Dr Rod Middleton

Uchafbwyntiau Ymchwil

1. Coe, S., Tektonidis, T., Coverdale, C., Penny, S., Collett, J., Chu, B., Izadi, H., Middleton, R., & Dawes, H. (2021). A cross sectional assessment of nutrient intake and the association of the inflammatory properties of nutrients and foods with symptom severity in a large cohort from the UK Multiple Sclerosis Registry. Nutrition Research, 85, 31-39.

   https://doi.org/10.1016/j.nutres.2020.11.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61488
2. Vickaryous, N., Jitlal, M., Jacobs, B., Middleton, R., Chandran, S., MacDougall, N., Giovannoni, G., & Dobson, R. (2020). Remote testing of vitamin D levels across the UK MS population—A case control study. PLOS ONE, 15(12), e0241459

   https://doi.org/10.1371/journal.pone.0241459, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61487
3. Ellenberger, D., Parciak, T., Brola, W., Hillert, J., Middleton, R., Stahmann, A., Thalheim, C., & Flachenecker, P. (2022). Comparison of employment among people with Multiple Sclerosis across Europe. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 8(2), 205521732210906

   https://doi.org/10.1177/20552173221090653, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61486
4. Kamudoni, P., Amtmann, D., Johns, J., Cook, K., Salem, R., Salek, S., Raab, J., Middleton, R., Repovic, P., Alschuler, K., Geldern, G., Wundes, A., Barrett, A., Olayinka-Amao, O., & Henke, C. (2022). The validity, responsiveness, and score interpretation of the PROMISnq Physical Function – Multiple Sclerosis 15a short form in multiple sclerosis. Multiple Sclerosis and Related Disorders, 62, 103753

   https://doi.org/10.1016/j.msard.2022.103753, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61485
5. Moore, H., Nair, K., Baster, K., Middleton, R., Paling, D., & Sharrack, B. (2022). Fatigue in multiple sclerosis: A UK MS-register based study. Multiple Sclerosis and Related Disorders, 64, 103954

   https://doi.org/10.1016/j.msard.2022.103954, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61484
6. Kamudoni, P., Johns, J., Cook, K., Salem, R., Salek, S., Raab, J., Middleton, R., Henke, C., & Amtmann, D. (2022). A comparison of the measurement properties of the PROMIS Fatigue (MS) 8a against legacy fatigue questionnaires. Multiple Sclerosis and Related Disorders, 66, 104048

   https://doi.org/10.1016/j.msard.2022.104048, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61483
7. Simpson-Yap, S., Pirmani, A., Brouwer, E., Peeters, L., Geys, L., Parciak, T., Helme, A., Hillert, J., Moreau, Y., Edan, G., Spelman, T., Sharmin, S., McBurney, R., Schmidt, H., Bergmann, A., Braune, S., Stahmann, A., Middleton, R., Salter, A...., & Kalincik, T. (2022). Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-β. Multiple Sclerosis and Related Disorders, 66, 104072

   https://doi.org/10.1016/j.msard.2022.104072, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61482
8. Meek, C., Nair, R., Evangelou, N., Middleton, R., Tuite-Dalton, K., & Moghaddam, N. (2022). Psychological flexibility, distress, and quality of life in secondary progressive multiple sclerosis: A cross-sectional study. Multiple Sclerosis and Related Disorders, 67, 104154

   https://doi.org/10.1016/j.msard.2022.104154, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61481
9. Frahm, N., Fneish, F., Ellenberger, D., Haas, J., Loebermann, M., Parciak, T., Peters, M., Pöhlau, D., Rodgers, J., Röper, A., Schilling, S., Stahmann, A., Temmes, H., Zettl, U., & Middleton, R. (2022). SARS-CoV-2 vaccination in patients with multiple sclerosis in Germany and the United Kingdom: Gender-specific results from a longitudinal observational study. The Lancet Regional Health - Europe, 22, 100502

   https://doi.org/10.1016/j.lanepe.2022.100502, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61480
10. Middleton, R., Balbuena, L., Middleton, R., Tuite-Dalton, K., Pouliou, T., Williams, K., & Noble, G. (2016). Sunshine, Sea, and Season of Birth: MS Incidence in Wales. PLOS ONE, 11(5), e0155181

    https://doi.org/10.1371/journal.pone.0155181, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29587
11. Middleton, R., Ford, D., Jones, K., Middleton, R., Lockhart-Jones, H., Maramba, I., Noble, G., Osborne, L., & Lyons, R. (2012). The feasibility of collecting information from people with Multiple Sclerosis for the UK MS Register via a web portal: characterising a cohort of people with MS. BMC Medical Informatics and Decision Making, 12(1), 73

    https://doi.org/10.1186/1472-6947-12-73, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11798
12. Middleton, R., Noble, J., Osborne, L., Jones, K., Middleton, R., Ford, D., Noble, G., Jones, K., & Ford, D. (2012). Commentary on 'Disability outcome measures in multiple sclerosis clinical trials'. Multiple Sclerosis Journal, 18(12), 1718-1720.

    https://doi.org/10.1177/1352458512457847, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12133
13. Middleton, R., Osborne, L., Noble, J., Lockhart-Jones, H., Middleton, R., Ellwood-Thompson, S., Maramba, I., Jones, K., Ford, D., & Noble, G. (2012). Sources of Discovery, Reasons for Registration, and Expectations of an Internet-Based Register for Multiple Sclerosis. International Journal of Healthcare Information Systems and Informatics, 7(3), 27-43.

    https://doi.org/10.4018/jhisi.2012070103, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12357
14. Middleton, R., Osborne, L., Lockhart-Jones, H., Middleton, R., Thompson, S., Maramba, I., Jones, K., Ford, D., Noble, J., & Noble, G. (2013). Identifying and Addressing the Barriers to the Use of an Internet-Register for Multiple Sclerosis. International Journal of Healthcare Information Systems and Informatics, 8(1)-16.

    https://doi.org/10.4018/jhisi.2013010101, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15161
15. Middleton, R., Osborne, L., Middleton, R., Jones, K., Ford, D., Noble, J., & Noble, G. (2013). Desirability and expectations of the UK MS Register: Views of people with MS. International Journal of Medical Informatics

    https://doi.org/10.1016/j.ijmedinf.2013.07.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15873

    http://www.sciencedirect.com/science/article/pii/S1386505613001603
16. Evangelou, N., Garjani, A., dasNair, R., Hunter, R., Tuite-Dalton, K., Craig, E., Rodgers, J., Coles, A., Dobson, R., Duddy, M., Ford, D., Hughes, S., Pearson, O., Middleton, L., Rog, D., Tallantyre, E., Friede, T., Middleton, R., & Nicholas, R. (2020). Self-diagnosed COVID-19 in people with multiple sclerosis: a community-based cohort of the UK MS Register. Journal of Neurology, Neurosurgery & Psychiatry, 92(1), 107-109.

    https://doi.org/10.1136/jnnp-2020-324449, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56803
17. Garjani, A., Middleton, R., Hunter, R., Tuite-Dalton, K., Coles, A., Dobson, R., Duddy, M., Hughes, S., Pearson, O., Rog, D., Tallantyre, E., Nair, R., Nicholas, R., & Evangelou, N. (2021). COVID-19 is associated with new symptoms of multiple sclerosis that are prevented by disease modifying therapies. Multiple Sclerosis and Related Disorders, 52, 102939

    https://doi.org/10.1016/j.msard.2021.102939, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56804
18. Garjani, A., Hunter, R., Law, G., Middleton, R., Tuite-Dalton, K., Dobson, R., Ford, D., Hughes, S., Pearson, O., Rog, D., Tallantyre, E., Nicholas, R., Morriss, R., Evangelou, N., & Nair, R. (2021). Mental health of people with multiple sclerosis during the COVID-19 outbreak: A prospective cohort and cross-sectional case–control study of the UK MS Register. Multiple Sclerosis Journal, 28(7), 135245852110204

    https://doi.org/10.1177/13524585211020435, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57028
19. Huang, Y., Rodgers, J., Middleton, R., Baheerathan, A., Tuite-Dalton, K., Ford, D., Nicholas, R., & Group, M. (2021). Willingness to receive a COVID-19 vaccine in people with multiple sclerosis - UK MS Register survey. Multiple sclerosis and related disorders, 55, 103175-103175.

    https://doi.org/10.1016/j.msard.2021.103175, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57795
20. Middleton, R., Craig, E., Rodgers, J., Tuite-Dalton, K., Garjani, A., Evangelou, N., Nair, R., Hunter, R., Tallantyre, E., Cauchi, M., Cairn, C., Paling, D., Fuller, S., McDonnell, G., Petheram, K., Liu, B., Nock, U., Ingram, G., Brownlee, W...., & Nicholas, R. (2021). COVID-19 in Multiple Sclerosis: Clinically reported outcomes from the UK Multiple Sclerosis Register. Multiple Sclerosis and Related Disorders, 56, 103317

    https://doi.org/10.1016/j.msard.2021.103317, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58395
21. Simpson-Yap, S., Brouwer, E., Kalincik, T., Rijke, N., Hillert, J., Walton, C., Edan, G., Moreau, Y., Spelman, T., Geys, L., Parciak, T., Gautrais, C., Lazovski, N., Pirmani, A., Ardeshirdavanai, A., Forsberg, L., Glaser, A., McBurney, R., Schmidt, H...., & Peeters, L. (2021). Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis. Neurology, 97(19), e1870-e1885.

    https://doi.org/10.1212/wnl.0000000000012753, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58429
22. Rodgers, J., Friede, T., Vonberg, F., Constantinescu, C., Coles, A., Chataway, J., Duddy, M., Emsley, H., Ford, H., Fisniku, L., Galea, I., Harrower, T., Hobart, J., Huseyin, H., Kipps, C., Marta, M., McDonnell, G., McLean, B., Pearson, O...., & Nicholas, R. (2022). The impact of smoking cessation on multiple sclerosis disease progression. Brain, 145(4), 1368-1378.

    https://doi.org/10.1093/brain/awab385, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58437
23. Das, J., Rog, D., Middleton, R., Rodgers, J., Fry, R., & Nicholas, R. (2022). The association between deprivation and the access to disease modifying therapies for multiple sclerosis: An England wide community-based study in the UK MS Register. Multiple Sclerosis and Related Disorders, 57, 103474

    https://doi.org/10.1016/j.msard.2021.103474, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59086
24. Garjani, A., Middleton, R., Nicholas, R., & Evangelou, N. (2022). Recovery From COVID-19 in Multiple Sclerosis: A Prospective and Longitudinal Cohort Study of the United Kingdom Multiple Sclerosis Register. Neurology - Neuroimmunology Neuroinflammation, 9(1), e1118

    https://doi.org/10.1212/nxi.0000000000001118, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59132
25. Peeters, L., Parciak, T., Walton, C., Geys, L., Moreau, Y., Brouwer, E., Raimondi, D., Pirmani, A., Kalincik, T., Edan, G., Simpson-Yap, S., Raedt, L., Dauxais, Y., Gautrais, C., Rodrigues, P., McKenna, L., Lazovski, N., Hillert, J., Forsberg, L...., & Rijke, N. (2020). COVID-19 in people with multiple sclerosis: A global data sharing initiative. Multiple Sclerosis Journal, 26(10), 1157-1162.

    https://doi.org/10.1177/1352458520941485, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61475
26. Tuite-Dalton, K., Middleton, R., Tuite-Dalton, K., Baker, E., Stennett, A., Albor, C., & Schmierer, K. (2020). Can We Improve the Monitoring of People With Multiple Sclerosis Using Simple Tools, Data Sharing, and Patient Engagement?. Frontiers in Neurology, 11

    https://doi.org/10.3389/fneur.2020.00464, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61476
27. Salter, A., Stahmann, A., Ellenberger, D., Fneish, F., Rodgers, J., Middleton, R., Nicholas, R., & Marrie, R. (2021). Data harmonization for collaborative research among MS registries: A case study in employment. Multiple Sclerosis Journal, 27(2), 281-289.

    https://doi.org/10.1177/1352458520910499, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61477
28. Nicholas, R., Heaven, M., Middleton, R., Chevli, M., Pulikottil-Jacob, R., Jones, K., & Ford, D. (2020). Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 6(1), 205521732090172

    https://doi.org/10.1177/2055217320901727, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61478
29. Flachenecker, P., Buckow, K., Pugliatti, M., Kes, V., Battaglia, M., Boyko, A., Confavreux, C., Ellenberger, D., Eskic, D., Ford, D., Friede, T., Fuge, J., Glaser, A., Hillert, J., Holloway, E., Ioannidou, E., Kappos, L., Kasilingam, E., Koch-Henriksen, N...., & Consortium*), . (2014). Multiple sclerosis registries in Europe – results of a systematic survey. Multiple Sclerosis Journal, 20(11), 1523-1532.

    https://doi.org/10.1177/1352458514528760, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61479
30. Middleton, R., Pearson, O., Ingram, G., Craig, E., Rodgers, J., Downing-Wood, H., Hill, J., Tuite-Dalton, K., Roberts, C., Watson, L., Ford, D., Nicholas, R., & Group), . (2020). A Rapid Electronic Cognitive Assessment Measure for Multiple Sclerosis: Validation of Cognitive Reaction, an Electronic Version of the Symbol Digit Modalities Test. Journal of Medical Internet Research, 22(9), e18234

    https://doi.org/10.2196/18234, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55412
31. Middleton, R., Ford, D., & Naeh, D. (2017). iConsent an Electronic Consent Platform with the MS Register. In International Journal of Population Data ScienceSwansea University.

    https://doi.org/10.23889/ijpds.v1i1.363, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53023
32. Jones, K., Ford, D., Jones, P., John, A., Middleton, R., Lockhart-Jones, H., Peng, J., Osborne, L., & Noble, G. (2013). How People with Multiple Sclerosis Rate Their Quality of Life: An EQ-5D Survey via the UK MS Register. PLoS ONE, 8(6), e65640

    https://doi.org/10.1371/journal.pone.0065640, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16841
33. Jones, K., Ford, D., Jones, P., John, A., Middleton, R., Lockhart-Jones, H., Peng, J., Osborne, L., Noble, G., & Jones, P. (2013). The Physical and Psychological Impact of Multiple Sclerosis Using the MSIS-29 via the Web Portal of the UK MS Register. PLoS ONE, 8(1), e55422

    https://doi.org/10.1371/journal.pone.0055422, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16846
34. Jones, K., Ford, D., Jones, P., John, A., Middleton, R., Lockhart-Jones, H., Osborne, L., & Noble, G. (2012). A Large-Scale Study of Anxiety and Depression in People with Multiple Sclerosis: A Survey via the Web Portal of the UK MS Register. PLoS ONE, 7(7), e41910

    https://doi.org/10.1371/journal.pone.0041910, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16849
35. Osborne, L., Noble, G., Maramba, I., Jones, K., Middleton, R., Lyons, R., Ford, D., & Reed, P. (2014). Outcome measures for multiple sclerosis. Physical Therapy Reviews, 19(1), 24-38.

    https://doi.org/10.1179/1743288x13y.0000000094, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18316
36. Jones, K., Jones, P., Middleton, R., Ford, D., Tuite-Dalton, K., Lockhart-Jones, H., Peng, J., Lyons, R., John, A., & Noble, G. (2014). Physical Disability, Anxiety and Depression in People with MS: An Internet-Based Survey via the UK MS Register. PLoS ONE, 9(8), e104604

    https://doi.org/10.1371/journal.pone.0104604, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18808

    https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0104604&type=printable
37. Baker, D., Anandhakrishnan, A., Tuite-Dalton, K., Lockhart-Jones, H., Middleton, R., Ford, D., Crowe, C., & Giovannoni, G. (2016). How to refer to people with disease in research outputs: The disconnection between academic practise and that preferred by people with multiple sclerosis. Multiple Sclerosis and Related Disorders, 10, 127-133.

    https://doi.org/10.1016/j.msard.2016.09.007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32027
38. Middleton, R., Akbari, A., Lockhart-Jones, H., Jones, J., Owen, C., Hughes, S., Gain, R., & Ford, D. (2017). Clinical Validation of the UKMS Register Minimal Dataset utilising Natural Language Processing. International Journal of Population Data Science, 1(1)

    https://doi.org/10.23889/ijpds.v1i1.288, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39436
39. Middleton, R., Rodgers, W., Chataway, J., Schmierer, K., Rog, D., Galea, I., Akbari, A., Tuite-Dalton, K., Lockhart-Jones, H., Griffiths, D., Noble, D., Jones, K., Al-Din, A., Craner, M., Evangelou, N., Harman, P., Harrower, T., Hobart, J., Husseyin, H...., & Ford, D. (2018). Validating the portal population of the United Kingdom Multiple Sclerosis Register. Multiple Sclerosis and Related Disorders, 24, 3-10.

    https://doi.org/10.1016/j.msard.2018.05.015, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40629
40. Glaser, A., Stahmann, A., Meissner, T., Flachenecker, P., Horáková, D., Zaratin, P., Brichetto, G., Pugliatti, M., Rienhoff, O., Vukusic, S., de Giacomoni, A., Battaglia, M., Brola, W., Butzkueven, H., Casey, R., Drulovic, J., Eichstädt, K., Hellwig, K., Iaffaldano, P...., & Middleton, R. (2019). Multiple sclerosis registries in Europe – An updated mapping survey. Multiple Sclerosis and Related Disorders, 27, 171-178.

    https://doi.org/10.1016/j.msard.2018.09.032, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45469
41. Lacey, A., Lyons, J., Akbari, A., Turner, S., Walters, A., Fonferko-Shadrach, B., Pickrell, O., Rees, M., Lyons, R., Ford, D., & Middleton, R. (2017). Codifying unstructured data: A Natural Language Processing approach to extract rich data from clinical letters. International Journal for Population Data Science, 1(1)

    https://doi.org/10.23889/ijpds.v1i1.354, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39437
42. Middleton, R., Rodgers, J., Giovannoni, G., Schmierer, K., Dobson, R., Allen-Philbey, K., Patterson, A., Tuite-Dalton, K., Ford, D., & Akbari, A. (2017). A Comparison of participant supplied EDSS scores and clinically submitted data via the UK MS Register. Multiple Sclerosis Journal, 23(3_suppl), 85-426.

    https://doi.org/10.1177/1352458517731404, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39440

    http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000413730200236&KeyUID=WOS:000413730200236
43. Middleton, R., Ford, D., Akbari, A., Lockhart-Jones, H., Jones, J., Hughes, S., & Owen, C. (2016). Natural language processing to capture MS clinical data. Multiple Sclerosis Journal, 22(3_suppl), 717-717.

    https://doi.org/10.1177/1352458516663067, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa44549
44. Middleton, R., Allen-Philby, K., Schmierer, K., Espasandin, M., C.Roberts, ., Nicholas, R., Rodgers, J., Lockhart-Jones, H., Tuite-Dalton, K., & Ford, D. (2019). 175 A model for participant engagement in research: the MS register. In Journal of Neurology, Neurosurgery and Psychiatry (pp. e46BMJ.

    https://doi.org/10.1136/jnnp-2019-ABN-2.155, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61927

    https://jnnp.bmj.com/content/90/12/e46.3.info
45. Middleton, R., Craig, E., Rodgers, W., Tuite-Dalton, K., Garjani, A., Evangelou, N., Hunter, R., DasNair, R., & Nicholas, R. (2022). 096  COVID-19 in MS: clinically reported outcomes from the UK MS register. In Journal of Neurology, Neurosurgery and Psychiatry (pp. A130.3-A130). BMJ.

    https://doi.org/10.1136/jnnp-2022-abn.421, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62044
46. Garjani, A., Middleton, R., Law, G., Tuite-Dalton, K., Hunter, R., Nair, R., Evangelou, N., & Nicholas, R. (2022). COVID-19 and multiple sclerosis: An updated report of the community-based longitudinal UK MS Register study. Journal of Neurology, Neurosurgery and Psychiatry, 93(6), A93.2-A93.

    https://doi.org/10.1136/jnnp-2022-abn.302, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62047
47. Knowles, S., Middleton, R., Cooze, B., Farkas, I., Leung, Y., Allen, K., WINSLADE, M., Owen, D., Magliozzi, R., Reynolds, R., Neal, J., Pearson, O., Nicholas, R., Pickrell, O., Howell, O., & Group), . (2024). Comparing the Pathology, Clinical, and Demographic Characteristics of Younger and Older‐Onset Multiple Sclerosis. Annals of Neurology, 95(3), 471-486.

    https://doi.org/10.1002/ana.26843, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65353

    http://dx.doi.org/10.1002/ana.26843
48. Nair, R., Hunter, R., Garjani, A., Middleton, R., Tuite-Dalton, K., Nicholas, R., & Evangelou, N. (2021). Challenges of developing, conducting, analysing and reporting a COVID-19 study as the COVID-19 pandemic unfolds: an online co-autoethnographic study. BMJ Open, 11(6), e048788

    https://doi.org/10.1136/bmjopen-2021-048788, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65365

    http://dx.doi.org/10.1136/bmjopen-2021-048788

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