Dr Lydia Powell

Research Highlights

1. Pritchard, M., Powell, L., Adams, J., Menzies, G., Khan, S., Tøndervik, A., Sletta, H., Aarstad, O., Skjåk-Bræk, G., McKenna, S., Buurma, N., Farnell, D., Rye, P., Hill, K., & Thomas, D. (2023). Structure–Activity Relationships of Low Molecular Weight Alginate Oligosaccharide Therapy against Pseudomonas aeruginosa. Biomolecules, 13(9), 1366

   https://doi.org/10.3390/biom13091366, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64609

   http://dx.doi.org/10.3390/biom13091366
2. Xue, W., Pritchard, M., Khan, S., Powell, L., Stokniene, J., Wu, J., Claydon, N., Reddell, P., Thomas, D., & Hill, K. (2023). Defining in vitro topical antimicrobial and antibiofilm activity of epoxy-tigliane structures against oral pathogens. Journal of Oral Microbiology, 15(1)

   https://doi.org/10.1080/20002297.2023.2241326, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64590

   http://dx.doi.org/10.1080/20002297.2023.2241326
3. Powell, L., Adams, J., Quoraishi, S., Py, C., Oger, A., Gazze, S., Francis, L., Ruhland, C., Owens, D., Rye, P., Hill, K., Pritchard, M., & Thomas, D. (2023). Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms. Frontiers in Cellular and Infection Microbiology, 13

   https://doi.org/10.3389/fcimb.2023.1122340, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62485
4. Powell, L. & Wright, C. (2010). Application of AFM from microbial cell to biofilm. Scanning

   https://doi.org/10.1002/sca.20193, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6185
5. Powell, L., Powell, L., Sowedan, A., Khan, S., Wright, C., Hawkins, K., Onsøyen, E., Myrvold, R., Hill, K., Thomas, D., & Wright, C. (2013). The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms. Biofouling, 29(4), 413-421.

   https://doi.org/10.1080/08927014.2013.777954, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14404
6. Powell, L., Chun, Y., Phuc Thi, H., Powell, L., Lee, J., Kim, D., Choi, D., Lovitt, R., Kim, I., Mitra, S., & Chang, I. (2012). Exploring microbial communities and differences of cartridge filters (CFs) and reverse osmosis (RO) membranes for seawater desalination processes. Desalination, 298, 85-92.

   https://doi.org/10.1016/j.desal.2012.05.007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15022
7. Powell, L., Powell, L., Pritchard, M., Emanuel, C., Onsøyen, E., Rye, P., Wright, C., Hill, K., Thomas, D., & Wright, C. (2014). A Nanoscale Characterization of the Interaction of a Novel Alginate Oligomer with the Cell Surface and Motility ofPseudomonas aeruginosa. American Journal of Respiratory Cell and Molecular Biology, 50(3), 483-492.

   https://doi.org/10.1165/rcmb.2013-0287OC, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17357
8. Powell, L. & Wright, C. (2014). Alginate Oligosaccharides Inhibit Fungal Cell Growth and Potentiate the Activity of Antifungals against Candida and Aspergillus spp.. PLoS ONE, 9(11)

   https://doi.org/10.1371/journal.pone.0112518, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa21099
9. Powell, L., Rees, A., Powell, L., Chinga-Carrasco, G., Gethin, D., Syverud, K., Hill, K., & Thomas, D. (2015). 3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications. BioMed Research International, 2015, 1-7.

   https://doi.org/10.1155/2015/925757, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22361
10. Powell, L., Powell, L., Khan, S., Chinga-Carrasco, G., Wright, C., Hill, K., Thomas, D., & Wright, C. (2016). An investigation of Pseudomonas aeruginosa biofilm growth on novel nanocellulose fibre dressings. Carbohydrate Polymers, 137, 191-197.

    https://doi.org/10.1016/j.carbpol.2015.10.024, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26367
11. Powell, L., Pritchard, M., Powell, L., Menzies, G., Lewis, P., Hawkins, K., Wright, C., Doull, I., Walsh, T., Onsøyen, E., Dessen, A., Myrvold, R., Rye, P., Myrset, A., Stevens, H., Hodges, L., MacGregor, G., Neilly, J., Hill, K...., & Wright, C. (2016). A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease. Molecular Pharmaceutics, 13(3), 863-872.

    https://doi.org/10.1021/acs.molpharmaceut.5b00794, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26822
12. Powell, L. & Wright, C. (2014). Atomic Force Microscopy. The Encyclopaedia of Food Microbiology 2nd Edition (pp. 666-675).

    https://doi.org/10.1016/B978-0-12-384730-0.00217-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29904
13. Powell, L., Powell, L., Wright, C., & Hilal, N. (2017). Atomic force microscopy study of the biofouling and mechanical properties of virgin and industrially fouled reverse osmosis membranes. Desalination, 404, 313-321.

    https://doi.org/10.1016/j.desal.2016.11.010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30863
14. Powell, L., Pritchard, M., Powell, L., Khan, S., Griffiths, P., Mansour, O., Schweins, R., Beck, K., Buurma, N., Dempsey, C., Wright, C., Rye, P., Hill, K., Thomas, D., Ferguson, E., & Wright, C. (2017). The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Scientific Reports (Nature group), 7, 44731

    https://doi.org/10.1038/srep44731, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32518
15. Powell, L., Powell, L., Pritchard, M., Ferguson, E., Powell, K., Patel, S., Rye, P., Sakellakou, S., Buurma, N., Brilliant, C., Copping, J., Menzies, G., Lewis, P., Hill, K., & Thomas, D. (2018). Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides. npj Biofilms and Microbiomes, 4(1)

    https://doi.org/10.1038/s41522-018-0056-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40672

    http://orca.cf.ac.uk/110780/
16. Powell, L., Roberts, A., Powell, L., Pritchard, M., Thomas, D., & Jenkins, R. (2019). Anti-pseudomonad Activity of Manuka Honey and Antibiotics in a Specialized ex vivo Model Simulating Cystic Fibrosis Lung Infection. Frontiers in Microbiology, 10

    https://doi.org/10.3389/fmicb.2019.00869, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50103
17. Powell, L., Cullen, J., Boyle, G., Ridder, T., Yap, P., Xue, W., Pierce, C., Pritchard, M., Menzies, G., Abdulkarim, M., Adams, J., Stokniene, J., Francis, L., Gumbleton, M., Johns, J., Hill, K., Jones, A., Parsons, P., Reddell, P., & Thomas, D. (2022). Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds. Science Translational Medicine, 14(662)

    https://doi.org/10.1126/scitranslmed.abn3758, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61593
18. Powell, L., Abdulkarim, M., Stokniene, J., Yang, Q., Walsh, T., Hill, K., Gumbleton, M., & Thomas, D. (2021). Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking. npj Biofilms and Microbiomes, 7(1)

    https://doi.org/10.1038/s41522-020-00172-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61610
19. Ahmed, Z., Powell, L., Matin, N., Mearns-Spragg, A., Thornton, C., Khan, I., & Francis, L. (2021). Jellyfish Collagen: A Biocompatible Collagen Source for 3D Scaffold Fabrication and Enhanced Chondrogenicity. Marine Drugs, 19(8), 405

    https://doi.org/10.3390/md19080405, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61611
20. Oakley, J., Weiser, R., Powell, L., Forton, J., Mahenthiralingam, E., Rye, P., Hill, K., Thomas, D., & Pritchard, M. (2021). Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy. mSphere, 6(1)

    https://doi.org/10.1128/msphere.01216-20, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61612
21. Stokniene, J., Powell, L., Aarstad, O., Aachmann, F., Rye, P., Hill, K., Thomas, D., & Ferguson, E. (2020). Bi-Functional Alginate Oligosaccharide–Polymyxin Conjugates for Improved Treatment of Multidrug-Resistant Gram-Negative Bacterial Infections. Pharmaceutics, 12(11), 1080

    https://doi.org/10.3390/pharmaceutics12111080, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61613
22. Yang, Q., MacLean, C., Papkou, A., Pritchard, M., Powell, L., Thomas, D., Andrey, D., Li, M., Spiller, B., Yang, W., & Walsh, T. (2020). Compensatory mutations modulate the competitiveness and dynamics of plasmid-mediated colistin resistance in Escherichia coli clones. The ISME Journal, 14(3), 861-865.

    https://doi.org/10.1038/s41396-019-0578-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61614
23. Jack, A., Nordli, H., Powell, L., Farnell, D., Pukstad, B., Rye, P., Thomas, D., Chinga-Carrasco, G., & Hill, K. (2019). Cellulose Nanofibril Formulations Incorporating a Low-Molecular-Weight Alginate Oligosaccharide Modify Bacterial Biofilm Development. Biomacromolecules, 20(8), 2953-2961.

    https://doi.org/10.1021/acs.biomac.9b00522, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61615
24. Varache, M., Powell, L., Aarstad, O., Williams, T., Wenzel, M., Thomas, D., & Ferguson, E. (2019). Polymer Masked–Unmasked Protein Therapy: Identification of the Active Species after Amylase Activation of Dextrin–Colistin Conjugates. Molecular Pharmaceutics, 16(7), 3199-3207.

    https://doi.org/10.1021/acs.molpharmaceut.9b00393, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61616
25. Jack, A., Khan, S., Powell, L., Pritchard, M., Beck, K., Sadh, H., Sutton, L., Cavaliere, A., Florance, H., Rye, P., Thomas, D., & Hill, K. (2018). Alginate Oligosaccharide-Induced Modification of the lasI-lasR and rhlI-rhlR Quorum-Sensing Systems in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 62(5)

    https://doi.org/10.1128/aac.02318-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61617
26. Ferguson, E., Naseer, S., Powell, L., Hardwicke, J., Young, F., Zhu, B., Liu, Q., Song, B., & Thomas, D. (2018). Controlled release of dextrin-conjugated growth factors to support growth and differentiation of neural stem cells. Stem Cell Research, 33, 69-78.

    https://doi.org/10.1016/j.scr.2018.10.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61618
27. Pritchard, M., Powell, L., Jack, A., Powell, K., Beck, K., Florance, H., Forton, J., Rye, P., Dessen, A., Hill, K., & Thomas, D. (2017). A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness. Antimicrobial Agents and Chemotherapy, 61(9)

    https://doi.org/10.1128/aac.00762-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61619
28. Pritchard, M., Jack, A., Powell, L., Sadh, H., Rye, P., Hill, K., & Thomas, D. (2017). Alginate oligosaccharides modify hyphal infiltration of Candida albicans in an in vitro model of invasive human candidosis. Journal of Applied Microbiology, 123(3), 625-636.

    https://doi.org/10.1111/jam.13516, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61620
29. Jack, A., Nordli, H., Powell, L., Powell, K., Kishnani, H., Johnsen, P., Pukstad, B., Thomas, D., Chinga-Carrasco, G., & Hill, K. (2017). The interaction of wood nanocellulose dressings and the wound pathogen P. aeruginosa. Carbohydrate Polymers, 157, 1955-1962.

    https://doi.org/10.1016/j.carbpol.2016.11.080, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61621
30. Yang, Q., Li, M., Spiller, O., Andrey, D., Hinchliffe, P., Li, H., MacLean, C., Niumsup, P., Powell, L., Pritchard, M., Papkou, A., Shen, Y., Portal, E., Sands, K., Spencer, J., Tansawai, U., Thomas, D., Wang, S., Wang, Y...., & Walsh, T. (2017). Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms. Nature Communications, 8(1)

    https://doi.org/10.1038/s41467-017-02149-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61622
31. Roberts, J., Khan, S., Emanuel, C., Powell, L., Pritchard, M., Onsøyen, E., Myrvold, R., Thomas, D., & Hill, K. (2013). An in vitro study of alginate oligomer therapies on oral biofilms. Journal of Dentistry, 41(10), 892-899.

    https://doi.org/10.1016/j.jdent.2013.07.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61623
32. Francis, L., Yao, S., Powell, L., Griffiths, S., Berquand, A., Piasecki, T., Howe, W., Gazze, A., Farach-Carson, M., Constantinou, P., Carson, D., Margarit, L., Gonzalez, D., & Conlan, S. (2021). Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface. Journal of Nanobiotechnology, 19(1)

    https://doi.org/10.1186/s12951-021-00793-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56223
33. Quintela Vazquez, M., James, D., Pociute, A., Powell, L., Edwards, K., Coombes, Z., Garcia, J., Garton, N., Das, N., Lutchman-Singh, K., Margarit, L., Beynon, A., Rioja, I., Prinjha, R., Harker, N., Gonzalez, D., Conlan, S., Francis, L., & Johnson, A. (2023). Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells. Clinical Epigenetics, 15(1)

    https://doi.org/10.1186/s13148-023-01477-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64098

    http://dx.doi.org/10.1186/s13148-023-01477-x

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