Yr Athro Lewis Francis

Athro, Biomedical Sciences

l.francis@abertawe.ac.uk

Siaradwr Cymraeg Rhugl

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

Trosolwg

Mae Dr Francis yn Athro Cysylltiol yn yr Ysgol Feddygaeth, yn y Grŵp Ymchwil Bioleg Atgenhedlu ac Oncoleg Gynaecolegol, lle mae'n arwain rhaglenni ymchwil Bioffiseg ac Epigeneteg y grŵp. Mae Lewis wedi datblygu dulliau ymchwil biocemegol a bioffisegol ar gyfer ymchwilio i feinweoedd, celloedd ac ymchwil foleciwlaidd at ddiben dadansoddiad celloedd a moleciwlaidd mewn meddygaeth atgenhedlu ac aildyfu ddynol. Drwy archwilio heterogenedd cellol mewn micro-amgylcheddau meinweoedd, mae ymchwil Lewis yn ceisio nodi poblogaethau celloedd penodol ar gyfer targedu therapiwtig drwy systemau cyflwyno cyffuriau uwch. Drwy fabwysiadu modelau ffenoteip ar gyfer clefydau penodol mewn systemau sy’n defnyddio llinellau celloedd a systemau sy'n seiliedig ar gelloedd cleifion, mae ei ymchwil yn canolbwyntio ar archwilio mynegiant biofarcwyr, rhwydweithiau rheoleiddio genynnau a rhyngweithiadau matricsau celloedd mewn meinweoedd penodol. Lewis hefyd yw cyfarwyddwr rhaglen ar gyfer y radd MSc mewn Nanofeddygaeth a Chyfarwyddwr ACNM yr Ysgol Feddygaeth a chyfarwyddwr prosiect CALIN.

Meysydd Arbenigedd

1. Bioffiseg celloedd a moleciwlaidd
2. Microsgopeg a nodweddu cydraniad uchel
3. Bioleg Atgenhedlu ac Oncoleg Gynaecolegol
4. Genomeg ac epigenomeg
5. Bioleg glycoprotein
6. Biowybodeg, dysgu peirianyddol a'r rhyngwyneb â deallusrwydd artiffisial

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Lewis yw cyfarwyddwr rhaglen ar gyfer y radd MSc mewn Nanofeddygaeth â chyfrifoldeb am fyfyrwyr MSCi Geneteg a Biocemeg. Mae'n darlithio ar amrywiaeth eang o gyrsiau israddedig (Dadansoddi Genetig, Geneteg Feddygol, Peirianneg Feddygol a Metaboledd Carbohydradau.

Ymchwil Prif Wobrau Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

PARADISO, F., Quintela Vazquez, M., Lenna, S., Serpelloni, S., James, D., Caserta, S., Conlan, S., Francis, L., & Taraballi, F. (2022). Studying Activated Fibroblast Phenotypes and Fibrosis‐Linked Mechanosensing Using 3D Biomimetic Models. Macromolecular Bioscience, 22(4), 2100450
https://doi.org/10.1002/mabi.202100450, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59159
Quinn, G., Abdel Hameed, A., Banat, I., Berrar, D., Doerr, S., Dudley, E., Francis, L., Gazze, S., Hallin, I., Matthews, G., Swain, M., Whalley, W., & Van Keulen, G. (2022). Complementary protein extraction methods increase the identification of the Park Grass Experiment metaproteome. Applied Soil Ecology, 173, 104388
https://doi.org/10.1016/j.apsoil.2022.104388, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59232
Rees, P., Bauza‐Mayol, G., Quintela Vazquez, M., Brozovich, A., Hopson, M., Shaikh, S., Cabrera, F., Shi, A., Niclot, F., Paradiso, F., Thomson, E., Jovic, T., Rees, P., Tasciotti, E., Francis, L., Mcculloch, P., & Taraballi, F. (2021). Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo. Advanced Healthcare Materials, 11(1), 2101127
https://doi.org/10.1002/adhm.202101127, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58476
Barton, H., Berbel-Filho, W., Consuegra, S., Francis, L., Tizaoui, C., Conlan, R., Teixeira, S., Conlan, S., & Consuegra del Olmo, S. (2018). Ultrasensitive environmental assessment of xeno-estrogens in water samples using label-free graphene immunosensors. Analytical Biochemistry, 548, 102-108.
https://doi.org/10.1016/j.ab.2018.02.027, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38938
Kyle, S., Jessop, Z., Al-Sabah, A., Hawkins, K., Lewis, A., Maffeis, T., Charbonneau, C., Gazze, A., Francis, L., Iakovlev, M., Nelson, K., Eichhorn, S., & Whitaker, I. (2018). Characterization of pulp derived nanocellulose hydrogels using AVAP® technology. Carbohydrate Polymers, 198, 270-280.
https://doi.org/10.1016/j.carbpol.2018.06.091, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40840

Holl Ymchwil

Erthyglau Cylchgronau

Johnson, A., Quintela, M., James, D., Garcia, J., Edwards, K., Margarit, L., Das, N., Lutchman-Singh, K., Beynon, A., Rioja, I., Prinjha, R., Harker, N., Gonzalez, D., Conlan, S., & Francis, L. (2023). In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer. British Journal of Cancer, 129(1), 163-174.
https://doi.org/10.1038/s41416-023-02274-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63224
http://dx.doi.org/10.1038/s41416-023-02274-2
TOUBHANS, B., Alkafri, N., Quintela Vazquez, M., James, D., Bissardon, C., Gazze, S., Knodel, F., Proux, O., Gourlan, A., Rathert, P., Bohic, S., Gonzalez, D., Francis, L., Charlet, L., & Conlan, S. (2023). Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion. Redox Biology, 61, 102641
https://doi.org/10.1016/j.redox.2023.102641, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62755
Quintela Vazquez, M., James, D., Pociute, A., Powell, L., Edwards, K., Coombes, Z., Garcia, J., Garton, N., Das, N., Lutchman-Singh, K., Margarit, L., Beynon, A., Rioja, I., Prinjha, R., Harker, N., Gonzalez, D., Conlan, S., Francis, L., & Johnson, A. (2023). Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells. Clinical Epigenetics, 15(1)
https://doi.org/10.1186/s13148-023-01477-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64098
http://dx.doi.org/10.1186/s13148-023-01477-x
Powell, L., Adams, J., Quoraishi, S., Py, C., Oger, A., Gazze, S., Francis, L., Ruhland, C., Owens, D., Rye, P., Hill, K., Pritchard, M., & Thomas, D. (2023). Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms. Frontiers in Cellular and Infection Microbiology, 13
https://doi.org/10.3389/fcimb.2023.1122340, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62485
Powell, L., Cullen, J., Boyle, G., Ridder, T., Yap, P., Xue, W., Pierce, C., Pritchard, M., Menzies, G., Abdulkarim, M., Adams, J., Stokniene, J., Francis, L., Gumbleton, M., Johns, J., Hill, K., Jones, A., Parsons, P., Reddell, P., & Thomas, D. (2022). Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds. Science Translational Medicine, 14(662)
https://doi.org/10.1126/scitranslmed.abn3758, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61593
Quinn, G., Abdel Hameed, A., Banat, I., Berrar, D., Doerr, S., Dudley, E., Francis, L., Gazze, S., Hallin, I., Matthews, G., Swain, M., Whalley, W., & Van Keulen, G. (2022). Complementary protein extraction methods increase the identification of the Park Grass Experiment metaproteome. Applied Soil Ecology, 173, 104388
https://doi.org/10.1016/j.apsoil.2022.104388, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59232
PARADISO, F., Quintela Vazquez, M., Lenna, S., Serpelloni, S., James, D., Caserta, S., Conlan, S., Francis, L., & Taraballi, F. (2022). Studying Activated Fibroblast Phenotypes and Fibrosis‐Linked Mechanosensing Using 3D Biomimetic Models. Macromolecular Bioscience, 22(4), 2100450
https://doi.org/10.1002/mabi.202100450, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59159
Rees, P., Bauza‐Mayol, G., Quintela Vazquez, M., Brozovich, A., Hopson, M., Shaikh, S., Cabrera, F., Shi, A., Niclot, F., Paradiso, F., Thomson, E., Jovic, T., Rees, P., Tasciotti, E., Francis, L., Mcculloch, P., & Taraballi, F. (2021). Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo. Advanced Healthcare Materials, 11(1), 2101127
https://doi.org/10.1002/adhm.202101127, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58476
Paradiso, F., Serpelloni, S., Francis, L., & Taraballi, F. (2021). Mechanical Studies of the Third Dimension in Cancer: From 2D to 3D Model. International Journal of Molecular Sciences, 22(18), 10098
https://doi.org/10.3390/ijms221810098, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58317
Edwards, K., Yao, S., Pisano, S., Feltracco, V., Bruesehafer, K., Samanta, S., Oommen, O., Gazze, S., Paravati, R., Maddison, H., Li, C., Gonzalez, D., Conlan, S., & Francis, L. (2021). Hyaluronic Acid-Functionalized Nanomicelles Enhance SAHA Efficacy in 3D Endometrial Cancer Models. Cancers, 13(16), 4032
https://doi.org/10.3390/cancers13164032, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57595
Bauer, T., Collmar, K., Kaltofen, T., Loeffler, A., Decker, L., Mueller, J., Pinter, S., Eisler, S., Mahner, S., Fraungruber, P., Kommoss, S., Staebler, A., Francis, L., Conlan, S., Zuber, J., Jeschke, U., Trillsch, F., & Rathert, P. (2021). Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development. Cancers, 13(15), 3801
https://doi.org/10.3390/cancers13153801, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57490
Ahmed, Z., Powell, L., Matin, N., Mearns-Spragg, A., Thornton, C., Khan, I., & Francis, L. (2021). Jellyfish Collagen: A Biocompatible Collagen Source for 3D Scaffold Fabrication and Enhanced Chondrogenicity. Marine Drugs, 19(8), 405
https://doi.org/10.3390/md19080405, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61611
James, D., Filby, A., Brown, R., Summers, H., Francis, L., & Rees, P. (2021). Data Driven Cell Cycle Model to Quantify the Efficacy of Cancer Therapeutics Targeting Specific Cell-Cycle Phases From Flow Cytometry Results. Frontiers in Bioinformatics, 1
https://doi.org/10.3389/fbinf.2021.662210, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56655
Gazze, S., Thomas, S., Garcia-Parra, J., James, D., Rees, P., Marsh-Durban, V., Corteling, R., Gonzalez, D., Conlan, S., & Francis, L. (2021). High content, quantitative AFM analysis of the scalable biomechanical properties of extracellular vesicles. Nanoscale, 13(12), 6129-6141.
https://doi.org/10.1039/d0nr09235e, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56477
Howard, D., James, D., Murphy, K., Garcia Parra, J., Pan Castillo, B., Rex, S., Moul, A., Jones, E., Bilbao Asensio, M., Michue-Seijas, S., Lutchman-Singh, K., Margarit, L., Francis, L., Rees, P., Gonzalez, D., & Conlan, S. (2021). Dinaciclib, a Bimodal Agent Effective against Endometrial Cancer. Cancers, 13(5), 1135
https://doi.org/10.3390/cancers13051135, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56783
Francis, L., Yao, S., Powell, L., Griffiths, S., Berquand, A., Piasecki, T., Howe, W., Gazze, A., Farach-Carson, M., Constantinou, P., Carson, D., Margarit, L., Gonzalez, D., & Conlan, S. (2021). Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00793-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56223
Toubhans, B., Gourlan, A., Telouk, P., Lutchman-Singh, K., Francis, L., Conlan, S., Margarit, L., Gonzalez, D., & Charlet, L. (2020). Cu isotope ratios are meaningful in ovarian cancer diagnosis. Journal of Trace Elements in Medicine and Biology, 62, 126611
https://doi.org/10.1016/j.jtemb.2020.126611, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54643
Bauza, G., Pasto, A., Mcculloch, P., Lintner, D., Brozovich, A., Niclot, F., Khan, I., Francis, L., Tasciotti, E., & Taraballi, F. (2020). Improving the immunosuppressive potential of articular chondroprogenitors in a three-dimensional culture setting. Scientific Reports, 10(1)
https://doi.org/10.1038/s41598-020-73188-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55672
Pisano, S., Wang, X., Garcia Parra, J., Gazze, S., Edwards, K., Feltracco, V., Hu, Y., He, L., Gonzalez, D., Francis, L., Conlan, S., & Li, C. (2020). Nanomicelles potentiate histone deacetylase inhibitor efficacy in vitro. Cancer Nanotechnology, 11(1)
https://doi.org/10.1186/s12645-020-00070-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55789
Paravati, R., De Mello, N., Onyido, E., Francis, L., Bruesehafer, K., Younas, K., Spencer-Harty, S., Conlan, S., Gonzalez, D., & Margarit, L. (2020). Differential regulation of osteopontin and CD44 correlates with infertility status in PCOS patients. Journal of Molecular Medicine, 98
https://doi.org/10.1007/s00109-020-01985-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55414
Toubhans, B., Gazze, S., Bissardon, C., Bohic, S., Gourlan, A., Gonzalez, D., Charlet, L., Conlan, S., & Francis, L. (2020). Selenium nanoparticles trigger alterations in ovarian cancer cell biomechanics. Nanomedicine: Nanotechnology, Biology and Medicine, 29, 102258
https://doi.org/10.1016/j.nano.2020.102258, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54635
Pisano, S., Pierini, I., Gu, J., Gazze, A., Francis, L., Gonzalez, D., Conlan, S., & Corradetti, B. (2020). Immune (Cell) Derived Exosome Mimetics (IDEM) as a Treatment for Ovarian Cancer. Frontiers in Cell and Developmental Biology, 8
https://doi.org/10.3389/fcell.2020.553576, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55036
Abreu, C., Thomas, V., Knaggs, P., Bunkheila, A., Cruz, A., Rodrigues Teixeira, S., Alpuim, P., Francis, L., Gebril, A., Ibrahim, A., Margarit, L., Gonzalez, D., Freitas, P., Conlan, S., & Pinto, I. (2020). Non-invasive molecular assessment of human embryo development and implantation potential. Biosensors and Bioelectronics, 157, 112144
https://doi.org/10.1016/j.bios.2020.112144, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53819
Friguglietti, J., Das, S., Le, P., Fraga, D., Quintela Vazquez, M., Gazze, S., McPhail, D., Gu, J., Sabek, O., Gaber, A., Francis, L., Zagozdzon-Wosik, W., & Merchant, F. (2020). Novel Silicon Titanium Diboride Micropatterned Substrates for Cellular Patterning. Biomaterials, 244, 119927
https://doi.org/10.1016/j.biomaterials.2020.119927, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54548
Morgan, B., Bauza-Mayol, G., Gardner, O., ZHANG, Y., Levato, R., Archer, C., Weeren, R., Malda, J., Conlan, S., Francis, L., & Khan, I. (2020). Bone Morphogenetic Protein-9 Is a Potent Chondrogenic and Morphogenic Factor for Articular Cartilage Chondroprogenitors. Stem Cells and Development, 29(14)
https://doi.org/10.1089/scd.2019.0209, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54205
Bissardon, C., Proux, O., Bureau, S., Suess, E., Winkel, L., Conlan, S., Francis, L., Khan, I., Charlet, L., Hazemann, J., & Bohic, S. (2019). Sub-ppm level high energy resolution fluorescence detected X-ray absorption spectroscopy of selenium in articular cartilage. The Analyst, 144(11), 3488-3493.
https://doi.org/10.1039/c9an00207c, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49778
http://dx.doi.org/10.1039/c9an00207c
Minardi, S., Taraballi, F., Cabrera, F., Eps, J., Wang, X., Gazze, S., Fernandez-Mourev, J., Tampieri, A., Francis, L., Weiner, B., Tasciotti, E., & Francis, L. (2019). Biomimetic hydroxyapatite/collagen composite drives bone niche recapitulation in a rabbit orthotopic model. Materials Today Bio, 2, 100005
https://doi.org/10.1016/j.mtbio.2019.100005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50993
Paradiso, F., Fitzgerald, J., Yao, S., Barry, F., Taraballi, F., Gonzalez, D., Conlan, S., & Francis, L. (2019). Marine Collagen Substrates for 2D and 3D Ovarian Cancer Cell Systems. Frontiers in Bioengineering and Biotechnology, 7
https://doi.org/10.3389/fbioe.2019.00343, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52699
Teixeira, S., Abreu, C., Parkes, L., Davies, J., Yao, S., Sawhney, M., Margarit, L., Gonzalez, D., Pinto, I., Francis, L., Conlan, R., Conlan, S., Gonzalez, D., & Francis, L. (2019). Direct monitoring of breast and endometrial cancer cell epigenetic response to DNA methyltransferase and histone deacetylase inhibitors. Biosensors and Bioelectronics, 141, 111386
https://doi.org/10.1016/j.bios.2019.111386, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50808
Younas, K., Quintela, M., Thomas, S., Garcia-Parra, J., Blake, L., Whiteland, H., Bunkheila, A., Francis, L., Margarit, L., Gonzalez, D., Conlan, S., & Francis, L. (2019). Delayed endometrial decidualisation in polycystic ovary syndrome; the role of AR-MAGEA11. Journal of Molecular Medicine, 97(9), 1315-1327.
https://doi.org/10.1007/s00109-019-01809-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50966
Pisano, S., Giustiniani, M., Francis, L., Gonzalez, D., Margarit, L., Sheldon, M., Paolino, D., Fresta, M., Sawhney, A., & Healey, G. (2019). Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract. Biomedical Microdevices, 21(2)
https://doi.org/10.1007/s10544-019-0385-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49813
Quintela, M., Sieglaff, D., Gazze, A., Zhang, A., Gonzalez, D., Francis, L., Webb, P., Conlan, R., & Conlan, S. (2019). HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells. Nanomedicine: Nanotechnology, Biology and Medicine, 17, 254-265.
https://doi.org/10.1016/j.nano.2019.01.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48863
Gazze, S., Hallin, I., Quinn, G., Dudley, E., Matthews, G., Rees, P., Van Keulen, G., Doerr, S., & Francis, L. (2018). Organic matter identifies the nano-mechanical properties of native soil aggregates. Nanoscale, 10(2), 520-525.
https://doi.org/10.1039/C7NR07070E, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37598
Pan-Castillo, B., Gazze, S., Thomas, S., Lucas, C., Margarit, L., Gonzalez, D., Francis, L., Conlan, R., & Conlan, S. (2018). Morphophysical dynamics of human endometrial cells during decidualization. Nanomedicine: Nanotechnology, Biology and Medicine, 14(7), 2235-2245.
https://doi.org/10.1016/J.NANO.2018.07.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43701
Terra, L., Dyson, P., Hitchings, M., Thomas, L., Abdelhameed, A., Banat, I., Gazze, S., Vujaklija, D., Facey, P., Francis, L., Quinn, G., & Dyson, P. (2018). A Novel Alkaliphilic Streptomyces Inhibits ESKAPE Pathogens. Frontiers in Microbiology, 9
https://doi.org/10.3389/fmicb.2018.02458, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa44961
http://dx.doi.org/10.3389/fmicb.2018.02458
Kyle, S., Jessop, Z., Al-Sabah, A., Hawkins, K., Lewis, A., Maffeis, T., Charbonneau, C., Gazze, A., Francis, L., Iakovlev, M., Nelson, K., Eichhorn, S., & Whitaker, I. (2018). Characterization of pulp derived nanocellulose hydrogels using AVAP® technology. Carbohydrate Polymers, 198, 270-280.
https://doi.org/10.1016/j.carbpol.2018.06.091, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40840
Matthews, G., Levy, C., Laudone, G., Jones, K., Ridgway, C., Hallin, I., Gazze, S., Francis, L., Whalley, W., Schoelkopf, J., & Gane, P. (2018). Improved Interpretation of Mercury Intrusion and Soil Water Retention Percolation Characteristics by Inverse Modelling and Void Cluster Analysis. Transport in Porous Media
https://doi.org/10.1007/s11242-018-1087-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40458
Barton, H., Berbel-Filho, W., Consuegra, S., Francis, L., Tizaoui, C., Conlan, R., Teixeira, S., Conlan, S., & Consuegra del Olmo, S. (2018). Ultrasensitive environmental assessment of xeno-estrogens in water samples using label-free graphene immunosensors. Analytical Biochemistry, 548, 102-108.
https://doi.org/10.1016/j.ab.2018.02.027, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38938
Stojković, M., Gonzalez-Garcia, J., Šupljika, F., Galiana-Rosello, C., Guijarro, L., Gazze, S., Francis, L., Piantanida, I., & Garcia-Espana, E. (2018). Specific and highly efficient condensation of GC and IC DNA by polyaza pyridinophane derivatives. International Journal of Biological Macromolecules
https://doi.org/10.1016/j.ijbiomac.2017.11.156, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37670
Zhang, Y., Morgan, B., Smith, R., Fellows, C., Thornton, C., Snow, M., Francis, L., & Khan, I. (2017). Platelet-rich plasma induces post-natal maturation of immature articular cartilage and correlates with LOXL1 activation. Scientific Reports, 7(1)
https://doi.org/10.1038/s41598-017-02297-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33950
Conlan, S. & Francis, L. (2016). Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB. Oncotarget
https://doi.org/10.18632/oncotarget.7652, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26528
Hornsby, A., Redhead, Y., Rees, D., Ratcliff, M., Reichenbach, A., Wells, T., Francis, L., Amstalden, K., Andrews, Z., & Davies, J. (2016). Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner. Psychoneuroendocrinology, 63, 198-207.
https://doi.org/10.1016/j.psyneuen.2015.09.023, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26484
Corradetti, B., Taraballi, F., Minardi, S., Van Eps, J., Cabrera, F., Francis, L., Gazze, S., Ferrari, M., Weiner, B., Tasciotti, E., & Francis, L. (2016). Chondroitin Sulfate Immobilized on a Biomimetic Scaffold Modulates Inflammation While Driving Chondrogenesis. Stem Cells Translational Medicine, 5(5), 670-682.
https://doi.org/10.5966/sctm.2015-0233, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27868
Teixeira, S., Lloyd, C., Yao, S., Gazze, ., Conlan, S., Francis, L., Azzopardi, E., & Whitaker, I. (2016). Polyaniline-graphene based α-amylase biosensor with a linear dynamic range in excess of 6 orders of magnitude. Biosensors and Bioelectronics, 85, 395-402.
https://doi.org/10.1016/j.bios.2016.05.034, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27755
http://dx.doi.org/10.1016/j.bios.2016.05.034
Howard, D., Garcia-Parra, J., Healey, G., Amakiri, C., Margarit, L., Francis, L., Gonzalez, D., Conlan, R., Conlan, S., & Garcia Parra, J. (2016). Antibody–drug conjugates and other nanomedicines: the frontier of gynaecological cancer treatment. Interface Focus, 6(6), 20160054
https://doi.org/10.1098/rsfs.2016.0054, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33095
Gonzalez, D., Hamidi, N., Sol, R., Benschop, J., Nancy, T., Li, C., Francis, L., Tzouros, M., Krijgsveld, J., Holstege, F., Conlan, S., & Del Sol Abascal, R. (2014). Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Proceedings of the National Academy of Sciences, 111(7), 2500-2505.
https://doi.org/10.1073/pnas.1307525111, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17235
Warren, C., Grindel, B., Francis, L., Carson, D., & Farach-Carson, M. (2014). Transcriptional Activation by NFκB Increases Perlecan/HSPG2 Expression in the Desmoplastic Prostate Tumor Microenvironment. Journal of Cellular Biochemistry, 115(7), 1322-1333.
https://doi.org/10.1002/jcb.24788, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27871
Dyson, P., Del Sol Abascal, R., Francis, L., & Facey, P. (2013). A novel bifunctional histone protein in Streptomyces: a candidate for structural coupling between DNA conformation and transcription during development and stress?. Nucleic Acids Research
https://doi.org/10.1093/nar/gkt180, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14456
Khan, I., Francis, L., Theobald, P., Perni, S., Young, R., Prokopovich, P., Conlan, R., Archer, C., & Conlan, S. (2013). In vitro growth factor-induced bio engineering of mature articular cartilage. Biomaterials, 34(5), 1478-1487.
https://doi.org/10.1016/j.biomaterials.2012.09.076, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13945
Khan, I., Gonzalez, L., Francis, L., Conlan, R., Gilbert, S., Singhrao, S., Burdon, D., Hollander, A., Duance, V., Archer, C., Conlan, S., & Francis, L. (2011). Interleukin-1β enhances cartilage-to-cartilage integration. European Cells and Materials, 22, 190-201.
https://doi.org/10.22203/eCM.v022a15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10738
FRANCIS, L., GONZALEZ, D., RYDER, T., BAER, K., REES, M., WHITE, J., CONLAN, R., WRIGHT, C., Wright, C., Conlan, S., Gonzalez, D., Rees, M., & Francis, L. (2010). Optimized sample preparation for high-resolution AFM characterization of fixed human cells. Journal of Microscopy, 240(2), 111-121.
https://doi.org/10.1111/j.1365-2818.2010.03392.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10686
Francis, L., Lewis, P., Wright, C., Conlan, R., Wright, C., Lewis, P., Conlan, S., & Francis, L. (2010). Atomic force microscopy comes of age. Biology of the Cell, 102(2), 133-143.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9824
https://onlinelibrary.wiley.com/doi/full/10.1042/BC20090127
Francis, L., Lewis, P., Gonzalez, D., Ryder, T., Webb, G., Joels, L., White, J., Wright, C., Conlan, R., Wright, C., & Conlan, S. (2009). Progesterone induces nano-scale molecular modifications on endometrial epithelial cell surfaces. Biology of the Cell, 101(8), 481-493.
https://doi.org/10.1042/BC20080189, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9823
Doak, S., Rogers, D., Jones, B., Wright, C., Doak, S., & Francis, L. (2008). High resolution imaging using a novel atomic force microscope and confocal laser scanning microscope hybrid instrument: essential sample preparation aspects. Histochemistry & cell biology, 130(5), 909-916.
https://doi.org/10.1007/s00418-008-0489-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10128

Goruchwyliaeth

Tumour microenvironment informed Nanomedicines for High Grade Serum Ovarian Cancer (cyfredol)

PhD

Goruchwyliwr arall: Prof Steve Conlan
AI based approaches multi-dimensional functional genomics in cancer patients«br /»«br /» (cyfredol)

PhD

Goruchwyliwr arall: Prof Steve Conlan
AIMLAC for functional genomics (cyfredol)

PhD

Goruchwyliwr arall: Prof Steve Conlan
Biodegradable Nanovectors for the Treatment of Advanced Ovarian Cancer. (dyfarnwyd 2024)

PhD

Goruchwyliwr arall: Prof Juan Mareque-Rivas
Investigating the effect of a histone methyltransferase inhibitor and a non- steroidal anti inflammatory drug in ovarian cancer (cyfredol)

MSc

Goruchwyliwr arall: Prof Steve Conlan
In Silico Analysis of Female Reproductive Cancer Multi-Omics Datasets to Aid Patient Diagnosis, and Guide Personalised Care (cyfredol)

MSc

Goruchwyliwr arall: Dr Matthew Hitchings
High-Grade Serous Ovarian Cancer Drug Development: Investigating the mechanism of action of PLK1 and BRD4 inhibitors in HGSOC (cyfredol)

MSc

Goruchwyliwr arall: Prof Deya Gonzalez
An investigation into BMP9-induced postnatal maturation of articular cartilage«br /» (cyfredol)

MSc

Goruchwyliwr arall: Dr Ilyas Khan

Modiwlau a Addysgir

PM-153 Epigenetics, Gene Regulation and Disease

Epigenetics and its role in gene expression.
PM-273 Advances in Toxicology: Pick Your Poison

We are surrounded by substances that may do our bodies harm i.e. poisons. The harm these poisons causes depends on our exposure - the dose. The science of toxicology, a discipline that crosscuts biology, chemistry, pharmacology, and medicine, is based on the principle that the dose makes the poison. This module is compulsory for BSc Medical Pharmacology students and acts as a follow on from PM-147 Introduction to Toxicology: The Dose Makes the Poison. This module will provide students with the opportunity to expand their toxicology knowledge and apply it to three distinct fields within toxicology; analytical toxicology, forensic toxicology and clinical toxicology. Students will learn about the experimental procedures and techniques we employ for the isolation and detection of compounds as well as their effects on biological systems. Students will then learn about the role of employing these methods in the field of forensic toxicology and the role of toxicology within the legal system. Within the module, students will also learn about the role of clinical toxicology and patient presentation following poisoning events and the techniques we have for detection and treatment of toxicology within the clinical setting.
PM-300 Medical Genetics

The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-355 Drug Development and Regulation

This is an applications and project management driven module designed to provide the student with an introduction to drug development and the key role of separation science and mass spectrometry within the pharmaceutical industry. This module will introduce Good Laboratory, Clinical and Manufacturing Practice (GLP, GCP, GMP), assay validation (as requested by the Food and Drug Administration (FDA)), the need and implementation of SOPs with particular focus on the pharmaceutical and medical industries, and how these correlate with stringent quality control procedures and health and safety existing due to current legislation. The ethical principles of research, including clinical trials and animal research (design, implementation and reporting) will be outlined, as well as the essential nature of the principles of reduction, refinement and replacement for the use of animals in research. Students will also be able to characterize and map the path of a drug from administration, to metabolism and elimination, for critical evaluation of drug design.
PM-358 Tissue Engineering and Regenerative Medicine

This module will provide students with a firm understanding of the principles of Regenerative Medicine that extend from cellular to tissue and organ repair and regeneration. This module will focus on the practical aspects of revolutionary technologies, generated through research, that have the potential to significantly improve how we treat injury, illness and disease.
PMLM01 Laboratory Measurement Techniques for Medicinal Chemistry and Nanomedicine

This module will enable students to understand the basic and advanced concepts of measurement techniques used in medicinal chemistry and nanomedicine, how they may be applied with relevant methods of detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to target molecule characteristics and method application.
PMLM22 Laboratory Measurement Techniques for Medical Sciences

This module will enable students to understand the basic and advanced concepts of laboratory and measurement techniques used in medical sciences, how they may be applied with relevant methods of detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to target molecule characteristics and method application.
PMNM11 Nanomedicines, pharmaceuticals and advanced therapeutics

This module will explore the history and development of molecular medicines and pharmaceuticals, providing the basis for an advanced understanding of next generation therapeutic approaches. Using landmark technology and chemical development phases informed by separation science and mass spectrometry, the module uses an application driven approach to provide the student with an extensive knowledgebase of drug development, the pharmaceutical industry and nanotherapeutics. Students will be able to characterize and map the path of a drug from administration, to metabolism and elimination, and critically evaluate drug design and delivery approaches. Traditional small chemical entities used in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. Common target oncology and non-oncology disorders will provide the context; with students encouraged to explore targeted nanoparticle fabrication, drug encapsulation and release profiling, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems. Future molecular medicines such as antibody drug conjugates and kinase inhibitors will be taught by guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.
PMNMD0 Postgraduate Taught Masters Dissertation

In this module the student will be able to gain extensive specialist expertise in a chosen topic which could be targeted to their future career in the field of nanomedicine. Students will be supervised by University academics and/or members of their research and innovation teams. A variety of project types are available that include: 1. Laboratory based experimental research and data analysis (dependant on laboratory access and capacity). 2. Analysis of experimental data originating from the project supervisor¿s laboratory* 3. Meta-analysis of publicly available experimental data* 4. Systematic analysis of publicly available reported data* *potentially linking with Swansea¿s data health science or clinical trials unit. Working with a dedicated academic supervisor students will develop a clear research question, experimental plan and derive, analyse and present research data. The research topic choice will be made in conjunction with the supervisor, based upon novelty, feasibility and practical considerations on a 'first come first served' basis. The final approval of the topic rests with the project supervisor. The module lead and academic tutor will provide additional support available throughout the module period. A series of information sessions and engagement events such as the 3 Minute Thesis and employability for an innovative and integral part of this module. A small number of placement opportunities may arise with external academic and industry partners. These opportunities will be highlighted early in the first semester, with placements, in the event of high demand, based on student academic performance.
PMZM15 Nanomedicines and Therapeutics

The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

Hanes Gyrfa

Athro Cysylltiol NanoFioleg, Prifysgol Abertawe

2018 - Presennol
Uwch-ddarlithydd, NanoFioleg, Prifysgol Abertawe

2014 - 2018
Darlithydd, NanoFioleg, Prifysgol Abertawe

2011 - 2014
Athro Cysylltiol Gwadd, Yr Adran Nanofeddygaeth, Sefydliad Ymchwil Ysbyty Methodistaidd Houston, Houston, Tecsas

2013 - 2013
Athro Cyfnod Penodol, Biocemeg a Bioleg Celloedd, Prifysgol RICE, Houston, Tecsas

2013 - 2013
Cynorthwy-ydd Ymchwil Ôl-ddoethurol, Grŵp Bioleg Atgenhedlu, Sefydliad y Gwyddorau Bywyd, Coleg Meddygaeth, Prifysgol Abertawe

2010 - 2011
Cynorthwy-ydd Ymchwil Ôl-ddoethurol, Actif Motif Europe, Ymchwil a Datblygu, Rixensart, Gwlad Belg

2009 - 2010

Cyflwyniadau, Darlithoedd a Chynadleddau a wahoddwyd

Arddangosfa MSc mewn Nanofeddygaeth

2020

Collaborate 2020, Prifysgol Abertawe
Large multidisciplinary data sets inform advanced therapeutics in gynaecological oncology

2019

Cynhadledd ELRIG, Alderley Park, Macclesfield, y DU
High throughput, large data sets to interpret gynaecological cancer heterogeneity

2019

Cyfarfod defnyddwyr In Cell Analyzer GE, Mannheim, yr Almaen
Large data, machine learning and AI in advanced therpaeutics

2019

Gweithdy CoreLife Analytics, Utrecht, yr Iseldiroedd
Epigenetic advances inform novel drug therapies in Endometrial cancer

2018

Rhwydwaith Ymchwil Cenedlaethol mewn Therapiwteg Uwch, Prifysgol Abertawe
Next generation, bespoke collagen matrices for advanced drug development and clinical applications in regenerative medicine

2018

Ymchwil Planhigion a Bwyd Seland Newydd, Nelson, Seland Newydd
Multiplex based immunosensing; flexible monitoring of the disease landscape

2017

Suzhou, Tsieina

Yr Athro Lewis Francis

Cyfeiriad ebost

Welsh language proficiency

Dolenni Ymchwil

Trosolwg

Meysydd Arbenigedd

Uchafbwyntiau Gyrfa

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Holl Ymchwil

Erthyglau Cylchgronau

Goruchwyliaeth

Tumour microenvironment informed Nanomedicines for High Grade Serum Ovarian Cancer (cyfredol)

AI based approaches multi-dimensional functional genomics in cancer patients«br /»«br /» (cyfredol)

AIMLAC for functional genomics (cyfredol)

Biodegradable Nanovectors for the Treatment of Advanced Ovarian Cancer. (dyfarnwyd 2024)

Investigating the effect of a histone methyltransferase inhibitor and a non- steroidal anti inflammatory drug in ovarian cancer (cyfredol)

In Silico Analysis of Female Reproductive Cancer Multi-Omics Datasets to Aid Patient Diagnosis, and Guide Personalised Care (cyfredol)

High-Grade Serous Ovarian Cancer Drug Development: Investigating the mechanism of action of PLK1 and BRD4 inhibitors in HGSOC (cyfredol)

An investigation into BMP9-induced postnatal maturation of articular cartilage«br /» (cyfredol)

Modiwlau a Addysgir

PM-153 Epigenetics, Gene Regulation and Disease

PM-273 Advances in Toxicology: Pick Your Poison

PM-300 Medical Genetics

PM-344 Capstone Project

PM-355 Drug Development and Regulation

PM-358 Tissue Engineering and Regenerative Medicine

PMLM01 Laboratory Measurement Techniques for Medicinal Chemistry and Nanomedicine

PMLM22 Laboratory Measurement Techniques for Medical Sciences

PMNM11 Nanomedicines, pharmaceuticals and advanced therapeutics

PMNMD0 Postgraduate Taught Masters Dissertation

PMZM15 Nanomedicines and Therapeutics

Hanes Gyrfa

Athro Cysylltiol NanoFioleg, Prifysgol Abertawe

Uwch-ddarlithydd, NanoFioleg, Prifysgol Abertawe

Darlithydd, NanoFioleg, Prifysgol Abertawe

Athro Cysylltiol Gwadd, Yr Adran Nanofeddygaeth, Sefydliad Ymchwil Ysbyty Methodistaidd Houston, Houston, Tecsas

Athro Cyfnod Penodol, Biocemeg a Bioleg Celloedd, Prifysgol RICE, Houston, Tecsas

Cynorthwy-ydd Ymchwil Ôl-ddoethurol, Grŵp Bioleg Atgenhedlu, Sefydliad y Gwyddorau Bywyd, Coleg Meddygaeth, Prifysgol Abertawe

Cynorthwy-ydd Ymchwil Ôl-ddoethurol, Actif Motif Europe, Ymchwil a Datblygu, Rixensart, Gwlad Belg

Cyflwyniadau, Darlithoedd a Chynadleddau a wahoddwyd

Arddangosfa MSc mewn Nanofeddygaeth

Large multidisciplinary data sets inform advanced therapeutics in gynaecological oncology

High throughput, large data sets to interpret gynaecological cancer heterogeneity

Large data, machine learning and AI in advanced therpaeutics

Epigenetic advances inform novel drug therapies in Endometrial cancer

Next generation, bespoke collagen matrices for advanced drug development and clinical applications in regenerative medicine

Multiplex based immunosensing; flexible monitoring of the disease landscape