Institute of Life Science 2 Internal Atrium

Dr Sze Chim Lee

Senior data scientist, Medicine

+44 (0) 1792 602538

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Research Links

https://orcid.org/0000-0001-5822-6633

Open Plan Office - 307
Third Floor
Data Science Building
Singleton Campus

Available For Postgraduate Supervision

About

Dr. Sze Chim Lee is a senior research data scientist of the Medical School.

Areas Of Expertise

Health Informatics
Biology
Hearing Science
Neuroscience
Statistics

Publications

Research Highlights

Beer-Hammer, S., Lee, S., Mauriac, S., Leiss, V., Groh, I., Novakovic, A., Piekorz, R., Bucher, K., Chen, C., Ni, K., Singer, W., Harasztosi, C., Schimmang, T., Zimmermann, U., Pfeffer, K., Birnbaumer, L., Forge, A., Montcouquiol, M., Knipper, M...., & Lee, S. (2018). Gα_i Proteins are Indispensable for Hearing. Cellular Physiology and Biochemistry, 1509-1532.
https://doi.org/10.1159/000490867, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40822
https://www.karger.com/Article/FullText/490867
del Pozo Banos, M., John, A., McGregor, J., Jones, I., Lee, S., Walters, J., Owen, M., O'Donovan, M., DelPozo-Banos, M., Berridge, D., Lloyd, K., & Lee, S. (2018). Premature mortality among people with severe mental illness — New evidence from linked primary care data. Schizophrenia Research, 199, 154-162.
https://doi.org/10.1016/j.schres.2018.04.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39476
Wilke, T., Mueller, S., Lee, S., Majer, I., Heisen, M., & Lee, S. (2017). Drug survival of second biological DMARD therapy in patients with rheumatoid arthritis: a retrospective non-interventional cohort analysis. BMC Musculoskeletal Disorders, 18(1)
https://doi.org/10.1186/s12891-017-1684-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38116
Mauriac, S., Hien, Y., Bird, J., Carvalho, S., Peyroutou, R., Lee, S., Moreau, M., Blanc, J., Geyser, A., Medina, C., Thoumine, O., Beer-Hammer, S., Friedman, T., Rüttiger, L., Forge, A., Nürnberg, B., Sans, N., Montcouquiol, M., & Lee, S. (2017). Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome. Nature Communications, 8, 14907
https://doi.org/10.1038/ncomms14907, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38115
Möhrle, D., Ni, K., Varakina, K., Bing, D., Lee, S., Zimmermann, U., Knipper, M., Rüttiger, L., & Lee, S. (2016). Loss of auditory sensitivity from inner hair cell synaptopathy can be centrally compensated in the young but not old brain. Neurobiology of Aging, 44, 173-184.
https://doi.org/10.1016/j.neurobiolaging.2016.05.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38113
Chumak, T., Rüttiger, L., Lee, S., Campanelli, D., Zuccotti, A., Singer, W., Popelář, J., Gutsche, K., Geisler, H., Schraven, S., Jaumann, M., Panford-Walsh, R., Hu, J., Schimmang, T., Zimmermann, U., Syka, J., Knipper, M., & Lee, S. (2015). BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury. Molecular Neurobiology, 53(8), 5607-5627.
https://doi.org/10.1007/s12035-015-9474-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38114
Bing, D., Lee, S., Campanelli, D., Xiong, H., Matsumoto, M., Panford-Walsh, R., Wolpert, S., Praetorius, M., Zimmermann, U., Chu, H., Knipper, M., Rüttiger, L., Singer, W., & Lee, S. (2015). Cochlear NMDA Receptors as a Therapeutic Target of Noise-Induced Tinnitus. Cellular Physiology and Biochemistry, 35(5), 1905-1923.
https://doi.org/10.1159/000374000, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38112
Dettling, J., Franz, C., Zimmermann, U., Lee, S., Bress, A., Brandt, N., Feil, R., Pfister, M., Engel, J., Flamant, F., Rüttiger, L., Knipper, M., & Lee, S. (2013). Autonomous functions of murine thyroid hormone receptor TRα and TRβ in cochlear hair cells. Molecular and Cellular Endocrinology, 382(1), 26-37.
https://doi.org/10.1016/j.mce.2013.08.025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38111
Zuccotti, A., Lee, S., Campanelli, D., Singer, W., Satheesh, S., Patriarchi, T., Geisler, H., Köpschall, I., Rohbock, K., Nothwang, H., Hu, J., Hell, J., Schimmang, T., Rüttiger, L., Knipper, M., & Lee, S. (2013). L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2-mediated control of cochlear BDNF expression. Frontiers in Molecular Neuroscience, 6
https://doi.org/10.3389/fnmol.2013.00020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38108
Rüttiger, L., Singer, W., Panford-Walsh, R., Matsumoto, M., Lee, S., Zuccotti, A., Zimmermann, U., Jaumann, M., Rohbock, K., Xiong, H., Knipper, M., & Lee, S. (2013). The Reduced Cochlear Output and the Failure to Adapt the Central Auditory Response Causes Tinnitus in Noise Exposed Rats. PLoS ONE, 8(3), e57247
https://doi.org/10.1371/journal.pone.0057247, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38110
Singer, W., Zuccotti, A., Jaumann, M., Lee, S., Panford-Walsh, R., Xiong, H., Zimmermann, U., Franz, C., Geisler, H., Köpschall, I., Rohbock, K., Varakina, K., Verpoorten, S., Reinbothe, T., Schimmang, T., Rüttiger, L., Knipper, M., & Lee, S. (2012). Noise-Induced Inner Hair Cell Ribbon Loss Disturbs Central Arc Mobilization: A Novel Molecular Paradigm for Understanding Tinnitus. Molecular Neurobiology, 47(1), 261-279.
https://doi.org/10.1007/s12035-012-8372-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38109
Rees, S., Akbari, A., Collins, H., Lee, S., Marchant, A., Rees, A., Thayer, D., Wang, T., Wood, S., & John, A. (2019). Developing a standardised approach to the aggregation of inpatient episodes into person-based spells in all specialties and psychiatric specialties. BMC Medical Informatics and Decision Making, 19(1)
https://doi.org/10.1186/s12911-019-0953-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53019
Lee, S., del Pozo Banos, M., Lloyd, K., Jones, I., Walters, J., Owen, M., O'Donovan, M., & John, A. (2020). Area deprivation, urbanicity, severe mental illness and social drift — A population-based linkage study using routinely collected primary and secondary care data. Schizophrenia Research, 220, 130-140.
https://doi.org/10.1016/j.schres.2020.03.044, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53852
Kendall, K., John, A., Lee, S., Rees, E., Pardiñas, A., del Pozo Banos, M., Owen, M., O'Donovan, M., Kirov, G., Lloyd, K., Jones, I., Legge, S., & Walters, J. (2020). Impact of schizophrenia genetic liability on the association between schizophrenia and physical illness: data-linkage study. BJPsych Open, 6(6)
https://doi.org/10.1192/bjo.2020.42, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55778

All Research

Journal Articles

Kendall, K., John, A., Lee, S., Rees, E., Pardiñas, A., del Pozo Banos, M., Owen, M., O'Donovan, M., Kirov, G., Lloyd, K., Jones, I., Legge, S., & Walters, J. (2020). Impact of schizophrenia genetic liability on the association between schizophrenia and physical illness: data-linkage study. BJPsych Open, 6(6)
https://doi.org/10.1192/bjo.2020.42, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55778
Lee, S., del Pozo Banos, M., Lloyd, K., Jones, I., Walters, J., Owen, M., O'Donovan, M., & John, A. (2020). Area deprivation, urbanicity, severe mental illness and social drift — A population-based linkage study using routinely collected primary and secondary care data. Schizophrenia Research, 220, 130-140.
https://doi.org/10.1016/j.schres.2020.03.044, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53852
Rees, S., Akbari, A., Collins, H., Lee, S., Marchant, A., Rees, A., Thayer, D., Wang, T., Wood, S., & John, A. (2019). Developing a standardised approach to the aggregation of inpatient episodes into person-based spells in all specialties and psychiatric specialties. BMC Medical Informatics and Decision Making, 19(1)
https://doi.org/10.1186/s12911-019-0953-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53019
Beer-Hammer, S., Lee, S., Mauriac, S., Leiss, V., Groh, I., Novakovic, A., Piekorz, R., Bucher, K., Chen, C., Ni, K., Singer, W., Harasztosi, C., Schimmang, T., Zimmermann, U., Pfeffer, K., Birnbaumer, L., Forge, A., Montcouquiol, M., Knipper, M...., & Lee, S. (2018). Gα_i Proteins are Indispensable for Hearing. Cellular Physiology and Biochemistry, 1509-1532.
https://doi.org/10.1159/000490867, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40822
https://www.karger.com/Article/FullText/490867
del Pozo Banos, M., John, A., McGregor, J., Jones, I., Lee, S., Walters, J., Owen, M., O'Donovan, M., DelPozo-Banos, M., Berridge, D., Lloyd, K., & Lee, S. (2018). Premature mortality among people with severe mental illness — New evidence from linked primary care data. Schizophrenia Research, 199, 154-162.
https://doi.org/10.1016/j.schres.2018.04.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39476
Wilke, T., Mueller, S., Lee, S., Majer, I., Heisen, M., & Lee, S. (2017). Drug survival of second biological DMARD therapy in patients with rheumatoid arthritis: a retrospective non-interventional cohort analysis. BMC Musculoskeletal Disorders, 18(1)
https://doi.org/10.1186/s12891-017-1684-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38116
Mauriac, S., Hien, Y., Bird, J., Carvalho, S., Peyroutou, R., Lee, S., Moreau, M., Blanc, J., Geyser, A., Medina, C., Thoumine, O., Beer-Hammer, S., Friedman, T., Rüttiger, L., Forge, A., Nürnberg, B., Sans, N., Montcouquiol, M., & Lee, S. (2017). Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome. Nature Communications, 8, 14907
https://doi.org/10.1038/ncomms14907, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38115
Möhrle, D., Ni, K., Varakina, K., Bing, D., Lee, S., Zimmermann, U., Knipper, M., Rüttiger, L., & Lee, S. (2016). Loss of auditory sensitivity from inner hair cell synaptopathy can be centrally compensated in the young but not old brain. Neurobiology of Aging, 44, 173-184.
https://doi.org/10.1016/j.neurobiolaging.2016.05.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38113
Chumak, T., Rüttiger, L., Lee, S., Campanelli, D., Zuccotti, A., Singer, W., Popelář, J., Gutsche, K., Geisler, H., Schraven, S., Jaumann, M., Panford-Walsh, R., Hu, J., Schimmang, T., Zimmermann, U., Syka, J., Knipper, M., & Lee, S. (2015). BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury. Molecular Neurobiology, 53(8), 5607-5627.
https://doi.org/10.1007/s12035-015-9474-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38114
Bing, D., Lee, S., Campanelli, D., Xiong, H., Matsumoto, M., Panford-Walsh, R., Wolpert, S., Praetorius, M., Zimmermann, U., Chu, H., Knipper, M., Rüttiger, L., Singer, W., & Lee, S. (2015). Cochlear NMDA Receptors as a Therapeutic Target of Noise-Induced Tinnitus. Cellular Physiology and Biochemistry, 35(5), 1905-1923.
https://doi.org/10.1159/000374000, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38112
Dettling, J., Franz, C., Zimmermann, U., Lee, S., Bress, A., Brandt, N., Feil, R., Pfister, M., Engel, J., Flamant, F., Rüttiger, L., Knipper, M., & Lee, S. (2013). Autonomous functions of murine thyroid hormone receptor TRα and TRβ in cochlear hair cells. Molecular and Cellular Endocrinology, 382(1), 26-37.
https://doi.org/10.1016/j.mce.2013.08.025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38111
Zuccotti, A., Lee, S., Campanelli, D., Singer, W., Satheesh, S., Patriarchi, T., Geisler, H., Köpschall, I., Rohbock, K., Nothwang, H., Hu, J., Hell, J., Schimmang, T., Rüttiger, L., Knipper, M., & Lee, S. (2013). L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2-mediated control of cochlear BDNF expression. Frontiers in Molecular Neuroscience, 6
https://doi.org/10.3389/fnmol.2013.00020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38108
Rüttiger, L., Singer, W., Panford-Walsh, R., Matsumoto, M., Lee, S., Zuccotti, A., Zimmermann, U., Jaumann, M., Rohbock, K., Xiong, H., Knipper, M., & Lee, S. (2013). The Reduced Cochlear Output and the Failure to Adapt the Central Auditory Response Causes Tinnitus in Noise Exposed Rats. PLoS ONE, 8(3), e57247
https://doi.org/10.1371/journal.pone.0057247, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38110
Singer, W., Zuccotti, A., Jaumann, M., Lee, S., Panford-Walsh, R., Xiong, H., Zimmermann, U., Franz, C., Geisler, H., Köpschall, I., Rohbock, K., Varakina, K., Verpoorten, S., Reinbothe, T., Schimmang, T., Rüttiger, L., Knipper, M., & Lee, S. (2012). Noise-Induced Inner Hair Cell Ribbon Loss Disturbs Central Arc Mobilization: A Novel Molecular Paradigm for Understanding Tinnitus. Molecular Neurobiology, 47(1), 261-279.
https://doi.org/10.1007/s12035-012-8372-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38109

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