Specialist Subjects: Stochastic Analysis, Systems Biology, Cytometry, Evolutionary Computing, Intelligent Large-Scale Data Analysis/Simulation, Fractal Generation and Analysis

Systems Cytometry/Microscopy

High throughput experimental techniques, such as flow cytometry, provide detailed information of cell-cycle characteristics for large-scale cellular populations (i.e. > 104 cells). The Systems Cytometry group, formed as an alliance between Swansea and Cardiff universities, employ various stochastic simulation techniques to interpret experimental measurements that allow elucidation and clarification of cellular response and recovery to pharamacodynamic agents' over multiple generations.

Blood Coagulation

Quantification of a blood clot is of extreme importance to the monitoring and treatment of blood diseases and disorders. At present, no universally accepted measure of blood clotting exists, here in Swansea, we have and continue to apply fractal based measures to inform on both incipient and mature clot forms. These measures provide insight into both spatial arrangement of mass and ensuing clot complexity.

Evolutionary Programming

Many population-based evolutionary strategies have their origin in physical-biological processes; here in Swansea we are developing alternative and complementary optimisers' and seek to employ these to solve 'real-life' optimisation problems.

Publications

  1. & Predicting effective control parameters for differential evolution using cluster analysis of objective function features. Journal of Heuristics
  2. & The origin of heterogeneous nanoparticle uptake by cells. Nature Communications 10(1)
  3. & A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells. Archives of Toxicology
  4. & European sea bass show behavioural resilience to near-future ocean acidification. Royal Society Open Science 3(11), 160656
  5. An Analysis of the Practicalities of Multi-Color Nanoparticle Cellular Bar-Coding. Combinatorial Chemistry & High Throughput Screening 19(5), 362-369.

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Teaching

  • EG-353 Research Project

    The module involves the application of scientific and engineering principles to the solution of a practical problem associated with engineering systems and processes. The student will gain experience in working independently on a substantial, individually assigned task, using accepted planning procedures. It will require and develop self-organisation and the critical evaluation of options and results, as well as developing technical knowledge in the chosen topic.

  • EGNM03 Nanoscale Simulation

    ¿ Quantum mechanics ¿ Bohr model of the atom, Schrodinger equation, energy eigenvalues and wave functions of the hydrogen atom. ¿ Application of quantum mechanics to nano-scale semiconductor structures ¿ Semiconductor band structure, effective mass approximation, quantum wells, wires and dots, density of states for electrons, quantum devices. ¿ Molecular modelling ¿ Basic atomic forces and bonding, small molecule models, proteins, molecular modelling packages. ¿ Transport of particles ¿ Electron transport; diffusion and conduction, nano-fluidics, rate equations and Monte Carlo simulations.

  • EGW353 Research Project (Welsh)

    The module involves the application of scientific and engineering principles to the solution of a practical problem associated with engineering systems and processes. The student will gain experience in working independently on a substantial, individually assigned task, using accepted planning procedures. It will require and develop self-organisation and the critical evaluation of options and results, as well as developing technical knowledge in the chosen topic.

Supervision

  • Untitled (current)

    Student name:
    MSc
    Other supervisor: Dr Elisabeth Williams
  • Novel Anti-Microbial Metallic Surfaces for Infection Control (current)

    Student name:
    MSc
    Other supervisor: Dr Rowena Jenkins
  • Investigation Head Impact Dynamics AND EXPOSURE in Female Ice Hockey (current)

    Student name:
    MSc
    Other supervisor: Dr Elisabeth Williams
  • Validation of a Bespoke Instrumented Mouthguard (current)

    Student name:
    MSc
    Other supervisor: Dr Elisabeth Williams
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Elisabeth Williams
  • Tracking and analysis of movement at different scales: from endosomes to humans (current)

    Student name:
    PhD
    Other supervisor: Dr Andrew King
    Other supervisor: Dr Ines Fuertbauer
  • Solving the MOVement Rubik’s Cube: uncovering intra and interspecific«br /»«br /»«br /» movement strategies of large herbivores subjected to 6«br /»«br /»«br /» major movement constraints (current)

    Student name:
    PhD
    Other supervisor: Prof Luca Borger
  • Alpine ungulates movement (ALPEN): Quantification of spatiotemporal environmental energetics and social interaction. (current)

    Student name:
    PhD
    Other supervisor: Prof Luca Borger
  • Thermoelectric energy harvesting, design and modelling (current)

    Student name:
    PhD
    Other supervisor: Prof Lijie Li
  • The assembly of novel collagens for regenerative medicine (current)

    Student name:
    MSc
    Other supervisor: Dr Christopher Wright
  • Collective behaviour: from cells to humans (awarded 2019)

    Student name:
    PhD
    Other supervisor: Dr Andrew King
    Other supervisor: Dr Ines Fuertbauer