Dr Lewis Francis

Research Highlights

1. Minardi, S., Taraballi, F., Cabrera, F., Eps, J., Wang, X., Gazze, S., Fernandez-Mourev, J., Tampieri, A., Francis, L., Weiner, B., Tasciotti, E., & Francis, L. (2019). Biomimetic hydroxyapatite/collagen composite drives bone niche recapitulation in a rabbit orthotopic model. Materials Today Bio, 2, 100005

   https://doi.org/10.1016/j.mtbio.2019.100005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50993
2. Matthews, G., Levy, C., Laudone, G., Jones, K., Ridgway, C., Hallin, I., Gazze, S., Francis, L., Whalley, W., Schoelkopf, J., & Gane, P. (2018). Improved Interpretation of Mercury Intrusion and Soil Water Retention Percolation Characteristics by Inverse Modelling and Void Cluster Analysis. Transport in Porous Media

   https://doi.org/10.1007/s11242-018-1087-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40458
3. Stojković, M., Gonzalez-Garcia, J., Šupljika, F., Galiana-Rosello, C., Guijarro, L., Gazze, S., Francis, L., Piantanida, I., & Garcia-Espana, E. (2018). Specific and highly efficient condensation of GC and IC DNA by polyaza pyridinophane derivatives. International Journal of Biological Macromolecules

   https://doi.org/10.1016/j.ijbiomac.2017.11.156, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37670
4. Hornsby, A., Redhead, Y., Rees, D., Ratcliff, M., Reichenbach, A., Wells, T., Francis, L., Amstalden, K., Andrews, Z., & Davies, J. (2016). Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner. Psychoneuroendocrinology, 63, 198-207.

   https://doi.org/10.1016/j.psyneuen.2015.09.023, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26484
5. Corradetti, B., Taraballi, F., Minardi, S., Van Eps, J., Cabrera, F., Francis, L., Gazze, S., Ferrari, M., Weiner, B., Tasciotti, E., & Francis, L. (2016). Chondroitin Sulfate Immobilized on a Biomimetic Scaffold Modulates Inflammation While Driving Chondrogenesis. Stem Cells Translational Medicine, 5(5), 670-682.

   https://doi.org/10.5966/sctm.2015-0233, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27868
6. Warren, C., Grindel, B., Francis, L., Carson, D., & Farach-Carson, M. (2014). Transcriptional Activation by NFκB Increases Perlecan/HSPG2 Expression in the Desmoplastic Prostate Tumor Microenvironment. Journal of Cellular Biochemistry, 115(7), 1322-1333.

   https://doi.org/10.1002/jcb.24788, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27871
7. Francis, L., Lewis, P., Gonzalez, D., Ryder, T., Webb, G., Joels, L., White, J., Wright, C., Conlan, R., Wright, C., & Conlan, S. (2009). Progesterone induces nano-scale molecular modifications on endometrial epithelial cell surfaces. Biology of the Cell, 101(8), 481-493.

   https://doi.org/10.1042/BC20080189, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9823
8. Francis, L., Lewis, P., Wright, C., Conlan, R., Wright, C., Lewis, P., Conlan, S., & Francis, L. (2010). Atomic force microscopy comes of age. Biology of the Cell, 102(2), 133-143.

   SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9824

   https://onlinelibrary.wiley.com/doi/full/10.1042/BC20090127
9. Doak, S., Rogers, D., Jones, B., Wright, C., Doak, S., & Francis, L. (2008). High resolution imaging using a novel atomic force microscope and confocal laser scanning microscope hybrid instrument: essential sample preparation aspects. Histochemistry & cell biology, 130(5), 909-916.

   https://doi.org/10.1007/s00418-008-0489-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10128
10. FRANCIS, L., GONZALEZ, D., RYDER, T., BAER, K., REES, M., WHITE, J., CONLAN, R., WRIGHT, C., Wright, C., Conlan, S., Gonzalez, D., Rees, M., & Francis, L. (2010). Optimized sample preparation for high-resolution AFM characterization of fixed human cells. Journal of Microscopy, 240(2), 111-121.

    https://doi.org/10.1111/j.1365-2818.2010.03392.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10686
11. Khan, I., Gonzalez, L., Francis, L., Conlan, R., Gilbert, S., Singhrao, S., Burdon, D., Hollander, A., Duance, V., Archer, C., Conlan, S., & Francis, L. (2011). Interleukin-1β enhances cartilage-to-cartilage integration. European Cells and Materials, 22, 190-201.

    https://doi.org/10.22203/eCM.v022a15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10738
12. Khan, I., Francis, L., Theobald, P., Perni, S., Young, R., Prokopovich, P., Conlan, R., Archer, C., & Conlan, S. (2013). In vitro growth factor-induced bio engineering of mature articular cartilage. Biomaterials, 34(5), 1478-1487.

    https://doi.org/10.1016/j.biomaterials.2012.09.076, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13945
13. Dyson, P., Del Sol Abascal, R., Francis, L., & Facey, P. (2013). A novel bifunctional histone protein in Streptomyces: a candidate for structural coupling between DNA conformation and transcription during development and stress?. Nucleic Acids Research

    https://doi.org/10.1093/nar/gkt180, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14456
14. Gonzalez, D., Hamidi, N., Sol, R., Benschop, J., Nancy, T., Li, C., Francis, L., Tzouros, M., Krijgsveld, J., Holstege, F., Conlan, S., & Del Sol Abascal, R. (2014). Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Proceedings of the National Academy of Sciences, 111(7), 2500-2505.

    https://doi.org/10.1073/pnas.1307525111, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17235
15. Conlan, S. & Francis, L. (2016). Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB. Oncotarget

    https://doi.org/10.18632/oncotarget.7652, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26528
16. Teixeira, S., Lloyd, C., Yao, S., Gazze, ., Conlan, S., Francis, L., Azzopardi, E., & Whitaker, I. (2016). Polyaniline-graphene based α-amylase biosensor with a linear dynamic range in excess of 6 orders of magnitude. Biosensors and Bioelectronics, 85, 395-402.

    https://doi.org/10.1016/j.bios.2016.05.034, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27755

    http://dx.doi.org/10.1016/j.bios.2016.05.034
17. Howard, D., Garcia-Parra, J., Healey, G., Amakiri, C., Margarit, L., Francis, L., Gonzalez, D., Conlan, R., Conlan, S., & Garcia Parra, J. (2016). Antibody–drug conjugates and other nanomedicines: the frontier of gynaecological cancer treatment. Interface Focus, 6(6), 20160054

    https://doi.org/10.1098/rsfs.2016.0054, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33095
18. Zhang, Y., Morgan, B., Smith, R., Fellows, C., Thornton, C., Snow, M., Francis, L., & Khan, I. (2017). Platelet-rich plasma induces post-natal maturation of immature articular cartilage and correlates with LOXL1 activation. Scientific Reports, 7(1)

    https://doi.org/10.1038/s41598-017-02297-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33950
19. Gazze, S., Hallin, I., Quinn, G., Dudley, E., Matthews, G., Rees, P., Van Keulen, G., Doerr, S., & Francis, L. (2018). Organic matter identifies the nano-mechanical properties of native soil aggregates. Nanoscale, 10(2), 520-525.

    https://doi.org/10.1039/C7NR07070E, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37598
20. Barton, H., Berbel-Filho, W., Consuegra, S., Francis, L., Tizaoui, C., Conlan, R., Teixeira, S., Conlan, S., & Consuegra del Olmo, S. (2018). Ultrasensitive environmental assessment of xeno-estrogens in water samples using label-free graphene immunosensors. Analytical Biochemistry, 548, 102-108.

    https://doi.org/10.1016/j.ab.2018.02.027, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38938
21. Kyle, S., Jessop, Z., Al-Sabah, A., Hawkins, K., Lewis, A., Maffeis, T., Charbonneau, C., Gazze, A., Francis, L., Iakovlev, M., Nelson, K., Eichhorn, S., & Whitaker, I. (2018). Characterization of pulp derived nanocellulose hydrogels using AVAP® technology. Carbohydrate Polymers, 198, 270-280.

    https://doi.org/10.1016/j.carbpol.2018.06.091, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40840
22. Pan-Castillo, B., Gazze, S., Thomas, S., Lucas, C., Margarit, L., Gonzalez, D., Francis, L., Conlan, R., & Conlan, S. (2018). Morphophysical dynamics of human endometrial cells during decidualization. Nanomedicine: Nanotechnology, Biology and Medicine, 14(7), 2235-2245.

    https://doi.org/10.1016/J.NANO.2018.07.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43701
23. Terra, L., Dyson, P., Hitchings, M., Thomas, L., Abdelhameed, A., Banat, I., Gazze, S., Vujaklija, D., Facey, P., Francis, L., Quinn, G., & Dyson, P. (2018). A Novel Alkaliphilic Streptomyces Inhibits ESKAPE Pathogens. Frontiers in Microbiology, 9

    https://doi.org/10.3389/fmicb.2018.02458, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa44961

    http://dx.doi.org/10.3389/fmicb.2018.02458
24. Quintela, M., Sieglaff, D., Gazze, A., Zhang, A., Gonzalez, D., Francis, L., Webb, P., Conlan, R., & Conlan, S. (2019). HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells. Nanomedicine: Nanotechnology, Biology and Medicine, 17, 254-265.

    https://doi.org/10.1016/j.nano.2019.01.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48863
25. Bissardon, C., Proux, O., Bureau, S., Suess, E., Winkel, L., Conlan, S., Francis, L., Khan, I., Charlet, L., Hazemann, J., & Bohic, S. (2019). Sub-ppm level high energy resolution fluorescence detected X-ray absorption spectroscopy of selenium in articular cartilage. The Analyst, 144(11), 3488-3493.

    https://doi.org/10.1039/c9an00207c, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49778

    http://dx.doi.org/10.1039/c9an00207c
26. Pisano, S., Giustiniani, M., Francis, L., Gonzalez, D., Margarit, L., Sheldon, M., Paolino, D., Fresta, M., Sawhney, A., & Healey, G. (2019). Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract. Biomedical Microdevices, 21(2)

    https://doi.org/10.1007/s10544-019-0385-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49813
27. Teixeira, S., Abreu, C., Parkes, L., Davies, J., Yao, S., Sawhney, M., Margarit, L., Gonzalez, D., Pinto, I., Francis, L., Conlan, R., Conlan, S., Gonzalez, D., & Francis, L. (2019). Direct monitoring of breast and endometrial cancer cell epigenetic response to DNA methyltransferase and histone deacetylase inhibitors. Biosensors and Bioelectronics, 141, 111386

    https://doi.org/10.1016/j.bios.2019.111386, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50808
28. Younas, K., Quintela, M., Thomas, S., Garcia-Parra, J., Blake, L., Whiteland, H., Bunkheila, A., Francis, L., Margarit, L., Gonzalez, D., Conlan, S., & Francis, L. (2019). Delayed endometrial decidualisation in polycystic ovary syndrome; the role of AR-MAGEA11. Journal of Molecular Medicine, 97(9), 1315-1327.

    https://doi.org/10.1007/s00109-019-01809-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50966
29. Paradiso, F., Fitzgerald, J., Yao, S., Barry, F., Taraballi, F., Gonzalez, D., Conlan, S., & Francis, L. (2019). Marine Collagen Substrates for 2D and 3D Ovarian Cancer Cell Systems. Frontiers in Bioengineering and Biotechnology, 7

    https://doi.org/10.3389/fbioe.2019.00343, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52699
30. Abreu, C., Thomas, V., Knaggs, P., Bunkheila, A., Cruz, A., Rodrigues Teixeira, S., Alpuim, P., Francis, L., Gebril, A., Ibrahim, A., Margarit, L., Gonzalez, D., Freitas, P., Conlan, S., & Pinto, I. (2020). Non-invasive molecular assessment of human embryo development and implantation potential. Biosensors and Bioelectronics, 157, 112144

    https://doi.org/10.1016/j.bios.2020.112144, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53819
31. Morgan, B., Bauza-Mayol, G., Gardner, O., Zhang, Y., Levato, R., Archer, C., Weeren, R., Malda, J., Conlan, S., Francis, L., & Khan, I. (2020). Bone Morphogenetic Protein-9 Is a Potent Chondrogenic and Morphogenic Factor for Articular Cartilage Chondroprogenitors. Stem Cells and Development, 29(14)

    https://doi.org/10.1089/scd.2019.0209, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54205
32. Friguglietti, J., Das, S., Le, P., Fraga, D., Quintela Vazquez, M., Gazze, S., McPhail, D., Gu, J., Sabek, O., Gaber, A., Francis, L., Zagozdzon-Wosik, W., & Merchant, F. (2020). Novel Silicon Titanium Diboride Micropatterned Substrates for Cellular Patterning. Biomaterials, 244, 119927

    https://doi.org/10.1016/j.biomaterials.2020.119927, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54548
33. Toubhans, B., Gazze, S., Bissardon, C., Bohic, S., Gourlan, A., Gonzalez, D., Charlet, L., Conlan, S., & Francis, L. (2020). Selenium nanoparticles trigger alterations in ovarian cancer cell biomechanics. Nanomedicine: Nanotechnology, Biology and Medicine, 29, 102258

    https://doi.org/10.1016/j.nano.2020.102258, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54635
34. Toubhans, B., Gourlan, A., Telouk, P., Lutchman-Singh, K., Francis, L., Conlan, S., Margarit, L., Gonzalez, D., & Charlet, L. (2020). Cu isotope ratios are meaningful in ovarian cancer diagnosis. Journal of Trace Elements in Medicine and Biology, 62, 126611

    https://doi.org/10.1016/j.jtemb.2020.126611, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54643
35. Pisano, S., Pierini, I., Gu, J., Gazze, A., Francis, L., Gonzalez, D., Conlan, S., & Corradetti, B. (2020). Immune (Cell) Derived Exosome Mimetics (IDEM) as a Treatment for Ovarian Cancer. Frontiers in Cell and Developmental Biology, 8

    https://doi.org/10.3389/fcell.2020.553576, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55036
36. Paravati, R., De Mello, N., Onyido, E., Francis, L., Bruesehafer, K., Younas, K., Spencer-Harty, S., Conlan, S., Gonzalez, D., & Margarit, L. (2020). Differential regulation of osteopontin and CD44 correlates with infertility status in PCOS patients. Journal of Molecular Medicine, 98

    https://doi.org/10.1007/s00109-020-01985-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55414
37. Bauza, G., Pasto, A., Mcculloch, P., Lintner, D., Brozovich, A., Niclot, F., Khan, I., Francis, L., Tasciotti, E., & Taraballi, F. (2020). Improving the immunosuppressive potential of articular chondroprogenitors in a three-dimensional culture setting. Scientific Reports, 10(1)

    https://doi.org/10.1038/s41598-020-73188-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55672
38. Pisano, S., Wang, X., Garcia Parra, J., Gazze, S., Edwards, K., Feltracco, V., Hu, Y., He, L., Gonzalez, D., Francis, L., Conlan, S., & Li, C. (2020). Nanomicelles potentiate histone deacetylase inhibitor efficacy in vitro. Cancer Nanotechnology, 11(1)

    https://doi.org/10.1186/s12645-020-00070-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55789
39. Francis, L., Yao, S., Powell, L., Griffiths, S., Berquand, A., Piasecki, T., Howe, W., Gazze, A., Farach-Carson, M., Constantinou, P., Carson, D., Margarit, L., Gonzalez, D., & Conlan, S. (2021). Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface. Journal of Nanobiotechnology, 19(1)

    https://doi.org/10.1186/s12951-021-00793-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56223
40. Gazze, S., Thomas, S., Garcia-Parra, J., James, D., Rees, P., Marsh-Durban, V., Corteling, R., Gonzalez, D., Conlan, S., & Francis, L. (n.d.) High content, quantitative AFM analysis of the scalable biomechanical properties of extracellular vesicles. Nanoscale

    https://doi.org/10.1039/d0nr09235e, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56477

    http://dx.doi.org/10.1039/d0nr09235e

All Research

• Biodegradable Nanovectors for the Treatment of Advanced Ovarian Cancer. (current)

  PhD

  Other supervisor: Prof Juan Mareque-Rivas

• The development and application of a MeDIP assay to determine a link between epigenetics and metabolism in ovarian cancer progression (current)

  PhD

  Other supervisor: Dr James Cronin

• 3D-patient derived ovarian tumour models to elucidate biophysical tumour-stroma interaction during high-grade serous ovarian cancer progression «br /»«br /» (current)

  PhD

  Other supervisor: Prof Deyarina Gonzalez

• Bio-Geochemistry of ovarian cancer: Role of selenium nanoparticles in treatment and copper isotopes in detection of ovarian cancer. (awarded 2021)

  PhD

  Other supervisor: Prof Steve Conlan

• 'The impact of HBO1 in Ovarian Cancer' (awarded 2018)

  PhD

  Other supervisor: Prof Steve Conlan

• Biomimetic approaches for articular cartilage regeneration (awarded 2020)

  PhD

  Other supervisor: Dr Ilyas Khan

• Development and Characterisation of Microneedle-Assisted Transfersomes for Transdermal Drug Delivery (awarded 2020)

  PhD

  Other supervisor: Dr Zhidao Xia

• Utilising Marine Collagen as a Niche Structure for Enhanced Osteoarthritic Repair (awarded 2019)

  PhD

  Other supervisor: Dr Ilyas Khan

• Identification and Characterisation of tracheal cartilage derived stem cells for airway tissue engineering (awarded 2019)

  PhD

  Other supervisor: Dr Ilyas Khan

• 'Aberrant Epigenetics and the Differentiation of Gynaecological Cancers' (awarded 2018)

  PhD

  Other supervisor: Prof Steve Conlan

• '''Atomic force microscopy study of the interactions between colloids and surfaces- membranes and cells''' (awarded 2018)

  PhD

  Other supervisor: Dr Yon Ju-Nam

  Other supervisor: Dr Christopher Wright

• The application of solid state chromatin Immunoprecipitation (ChIP) for epigenetic profiling of insects. (awarded 2019)

  MRes

  Other supervisor: Dr Chris Cunningham

• Feasibility testing of a new nanotherapy for ovarian cancer (current)

  MSc

  Other supervisor: Dr Ruth Godfrey

• An investigation into molecular pathways activated during BMP9-induced post-natal maturation of articular cartilage (current)

  MSc

  Other supervisor: Dr Ilyas Khan

• Epigenetic mechanisms drive potential therapeutic development in gynaecological cancers (current)

  MSc

  Other supervisor: Prof Deyarina Gonzalez

• PM-153 Epigenetics, Gene Regulation and Disease

  Epigenetics and its role in gene expression.

• PM-243 Clinical Biochemistry & Physiology

  The module begins with a discussion of selected metabolic disorders of carbohydrate metabolism and their pathological consequences with particular emphasis on diabetes mellitus. The molecular mechanisms underlying polycystic ovarian syndrome are then considered. The role of glycosyltransferases in the synthesis of oligo- and polysaccharides, including glycoprotein assembly, is also explained Finally the module reviews mechanisms of protein transport and their relevance to storage diseases.

• PM-273 Advances in Toxicology: Pick Your Poison

  We are surrounded by substances that may do our bodies harm i.e. poisons. The harm these poisons causes depends on our exposure - the dose. The science of toxicology, a discipline that crosscuts biology, chemistry, pharmacology, and medicine, is based on the principle that the dose makes the poison. This module is compulsory for BSc Medical Pharmacology students and acts as a follow on from PM-147 Introduction to Toxicology: The Dose Makes the Poison. This module will provide students with the opportunity to expand their toxicology knowledge and apply it to three distinct fields within toxicology; analytical toxicology, forensic toxicology and clinical toxicology. Students will learn about the experimental procedures and techniques we employ for the isolation and detection of compounds as well as their effects on biological systems. Students will then learn about the role of employing these methods in the field of forensic toxicology and the role of toxicology within the legal system. Within the module, students will also learn about the role of clinical toxicology and patient presentation following poisoning events and the techniques we have for detection and treatment of toxicology within the clinical setting.

• PM-300 Medical Genetics

  The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.

• PM-357 Biomedical Laboratory Techniques

  The module will provide practical and in depth theory of applications and equipment available to MSci students in the biomedical research laboratories based at the Medical School. The module will provide guidelines and rationale for experimental design, and data and statistical analysis.

• PM-357C Technegau Labordy Biofeddygol

  Bydd y modiwl yn darparu damcaniaeth ymarferol a manwl o¿r cymwysiadau ac offer sydd ar gael i fyfyrwyr MSci yn y labordai ymchwil biofeddygol sydd wedi'u lleoli yn yr Ysgol Feddygaeth. Bydd y modiwl yn darparu canllawiau a rhesymeg ar gyfer cynlluniau arbrofol, a dadansoddiad data ac ystadegau.

• PM-358 Tissue Engineering and Regenerative Medicine

  This module will provide students with a firm understanding of the principles of Regenerative Medicine that extend from cellular to tissue and organ repair and regeneration. This module will focus on the practical aspects of revolutionary technologies, generated through research, that have the potential to significantly improve how we treat injury, illness and disease.

• PMLM01 Analytical Techniques for Medicinal Chemistry and Nanomedicine

  This module will enable students to understand the basic and advanced concepts of separation science, how it is integrated with several forms of compound detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to compound chemical characteristics and method application.

• PMNM11 Nanomedicines, pharmaceuticals and advanced therapeutics

  This module will explore the history and development of molecular medicines and pharmaceuticals, providing the basis for an advanced understanding of next generation therapeutic approaches. Using landmark technology and chemical development phases informed by separation science and mass spectrometry, the module uses an application driven approach to provide the student with an extensive knowledgebase of drug development, the pharmaceutical industry and nanotherapeutics. Students will be able to characterize and map the path of a drug from administration, to metabolism and elimination, and critically evaluate drug design and delivery approaches. Traditional small chemical entities used in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. Common target oncology and non-oncology disorders will provide the context; with students encouraged to explore targeted nanoparticle fabrication, drug encapsulation and release profiling, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems. Future molecular medicines such as antibody drug conjugates and kinase inhibitors will be taught by guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

• PMNMD0 Postgraduate Taught Masters Dissertation

  In this module the student will be able to gain extensive specialist expertise in a chosen topic which could be targeted to their future career in the field of nanomedicine. Students will be supervised by University academics and/or members of their research and innovation teams. A variety of project types are available that include: 1. Laboratory based experimental research and data analysis (dependant on laboratory access and capacity). 2. Analysis of experimental data originating from the project supervisor¿s laboratory* 3. Meta-analysis of publicly available experimental data* 4. Systematic analysis of publicly available reported data* *potentially linking with Swansea¿s data health science or clinical trials unit. Working with a dedicated academic supervisor students will develop a clear research question, experimental plan and derive, analyse and present research data. The research topic choice will be made in conjunction with the supervisor, based upon novelty, feasibility and practical considerations on a 'first come first served' basis. The final approval of the topic rests with the project supervisor. The module lead and academic tutor will provide additional support available throughout the module period. A series of information sessions and engagement events such as the 3 Minute Thesis and employability for an innovative and integral part of this module. A small number of placement opportunities may arise with external academic and industry partners. These opportunities will be highlighted early in the first semester, with placements, in the event of high demand, based on student academic performance.

• PMZM15 Nanomedicines and Therapeutics

  The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

• Senior Lecturer, NanoBiology, Swansea University

  March 2011 - March 2014

• Invited Associate Professor, Department of Nanomedicine, Houston Methodist Hospital Research Institute, Houston, Texas

  2013 - 2013

• Adjunct Professor, Biochemistry and Cell Biology, RICE University, Houston, Texas

  2013 - 2013

• Postdoctoral Research Assistant, Reproductive Biology Group, Institute of Life Sciences, College of Medicine, Swansea University

  2010 - 2011

• Postdoctoral Research Assistant, Active Motif Europe, Research and Development, Rixensart, Belgium

  2009 - 2010

• Medical Technical Officer, grade 2, Clinical and Molecular Cytogenetics, University Hospital of Wales, Cardiff and the Vale NHS Trust, Cardiff, UK

  2003 - 2005

• Research Assistant, Research and Development Section, Ortho-Clinical Diagnostics, Johnson and Johnson, Cardiff Laboratories,

  2003 - 2003

• Nanomedicine MSc Showcase

  February 2020

  Collaborate 2020, Swansea University

• Large multidisciplinary data sets inform advanced therapeutics in gynaecological oncology

  September 2019

  ELRIG conference, Alderley Park, Macclsfield, UK

• High throughput, large data sets to interpret gynaecological cancer heterogeneity

  October 2019

  GE In cell user meeting, Mannheim, Germany

• Large data, machine learning and AI in advanced therpaeutics

  November 2019

  CoreLife Analytics Workshop, Utrecht, Netherlands

• Epigenetic advances inform novel drug therapies in Endometrial cancer

  November 2018

  NRN Advanced Therapeutics, Swansea University

• Next generation, bespoke collagen matrices for advanced drug development and clinical applications in regenerative medicine

  June 2018

  New Zealand Plant and Food, Nelson, New Zealand

• Multiplex based immunosensing; flexible monitoring of the disease landscape

  2017

  Suzhou, China