Senior Lecturer
Medicine
Telephone: (01792) 606409
Room: Academic Office - 427
Fourth Floor
Institute of Life Science 1
Singleton Campus

I am interested in the roles metabolism and the immune system play in disease progression. In particular, I focus on the aberrant cell signalling pathways that lead to chronic inflammatory diseases and resistance to chemotherapy in cancer. I obtained my BSc in Medical Microbiology from King’s College London and was awarded a PhD from Swansea University Medical School for investigating the role inflammation plays in throat cancer progression. I am a Senior Lecturer for our Genetics and Biochemistry Degree programmes and a Fellow of The Higher Education Academy. I teach Human Immunology, Medical Genetics (Module coordinator), Biomedical techniques (Module coordinator) and Cancer Immunotherapy to BSc and Masters students.

Areas of Expertise

  • Cancer
  • Immunology
  • Cell signalling
  • Metabolism

Publications

  1. & Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation. Nature Communications 10(1)
  2. & Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation. Frontiers in Immunology 8
  3. & Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunology 9(5), 1125-1136.
  4. & Coordinated Role of Toll-Like Receptor-3 and Retinoic Acid-Inducible Gene-I in the Innate Response of Bovine Endometrial Cells to Virus. Frontiers in Immunology 8
  5. & Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. The FASEB Journal 29(4), 1516-1528.

See more...

Teaching

  • PM-249 Human Immunology

    The course is designed as an introduction to immunology and the human immune system. The course covers the fundamentals of immunology including functional perturbations associated with disease and experimental approaches to the study of immunology.

  • PM-300 Medical Genetics

    The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.

  • PM-304 Biomolecular Research Project

    *

  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

  • PM-344 Capstone Project

    The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

  • PM-347 Human Immunopathology

    The module aims to provide students with a greater understanding of the human immune system and the causes of a range of diseases associated with immune dysfunction including autoimmune diseases, metabolic disorders and neurological conditions.

  • PM-357 Biomedical Laboratory Techniques

    The module will provide practical and in depth theory of applications and equipment available to MSci students in the biomedical research laboratories based at the Medical School. The module will provide guidelines and rationale for experimental design, and data and statistical analysis.

  • PM-357C Technegau Labordy Biofeddygol

    Bydd y modiwl yn darparu damcaniaeth ymarferol a manwl o¿r cymwysiadau ac offer sydd ar gael i fyfyrwyr MSci yn y labordai ymchwil biofeddygol sydd wedi'u lleoli yn yr Ysgol Feddygaeth. Bydd y modiwl yn darparu canllawiau a rhesymeg ar gyfer cynlluniau arbrofol, a dadansoddiad data ac ystadegau.

  • PM-400 Advanced Research Project A

    The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an 9-month period. The project will fall into one of the current medically-related research themes: Biomarkers and Genes; Microbes and Immunity; Devices. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title. For example, a Genetics student could be assigned a project investigating gene function in an insect vector of a tropical disease, using the technique of RNA interference. The advanced research project is divided between 2 modules, PM-400 and PM-402. PM-400 includes the following components: (1) Preparation of a research poster, (2) A 15-minute audio recording giving a presentation of the research area, (3) Lab performance and (4) Oral defence of the project in an open viva (20-minute presentation followed by 10-minutes of questions).

  • PMNM04 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

  • PMNMD0 Postgraduate Taught Masters Dissertation

    Students will have the opportunity to join an established research group to work in a modern and well equipped laboratory or alternatively undertake a suitable non-laboratory based project. In this module the student will be able to gain extensive `hands on¿ specialist expertise in a chosen topic which could be targeted to their future career in the field of mass spectrometry. Please note that the topic choice will be made in conjunction with the supervisor, based upon novelty, feasibility and practical considerations on a 'first come first served' basis. The final approval of the topic rests with the module lead.

  • PMZM15 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

Supervision

  • Cellular regulation of protection against cholesterol-dependent cytolysins by steroids and oxysterols (current)

    Student name:
    MPhil
    Other supervisor: Prof Martin Sheldon
  • Maternal Immunological Adaptation to Pregnancy (current)

    Student name:
    MPhil
    Other supervisor: Prof Catherine Thornton
  • Candidate gene vs genome-wide association study approaches in ASD: A systematic review to determine any overlapping genes (current)

    Student name:
    MRes
    Other supervisor: Dr Owen Bodger
  • Investigating the genotoxicity of N-nitrosodimethylamine (NDMA) coupled with automated scoring of the micronucleus assay after using imaging flow cytometry. (current)

    Student name:
    MSc
    Other supervisor: Dr George Johnson
  • Analysis and Toxicological Assay Development Following the Assessment of Micronuclei Induction and Immune Response Pathways in Chemo-Sensitive and Chemo-Resistant Ovarian Cancer Models (current)

    Student name:
    MSc
    Other supervisor: Dr George Johnson
  • The role of cysteine desulfurase (NFS1) in iron nanoparticle-induced ferroptotic cancer cell death (current)

    Student name:
    PhD
    Other supervisor: Prof Martin Sheldon
  • Application of Benchmark Dose analysis to in vitro genotoxicity data for compound risk characterisation (current)

    Student name:
    MPhil
    Other supervisor: Dr George Johnson
  • Regulation of Metabolism in Multiple Myeloma (MM) in Humans (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
  • The development and application of a MeDIP assay to determine a link between epigenetics and metabolism in ovarian cancer progression (current)

    Student name:
    PhD
    Other supervisor: Dr Lewis Francis
  • Role of Mitochondrial pyruvate carrier in ovarian cancer progression (current)

    Student name:
    PhD
    Other supervisor: Prof Martin Sheldon
    Other supervisor: Prof Deyarina Gonzalez
  • Manipulation of squalene synthase to increase cytoprotection against cholesterol-dependent cytolysins (current)

    Student name:
    PhD
    Other supervisor: Prof Martin Sheldon
  • Multiplexed in vitro assay for genetic toxicology screening (current)

    Student name:
    PhD
    Other supervisor: Prof Paul Rees
    Other supervisor: Dr George Johnson
  • Targeting Therapy-Resistant Ovarian Cancer by Induction of Ferroptotic Cell Death (awarded 2019)

    Student name:
    MSc
    Other supervisor: Prof Martin Sheldon

Administrative Responsibilities

  • Co-Director - Swansea University Medical School Postgraduate Research

    2017 - Present

  • Co-Chair - Swansea University Medical School Postgraduate Research Committee

    2017 - Present

  • Co-Director - Swansea University Medical School Postgraduate Admissions

    2017 - Present

  • Member - Athena SWAN Communications and Culture Working Group

    2017 - Present

Career History

Start Date End Date Position Held Location
2017 Present Senior Lecturer Swansea University Medical School
2014 2017 Lecturer Swansea University Medical School

Key Grants and Projects

  • Countering the unrestrained inflammation of sepsis by targeting the JAK-STAT pathway in human macrophages 2016 - 2017

    Research Project reference: NRNRGMar010 , with Professor Martin Sheldon (Swansea University), Dr Jenna Bowen (Cardiff University)

Research Groups

  • Sheldon/Cronin Research Group

    Sheldon/Cronin Research Group