Professor Catherine Thornton

Professor Catherine Thornton
Personal Chair
Medicine
Telephone: (01792) 602122
Room: Academic Office - 214
Second Floor
Institute of Life Science 1
Singleton Campus

Publications

  1. & Label‐Free Identification of White Blood Cells Using Machine Learning. Cytometry Part A
  2. & Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation. Nature Communications 10(1)
  3. & Maternal serum, an isolation and expansion tool for umbilical cord matrix mesenchymal stromal cells. Tissue Engineering Part C: Methods
  4. & Artificial Shear Stress Effects on Leukocytes at a Biomaterial Interface. Artificial Organs
  5. & The Inflammatory Response to Ventricular Assist Devices. Frontiers in Immunology 9

See more...

Teaching

  • PM-249 Human Immunology

    The course is designed as an introduction to immunology and the human immune system. The course covers the fundamentals of immunology including functional perturbations associated with disease and experimental approaches to the study of immunology.

  • PM-304 Biomolecular Research Project

    *

  • PM-341 Human Biology and the Environment

    This module is intended to provide an understanding of how our environmental factors impact on key aspects of human biology. Various environmental factors such as diet, stress, and pollution will be considered with a focus on their effects on epigenetics, inflammation, gut microbiota, mitochondrial health, and oxidative stress in non-communicable diseases in particular (e.g. chronic respiratory disease, cancer and metabolic disorders). The effect of extreme environments (e.g. altitude, space) and ageing on multiple organ systems will be considered. Students will gain practical experience in communicating these issues to scientific and non-scientific audiences.

  • PM-344 Capstone Project

    The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

  • PM-347 Human Immunopathology

    The module aims to provide students with a greater understanding of the human immune system and the causes of a range of diseases associated with immune dysfunction including autoimmune diseases, metabolic disorders and neurological conditions.

  • PM-400 Advanced Research Project A

    The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an 9-month period. The project will fall into one of the current medically-related research themes: Biomarkers and Genes; Microbes and Immunity; Devices. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title. For example, a Genetics student could be assigned a project investigating gene function in an insect vector of a tropical disease, using the technique of RNA interference. The advanced research project is divided between 2 modules, PM-400 and PM-402. PM-400 includes the following components: (1) Preparation of a research poster, (2) A 15-minute audio recording giving a presentation of the research area, (3) Lab performance and (4) Oral defence of the project in an open viva (20-minute presentation followed by 10-minutes of questions).

  • PM-400C Prosiect Ymchwil Uwch A

    Mae'r prosiect ymchwil uwch yn elfen allweddol o'r flwyddyn astudio olaf. Mae'n rhoi cyfle i fyfyrwyr gael profiad o ymgymryd ag ymchwil arloesol yn y Sefydliad Gwyddor Bywyd a'r Ganolfan NanoIechyd am naw mis. Bydd y prosiect yn canolbwyntio ar un o'r themâu ymchwil canlynol sy'n berthnasol i'r gwyddorau meddygol: Biofarcwyr a Genynnau; Microbau ac Imiwnedd; Dyfeisiau. Bydd myfyrwyr yn defnyddio amrywiaeth o dechnegau dadansoddi uwch i ymchwilio i bwnc penodol. Yn ogystal, byddant yn cael profiad o lunio cynnig ymchwil a chyflwyno eu data mewn amrywiaeth o fformatau. Dynodir themâu ymchwil sy'n briodol i deitl gradd penodol. Er enghraifft, os yw myfyriwr yn astudio Geneteg, gellir dynodi prosiect yn ymchwilio i weithrediad gennyn mewn fector pryfed clefyd trofannol, gan ddefnyddio techneg ymyrraeth RNA. Rhennir y prosiect ymchwil uwch rhwng dau fodiwl, PM-400 a PM-402. Mae PM-400 yn cynnwys y cydrannau canlynol: (1) Llunio poster ymchwil; (2) Recordiad sain 15 munud sy'n cyflwyno'r maes ymchwil; (3) Perfformiad yn y labordy a (4) Amddiffyn y prosiect mewn arholiad llafar agored (cyflwyniad 20 munud i'w ddilyn gan 10 munud o gwestiynau).

  • PMLM01 Analytical Techniques for Medicinal Chemistry and Nanomedicine

    This module will enable students to understand the basic and advanced concepts of separation science, how it is integrated with several forms of compound detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to compound chemical characteristics and method application.

  • PMLM05 LC/MS Applications IV: Medical and life sciences

    Students will have the opportunity to gain extensive knowledge of the role mass spectrometry plays in biomarker discovery (proteins and small molecules).with its application to clinical diagnosis including the analysis of carbohydrates, glycoproteins and nucleic acids using activity-based proteomics and techniques for affinity pull-down.

Supervision

  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Nicholas Jones
    Other supervisor: Prof Catherine Thornton
  • Exploring metabolomic biomarkers using mass spectrometry (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Ed Dudley
  • Characterisation of proteins by Raman Spectroscopy and linkage to performance of commercial immunoassays. (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Prof Peter Dunstan
  • Investigation of Candida albicans diversity in an infertile cohort using next generation genetic analysis (current)

    Student name:
    PhD
    Other supervisor: Prof Paul Dyson
    Other supervisor: Prof Catherine Thornton
  • Ghrelin AMPK mediated mitochondrial dynamics (current)

    Student name:
    MSc
    Other supervisor: Dr Alwena Morgan
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Jeffrey Davies
  • Improving vibrational spectroscopy prospects in frontline clinical diagnosis. (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Deb Roy
  • Inhibiting IL-17 Production by Blocking Endogenous RORγt Agonists for the Treatment of Autoimmune Diseases (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Prof William Griffiths
    Other supervisor: Dr Jonathan Mullins
    Other supervisor: Prof Yuqin Wang
  • Machine Learning in Raman Spectroscopy for Cancer Diagnosis (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Prof Kenith Meissner
    Other supervisor: Prof Peter Dunstan
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Nicholas Jones
    Other supervisor: Prof Catherine Thornton
  • Disrupting the diagnostic paradigm for gestational diabetes using blood-based Raman spectroscopy. (current)

    Student name:
    PhD
    Other supervisor: Dr Ed Dudley
    Other supervisor: Prof Catherine Thornton
  • Spectroscopy and spectrometry approaches to elucidating the anti-cancer immune response (current)

    Student name:
    PhD
    Other supervisor: Dr Ed Dudley
    Other supervisor: Prof Catherine Thornton
  • Regulation of Metabolism in Multiple Myeloma (MM) in Humans (current)

    Student name:
    PhD
    Other supervisor: Dr James Cronin
    Other supervisor: Prof Catherine Thornton
  • Assessing the Role of the Ghrelin-axis in Extra-Hypothalamic Brain Function (awarded 2019)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Jeffrey Davies
  • Raman spectroscopy and colorectal cancer: towards early diagnosis and personalised medicine (awarded 2019)

    Student name:
    PhD
    Other supervisor: Prof Peter Dunstan
    Other supervisor: Prof Catherine Thornton
  • 3D Bioprinting Facial Cartilage Using Tissue Specific Stem/Progenitor Cells And Novel Nanocellulose Bioinks (awarded 2019)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Prof Iain Whitaker
  • The X4A trial: exercise for Asthma (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Gareth Stratton
    Other supervisor: Prof Gwyneth Davies
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Melitta Mcnarry
  • 'Assessing the effects of a viral mimic Poly (I:C) on insect (Galleria mellonella) innate immunity' (awarded 2018)

    Student name:
    MRes
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Christopher Coates
  • 'Determining the bioenergetic capacity of insect (Galleria mellonella) haemocytes' (awarded 2018)

    Student name:
    MRes
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Christopher Coates
  • 'Impact of ventricular assist devices on the activity of white blood cells and the implications for device design and testing.' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Karl Hawkins
    Other supervisor: Prof Catherine Thornton
  • 'Natural and Synthetic GHSR1a Agonists as Neuroprotective Agents in Models of Parkinson's Disease' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Jeffrey Davies