Dr Wendy Francis

Research Highlights

1. Francis, W., Ireland, R., Spear, A., Jenner, D., Watts, S., Kirkman, E., & Pallister, I. (2019). Flow Cytometric Analysis of Hematopoietic Populations in Rat Bone Marrow. Impact of Trauma and Hemorrhagic Shock. Cytometry Part A, 95(11), 1167-1177.

   https://doi.org/10.1002/cyto.a.23903, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51993
2. Jessop, Z., Al-Sabah, A., Francis, W., & Whitaker, I. (2016). Transforming healthcare through regenerative medicine. BMC Medicine, 14(1)

   https://doi.org/10.1186/s12916-016-0669-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29742
3. Francis, W., Bodger, O., & Pallister, I. (2012). Altered leucocyte progenitor profile in human bone marrow from patients with major trauma during the recovery phase.. Br J Surg, 99(11), 1591-1599.

   https://doi.org/10.1002/bjs.8919, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13008
4. Tu, Y., Xue, H., Francis, W., Davies, A., Pallister, I., Kanamarlapudi, V., & Xia, Z. (2013). Lactoferrin inhibits dexamethasone-induced chondrocyte impairment from osteoarthritic cartilage through up-regulation of extracellular signal-regulated kinase 1/2 and suppression of FASL, FAS, and Caspase 3. Biochemical and Biophysical Research Communications, 441(1), 249-255.

   https://doi.org/10.1016/j.bbrc.2013.10.047, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16395
5. Naderi, N., Wilde, C., Haque, T., Francis, W., Seifalian, A., Thornton, C., Xia, Z., & Whitaker, I. (2014). Adipogenic differentiation of adipose-derived stem cells in 3-dimensional spheroid cultures (microtissue): Implications for the reconstructive surgeon. Journal of Plastic, Reconstructive & Aesthetic Surgery, 67(12), 1726-1734.

   https://doi.org/10.1016/j.bjps.2014.08.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18931
6. Xia, Z., Francis, W., Kanamarlapudi, V., & Owens, S. (2014). The temporal expression of estrogen receptor alpha-36 and runx2 in human bone marrow derived mesenchymal stromal cells during osteogenesis. Biochem Biophys Res Commun

   https://doi.org/10.1016/j.bbrc.2014.09.111, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19126

   http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=25281901
7. Day, A., Francis, W., Fu, K., Pieper, I., Guy, O., Xia, Z., Guy, O., Francis, W., & Xia, Z. (2018). Osteogenic Potential of Human Umbilical Cord Mesenchymal Stem Cells on Coralline Hydroxyapatite/Calcium Carbonate Microparticles. Stem Cells International, 2018, 1-9.

   https://doi.org/10.1155/2018/4258613, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa46128

All Research

• PM-120 Skills for Geneticists

  This module is designed to develop the skills required for students of genetics and medical genetics.Students will meet with tutors and be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.Joint sessions will cover generic skills such as internet searching for scientific sources, referencing and plagiarism.

• PM-132 Eukaryotic Cell Biology

  This module will provide a broad introduction to fundamental concepts in Eukaryotic cell biology investigating the origins of the cell, cell structure and specialised cells and cells in disease. There will be a general focus on human cells throughout with reference to other organisms when needed. Students will gain practical experience in identification, differentiation of cells from different human and animal species.

• PM-132C Bioleg Celloedd Ewcaryotig

  Bydd y modiwl hwn yn darparu cyflwyniad bras i gysyniadau sylfaenol ym maes bioleg celloedd Ewcaryotig, gan ymchwilio i darddiad y gell, strwythur y gell a chelloedd arbenigol a chelloedd mewn clefyd. Bydd ffocws cyffredinol ar gelloedd dynol drwy gydol y modiwl, gan gyfeirio at organebau eraill yn ôl yr angen. Bydd myfyrwyr yn cael profiad ymarferol o nodi celloedd, gwahaniaethu rhwng gwahanol gelloedd dynol a rhywogaethau o anifeiliaid.

• PM-155 Introduction to Genetics and Evolution

  The module will provide an introduction to genetics and evolution. Concepts such as DNA discovery, structure and replication, gene transcription and translation, mechanisms of gene transmission, genome organisation, epigenetic modifications and mutations will be covered with an appreciation of how how these mechanisms have an impact on human disease and antibiotic resistance. The latter part of the module will cover the theory of evolution including natural selection, and explore the processes involved in speciation and how they can be applied at both the gene and whole organismal level.

• PM-200 Skills For Geneticists II

  This module will give assignments designed to build on essay writing and oral presentation skills introduced in level 1. It will also develop critical evaluation, analysis skills for the understanding of peer-reviewed research papers.

• PM-280 Skills for Researchers

  The modern scientist graduate is expected to have gained extensive laboratory-based experience and this is certainly essential for any student intent on pursuing a research-based career. Skills for Researchers provides students with the opportunity to acquire the core skills to be able to conduct, analyse, interpret and present scientific experiments. A large proportion of the module will be spent in the laboratory gaining hands-on experience. Skills acquired in this module will form the basis for future experimental work, including the final year project. Students will have the opportunity to provide feedback to peers and engage with a variety of online learning materials.

• PM-344 Capstone Project

  The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

• PM-347 Human Immunopathology

  The module aims to provide students with a greater understanding of the human immune system and the causes of a range of diseases associated with immune dysfunction including autoimmune diseases, metabolic disorders and neurological conditions.

• PM-358 Tissue Engineering and Regenerative Medicine

  This module will provide students with a firm understanding of the principles of Regenerative Medicine that extend from cellular to tissue and organ repair and regeneration. This module will focus on the practical aspects of revolutionary technologies, generated through research, that have the potential to significantly improve how we treat injury, illness and disease.

• PMGM11 Introduction to Human Genetics and Genomics

  The Introduction to Human Genetics and Genomics module is a subject-specific module in the MSc Genomic Medicine programme. This unit will provide essential and contemporary knowledge relating to genetic science and genetic disease. The module will prepare participants to understand disease genetics, how genomic medicine can be utilised to elucidate disease mechanisms and biology in the context of genomic medicine. It will provide core knowledge underpinning later modules.