Owain Howell and his research team are interested in the biology of neuroinflammation and study the disease mechanisms of multiple sclerosis. Although great strides have been made in treating those people with the early form of the disease, we still do not understand why some people will experience a more severe, progressive disease. Our work looks at the pathomechanisms of multiple sclerosis using patient samples, cell cultures and post-mortem brain tissues.
Owain Howell leads undergraduate neuroscience teaching at Swansea University. Owain teaches undergraduate and postgraduate students and is a guest lecturer on the MSc in Translational Neuroscience program at Imperial College London.
Current projects focus on the role of complement in chronic neuroinflammatory disease, mapping cholesterol and oxysterols to sites of multiple sclerosis (MS) pathology and using digital pathology approaches to understand the pathophysiology of progressive MS.
We have active collaborations with Profs William Griffiths and Yuqin Wang and Dr Jeff Davies at Swansea University, Prof Richard Reynolds and Dr David Owen at Imperial College, Dr Roberta Magliozzi at the University Hospital Verona and with Prof Denise Fitzgerald at Queen’s University Belfast. We work in partnership with Prof William Gray, Cardiff University, as part of BRAIN.
This module will provide students with a broad introduction to fundamental concepts in Eukaryotic cell biology, such as investigating the origins of the cell, the structure or eukaryotic cells, the different types of specialised cells, and cells which help prevent disease. There will be a general focus on human cells throughout the module with some references to other organisms when needed. Students will gain practical experience in identification and differentiation of cells from different human and animal species.
In order to help students understand the biological basis for behavioural neuroscience and neurological disorders, this module seeks to integrate cell biology, physiology and biochemistry to understand the founding principles of neuroscience. The aim is to gain a mechanistic and holistic knowledge of the nervous system that builds from the molecular, cellular and developmental, to the systems level. In addition to exploring normal function, this module will introduce common disorders of the central and peripheral nervous systems in an integrated way. Students will be guided in exploring the scientific evidence around what is known and unknown and will be introduced to current research findings in the scientific literature.
Building on `An introduction to Neuroscience¿ this module will combine fundamental neuroscience with clinical neurology to provide a comprehensive understanding of the nervous system in health and disease.
The modern scientist graduate is expected to have gained extensive laboratory-based experience and this is certainly essential for any student intent on pursuing a research-based career. Skills for Researchers provides students with the opportunity to acquire the core skills to be able to conduct, analyse, interpret and present scientific experiments. A proportion of the module will be spent in the laboratory gaining hands-on experience. Skills acquired in this module will form the basis for future experimental work, including the final year project. Students will have the opportunity to provide feedback to peers and engage with a variety of online learning materials.
Nod y modiwl hwn yw rhoi cyfle i fyfyrwyr gael profiad dysgu capfaen drwy gymryd rhan yn eu prosiect eu hunain yn seiliedig ar gwestiwn ymchwil. Gall y prosiect fod mewn labordy neu heb fod yn labordy ond bydd bob amser yn cynnwys cwestiwn ymchwil sy'n deillio o'r llenyddiaeth, ac sy'n canolbwyntio ar bwnc perthnasol i wyddor feddygol. Bydd yn gofyn cwestiwn ymchwil newydd ac yn cynnwys dadansoddiad beirniadol o ganfyddiadau ymchwil. Bydd myfyrwyr yn mireinio eu sgiliau cyfathrebu llafar ac ysgrifenedig i lefel raddedig, drwy lunio cyflwyniad rhagarweiniol ar gefndir y prosiect, ynghyd â thraethawd estynedig a chyflwyniad llafar ar ganfyddiadau eu hymchwil.
The module aims to provide students with a greater understanding of the human immune system and the causes of a range of diseases associated with immune dysfunction including autoimmune diseases, metabolic disorders and neurological conditions.
The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an extended period. The projects undertaken will fall into one of the current medically-related research themes. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title.
This module will provide an introduction to the clinical presentation and manifestations of rare inherited and common diseases, and considers the patient and family perspective with respect to the role and impact of genomics. It reviews traditional and current strategies and techniques used to identify genes responsible for both common multifactorial and rare inherited diseases.
