We use a number of different NMR strategies to investigate binding of our novel small molecules to their targets. This allows us to obtain atomic-level information about the nature of the binding, and so inform further synthetic work.
Top: 1D 1H NMR spectrum of a peptide target alone (red) and with a small molecule bound (blue-green).
Bottom: 2D 1H-15N HSQC NMR spectrum of a protein target alone (black) and with a small molecule bound (red).