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Lewis Francis Profile Picture

Dr Lewis Francis

Associate Professor, Biomedical Sciences

Telephone number

+44 (0) 1792 602716

Email address

Welsh language proficiency

Fluent Welsh Speaker

Research Links

Available For Postgraduate Supervision

About

Based at the Medical School, Dr Francis is an Associate Professor in Reproductive Biology and Gynaecological Oncology Research Group (RBGO), leading the groups Biophysics and Epigenetics research programmes. Lewis has developed tissue, cell and molecular biochemical and biophysical research approaches for functional cell and molecular analysis, in both human reproductive and regenerative medicine. Exploring cellular heterogeneity in complex tissue micro-environments, Lewis’ research aims to identify distinct cell populations for therapeutic targeting through advanced drug delivery systems. By adopting disease specific phenotype models in both cell line and patient derived systems, his research focuses on the exploration of biomarker expression, gene regulation networks and cell-matrix interactions in niche tissue spaces. Lewis is also programme director for the Nanomedicine MSc and, the Medical School director of ACNM, and deputy director of the CALIN project. 

Areas Of Expertise

  • Cell and molecular biophysics
  • High resolution microscopy
  • Reproductive Biology and Gynaecological Oncology
  • Genomics and epigenomics
  • Glycoprotein biology
  • Bioinformatics, machine learning and AI
  • Regenerative medicine

Career Highlights

Teaching Interests

Lewis is the programme director for the Nanomedicine MSc, hosts Genetic and Biochemistry MSCi students and lectures on a wide range of undergraduate courses (Genetic Analysis, Medical Genetics, Medical Engineering and Carbohydrate Metabolism).

Research

Utilising RBGO’s established clinical networks in ABMU, Lewis aims to provide high throughput, patient derived models for drug testing and analysis, interfacing with advanced biotechnology approaches. These approaches are also applicable to whole tissue animal model systems used to identify advanced repair approaches for degenerative diseases such as Osteoarthritis. He has become heavily involved in the development of advanced mathematical approaches and software tools for identifying and analysing correlative trends in large cell (fluorescence based), mechanobiology (topographical and mechanical) and epi-genomics research data analysis. 

Award Highlights

2016. Derek Brewer Invited Research Fellow; Cambridge University, Emmanuel College
2013. Invited Adjunct Professor; Biochemistry and Cell Biology, RICE University, Houston, Texas

 

Collaborations

Professor Cindy Farach-Carson; Director Clinical and Translational Research; University Texas, Health Science Centre at Houston
Professor Dan Carson; RICE University, Houston, Texas
Dr Francesca Taraballi; Houston Methodist Research Institute, Houston, Texas
Dr Fatima Merchant; College of Technology, University of Houston, Texas
Professor Clemens Kaminski; Department of Chemical Engineering and Biotechnology, Cambridge University
Dr Robert Henderson; Pharmacology, Cambridge University
Professor Frank Barry; REMEDI, National University of Ireland, Galway
Dr Matthew Cumming, New Zealand Plant and Food, New Zealand
Dr Laurent Charlet; University Grenoble Alpes, France
Dr Oomenn P Oomenn; Faculty of Medicine, University of Tempere, Finland
Significant Industrial Partnerships with; Porvair; Axis Bio; GSK; Bruker-nano; Reneuron; GE and others.