Mr Matthew Lawrence

Research Highlights

1. Sabra, A., Stanford, S., Storton, S., Lawrence, M., D’Silva, L., Morris, R., Evans, V., Wani, M., Potter, J., Evans, P., & Evans, A. (2016). Assessment of platelet function in patients with stroke using multiple electrode platelet aggregometry: a prospective observational study. BMC Neurology, 16(1)

   https://doi.org/10.1186/s12883-016-0778-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33047

   http://europepmc.org/abstract/med/27938345
2. Lawrence, M., Marsden, N., Kaczynski, J., Davies, G., Davies, N., Hawkins, K., Perumal, S., Brown, M., Morris, K., Davidson, S., Williams, P., & Evans, P. (2016). An Investigation Into the Effects of In Vitro Dilution With Different Colloid Resuscitation Fluids on Clot Microstructure Formation. Anesthesia & Analgesia, 123(5), 1081-1088.

   https://doi.org/10.1213/ANE.0000000000001536, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30087
3. Lawrence, M., Marsden, N., Mothukuri, R., Morris, R., Davies, G., Hawkins, K., Curtis, D., Brown, M., Williams, P., Evans, P., Williams, R., Brown, R., & Evans, A. (2016). The Effects of Temperature on Clot Microstructure and Strength in Healthy Volunteers. Anesthesia & Analgesia, 122(1), 21-26.

   https://doi.org/10.1213/ANE.0000000000000992, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27872

   http://www.scopus.com/inward/record.url?eid=2-s2.0-84951567216&partnerID=MN8TOARS
4. Lawrence, M., Sabra, A., Mills, G., Pillai, S., Abdullah, W., Hawkins, K., Morris, R., Davidson, S., D'Silva, L., Curtis, D., Brown, R., Weisel, J., Williams, R., & Evans, A. (2015). A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism. British Journal of Haematology, 168(4), 571-575.

   https://doi.org/10.1111/bjh.13173, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27555

   http://dx.doi.org/10.1111/bjh.13173
5. Lawrence, M., Sabra, A., Thomas, P., Obaid, D., D'Silva, L., Morris, R., Hawkins, K., Brown, R., Williams, R., Davidson, S., Chase, A., Smith, D., Evans, P., Lawrence, M., Evans, A., & Obaid, D. (2015). Fractal dimension: A novel clot microstructure biomarker use in ST elevation myocardial infarction patients. Atherosclerosis, 240(2), 402-407.

   https://doi.org/10.1016/j.atherosclerosis.2015.04.012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27876

   http://dx.doi.org/10.1016/j.atherosclerosis.2015.04.012
6. Evans, P., Hawkins, K., Lawrence, M., Barrow, M., Williams, P., Williams, R., Hawkins, K., & Lawrence, M. (2008). Studies of whole blood coagulation by oscillatory shear, thromboelastography and free oscillation rheometry. Clinical Hemorheology and Microcirculation, 38

   SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27886

   http://www.scopus.com/inward/record.url?eid=2-s2.0-42049090153&partnerID=MN8TOARS
7. Evans, P., Hawkins, K., Lawrence, M., Williams, P., Williams, R., Hawkins, K., Lawrence, M., & Evans, A. (2008). Rheometrical studies of blood clot formation by oscillatory shear, thromboelastography, sonoclot analysis and free oscillation rheometry. In AIP Conference Proceedings

   https://doi.org/10.1063/1.2964777, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27888

   http://www.scopus.com/inward/record.url?eid=2-s2.0-51149108508&partnerID=MN8TOARS
8. Evans, P., Hawkins, K., Morris, R., Thirumalai, N., Munro, R., Wakeman, L., Lawrence, M., Williams, P., Williams, R., Hawkins, K., Lawrence, M., & Evans, A. (2010). Gel point and fractal microstructure of incipient blood clots are significant new markers of hemostasis for healthy and anticoagulated blood. Blood, 116(17), 3341-3346.

   https://doi.org/10.1182/blood-2010-02-269324, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9876
9. Hawkins, K., Lawrence, M., Williams, P., Williams, R., Hawkins, K., & Lawrence, M. (2008). A study of gelatin gelation by Fourier transform mechanical spectroscopy. Journal of Non-Newtonian Fluid Mechanics, 148(1-3), 127-133.

   https://doi.org/10.1016/j.jnnfm.2007.05.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9877
10. Hawkins, K., Evans, P., Lawrence, M., Curtis, D., Davies, M., Williams, P., Williams, R., & Evans, A. (2010). The development of rheometry for strain-sensitive gelling systems and its application in a study of fibrin–thrombin gel formation. Rheologica Acta, 49(9), 891-900.

    https://doi.org/10.1007/s00397-010-0473-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10210
11. Evans, P., Hawkins, K., Lawrence, M., Williams, R., Barrow, M., Thirumalai, N., Williams, P., Barrow, M., Hawkins, K., Lawrence, M., & Evans, A. (2008). Rheometry and associated techniques for blood coagulation studies. Medical Engineering & Physics, 30(6), 671-679.

    https://doi.org/10.1016/j.medengphy.2007.08.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10211
12. Evans, P., Lawrence, M., Morris, R., Thirumalai, N., Munro, R., Wakeman, L., Beddel, A., Williams, P., Barrow, M., Curtis, D., Brown, M., Hawkins, K., Williams, R., Brown, R., & Evans, A. (2010). Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation. Rheologica Acta, 49(9), 901-908.

    https://doi.org/10.1007/s00397-010-0472-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10212
13. Curtis, D., Brown, M., Hawkins, K., Evans, P., Lawrence, M., Rees, P., Williams, P., Williams, R., Hawkins, K., Brown, R., Rees, P., Lawrence, M., Curtis, D., & Evans, A. (2011). Rheometrical and molecular dynamics simulation studies of incipient clot formation in fibrin-thrombin gels: An activation limited aggregation approach. Journal of Non-Newtonian Fluid Mechanics, 166(16), 932-938.

    https://doi.org/10.1016/j.jnnfm.2011.04.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12137
14. Lawrence, M., Kumar, S., Hawkins, K., Boden, S., Rutt, H., Mills, G., Sabra, A., Morris, R., Davidson, S., Badiei, N., Brown, M., Williams, P., Evans, P., Williams, R., Brown, R., & Evans, A. (2014). A new structural biomarker that quantifies and predicts changes in clot strength and quality in a model of progressive haemodilution. Thrombosis Research, 134(2), 488-494.

    https://doi.org/10.1016/j.thromres.2014.05.039, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18269
15. Stanford, S., Sabra, A., Lawrence, M., Morris, R., Storton, S., Wani, M., Hawkins, K., Williams, P., Potter, J., Evans, P., Williams, R., & Evans, A. (2014). Prospective Evaluation of Blood Coagulability and Effect of Treatment in Patients with Stroke Using Rotational Thromboelastometry. Journal of Stroke and Cerebrovascular Diseases

    https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.08.028, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19733
16. Davies, G., Stanford, S., Lawrence, M., Gill, D., Williams, P., Morris, K., Thomas, D., Evans, P., Williams, R., Lawrence, M., Evans, A., & Davies, G. (2012). Fractal analysis: a new biomarker for determining clot characteristics in critically ill patients. Critical Care, 16(Suppl 1), P430

    https://doi.org/10.1186/cc11037, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20027
17. Curtis, D., Badiei, N., Holder, A., Claypole, J., Deganello, D., Brown, R., Lawrence, M., Evans, A., Williams, R., & Hawkins, K. (2015). Assessment of the stress relaxation characteristics of critical gels formed under unidirectional shear flow by controlled stress parallel superposition rheometry. Journal of Non-Newtonian Fluid Mechanics, 222, 227-233.

    https://doi.org/10.1016/j.jnnfm.2014.12.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20274

    http://www.sciencedirect.com/science/article/pii/S0377025714002213
18. Badiei, N., Sowedan, A., Curtis, D., Brown, M., Lawrence, M., Campbell, A., Sabra, A., Evans, P., Weisel, J., Chernysh, I., Nagaswami, C., Williams, P., Hawkins, K., Williams, R., Hawkins, K., Brown, R., Lawrence, M., Curtis, D., & Evans, A. (2015). Effects of unidirectional flow shear stresses on the formation, fractal microstructure and rigidity of incipient whole blood clots and fibrin gels. Clinical Hemorheology and Microcirculation, 60(4), 451-464.

    https://doi.org/10.3233/CH-151924, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20275

    http://iospress.metapress.com/content/x8n12v54t223k178/?p=cbe5bd0efef946e0a0e2c9d4dd2f4b1c&pi=2
19. Stanford, S., Sabra, A., D’Silva, L., Lawrence, M., Morris, R., Storton, S., Brown, M., Evans, V., Hawkins, K., Williams, P., Davidson, S., Wani, M., Potter, J., Evans, P., Williams, R., Brown, R., & Evans, A. (2015). The changes in clot microstructure in patients with ischaemic stroke and the effects of therapeutic intervention: a prospective observational study. BMC Neurology, 15(1)

    https://doi.org/10.1186/s12883-015-0289-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20524
20. Davies, N., Harrison, N., Sabra, A., Lawrence, M., Noble, S., Davidson, S., Evans, V., Morris, R., Hawkins, K., Williams, P., Evans, P., Williams, R., Hawkins, K., Lawrence, M., Evans, A., & Davies, N. (2015). Application of ROTEM to assess hypercoagulability in patients with lung cancer. Thrombosis Research

    https://doi.org/10.1016/j.thromres.2015.03.021, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20596
21. Davies, G., Mills, G., Lawrence, M., Battle, C., Morris, K., Hawkins, K., Williams, P., Davidson, S., Thomas, D., Evans, P., Williams, R., & Evans, A. (2014). The Role of Whole Blood Impedance Aggregometry and Its Utilisation in the Diagnosis and Prognosis of Patients with Systemic Inflammatory Response Syndrome and Sepsis in Acute Critical Illness. PLoS ONE, 9(9), e108589

    https://doi.org/10.1371/journal.pone.0108589, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa21117
22. Davies, N., Harrison, N., Morris, R., Noble, S., Lawrence, M., D'Silva, L., Broome, L., Brown, R., Hawkins, K., Williams, R., Davidson, S., & Evans, A. (2015). Fractal dimension (df) as a new structural biomarker of clot microstructure in different stages of lung cancer. Thrombosis and Haemostasis, 114(6), 1251-1259.

    https://doi.org/10.1160/TH15-04-0357, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22970
23. Hawkins, K., Badiei, N., Weisel, J., Chernysh, I., Williams, P., Lawrence, M., Evans, P., Lawrence, M., & Evans, A. (2012). Fractal dimension: a biomarker for detecting acute thromboembolic disease. Critical Care, 16(Suppl 1), P431

    https://doi.org/10.1186/cc11038, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa28381

    http://europepmc.org/abstract/PMC/PMC3363849
24. D׳Silva, L., Wilczynska, M., Lewis, K., Lawrence, M., Hawkins, K., Williams, R., Stanford, S., Davidson, S., Morris, K., & Evans, A. (2016). Altered clot microstructure detected in obstructive sleep apnoea hypopnoea syndrome. Sleep Science, 9(1), 14-19.

    https://doi.org/10.1016/j.slsci.2016.02.175, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29370
25. Davies, N., Llwyd, O., Brugniaux, J., Davies, G., Marley, C., Hodson, D., Lawrence, M., D'Silva, L., Morris, R., Hawkins, K., Williams, P., Bailey, D., Evans, P., Williams, R., Hawkins, K., Lawrence, M., Evans, A., & Davies, N. (2016). Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals. Thrombosis Research, 143, 130-136.

    https://doi.org/10.1016/j.thromres.2016.05.018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29486
26. Davies, G., Pillai, S., Lawrence, M., Mills, G., Aubrey, R., D’Silva, L., Battle, C., Williams, R., Brown, R., Thomas, D., Morris, K., & Evans, A. (2016). The effect of sepsis and its inflammatory response on mechanical clot characteristics: a prospective observational study. Intensive Care Medicine, 42(12), 1990-1998.

    https://doi.org/10.1007/s00134-016-4496-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30088

    http://dx.doi.org/10.1007/s00134-016-4496-z
27. Lawrence, M., Marsden, N., Kaczynski, J., Davies, G., Davies, N., Hawkins, K., Perumal, S., Brown, M., Morris, K., Davidson, S., Williams, P., Evans, P., Brown, R., & Evans, A. (2016). An Investigation Into the Effects of In Vitro Dilution With Different Colloid Resuscitation Fluids on Clot Microstructure Formation. Anesthesia & Analgesia, 1

    https://doi.org/10.1213/ANE.0000000000001536, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30371
28. Broome, L., Battle, C., Lawrence, M., Evans, P., Dennis, M., & Evans, A. (2016). Cognitive Outcomes following Thrombolysis in Acute Ischemic Stroke: A Systematic Review. Journal of Stroke and Cerebrovascular Diseases, 25(12), 2868-2875.

    https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.07.048, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31585
29. Knowles, R., Lawrence, M., Ferreira, P., Hayman, M., D’Silva, L., Stanford, S., Sabra, A., Tucker, A., Hawkins, K., Williams, P., Warner, T., Evans, P., & Williams, R. (2017). Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties. Platelets, 1-9.

    https://doi.org/10.1080/09537104.2017.1306039, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33740
30. Davies, G., Lawrence, M., Pillai, S., Mills, G., Aubrey, R., Thomas, D., Williams, R., Morris, K., Evans, P., & Evans, A. (2018). The effect of sepsis and septic shock on the viscoelastic properties of clot quality and mass using rotational thromboelastometry: A prospective observational study. Journal of Critical Care, 44, 7-11.

    https://doi.org/10.1016/j.jcrc.2017.09.183, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35869
31. Lawrence, M., Davies, G., Nyberg, M., Whitley, J., Evans, V., Williams, R., Hellsten, Y., Evans, P., & Evans, A. (2018). The effect of tyramine infusion and exercise on blood flow, coagulation and clot microstructure in healthy individuals. Thrombosis Research, 170, 32-37.

    https://doi.org/10.1016/j.thromres.2018.07.025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43363
32. Sabra, A., Lawrence, M., Curtis, D., Hawkins, K., Williams, R., & Evans, A. (2020). In vitro clot model to evaluate fibrin-thrombin effects on fractal dimension of incipient blood clot. Clinical Hemorheology and Microcirculation, 74(2), 147-153.

    https://doi.org/10.3233/ch-190615, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51304
33. Marsden, N., Lawrence, M., Davies, N., Davies, G., Morris, K., Williams, R., Whitaker, I., Evans, P., Davies, N., Whitaker, I., & Evans, A. (n.d.) The effect of the acute inflammatory response of burns and its treatment on clot characteristics and quality: A prospective case controlled study. Burns

    https://doi.org/10.1016/j.burns.2019.11.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53052

All Research

• PM-230 Selected Medical Diagnostic Techniques

  This module looks at the design and operation of a wide range of instrumentation used to make measurements for diagnostic and monitoring of health and disease. The emphasis is on the underlying electrical, mechanical, chemical, optical and other engineering principles together with the advantages and limitations of techniques.

• PM-259 Contemporary themes and techniques in medical sciences

  This module aims to give students an overview of current and emerging themes in medical sciences, both from clinical and laboratory perspectives. This will cover topics generating high media interest, such as the zika virus and alternative methods of transplantation as well as new laboratory techniques. In addition, the module will be supported by two practical classes for which students will be required to conduct mini-projects based around the identification of patient samples and how these are presented as research cases. The module will also involve a one-day "conference", during which students will present data while experiencing a research conference atmosphere.

• PM-259C Themâu a thechnegau cyfoes yn y gwyddorau meddygol

  Nod y modiwl hwn yw rhoi trosolwg i fyfyrwyr o'r themâu presennol a'r rhai sy'n datblygu yn y gwyddorau meddygol, o safbwynt clinigol a'r labordy. Bydd yn ymdrin â phynciau sy'n denu sylw sylweddol yn y cyfryngau, megis y firws Zika a dulliau trawsblannu amgen yn ogystal â thechnegau labordy newydd. Yn ogystal, ategir y modiwl gan ddau ddosbarth ymarferol - disgwylir i fyfyrwyr ymgymryd â phrosiectau bach ar sail dadansoddi samplau cleifion, a sut caiff y rhain eu cyflwyno fel astudiaethau ymchwil. Bydd y modiwl hefyd yn cynnwys 'cynhadledd' undydd pan fydd myfyrwyr yn cyflwyno data ac yn cael profiad o awyrgylch cynhadledd ymchwil.

• Fractal dimension (Df) as a biomarker of thrombogenicity in blood from people with lung cancer. 2019 - 2021

  Funder: Stepping Stones grant, Velindre NHS Trust , £100,063

• Characterisation of clotting characteristics in atrial fibrillation patients presenting with stroke and their response to anticoagulant treatment 2017 - 2020

  Funder: Bristol Myers-Squibb (ERISTA Research Programme), £124,000

• Chairman of Wales REC 6, Health and Care Research Wales

  2018 - 2022