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PM-273
Advances in Toxicology: Pick Your Poison
We are surrounded by substances that may do our bodies harm; these may be compounds used both clinically and recreationally. All compounds have the potential to do harm, depending on the dose.
This module will examine how we monitor drug exposure and the importance of pharmaco-/toxico-kinetics (i.e. a compounds absorption, distribution, metabolism and excretion). The module will also examine how patients can become tolerant and/or addicted to compounds, and the underlying physiological changes which drive these processes.
This module will provide students with the opportunity to expand their toxicology knowledge and apply it to analytical, forensic toxicology and clinical toxicology. Students will learn about the experimental procedures and techniques we employ for the isolation and detection of compounds as well as their effects on biological systems. Students will then learn about the role of employing these methods in the field of forensic toxicology, the role of toxicology within the legal system and the role of clinical toxicology and patient presentation following poisoning events and the techniques we have for detection and treatment of toxicology within the clinical setting.
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PM-273C
Clinical Pharmacology & Toxicology (Awaiting Translation)
We are surrounded by substances that may do our bodies harm; these may be compounds used both clinically and recreationally. All compounds have the potential to do harm, depending on the dose.
This module will examine how we monitor drug exposure and the importance of pharmaco-/toxico-kinetics (i.e. a compounds absorption, distribution, metabolism and excretion). The module will also examine how patients can become tolerant and/or addicted to compounds, and the underlying physiological changes which drive these processes.
This module will provide students with the opportunity to expand their toxicology knowledge and apply it to analytical, forensic toxicology and clinical toxicology. Students will learn about the experimental procedures and techniques we employ for the isolation and detection of compounds as well as their effects on biological systems. Students will then learn about the role of employing these methods in the field of forensic toxicology, the role of toxicology within the legal system and the role of clinical toxicology and patient presentation following poisoning events and the techniques we have for detection and treatment of toxicology within the clinical setting.
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PM-278
Advanced Metabolism
This module provides an in-depth exploration of the metabolic processes governing the major macronutrients carbohydrates and fatty acids. It focuses on the central biochemical pathways through which energy derived from food is converted into ATP, the cell¿s primary energy currency. Key pathways such as glycolysis, the citric acid cycle, and oxidative phosphorylation are examined in detail.
The module will also provide an understanding of tissue and organ specificity in metabolism. The module also covers the uptake and metabolism of glucose and other common carbohydrates, emphasizing their integration into central metabolic networks. Alternative and linked carbohydrate metabolic pathways, including the pentose phosphate pathway, the Entner-Doudoroff pathway, and glycogen metabolism are discussed, along with their relevance to health and disease.
In addition, the module covers the ß-oxidation and biosynthesis of fatty acids, with a focus on its clinical implications. Finally, the structural and functional roles of sugars in glycobiology are explored, particularly in the context of health and disease.
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PM-288
Human & Medical Genetics
This module introduces fundamental concepts in human genetics, with a focus on the application of genetic principles to medicine. It covers the role of genetics in human health and disease. The course also explores methods for assessing genotypes in human populations, and examples of how this information can be used for assessment and treatment.
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PM-288C
Geneteg Dynol a Meddygol
Mae¿r modiwl hwn wedi'i gynllunio i gyflwyno cysyniadau sylfaenol wrth astudio geneteg ddynol gan gyfeirio'n benodol at gymhwyso'r egwyddorion geneteg i feddygaeth. Mae'n ymdrin â rôl geneteg mewn iechyd dynol a chlefydau. Mae¿r cwrs hefyd yn ymchwilio i ddulliau ar gyfer asesu genoteipiau mewn poblogaethau dynol, ac esiamplau o sut gall y wybodaeth hon gael ei defnyddio ar gyfer asesu a thrin.
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PM-300
Medical Genetics
The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.
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PM-344
Capstone Project
The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
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PM-355
Drug Development and Regulation
This module offers a comprehensive introduction to clinical trials and drug development, focusing on both research methodology and applications in the pharmaceutical industry.
It covers the design, conduct, analysis, and critical appraisal of clinical trials using real, published studies. Students will explore early to late-phase trials, simple and complex designs, and how treatment effectiveness can vary across different populations.
In parallel, the module delves into the role of separation science and mass spectrometry in drug development, introducing key regulatory practices. Additionally, students will learn to track a drugs path through the body and critically evaluate its design.
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PM-358
Tissue Engineering and Regenerative Medicine
This module will provide students with a firm understanding of the principles of Regenerative Medicine that extend from cellular to tissue and organ repair and regeneration.
This module will focus on the practical aspects of revolutionary technologies, generated through research, that have the potential to significantly improve how we treat injury, illness and disease.
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PMLM22
Laboratory Measurement Techniques for Medical Sciences
This module will enable students to understand the basic and advanced concepts of laboratory and measurement techniques used in medical sciences, how they may be applied with relevant methods of detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to target molecule characteristics and method application.
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PMNM11
Nanomedicines, pharmaceuticals and advanced therapeutics
This module will explore the history and development of molecular medicines and pharmaceuticals, providing the basis for an advanced understanding of next generation therapeutic approaches. Using landmark technology and chemical development phases informed by separation science and mass spectrometry, the module uses an application driven approach to provide the student with an extensive knowledgebase of drug development, the pharmaceutical industry and nanotherapeutics. Students will be able to characterize and map the path of a drug from administration, to metabolism and elimination, and critically evaluate drug design and delivery approaches. Traditional small chemical entities used in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. Common target oncology and non-oncology disorders will provide the context; with students encouraged to explore targeted nanoparticle fabrication, drug encapsulation and release profiling, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems. Future molecular medicines such as antibody drug conjugates and kinase inhibitors will be taught by guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.
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PMNMD0
Postgraduate Taught Masters Dissertation
In this module the student will be able to gain extensive specialist expertise in a chosen topic which could be targeted to their future career in the field of nanomedicine.
Students will be supervised by University academics and/or members of their research and innovation teams. A variety of project types are available that include:
1. Laboratory based experimental research and data analysis (dependant on laboratory access and capacity).
2. Analysis of experimental data originating from the project supervisor¿s laboratory*
3. Meta-analysis of publicly available experimental data*
4. Systematic analysis of publicly available reported data*
*potentially linking with Swansea¿s data health science or clinical trials unit.
Working with a dedicated academic supervisor students will develop a clear research question, experimental plan and derive, analyse and present research data.
The research topic choice will be made in conjunction with the supervisor, based upon novelty, feasibility and practical considerations on a 'first come first served' basis. The final approval of the topic rests with the project supervisor.
The module lead and academic tutor will provide additional support available throughout the module period.
A series of information sessions and engagement events such as the 3 Minute Thesis and employability for an innovative and integral part of this module.
A small number of placement opportunities may arise with external academic and industry partners. These opportunities will be highlighted early in the first semester, with placements, in the event of high demand, based on student academic performance.
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PMP401
Emerging Therapies and Complex Patients
In this module, students will focus on the broader definition of health, advanced therapies and the complexities of patient care.
The module will continue to build on the foundational-science-based knowledge and clinical skills developed in Years 1 to 3, and will delve deeper into population health, future medicines, and complex clinical scenarios.
This module encourages further development of transferable skills and application of prior knowledge into progressively complex scenarios. This learning will be supported by robust contextualisation of science into pharmacy practice and working with other healthcare professionals (interprofessional education) through multi-disciplinary teaching & learning.
