearn, metaloensymau a (bio)fineralau â strwythurau a ddiffinnir) fodiwleiddio ymatebion imiwnedd. Rydym yn gweithio gyda metalogyffuriau a pro-gyffuriau (e.e. cyfryngau gwrthganser sy’n seiliedig ar blatinwm) a chyfryngau delweddu clinigol – wedi’u hail-gynllunio/ailbwrpasu i sbarduno a chynyddu imiwnedd gwrth-diwmor, i ecsbloetio neu ailraglennu microamgylchedd y tiwmor er mwyn gwella imiwnotherapi canser, ac i fonoitro’r system imiwnedd a’r imiwnotherapi.

Datblygu platfformau brechlyn wedi’u rhaglennu’n gemegol. Yma mae ein gwaith ymchwil yn ceisio datblygu strategaethau i reoli’r broses gydosod/datosod wrth y targed biolegol, er mwyn sbarduno actifadu biolegol drwy ysgogiad mewnol/allanol, i ddefnyddio prif lwyth therapi cyfunol, i hyrwyddo’r defnydd cellol o neo-antigenau peptid/mRNA i greu brechlynau personol ac ati.

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Traini, G., Ruiz-de-Angulo, A., Blanco-Canosa, J., Bascarán, K., Molinaro, A., Silipo, A., Escors, D., & Mareque-Rivas, J. (2019). Cancer Immunotherapy of TLR4 Agonist-Antigen Constructs Enhanced with Pathogen-Mimicking Magnetite Nanoparticles and Checkpoint Blockade of PD-L1. Small, 15(4), 1803993
https://doi.org/10.1002/smll.201803993, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48048
Gondan, A., Ruiz-de-Angulo, A., Zabaleta, A., Blanco, N., Cobaleda-Siles, B., García-Granda, M., Padro, D., Llop, J., Arnaiz, B., Gato, M., Escors, D., Mareque-Rivas, J., & Mareque-Rivas, J. (2018). Effective cancer immunotherapy in mice by polyIC-imiquimod complexes and engineered magnetic nanoparticles. Biomaterials, 170, 95-115.
https://doi.org/10.1016/j.biomaterials.2018.04.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39420
Castro, S., Ruggiero, E., Ruiz-de-Angulo, A., Rezabal, E., Mareque-Rivas, J., Lopez, X., López-Gallego, F., & Salassa, L. (2017). Riboflavin as a bioorthogonal photocatalyst for the activation of a PtIV prodrug. Chemical Science, 8(6), 4619-4625.
https://doi.org/10.1039/c7sc01109a, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39419
Ruiz-de-Angulo, A., Zabaleta, A., Gómez-Vallejo, V., Llop, J., & Mareque-Rivas, J. (2016). Microdosed Lipid-Coated67Ga-Magnetite Enhances Antigen-Specific Immunity by Image Tracked Delivery of Antigen and CpG to Lymph Nodes. ACS Nano, 10(1), 1602-1618.
https://doi.org/10.1021/acsnano.5b07253, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30761
Hernández-Gil, J., Cobaleda-Siles, M., Zabaleta, A., Salassa, L., Calvo, J., & Mareque-Rivas, J. (2015). An Iron Oxide Nanocarrier Loaded with a Pt(IV) Prodrug and Immunostimulatory dsRNA for Combining Complementary Cancer Killing Effects. Advanced Healthcare Materials, 4(7), 1034-1042.
https://doi.org/10.1002/adhm.201500080, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30762
Cobaleda-Siles, M., Henriksen-Lacey, M., de Angulo, A., Bernecker, A., Vallejo, V., Szczupak, B., Llop, J., Pastor, G., Plaza-Garcia, S., Jauregui-Osoro, M., Meszaros, L., & Mareque-Rivas, J. (2014). An Iron Oxide Nanocarrier for dsRNA to Target Lymph Nodes and Strongly Activate Cells of the Immune System. Small, n/a-n/a.
https://doi.org/10.1002/smll.201401353, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30767
Ruggiero, E., Hernández-Gil, J., Mareque-Rivas, J., & Salassa, L. (2015). Near infrared activation of an anticancer PtIVcomplex by Tm-doped upconversion nanoparticles. Chem. Commun., 51(11), 2091-2094.
https://doi.org/10.1039/C4CC07960D, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30764
Garaikoetxea Arguinzoniz, A., Gómez Blanco, N., Ansorena Legarra, P., Mareque-Rivas, J., & Mareque-Rivas, J. (2015). Enhanced cancer cell killing of a Pt(iv) prodrug promoted by outer-sphere coordination with polyethyleneimines. Dalton Trans., 44(16), 7135-7138.
https://doi.org/10.1039/C5DT00175G, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30766
Ruggiero, E., Garino, C., Mareque-Rivas, J., Habtemariam, A., & Salassa, L. (2016). Upconverting Nanoparticles Prompt Remote Near-Infrared Photoactivation of Ru(II)-Arene Complexes. Chemistry - A European Journal, 22(8), 2801-2811.
https://doi.org/10.1002/chem.201503991, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30763
Maldonado, C., Salassa, L., Gomez-Blanco, N., & Mareque-Rivas, J. (2013). Nano-functionalization of metal complexes for molecular imaging and anticancer therapy. Coordination Chemistry Reviews, 257(19-20), 2668-2688.
https://doi.org/10.1016/j.ccr.2013.04.014, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30771

Holl Ymchwil

Erthyglau Cylchgronau

Bilbao Asensio, M., Ruiz‐de‐Angulo, A., Arguinzoniz, A., Cronin, J., Llop, J., Zabaleta, A., Michue-Seijas, S., Sosnowska, D., Arnold, J., & Mareque-Rivas, J. (2022). Redox‐Triggered Nanomedicine via Lymphatic Delivery: Inhibition of Melanoma Growth by Ferroptosis Enhancement and a Pt(IV)‐Prodrug Chemoimmunotherapy Approach. Advanced Therapeutics, 6(2), 2200179
https://doi.org/10.1002/adtp.202200179, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61668
Ruiz-de-Angulo, A., Bilbao Asensio, M., Cronin, J., Evans, S., Clift, M., Llop, J., Feiner, I., Beadman, R., Bascarán, K., & Mareque-Rivas, J. (2020). Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis. iScience, 23(9), 101499
https://doi.org/10.1016/j.isci.2020.101499, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55075
Traini, G., Ruiz-de-Angulo, A., Blanco-Canosa, J., Bascarán, K., Molinaro, A., Silipo, A., Escors, D., & Mareque-Rivas, J. (2019). Cancer Immunotherapy of TLR4 Agonist-Antigen Constructs Enhanced with Pathogen-Mimicking Magnetite Nanoparticles and Checkpoint Blockade of PD-L1. Small, 15(4), 1803993
https://doi.org/10.1002/smll.201803993, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48048
Gondan, A., Ruiz-de-Angulo, A., Zabaleta, A., Blanco, N., Cobaleda-Siles, B., García-Granda, M., Padro, D., Llop, J., Arnaiz, B., Gato, M., Escors, D., Mareque-Rivas, J., & Mareque-Rivas, J. (2018). Effective cancer immunotherapy in mice by polyIC-imiquimod complexes and engineered magnetic nanoparticles. Biomaterials, 170, 95-115.
https://doi.org/10.1016/j.biomaterials.2018.04.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39420
Castro, S., Ruggiero, E., Ruiz-de-Angulo, A., Rezabal, E., Mareque-Rivas, J., Lopez, X., López-Gallego, F., & Salassa, L. (2017). Riboflavin as a bioorthogonal photocatalyst for the activation of a PtIV prodrug. Chemical Science, 8(6), 4619-4625.
https://doi.org/10.1039/c7sc01109a, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39419
Ruiz-de-Angulo, A., Zabaleta, A., Gómez-Vallejo, V., Llop, J., & Mareque-Rivas, J. (2016). Microdosed Lipid-Coated67Ga-Magnetite Enhances Antigen-Specific Immunity by Image Tracked Delivery of Antigen and CpG to Lymph Nodes. ACS Nano, 10(1), 1602-1618.
https://doi.org/10.1021/acsnano.5b07253, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30761
Ruggiero, E., Garino, C., Mareque-Rivas, J., Habtemariam, A., & Salassa, L. (2016). Upconverting Nanoparticles Prompt Remote Near-Infrared Photoactivation of Ru(II)-Arene Complexes. Chemistry - A European Journal, 22(8), 2801-2811.
https://doi.org/10.1002/chem.201503991, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30763
Hernández-Gil, J., Cobaleda-Siles, M., Zabaleta, A., Salassa, L., Calvo, J., & Mareque-Rivas, J. (2015). An Iron Oxide Nanocarrier Loaded with a Pt(IV) Prodrug and Immunostimulatory dsRNA for Combining Complementary Cancer Killing Effects. Advanced Healthcare Materials, 4(7), 1034-1042.
https://doi.org/10.1002/adhm.201500080, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30762
Ruggiero, E., Hernández-Gil, J., Mareque-Rivas, J., & Salassa, L. (2015). Near infrared activation of an anticancer PtIVcomplex by Tm-doped upconversion nanoparticles. Chem. Commun., 51(11), 2091-2094.
https://doi.org/10.1039/C4CC07960D, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30764
Garaikoetxea Arguinzoniz, A., Gómez Blanco, N., Ansorena Legarra, P., Mareque-Rivas, J., & Mareque-Rivas, J. (2015). Enhanced cancer cell killing of a Pt(iv) prodrug promoted by outer-sphere coordination with polyethyleneimines. Dalton Trans., 44(16), 7135-7138.
https://doi.org/10.1039/C5DT00175G, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30766
Cobaleda-Siles, M., Henriksen-Lacey, M., de Angulo, A., Bernecker, A., Vallejo, V., Szczupak, B., Llop, J., Pastor, G., Plaza-Garcia, S., Jauregui-Osoro, M., Meszaros, L., & Mareque-Rivas, J. (2014). An Iron Oxide Nanocarrier for dsRNA to Target Lymph Nodes and Strongly Activate Cells of the Immune System. Small, n/a-n/a.
https://doi.org/10.1002/smll.201401353, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30767
Arguinzoniz, A., Ruggiero, E., Habtemariam, A., Hernández-Gil, J., Salassa, L., & Mareque-Rivas, J. (2014). Light Harvesting and Photoemission by Nanoparticles for Photodynamic Therapy. Particle & Particle Systems Characterization, 31(1), 46-75.
https://doi.org/10.1002/ppsc.201300314, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30770
Ruggiero, E., Habtemariam, A., Yate, L., Mareque-Rivas, J., Salassa, L., & Mareque-Rivas, J. (2014). Near infrared photolysis of a Ru polypyridyl complex by upconverting nanoparticles. Chemical Communications, 50(14), 1715
https://doi.org/10.1039/C3CC47601D, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30778
Infante, I., Azpiroz, J., Blanco, N., Ruggiero, E., Ugalde, J., Mareque-Rivas, J., & Salassa, L. (2014). Quantum Dot Photoactivation of Pt(IV) Anticancer Agents: Evidence of an Electron Transfer Mechanism Driven by Electronic Coupling. The Journal of Physical Chemistry C, 118(16), 8712-8721.
https://doi.org/10.1021/jp501447q, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30777
Hernández-Gil, J., Ferrer, S., Castiñeiras, A., Liu-González, M., Lloret, F., Ribes, Á., Čoga, L., Bernecker, A., & Mareque-Rivas, J. (2014). Two Novel Ternary Dicopper(II) μ-Guanazole Complexes with Aromatic Amines Strongly Activated by Quantum Dots for DNA Cleavage. Inorganic Chemistry, 53(1), 578-593.
https://doi.org/10.1021/ic4027249, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30769
Maldonado, C., Salassa, L., Gomez-Blanco, N., & Mareque-Rivas, J. (2013). Nano-functionalization of metal complexes for molecular imaging and anticancer therapy. Coordination Chemistry Reviews, 257(19-20), 2668-2688.
https://doi.org/10.1016/j.ccr.2013.04.014, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30771
Maldonado, C., Gómez-Blanco, N., Jauregui-Osoro, M., Brunton, V., Yate, L., & Mareque-Rivas, J. (2013). QD-filled micelles which combine SPECT and optical imaging with light-induced activation of a platinum(iv) prodrug for anticancer applications. Chemical Communications, 49(38), 3985
https://doi.org/10.1039/C3CC39104C, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30772
Hernández-Gil, J., Ferrer, S., Salvador, E., Calvo, J., Garcia-España, E., & Mareque-Rivas, J. (2013). A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion. Chemical Communications, 49(35), 3655
https://doi.org/10.1039/C3CC39067E, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30773
Blanco, N., Jauregui-Osoro, M., Cobaleda-Siles, M., Maldonado, C., Henriksen-Lacey, M., Padro, D., Clark, S., & Mareque-Rivas, J. (2012). Iron oxide-filled micelles as ligands for fac-[M(CO)3]+ (M = 99mTc, Re). Chemical Communications, 48(35), 4211
https://doi.org/10.1039/C2CC31045G, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30774
Maldonado, C., Touceda-Varela, A., Jones, A., & Mareque-Rivas, J. (2011). A turn-on fluorescence sensor for cyanide from mechanochemical reactions between quantum dots and copper complexes. Chemical Communications, 47(42), 11700
https://doi.org/10.1039/C1CC14565G, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30775
Hernández-Gil, J., Llusar, S., Maldonado, C., & Mareque-Rivas, J. (2011). Synergy between quantum dots and 1,10-phenanthroline–copper(ii) complex towards cleaving DNA. Chemical Communications, 47(10), 2955
https://doi.org/10.1039/C0CC04163G, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30776
Blanco, N., Maldonado, C., & Mareque-Rivas, J. (2009). Effective photoreduction of a Pt(iv) complex with quantum dots: a feasible new light-induced method of releasing anticancer Pt(ii) drugs. Chemical Communications(35), 5257
https://doi.org/10.1039/B910000H, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30782
Ganesh, V., Bodewits, K., Bartholdson, S., Natale, D., Campopiano, D., Mareque-Rivas, J., & Mareque-Rivas, J. (2009). Effective Binding and Sensing of Lipopolysaccharide: Combining Complementary Pattern Recognition Receptors. Angewandte Chemie International Edition, 48(2), 356-360.
https://doi.org/10.1002/anie.200804168, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30781
Touceda-Varela, A., Stevenson, E., Galve-Gasión, J., Dryden, D., & Mareque-Rivas, J. (2008). Selective turn-on fluorescence detection of cyanide in water using hydrophobic CdSe quantum dots. Chemical Communications(17), 1998
https://doi.org/10.1039/B716194H, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30780
Natale, D. & Mareque-Rivas, J. (2008). The combination of transition metal ions and hydrogen-bonding interactions. Chem. Commun.(4), 425-437.
https://doi.org/10.1039/B709650J, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30783
Gupta, M., Caniard, A., Touceda-Varela, A., Campopiano, D., & Mareque-Rivas, J. (2008). Nitrilotriacetic Acid-Derivatized Quantum Dots for Simple Purification and Site-Selective Fluorescent Labeling of Active Proteins in a Single Step. Bioconjugate Chemistry, 19(10), 1964-1967.
https://doi.org/10.1021/bc800273j, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30787
Ganesh, V., Calatayud Sanz, M., & Mareque-Rivas, J. (2007). Effective anion sensing based on the ability of copper to affect electron transport across self-assembled monolayers. Chemical Communications(47), 5010
https://doi.org/10.1039/B712857F, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30786
Feng, G., Natale, D., Prabaharan, R., Mareque-Rivas, J., & Williams, N. (2006). Efficient Phosphodiester Binding and Cleavage by a ZnII Complex Combining Hydrogen-Bonding Interactions and Double Lewis Acid Activation. Angewandte Chemie International Edition, 45(42), 7056-7059.
https://doi.org/10.1002/anie.200602532, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30784
Feng, G., Mareque-Rivas, J., Torres Martín de Rosales, R., & Williams, N. (2005). A Highly Reactive Mononuclear Zn(II) Complex for Phosphodiester Cleavage. Journal of the American Chemical Society, 127(39), 13470-13471.
https://doi.org/10.1021/ja054003t, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30785
Mareque-Rivas, J., Prabaharan, R., & Martín de Rosales, R. (2004). Relative importance of hydrogen bonding and coordinating groups in modulating the zinc–water acidity. Chem. Commun.(1), 76-77.
https://doi.org/10.1039/B310956A, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30788

Goruchwyliaeth

Nanoparticles in Synergy with Small Molecules for Iron Oxide-Mediated Cancer Cell Death (cyfredol)

PhD

Goruchwyliwr arall: Prof Owen Guy
Development of biomaterials for development of enhanced vaccines against infectious disease and cancer (cyfredol)

PhD

Goruchwyliwr arall: Dr James Cronin
Biodegradable Nanovectors for the Treatment of Advanced Ovarian Cancer. (dyfarnwyd 2024)

PhD

Goruchwyliwr arall: Prof Lewis Francis
Polymers of Intrinsic Microporosity for Heterogeneous Base Catalysis (dyfarnwyd 2023)

PhD

Goruchwyliwr arall: Dr Mariolino Carta
Biomaterial-based transdermal and implantable vaccine delivery systems for cancer immunotherapy (dyfarnwyd 2022)

PhD

Goruchwyliwr arall: Prof Owen Guy
Investigation of the photophysical and DNA binding properties of [Ru(5,5’-dmbpy)2(10,11-dmdppz)]2+ and [Ru(bpy)2(10,11-dmdppz)]2+ (dyfarnwyd 2023)

MSc

Goruchwyliwr arall: Dr Martin Gill
Platinum(IV) Prodrugs Conjugated to DSPE-PEG for Development of Iron Oxide Nanoparticle Micelles for Multimodal Cancer Therapy (cyfredol)

MSc

Goruchwyliwr arall: Dr Mariolino Carta

Modiwlau a Addysgir

CH-127 Chemical Practice

This module will introduce students to the three broad employment areas for chemistry: research, teaching or industrial positions. The lecture portion will cover fundamental aspects of being a professional chemist including safety, report writing, project management, and teaching skills. Students will attend research seminars and workshops, industrial field trips, and supervise school pupils in the laboratory. Assessment will be by coursework and a written report.
CH-232 Further Inorganic Chemistry

This module will continue discussion of concepts traditionally considered to be inorganic chemistry studying the structure and bonding of main group and transition metal compounds and major classes of reactions. Symmetry and group theory will also be introduced in this module. Note: it is expected that material, techniques and skills covered in the course of this module will require understanding of any prior module. The module will have a variety of formative assessment opportunities and summative assessments that include writing of technical reports, a presentation, homework, workshops, and an exam.
CH-340 Advanced Topics in Inorganic and Materials Chemistry

This module will provide a fuller and more comprehensive understanding of inorganic chemistry built upon the principles introduced in Years 1 and 2. It will illustrate how various classes of inorganic compounds and materials, including coordination compounds and coordination polymers, cluster compounds, organometallic compounds, nanomaterials and colloidal inorganic nanoparticles, porous materials and supramolecular systems are prepared and characterised. The student will gain an understanding of inorganic materials properties and of the principles and experimental techniques that underpin their synthesis. The module will illustrate specific applications of inorganic materials and nanomaterials and will show the importance and use of inorganic chemistry, nanomaterials and metal-containing units in biology and medicine.
CH-344 Chemistry Project

3rd year projects are the opportunity to bring all you've learnt during your degree together and apply that knowledge to solve a problem. In Swansea these projects can be embedded in active research groups across the colleges of science, engineering or medicine, allowing you to build a network and experience in your chosen specialism within the chemical sciences. These projects are your opportunity to demonstrate to employers that you have a full understanding of your course and are able to direct your own studies, manage an independent research project and effectively communicate your findings. This selection suggests an interest in a project embedded within a research group in engineering, focusing on materials chemistry or chemical engineering
CH-349 Integrated Topics in Chemistry

This module gives students the opportunity to explore options within Chemistry, giving opportunity to apply prior learning to advanced research topics and allowing students to pursue more specialised topics related to their research interests and aligned with the research areas represented within the Department. Study areas available will include advanced spectroscopic techniques, the application of instrumentation in chemistry, as well as more advanced synthetic pathways and a return to more integrated study of the traditional branches of organic/inorganic/physical chemistry. The module will also include a mandatory employability component. Classes will be supported with workshops which will help students gain a thorough understanding of the integrated nature of Chemistry at an advanced level. Where possible, topics will be taught using relevant examples from primary literature, encouraging students to evaluate and appraise a range of primary literature sources and locate appropriate new sources. The module is designed to be flexible to allow the content to vary with the research areas represented within the Department and wider university.
CH-409 MChem Research Project

MChem projects are the defining feature of the integrated masters with a chance to contribute research work of potentially publishable standard to an active research group within the University. In Swansea these projects can be embedded in active research groups across the Faculty of Science and Engineering or the Faculty of Medicine, Health and Life Science, allowing you to build a network and experience in your chosen specialism within the chemical sciences. These projects are an excellent way of managing the transition on to your next destination after undergraduate study, whether that is a postgraduate research studentship or into employment. The skills developed in the MChem projects demonstrate the ability to successfully deliver all aspects of a 60 credit research project and on exit you will have demonstrated the academic equivalence and begun developing the other skills required for entry into professional development schemes leading to chartership. This selection suggests an interest in a project embedded within a research group in science, focusing on straight chemistry, or interacting and collaborating with another department such as bioscience, geography, physics, maths or computer science.
CH-413 Advanced Integrated Topics in Chemistry Part 2

This module gives students the opportunity to explore options within Chemistry, giving opportunity to apply prior learning to advanced research topics and allowing students to pursue more specialised topics related to their research interests and aligned with the research areas represented within the Department. Study areas available will include advanced spectroscopic techniques, the application of instrumentation in chemistry, as well as more advanced synthetic pathways and a return to more integrated study of the traditional branches of organic/inorganic/physical chemistry. Classes will be supported with workshops which will help students gain a thorough understanding of the integrated nature of Chemistry at an advanced level. Where possible, topics will be taught using relevant examples from primary literature, encouraging students to evaluate and appraise a range of primary literature sources and locate appropriate new sources. The module is designed to be flexible to allow the content to vary with the research areas represented within the Department.

Yr Athro Juan Mareque-Rivas

Cyfeiriad ebost

Dolenni Ymchwil

Trosolwg

Meysydd Arbenigedd

Uchafbwyntiau Gyrfa

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Holl Ymchwil

Erthyglau Cylchgronau

Goruchwyliaeth

Nanoparticles in Synergy with Small Molecules for Iron Oxide-Mediated Cancer Cell Death (cyfredol)

Development of biomaterials for development of enhanced vaccines against infectious disease and cancer (cyfredol)

Biodegradable Nanovectors for the Treatment of Advanced Ovarian Cancer. (dyfarnwyd 2024)

Polymers of Intrinsic Microporosity for Heterogeneous Base Catalysis (dyfarnwyd 2023)

Biomaterial-based transdermal and implantable vaccine delivery systems for cancer immunotherapy (dyfarnwyd 2022)

Investigation of the photophysical and DNA binding properties of [Ru(5,5’-dmbpy)2(10,11-dmdppz)]2+ and [Ru(bpy)2(10,11-dmdppz)]2+ (dyfarnwyd 2023)

Platinum(IV) Prodrugs Conjugated to DSPE-PEG for Development of Iron Oxide Nanoparticle Micelles for Multimodal Cancer Therapy (cyfredol)

Modiwlau a Addysgir

CH-127 Chemical Practice

CH-232 Further Inorganic Chemistry

CH-340 Advanced Topics in Inorganic and Materials Chemistry

CH-344 Chemistry Project

CH-349 Integrated Topics in Chemistry

CH-409 MChem Research Project

CH-413 Advanced Integrated Topics in Chemistry Part 2