Coronavirus: latest information
ILS1 Internal Atrium
Diane Kelly Profile Picture

Professor Diane Kelly

Personal Chair, Biomedical Sciences

Telephone number

+44 (0) 1792 602184

Email address

Research Links

Academic Office - 532
Fifth Floor
Institute of Life Science 1
Singleton Campus
Available For Postgraduate Supervision

About

Diane became interested in "Bio-transformations and Cytochromes P450" as an undergraduate and this was developed further during her PhD, a joint project between Imperial Cancer Research Fund, (now CRUK) and Swansea University (SU).  Her post-doctoral career began at Sheffield University, firstly in the Genetics Department and later in the Wolfson Institute of Biotechnology, where she has pursued a research focus on moctobial cytochrome P450 ever since.

After a move from Sheffield to Aberystwyth University, Diane came full circle to Swansea University as a Reader and then Professor in the newly formed Swansea Clinical School, in 2004.  Her research continues to be on Microbial Cytochrome P450 related to their biodiversity, including mycobacterial P450's and a range of fungi, with an emphasis on identifying targets for antimicrobial agents in both medicine and agriculture and the associated rise in resistance to current therapies.  Diane has published more than 200 related peer reviewed papers.

Diane is SU Co-lead on a European Regional Development Fund (ERDF) funded project, BEACON.  This is a £18.3 million project backed by EU and the Welsh Government.  BEACON won the 2014 RegioStars prize for the best Regional Project in the EU and is celebrating 10 years (2020) of successful collaborations between Welsh HEI's and Industry.

Diane is a panel reviewer for UKRC grants and for the Netherlands Organisation for Scientific Research (NWO), Vidi grants within the Innovational Research Incentives Scheme of the Domain Science.

Diane sits on the University's Nominations Committee.

Throughout her career Diane has always been passionate about equality both in and out of the work place and has been part of the SU Athena SWAN charter work since 2008, first as a member of the SU self-assessment tear (SAT) gaining the Bronze award in 2009 and then as chair for the successful Bronze Award renewal in 2012.  She has continued as a member of the SU SAT which gained a Silver Institutional award in 2017.  Diane chairs the Medical School's EDI committee and SAT, the School was awarded Bronze in 2014, Silver in 2016 and Silver 2019.  She is a founding member of the University Athena SWAN Strategy group and chairs and sits on UK Athena SWAN assessment panels.  She acts as a critical friend to other departments within her own and other Institutions preparing their submissions.

 

Areas Of Expertise

  • Microbial Cytochromes P450 (CYP’S)
  • Redox partners (from genes to proteins and biodiversity).
  • Fungal sterol biology
  • Antimicrobial resistance

Career Highlights

Research

The human burden of fungal disease has been shown to be larger than breast cancer, malaria or TB. In agriculture fungal disease is a major issue for Food Secruity.  The global market is $13.7bn for drugs and $7bn for fungicides pa. 

A major research emphasis that Diane is par of (http://www.p450swansea.co.uk/)has been to study function, structure and inhibition of cytochromes P450 (CYPs) in particular CYP51, the target for imidazole and triazole anti-fungals.  CYP51 is an enzyme in sterol biosynthesis (14a-demethylation of lanosterol) leading utimately to ergosterol in fungal membranes, or cholesterol in human cell membranes, respectively.  There is a pressing need to develop new drugs that are selective, lack adverse drug/drug interactions (as the mjor metabolism of drugs is by other CYPs) and combat the drug resistance problem in fungi.  Often the patients are immune-compromised and on prolonged or prophylatic treatment.

Research at Swansea has led to the development of materials and methods that include isolation and characterization of novel CYP proteins from medical and plant fungal pathogens, with an emphasis on identifying mode of action and mechanisms of resistance.  

Award Highlights

2017:  Diane was elected as Fellow of the Learned Society of Wales.  She is a member of the Society's A2 scrutiny panel.

Collaborations

Rothamsted Research

Universidade Estadual Paulista “Julio de Mesquita”, San Paulo Brazil

Aberystwyth University

Bangor University

Cardiff University (Pharmacy)

University of South Wales

UK Medical Schools Equalities Network