Dr Luke Davies

Darlithydd, Biomedical Sciences

l.c.davies@abertawe.ac.uk

Siaradwr Cymraeg Sylfaenol

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

https://orcid.org/0000-0001-7767-4060

ResearchGate

Google Scholar

Trosolwg

Mae Dr Luke Davies yn ddarlithydd ar y llwybr ymchwil mewn Imiwnometaboledd yn y Gyfadran Meddygaeth, Iechyd a Gwyddor Bywyd. Mae ganddo gefndir ym maes biocemeg (BSc) ac imiwnoleg (PhD) yng Nghymru, ac enillodd Gymrodoriaeth Henry Wellcome uchel ei bri i gefnogi ei ymchwil i imiwnometaboledd yn y Sefydliadau Cenedlaethol Iechyd yn Maryland, Unol Daleithiau America. Bydd Dr Davies bellach yn cymhwyso'r gwersi a ddysgwyd yn ystod ei ddegawd o archwiliadau i lid ac imiwnedd i addysgu yn Ysgol Feddygaeth Prifysgol Abertawe ac ymchwilio ymhellach i drin clefyd dynol.

Meysydd Arbenigedd

Imiwnoleg celloedd myeloid
Imiwnedd Cynhenid
Imiwnometaboledd
Metaboledd
Ffisioleg beritoneaidd
Clefyd yr arennau
Haint
Llid

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Mae Dr Davies wedi meithrin sylfaen wybodaeth eang ym meysydd biocemeg, bioleg foleciwlaidd a geneteg. Fodd bynnag, mae ei ddiddordebau addysgu'n canolbwyntio'n benodol ar imiwnoleg, metaboledd, haint a ffisioleg meinweoedd. Mae ef wedi meithrin gwybodaeth ymarferol gref am ystod eang o dechnegau biofeddygol yn ystod degawd o ymchwil hynod weithredol, ac mae ef ar gael i gefnogi ymchwilwyr israddedig ar gyfer eu prosiectau blwyddyn olaf yn y labordy.

Ymchwil Prif Wobrau Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Jenkins, R., Davies, L., Taylor, P., Akiyama, H., Cumbes, B., Beltrami, C., Carrington, C., Phillips, A., Bowen, T., Fraser, D., & Cumbes, B. (2014). miR-192 Induces G2/M Growth Arrest in Aristolochic Acid Nephropathy. The American Journal of Pathology, 184(4), 996-1009.
https://doi.org/10.1016/j.ajpath.2013.12.028, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34142
http://dx.doi.org/10.1016/j.ajpath.2013.12.028
Dievernich, A., Achenbach, P., Davies, L., & Klinge, U. (2020). Tissue remodeling macrophages morphologically dominate at the interface of polypropylene surgical meshes in the human abdomen. Hernia, 24(6), 1175-1189.
https://doi.org/10.1007/s10029-020-02315-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61680
Misheva, M., Kotzamanis, K., Davies, L., Tyrrell, V., Rodrigues, P., Benavides, G., Hinz, C., Murphy, R., Kennedy, P., Taylor, P., Rosas, M., Jones, S., McLaren, J., Deshpande, S., Andrews, R., Schebb, N., Czubala, M., Gurney, M., Aldrovandi, M...., & O’Donnell, V. (2022). Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications, 13(1)
https://doi.org/10.1038/s41467-021-27766-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61681
Ipseiz, N., Pickering, R., Rosas, M., Tyrrell, V., Davies, L., Orr, S., Czubala, M., Fathalla, D., Robertson, A., Bryant, C., O'Donnell, V., & Taylor, P. (2020). Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. The EMBO Journal, 39(14)
https://doi.org/10.15252/embj.2019103454, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61683
Klinge, U., Dievernich, A., Tolba, R., Klosterhalfen, B., & Davies, L. (2020). CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108(8), 3134-3146.
https://doi.org/10.1002/jbm.b.34639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61684
Palmieri, E., Gonzalez-Cotto, M., Baseler, W., Davies, L., Ghesquière, B., Maio, N., Rice, C., Rouault, T., Cassel, T., Higashi, R., Lane, A., Fan, T., Wink, D., & McVicar, D. (2020). Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase. Nature Communications, 11(1)
https://doi.org/10.1038/s41467-020-14433-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61685
Coveney, C., Tellier, M., Lu, F., Maleki-Toyserkani, S., Jones, R., Bart, V., Pring, E., Alrubayyi, A., Richter, F., Scourfield, D., Rehwinkel, J., Rodrigues, P., Davies, L., Gea-Mallorquí, E., & Consortium), . (2020). Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion. Oxford Open Immunology, 1(1)
https://doi.org/10.1093/oxfimm/iqaa004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61691
Sharma, S., Zaher, S., Rodrigues, P., Davies, L., Edkins, S., Strang, A., Chakraborty, M., Watkins, W., Andrews, R., Parkinson, E., Angelopoulos, N., Moet, L., Shepherd, F., Davies, K., White, D., Oram, S., Siddall, K., Keeping, V., Simpson, K...., & Ghazal, P. (2022). mSep: investigating physiological and immune-metabolic biomarkers in septic and healthy pregnant women to predict feto-maternal immune health – a prospective observational cohort study protocol. BMJ Open, 12(9), e066382
https://doi.org/10.1136/bmjopen-2022-066382, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61692
Dievernich, A., Achenbach, P., Davies, L., & Klinge, U. (2022). Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen. Hernia, 26(1), 309-323.
https://doi.org/10.1007/s10029-021-02396-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61693
Chakraborty, M., Rodrigues, P., Watkins, W., Hayward, A., Sharma, A., Hayward, R., Smit, E., Jones, R., Goel, N., Asokkumar, A., Calvert, J., Odd, D., Morris, I., Doherty, C., Elliott, S., Strang, A., Andrews, R., Zaher, S., Sharma, S...., & Ghazal, P. (2021). nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis—protocol for a prospective multicohort study. BMJ Open, 11(12), e050100
https://doi.org/10.1136/bmjopen-2021-050100, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61694
Crittenden, S., Goepp, M., Pollock, J., Robb, C., Smyth, D., Zhou, Y., Andrews, R., Tyrrell, V., Gkikas, K., Adima, A., O’Connor, R., Davies, L., Li, X., Yao, H., Ho, G., Zheng, X., Mair, A., Vermeren, S., Qian, B...., & Yao, C. (2021). Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances, 7(7)
https://doi.org/10.1126/sciadv.abd7954, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61695
Rodrigues, P., Alrubayyi, A., Pring, E., Bart, V., Jones, R., Coveney, C., Lu, F., Tellier, M., Maleki-Toyserkani, S., Richter, F., Scourfield, D., Gea-Mallorquí, E., & Davies, L. (2020). Innate immunology in COVID-19—a living review. Part II: dysregulated inflammation drives immunopathology. Oxford Open Immunology, 1(1)
https://doi.org/10.1093/oxfimm/iqaa005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61696
Ipseiz, N., Czubala, M., Bart, V., Davies, L., Jenkins, R., Brennan, P., & Taylor, P. (2020). Effective In Vivo Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors. Molecular Therapy - Methods & Clinical Development, 16, 21-31.
https://doi.org/10.1016/j.omtm.2019.10.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61697
Thompson, A., Davies, L., Liao, C., Fonseca, D., Griffiths, J., Andrews, R., Jones, A., Clement, M., Brown, G., Humphreys, I., Taylor, P., & Orr, S. (2019). The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLOS Pathogens, 15(6), e1007850
https://doi.org/10.1371/journal.ppat.1007850, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61698
Davies, L., Rice, C., McVicar, D., & Weiss, J. (2019). Diversity and environmental adaptation of phagocytic cell metabolism. Journal of Leukocyte Biology, 105(1), 37-48.
https://doi.org/10.1002/jlb.4ri0518-195r, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61699
Weiss, J., Davies, L., Karwan, M., Ileva, L., Ozaki, M., Cheng, R., Ridnour, L., Annunziata, C., Wink, D., & McVicar, D. (2018). Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Journal of Clinical Investigation, 128(9), 3794-3805.
https://doi.org/10.1172/jci99169, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61700
Rice, C., Davies, L., Subleski, J., Maio, N., Gonzalez-Cotto, M., Andrews, C., Patel, N., Palmieri, E., Weiss, J., Lee, J., Annunziata, C., Rouault, T., Durum, S., & McVicar, D. (2018). Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression. Nature Communications, 9(1)
https://doi.org/10.1038/s41467-018-07505-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61701
Davies, L., Rice, C., Palmieri, E., Taylor, P., Kuhns, D., & McVicar, D. (2017). Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels. Nature Communications, 8(1)
https://doi.org/10.1038/s41467-017-02092-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61702
McLean, M., Andrews, C., Hanson, M., Baseler, W., Anver, M., Senkevitch, E., Staniszewska, A., Smith, C., Davies, L., Hixon, J., Li, W., Shen, W., Steidler, L., & Durum, S. (2017). Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10–Dependent, T-Cell–Independent Attenuation of Colonic Mucosal Innate Immune Responses. Inflammatory Bowel Diseases, 23(11), 1983-1995.
https://doi.org/10.1097/mib.0000000000001274, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61703
Baseler, W., Davies, L., Quigley, L., Ridnour, L., Weiss, J., Hussain, S., Wink, D., & McVicar, D. (2016). Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production. Redox Biology, 10, 12-23.
https://doi.org/10.1016/j.redox.2016.09.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61704
Liao, C., Rosas, M., Davies, L., Giles, P., Tyrrell, V., O'Donnell, V., Topley, N., Humphreys, I., Fraser, D., Jones, S., & Taylor, P. (2016). IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation. European Journal of Immunology, 46(9), 2222-2232.
https://doi.org/10.1002/eji.201646528, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61705
Davies, L. & Taylor, P. (2015). Tissue‐resident macrophages: then and now. Immunology, 144(4), 541-548.
https://doi.org/10.1111/imm.12451, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61706
Rosas, M., Davies, L., Giles, P., Liao, C., Kharfan, B., Stone, T., O’Donnell, V., Fraser, D., Jones, S., & Taylor, P. (2014). The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal. Science, 344(6184), 645-648.
https://doi.org/10.1126/science.1251414, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61707
Davies, L., Rosas, M., Jenkins, S., Liao, C., Scurr, M., Brombacher, F., Fraser, D., Allen, J., Jones, S., & Taylor, P. (2013). Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature Communications, 4(1)
https://doi.org/10.1038/ncomms2877, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61708
Davies, L., Jenkins, S., Allen, J., & Taylor, P. (2013). Tissue-resident macrophages. Nature Immunology, 14(10), 986-995.
https://doi.org/10.1038/ni.2705, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61709
Davies, L., Rosas, M., Smith, P., Fraser, D., Jones, S., & Taylor, P. (2011). A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European Journal of Immunology, 41(8), 2155-2164.
https://doi.org/10.1002/eji.201141817, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61710
Rosas, M., Osorio, F., Robinson, M., Davies, L., Dierkes, N., Jones, S., Sousa, C., & Taylor, P. (2011). Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells. European Journal of Immunology, 41(2), 356-365.
https://doi.org/10.1002/eji.201040962, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61711
Liddiard, K., Rosas, M., Davies, L., Jones, S., & Taylor, P. (2011). Macrophage heterogeneity and acute inflammation. European Journal of Immunology, 41(9), 2503-2508.
https://doi.org/10.1002/eji.201141743, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61712
Sharma, S., Rodrigues, P., Zaher, S., Davies, L., & Ghazal, P. (2022). Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis. eBioMedicine, 86, 104337
https://doi.org/10.1016/j.ebiom.2022.104337, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62112
Rees, A., Jenkins, B., Angelini, R., Davies, L., Cronin, J., Jones, N., & Thornton, C. (n.d.) Immunometabolic adaptation in monocytes underpins functional changes during pregnancy.. iScience
https://doi.org/10.1016/j.isci.2024.109779, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66076

Holl Ymchwil

Erthyglau Cylchgronau

Sharma, S., Rodrigues, P., Zaher, S., Davies, L., & Ghazal, P. (2022). Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis. eBioMedicine, 86, 104337
https://doi.org/10.1016/j.ebiom.2022.104337, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62112
Sharma, S., Zaher, S., Rodrigues, P., Davies, L., Edkins, S., Strang, A., Chakraborty, M., Watkins, W., Andrews, R., Parkinson, E., Angelopoulos, N., Moet, L., Shepherd, F., Davies, K., White, D., Oram, S., Siddall, K., Keeping, V., Simpson, K...., & Ghazal, P. (2022). mSep: investigating physiological and immune-metabolic biomarkers in septic and healthy pregnant women to predict feto-maternal immune health – a prospective observational cohort study protocol. BMJ Open, 12(9), e066382
https://doi.org/10.1136/bmjopen-2022-066382, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61692
Dievernich, A., Achenbach, P., Davies, L., & Klinge, U. (2022). Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen. Hernia, 26(1), 309-323.
https://doi.org/10.1007/s10029-021-02396-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61693
Misheva, M., Kotzamanis, K., Davies, L., Tyrrell, V., Rodrigues, P., Benavides, G., Hinz, C., Murphy, R., Kennedy, P., Taylor, P., Rosas, M., Jones, S., McLaren, J., Deshpande, S., Andrews, R., Schebb, N., Czubala, M., Gurney, M., Aldrovandi, M...., & O’Donnell, V. (2022). Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications, 13(1)
https://doi.org/10.1038/s41467-021-27766-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61681
Chakraborty, M., Rodrigues, P., Watkins, W., Hayward, A., Sharma, A., Hayward, R., Smit, E., Jones, R., Goel, N., Asokkumar, A., Calvert, J., Odd, D., Morris, I., Doherty, C., Elliott, S., Strang, A., Andrews, R., Zaher, S., Sharma, S...., & Ghazal, P. (2021). nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis—protocol for a prospective multicohort study. BMJ Open, 11(12), e050100
https://doi.org/10.1136/bmjopen-2021-050100, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61694
Crittenden, S., Goepp, M., Pollock, J., Robb, C., Smyth, D., Zhou, Y., Andrews, R., Tyrrell, V., Gkikas, K., Adima, A., O’Connor, R., Davies, L., Li, X., Yao, H., Ho, G., Zheng, X., Mair, A., Vermeren, S., Qian, B...., & Yao, C. (2021). Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances, 7(7)
https://doi.org/10.1126/sciadv.abd7954, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61695
Coveney, C., Tellier, M., Lu, F., Maleki-Toyserkani, S., Jones, R., Bart, V., Pring, E., Alrubayyi, A., Richter, F., Scourfield, D., Rehwinkel, J., Rodrigues, P., Davies, L., Gea-Mallorquí, E., & Consortium), . (2020). Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion. Oxford Open Immunology, 1(1)
https://doi.org/10.1093/oxfimm/iqaa004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61691
Rodrigues, P., Alrubayyi, A., Pring, E., Bart, V., Jones, R., Coveney, C., Lu, F., Tellier, M., Maleki-Toyserkani, S., Richter, F., Scourfield, D., Gea-Mallorquí, E., & Davies, L. (2020). Innate immunology in COVID-19—a living review. Part II: dysregulated inflammation drives immunopathology. Oxford Open Immunology, 1(1)
https://doi.org/10.1093/oxfimm/iqaa005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61696
Dievernich, A., Achenbach, P., Davies, L., & Klinge, U. (2020). Tissue remodeling macrophages morphologically dominate at the interface of polypropylene surgical meshes in the human abdomen. Hernia, 24(6), 1175-1189.
https://doi.org/10.1007/s10029-020-02315-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61680
Klinge, U., Dievernich, A., Tolba, R., Klosterhalfen, B., & Davies, L. (2020). CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108(8), 3134-3146.
https://doi.org/10.1002/jbm.b.34639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61684
Ipseiz, N., Pickering, R., Rosas, M., Tyrrell, V., Davies, L., Orr, S., Czubala, M., Fathalla, D., Robertson, A., Bryant, C., O'Donnell, V., & Taylor, P. (2020). Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. The EMBO Journal, 39(14)
https://doi.org/10.15252/embj.2019103454, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61683
Ipseiz, N., Czubala, M., Bart, V., Davies, L., Jenkins, R., Brennan, P., & Taylor, P. (2020). Effective In Vivo Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors. Molecular Therapy - Methods & Clinical Development, 16, 21-31.
https://doi.org/10.1016/j.omtm.2019.10.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61697
Palmieri, E., Gonzalez-Cotto, M., Baseler, W., Davies, L., Ghesquière, B., Maio, N., Rice, C., Rouault, T., Cassel, T., Higashi, R., Lane, A., Fan, T., Wink, D., & McVicar, D. (2020). Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase. Nature Communications, 11(1)
https://doi.org/10.1038/s41467-020-14433-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61685
Thompson, A., Davies, L., Liao, C., Fonseca, D., Griffiths, J., Andrews, R., Jones, A., Clement, M., Brown, G., Humphreys, I., Taylor, P., & Orr, S. (2019). The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLOS Pathogens, 15(6), e1007850
https://doi.org/10.1371/journal.ppat.1007850, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61698
Davies, L., Rice, C., McVicar, D., & Weiss, J. (2019). Diversity and environmental adaptation of phagocytic cell metabolism. Journal of Leukocyte Biology, 105(1), 37-48.
https://doi.org/10.1002/jlb.4ri0518-195r, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61699
Rice, C., Davies, L., Subleski, J., Maio, N., Gonzalez-Cotto, M., Andrews, C., Patel, N., Palmieri, E., Weiss, J., Lee, J., Annunziata, C., Rouault, T., Durum, S., & McVicar, D. (2018). Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression. Nature Communications, 9(1)
https://doi.org/10.1038/s41467-018-07505-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61701
Weiss, J., Davies, L., Karwan, M., Ileva, L., Ozaki, M., Cheng, R., Ridnour, L., Annunziata, C., Wink, D., & McVicar, D. (2018). Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Journal of Clinical Investigation, 128(9), 3794-3805.
https://doi.org/10.1172/jci99169, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61700
Davies, L., Rice, C., Palmieri, E., Taylor, P., Kuhns, D., & McVicar, D. (2017). Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels. Nature Communications, 8(1)
https://doi.org/10.1038/s41467-017-02092-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61702
McLean, M., Andrews, C., Hanson, M., Baseler, W., Anver, M., Senkevitch, E., Staniszewska, A., Smith, C., Davies, L., Hixon, J., Li, W., Shen, W., Steidler, L., & Durum, S. (2017). Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10–Dependent, T-Cell–Independent Attenuation of Colonic Mucosal Innate Immune Responses. Inflammatory Bowel Diseases, 23(11), 1983-1995.
https://doi.org/10.1097/mib.0000000000001274, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61703
Baseler, W., Davies, L., Quigley, L., Ridnour, L., Weiss, J., Hussain, S., Wink, D., & McVicar, D. (2016). Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production. Redox Biology, 10, 12-23.
https://doi.org/10.1016/j.redox.2016.09.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61704
Liao, C., Rosas, M., Davies, L., Giles, P., Tyrrell, V., O'Donnell, V., Topley, N., Humphreys, I., Fraser, D., Jones, S., & Taylor, P. (2016). IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation. European Journal of Immunology, 46(9), 2222-2232.
https://doi.org/10.1002/eji.201646528, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61705
Davies, L. & Taylor, P. (2015). Tissue‐resident macrophages: then and now. Immunology, 144(4), 541-548.
https://doi.org/10.1111/imm.12451, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61706
Rosas, M., Davies, L., Giles, P., Liao, C., Kharfan, B., Stone, T., O’Donnell, V., Fraser, D., Jones, S., & Taylor, P. (2014). The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal. Science, 344(6184), 645-648.
https://doi.org/10.1126/science.1251414, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61707
Jenkins, R., Davies, L., Taylor, P., Akiyama, H., Cumbes, B., Beltrami, C., Carrington, C., Phillips, A., Bowen, T., Fraser, D., & Cumbes, B. (2014). miR-192 Induces G2/M Growth Arrest in Aristolochic Acid Nephropathy. The American Journal of Pathology, 184(4), 996-1009.
https://doi.org/10.1016/j.ajpath.2013.12.028, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34142
http://dx.doi.org/10.1016/j.ajpath.2013.12.028
Davies, L., Jenkins, S., Allen, J., & Taylor, P. (2013). Tissue-resident macrophages. Nature Immunology, 14(10), 986-995.
https://doi.org/10.1038/ni.2705, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61709
Davies, L., Rosas, M., Jenkins, S., Liao, C., Scurr, M., Brombacher, F., Fraser, D., Allen, J., Jones, S., & Taylor, P. (2013). Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature Communications, 4(1)
https://doi.org/10.1038/ncomms2877, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61708
Liddiard, K., Rosas, M., Davies, L., Jones, S., & Taylor, P. (2011). Macrophage heterogeneity and acute inflammation. European Journal of Immunology, 41(9), 2503-2508.
https://doi.org/10.1002/eji.201141743, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61712
Davies, L., Rosas, M., Smith, P., Fraser, D., Jones, S., & Taylor, P. (2011). A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European Journal of Immunology, 41(8), 2155-2164.
https://doi.org/10.1002/eji.201141817, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61710
Rosas, M., Osorio, F., Robinson, M., Davies, L., Dierkes, N., Jones, S., Sousa, C., & Taylor, P. (2011). Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells. European Journal of Immunology, 41(2), 356-365.
https://doi.org/10.1002/eji.201040962, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61711
Rees, A., Jenkins, B., Angelini, R., Davies, L., Cronin, J., Jones, N., & Thornton, C. (n.d.) Immunometabolic adaptation in monocytes underpins functional changes during pregnancy.. iScience
https://doi.org/10.1016/j.isci.2024.109779, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66076

Modiwlau a Addysgir

PM-130 Fundamental Research Skills

This module is designed to develop the skills required for students of biochemistry and genetics degree programmes. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.
PM-154 Human Physiology

Human physiology is the study of how our body works in an integrated way. A central principle of human physiology is homeostasis, the maintenance of a relatively stable internal environment. Failure to maintain homeostasis disrupts normal function that may lead to disease (or pathophysiology). Students will be taught the key concepts of homeostasis in the physiological systems of the body, enabling the student to understand the consequences of pathophysiology to human health. Emphasis will be given to how malfunction of key physiological systems gives rise to disease, using specific examples to enable students to appreciate the relationship between physiology/anatomy and medicine. Fundamental principles of physiology will be illustrated with appropriate clinical examples and during lectures and in practical assignments. Students will gain practical experience in assessing physiological function during four laboratory-based exercises. The impact of pathophysiology of such systems will be assessed through clinical case studies.
PM-154C Ffisioleg Ddynol

Ffisioleg Ddynol yw astudio sut mae ein cyrff yn gweithio mewn ffordd integredig. Egwyddor sydd wrth wraidd ffisioleg ddynol yw homeostasis, sef cynnal amgylchedd mewnol cymharol sefydlog. Os na chynhelir homeostasis, bydd yn amharu ar swyddogaeth arferol a allai arwain at glefyd (neu bathoffisioleg). Caiff myfyrwyr eu haddysgu am gysyniadau allweddol homeostasis yn systemau ffisiolegol y corff, gan alluogi'r myfyriwr i ddeall canlyniadau pathoffisioleg i iechyd pobl.Rhoddir pwyslais ar y ffordd y mae methiannau systemau ffisiolegol allweddol yn arwain at glefyd, gan ddefnyddio enghreifftiau penodol i alluogi myfyrwyr i werthfawrogi'r berthynas rhwng ffisioleg/anatomeg a meddygaeth.Caiff egwyddorion sylfaenol ffisioleg eu hesbonio ag enghreifftiau clinigol priodol ac yn ystod darlithoedd ac mewn aseiniadau ymarferol.Bydd myfyrwyr yn cael profiad ymarferol o asesu swyddogaeth ffisiolegol yn ystod pedwar ymarfer yn y labordy. Asesir effaith pathoffisioleg mewn systemau o'r fath drwy astudiaethau achos clinigol.
PM-300 Medical Genetics

The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-347 Human Immunopathology

The module aims to provide students with a greater understanding of the human immune system and the causes of a range of diseases associated with immune dysfunction including autoimmune diseases, metabolic disorders and neurological conditions.
PMBM06J Fundamentals of Biomedical Sciences 2

This module has been designed to provide students with the fundamental knowledge and principle concepts of biomedical science from a scientific and practice basis. The module will cover the following key topics across the life span: ¿ Human Anatomy and Physiology ¿ across the life span ¿ Cellular biology from structure to pathology ¿ Good laboratory practice and Sustainability ¿ Key principles of cell pathology, clinical biochemistry, clinical microbiology, clinical immunology, clinical genetics and haematology ¿ Clinical Pathology ¿ Quality Management

Dr Luke Davies

Cyfeiriad ebost

Welsh language proficiency

LinkedIn Account

Dolenni Ymchwil

Trosolwg

Meysydd Arbenigedd

Uchafbwyntiau Gyrfa

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Holl Ymchwil

Erthyglau Cylchgronau

Modiwlau a Addysgir

PM-130 Fundamental Research Skills

PM-154 Human Physiology

PM-154C Ffisioleg Ddynol

PM-300 Medical Genetics

PM-344 Capstone Project

PM-347 Human Immunopathology

PMBM06J Fundamentals of Biomedical Sciences 2