Institute of Life Science 2 Internal Atrium

Dr Marcos Quintela Vazquez

Aelod Cyswllt, Other/Subsidiary Companies - Not Defined

m.quintelavazquez@abertawe.ac.uk

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

Trosolwg

Mae Dr Quintela yn gweithio yn yr Ysgol Feddygaeth ac yn Swyddog Arloesi Ymchwil a Datblygu yn y grŵp ymchwil Bioleg Atgenhedlu ac Oncoleg Gynaecolegol (RBGO). Graddiodd Dr Quintela gyda gradd baglor ym Mhrifysgol Salamanca (Sbaen) yn 2012. Yna dilynodd gwrs gradd meistr mewn Biotechnoleg yn yr Autonomous University of Barcelona (Sbaen) ac yn 2014 symudodd i’r DU i gychwyn Doethuriaeth mewn Nanofeddygaeth ym Mhrifysgol Abertawe. Gwnaeth ei Ddoethuriaeth mewn partneriaeth â’r Houston Methodist Research Institute, lle treuliodd ddwy flynedd yn gweithio fel Cymrawd Ymchwil Graddedig. Ar ôl cwblhau ei Ddoethuriaeth, ymunodd Marcos â’r Coleg Meddygaeth fel ymchwilydd, gan weithio yn gyntaf yn yr adran Gwyddor Data ac erbyn hyn mae’n rhan o’r grŵp RBGO.

Meysydd Arbenigedd

Bioleg celloedd a moleciwlau
Genomeg ac epigenomeg
Biowybodeg, dadansoddi data omics
Bioleg Atgenhedlu ac Oncoleg Gynaecolegol
Datblygu cyffuriau

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Mae Marcos yn darlithio ar y cwrs MSc mewn Nanofeddygaeth mewn amrywiaeth eang o fodiwlau.

Ymchwil Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Friguglietti, J., Das, S., Le, P., Fraga, D., Quintela Vazquez, M., Gazze, S., McPhail, D., Gu, J., Sabek, O., Gaber, A., Francis, L., Zagozdzon-Wosik, W., & Merchant, F. (2020). Novel Silicon Titanium Diboride Micropatterned Substrates for Cellular Patterning. Biomaterials, 244, 119927
https://doi.org/10.1016/j.biomaterials.2020.119927, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54548
Rees, P., Bauza‐Mayol, G., Quintela Vazquez, M., Brozovich, A., Hopson, M., Shaikh, S., Cabrera, F., Shi, A., Niclot, F., Paradiso, F., Thomson, E., Jovic, T., Rees, P., Tasciotti, E., Francis, L., Mcculloch, P., & Taraballi, F. (2021). Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo. Advanced Healthcare Materials, 11(1), 2101127
https://doi.org/10.1002/adhm.202101127, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58476
PARADISO, F., Quintela Vazquez, M., Lenna, S., Serpelloni, S., James, D., Caserta, S., Conlan, S., Francis, L., & Taraballi, F. (2022). Studying Activated Fibroblast Phenotypes and Fibrosis‐Linked Mechanosensing Using 3D Biomimetic Models. Macromolecular Bioscience, 22(4), 2100450
https://doi.org/10.1002/mabi.202100450, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59159
TOUBHANS, B., Alkafri, N., Quintela Vazquez, M., James, D., Bissardon, C., Gazze, S., Knodel, F., Proux, O., Gourlan, A., Rathert, P., Bohic, S., Gonzalez, D., Francis, L., Charlet, L., & Conlan, S. (2023). Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion. Redox Biology, 61, 102641
https://doi.org/10.1016/j.redox.2023.102641, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62755
Quintela Vazquez, M., James, D., Pociute, A., Powell, L., Edwards, K., Coombes, Z., Garcia, J., Garton, N., Das, N., Lutchman-Singh, K., Margarit, L., Beynon, A., Rioja, I., Prinjha, R., Harker, N., Gonzalez, D., Conlan, S., Francis, L., & Johnson, A. (2023). Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells. Clinical Epigenetics, 15(1)
https://doi.org/10.1186/s13148-023-01477-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64098
http://dx.doi.org/10.1186/s13148-023-01477-x

Holl Ymchwil

Erthyglau Cylchgronau

TOUBHANS, B., Alkafri, N., Quintela Vazquez, M., James, D., Bissardon, C., Gazze, S., Knodel, F., Proux, O., Gourlan, A., Rathert, P., Bohic, S., Gonzalez, D., Francis, L., Charlet, L., & Conlan, S. (2023). Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion. Redox Biology, 61, 102641
https://doi.org/10.1016/j.redox.2023.102641, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62755
Quintela Vazquez, M., James, D., Pociute, A., Powell, L., Edwards, K., Coombes, Z., Garcia, J., Garton, N., Das, N., Lutchman-Singh, K., Margarit, L., Beynon, A., Rioja, I., Prinjha, R., Harker, N., Gonzalez, D., Conlan, S., Francis, L., & Johnson, A. (2023). Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells. Clinical Epigenetics, 15(1)
https://doi.org/10.1186/s13148-023-01477-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64098
http://dx.doi.org/10.1186/s13148-023-01477-x
PARADISO, F., Quintela Vazquez, M., Lenna, S., Serpelloni, S., James, D., Caserta, S., Conlan, S., Francis, L., & Taraballi, F. (2022). Studying Activated Fibroblast Phenotypes and Fibrosis‐Linked Mechanosensing Using 3D Biomimetic Models. Macromolecular Bioscience, 22(4), 2100450
https://doi.org/10.1002/mabi.202100450, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59159
Rees, P., Bauza‐Mayol, G., Quintela Vazquez, M., Brozovich, A., Hopson, M., Shaikh, S., Cabrera, F., Shi, A., Niclot, F., Paradiso, F., Thomson, E., Jovic, T., Rees, P., Tasciotti, E., Francis, L., Mcculloch, P., & Taraballi, F. (2021). Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo. Advanced Healthcare Materials, 11(1), 2101127
https://doi.org/10.1002/adhm.202101127, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58476
Friguglietti, J., Das, S., Le, P., Fraga, D., Quintela Vazquez, M., Gazze, S., McPhail, D., Gu, J., Sabek, O., Gaber, A., Francis, L., Zagozdzon-Wosik, W., & Merchant, F. (2020). Novel Silicon Titanium Diboride Micropatterned Substrates for Cellular Patterning. Biomaterials, 244, 119927
https://doi.org/10.1016/j.biomaterials.2020.119927, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54548

Modiwlau a Addysgir

PMLM01 Laboratory Measurement Techniques for Medicinal Chemistry and Nanomedicine

This module will enable students to understand the basic and advanced concepts of measurement techniques used in medicinal chemistry and nanomedicine, how they may be applied with relevant methods of detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to target molecule characteristics and method application.
PMNM11 Nanomedicines, pharmaceuticals and advanced therapeutics

This module will explore the history and development of molecular medicines and pharmaceuticals, providing the basis for an advanced understanding of next generation therapeutic approaches. Using landmark technology and chemical development phases informed by separation science and mass spectrometry, the module uses an application driven approach to provide the student with an extensive knowledgebase of drug development, the pharmaceutical industry and nanotherapeutics. Students will be able to characterize and map the path of a drug from administration, to metabolism and elimination, and critically evaluate drug design and delivery approaches. Traditional small chemical entities used in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. Common target oncology and non-oncology disorders will provide the context; with students encouraged to explore targeted nanoparticle fabrication, drug encapsulation and release profiling, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems. Future molecular medicines such as antibody drug conjugates and kinase inhibitors will be taught by guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.