Research in Lab Coat looking at results on screen.

Accelerating Biomedical Discoveries into Clinical Treatments

Translating research into new innovative therapies and treatments is a driving force for the Biomarkers and Genes research theme at the Medical School.

Research scientists employ a wide range of approaches from laboratory, mass spectrometry, computer modelling, and epidemiological studies to applied problems in the identification and use of biomarkers.

Working with the British Heart Foundation Cymru and expert researchers from across the world, the Medical School is developing new treatments for heart disease and helping improve the clinical management of patients. The Medical School has strong partnerships with clinicians, engineers and computer scientists from across Swansea University cementing it as Wales’s home for cardiovascular research.

With more than 20 Principal Investigators, the Medical School is also accelerating biomedical discoveries into clinical treatments for other major diseases, including neurological disorders, diabetes and cancer - with a strong focus on nanotoxicology.

Research Highlights

The Biomarkers and Genes theme has been key to much of our translation impact when it comes to improving outcomes for patients and insights for medical and public health professionals.

Our identification, understanding and use of Biomarkers coupled with world leading expertise in Genes allows us to continue to have significant impact upon the world’s premiere global health challenges, building upon our pioneering research contributions in genetic toxicology, DNA  repair mechanisms, and the genetics of microbes and cell organelles.

Self-Monitoring of Blood Glucose in non-insulin treated T2D: The SMBG Study

The value of Self-Monitoring of Blood Glucose (SMBG) in people with non-insulin treated T2D has been debated for many years with current UK guidelines limiting its use. We led a study across Wales and England to evaluate ‘Structured SMBG’ and demonstrated that it can provide clinically significant improvements in blood glucose control. We also found that it improved an individual’s quality of life. This evidence demonstrates that SMBG is a useful aide in diabetes self-management.

Cholesterol metabolites in Parkinson's disease diagnosis and therapy.

Parkinson's disease (PD) is a degenerative disorder of the central nervous system. We and others have previously shown that endogenous cholesterol metabolites are key factors for neurogenesis and neuronal survival. We currently study the function and mechanism of action of specific cholesterol metabolites that are up- or down-regulated in PD patients. Our aim is to utilise these metabolites as well as related compounds to ameliorate PD symptoms in rodent models of PD.

Biomarkers and Genes Core Research Focus

The critical mass of the Biomarkers and Genes theme comes from 4 key and distinct sub-themes, these sub-themes contribute to the collaborative and innovative culture of the Medical School’s research, each attracting significant and prestigious investment and a wealth of PhD and other research students.

Our Biomarkers and Genes Experts

Dr Roberto Angelini

Lecturer, Biomedical Sciences
+44 (0) 1792 602851
Available For Postgraduate Supervision

Dr Martin Clift

Associate Professor, Biomedical Sciences
+44 (0) 1792 602742
Available For Postgraduate Supervision

Professor Steve Bain

Professor in Medicine(Diabetes), Biomedical Sciences
+44 (0) 1792 602205
Available For Postgraduate Supervision

Professor Steve Conlan

Personal Chair, Biomedical Sciences
+44 (0) 1792 295386
Available For Postgraduate Supervision

Dr Jeffrey Davies

Associate Professor, Biomedical Sciences
+44 (0) 1792 602209
Available For Postgraduate Supervision

Professor Christopher George

Professor, Biomedical Sciences
+44 (0) 1792 513456
Available For Postgraduate Supervision

Professor Deya Gonzalez

Professor, Biomedical Sciences
+44 (0) 1792 295384
Available For Postgraduate Supervision

Professor Michael Gravenor

Professor, Health Data Science
+44 (0) 1792 602021
Available For Postgraduate Supervision

Professor William Griffiths

Professor in Mass Spectrometry, Biomedical Sciences
+44 (0) 1792 295562
Available For Postgraduate Supervision

Dr Owain Howell

Associate Professor, Biomedical Sciences
+44 (0) 1792 295066
Available For Postgraduate Supervision

Professor Gareth Jenkins

Personal Chair, Biomedical Sciences
+44 (0) 1792 602512
Available For Postgraduate Supervision

Dr George Johnson

Associate Professor, Biomedical Sciences
+44 (0) 1792 295158
Available For Postgraduate Supervision
Professor Paul Lewis

Professor Paul Lewis

Professor Emeritus (School of Management), Planning, Resources and Operations
Available For Postgraduate Supervision

Professor Steve Luzio

Personal Chair, Biomedical Sciences
+44 (0) 1792 295078
Available For Postgraduate Supervision

Dr Alwena Morgan

Senior Lecturer, Biomedical Sciences
+44 (0) 1792 602051
Available For Postgraduate Supervision

Professor David Owens

Chair, Biomedical Sciences
+44 (0) 1792 602208
Available For Postgraduate Supervision

Dr Owen Pickrell

Honorary Appointment (Medicine), Medicine
+44 (0) 1792 295134
Available For Postgraduate Supervision

Dr Sarah Prior

Senior Lecturer, Biomedical Sciences
+44 (0) 1792 602741
Available For Postgraduate Supervision

Professor David Skibinski

Professor Emeritus (Medicine), Medicine
+44 (0) 1792 295390

Professor Jeffrey Stephens

Personal Chair, Biomedical Sciences
+44 (0) 1792 602208
Available For Postgraduate Supervision

Professor Ian Pallister

Honorary Professor, Medicine
Available For Postgraduate Supervision

Dr Spyridon Theofilopoulos

Ser Cymru II Rising Star Fellow, Biomedical Sciences
+44 (0) 1792 513603
Available For Postgraduate Supervision