Publications

Journal Articles

  1. Warrilow, A., Nishimoto, A., Parker, J., Price, C., Flowers, S., Kelly, D., Rogers, P., Kelly, S. The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions Antimicrobial Agents and Chemotherapy
  2. Warrilow, A., Parker, J., Price, C., Rolley, N., Nes, W., Kelly, D., Kelly, S. Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens International Journal of Antimicrobial Agents
  3. Lamb, D., Follmer, A., Goldstone, J., Nelson, D., Warrilow, A., Price, C., True, M., Kelly, S., Poulos, T., Stegeman, J. On the occurrence of cytochrome P450 in viruses Proceedings of the National Academy of Sciences 116 25 12343 12352
  4. Zhou, W., Warrilow, A., Thomas, C., Ramos, E., Parker, J., Price, C., Vanderloop, B., Fisher, P., Loftis, M., Kelly, D., Kelly, S., Nes, W. Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1863 10 1164 1178
  5. Colley, T., Sehra, G., Chowdhary, A., Alanio, A., Kelly, S., Kizawa, Y., Armstrong-James, D., Fisher, M., Warrilow, A., Parker, J., Kelly, D., Kimura, G., Nishimoto, Y., Sunose, M., Onions, S., Crepin, D., Lagasse, F., Crittall, M., Shannon, J., McConville, M., King-Underwood, J., Naylor, A., Bretagne, S., Murray, J., Ito, K., Strong, P., Rapeport, G. In Vitro and In Vivo Efficacy of a Novel and Long Acting Fungicidal Azole, PC1244 on Aspergillus fumigatus Infection Antimicrobial Agents and Chemotherapy AAC.01941-17
  6. Hull, C., Warrilow, A., Rolley, N., Price, C., Donnison, I., Kelly, D., Kelly, S. Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases Biotechnology for Biofuels 10 1
  7. Warrilow, A., Parker, J., Price, C., Garvey, E., Hoekstra, W., Schotzinger, R., Wiederhold, N., Nes, W., Kelly, D., Kelly, S. The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51 Antimicrobial Agents and Chemotherapy 61 7 e00333-17
  8. Colley, T., Alanio, A., Kelly, S., Sehra, G., Kizawa, Y., Warrilow, A., Parker, J., Kelly, D., Kimura, G., Anderson-Dring, L., Nakaoki, T., Sunose, M., Onions, S., Crepin, D., Lagasse, F., Crittall, M., Shannon, J., Cooke, M., Bretagne, S., King-Underwood, J., Murray, J., Ito, K., Strong, P., Rapeport, G. In vitro and in vivo antifungal profile of a novel and long acting inhaled azole, PC945, on Aspergillus fumigatus infection Antimicrobial Agents and Chemotherapy AAC.02280-16
  9. Warrilow, A., Price, C., Parker, J., Rolley, N., Smyrniotis, C., Hughes, D., Thoss, V., Nes, W., Kelly, D., Holman, T., Kelly, S. Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa Scientific Reports 6 1
  10. Warrilow, A., Parker, J., Price, C., Nes, W., Garvey, E., Hoekstra, W., Schotzinger, R., Kelly, D., Kelly, S. The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme Antimicrobial Agents and Chemotherapy 60 8 4530 4538
  11. Price, C., Parker, J., Warrilow, A., Kelly, D., Kelly, S. Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens Pest Management Science n/a n/a
  12. Lamb, D., Warrilow, A., Rolley, N., Parker, J., Nes, W., Smith, S., Kelly, D., Kelly, S. Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51) Antimicrobial Agents and Chemotherapy 59 8 4707 4713
  13. Price, C., Warrilow, A., Parker, J., Mullins, J., Nes, W., Kelly, D., Kelly, S., Schottel, J. Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase Applied and Environmental Microbiology 81 10 3379 3386
  14. Parker, J., Warrilow, A., Price, C., Mullins, J., Kelly, D., Kelly, S. Resistance to antifungals that target CYP51 Journal of Chemical Biology 7 4 143 161
  15. Warrilow, A., Hull, C., Rolley, N., Parker, J., Nes, W., Smith, S., Kelly, D., Kelly, S., Kelly, S., Kelly, D., Parker, J., Hull, C., Warrilow, A. Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51) Applied and Environmental Microbiology 80 19 6154 6166
  16. Warrilow, A., Hull, C., Parker, J., Garvey, E., Hoekstra, W., Moore, W., Schotzinger, R., Kelly, D., Kelly, S., Kelly, S., Kelly, D., Parker, J., Hull, C., Warrilow, A. The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme Antimicrobial Agents and Chemotherapy 58 12 7121 7127
  17. Nie, D., Hoobler, E., Rai, G., Warrilow, A., Perry, S., Smyrniotis, C., Jadhav, A., Simeonov, A., Parker, J., Kelly, D., Maloney, D., Kelly, S., Holman, T., Kelly, S. Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy PLoS ONE 8 6
  18. Kelly, S., Kelly, D., Parker, J., Warrilow, A. Azole Affinity of Sterol 14alpha-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens Antimicrobial Agents and Chemotherapy 57 3 1360
  19. Hull, C., Bader, O., Parker, J., Weig, M., Gross, U., Warrilow, A., Kelly, D., Kelly, S., Kelly, D., Parker, J., Hull, C., Warrilow, A. Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations in ERG2 Antimicrobial Agents and Chemotherapy 56 12 6421
  20. Hull, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Kelly, D., Kelly, S., Kelly, D., Parker, J., Hull, C., Warrilow, A. Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B Antimicrobial Agents and Chemotherapy 56 8 4223 4232
  21. Warrilow, A., Mullins, J., Hull, C., Parker, J., Lamb, D., Kelly, D., Kelly, S., Mullins, J., Kelly, D., Parker, J., Hull, C., Warrilow, A. S279 Point Mutations in Candida albicans Sterol 14-  Demethylase (CYP51) Reduces in vitro Inhibition by Fluconazole. Antimicrobial Agents and Chemotherapy
  22. Agnew, C., Warrilow, A., Burton, N., Lamb, D., Kelly, S., Brady, R., Kelly, S., Warrilow, A. An Enlarged, Adaptable Active Site in CYP164 Family P450 Enzymes, the Sole P450 in Mycobacterium leprae Antimicrobial Agents and Chemotherapy 56 1 391 402
  23. Martel, C., Parker, J., Jackson, C., Warrilow, A., Rolley, N., Greig, C., Morris, S., Donnison, I., Kelly, D., Kelly, S., Kelly, S., Kelly, D., Parker, J., Hull, C., Greig, C., Warrilow, A. Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol Bioresource Technology 102 2 1503 1508
  24. Warrilow, A., Martel, C., Parker, J., Melo, N., Lamb, D., Nes, W., Kelly, D., Kelly, S., Kelly, S., Kelly, D., Parker, J., Hull, C., Warrilow, A. Azole Binding Properties of Candida albicans Sterol 14alpha-Demethylase (CaCYP51) Antimicrobial Agents and Chemotherapy 54 10 4235 4245
  25. Parker, J., Warrilow, A., Cools, H., Martel, C., Nes, W., Fraaije, B., Lucas, J., Kelly, D., Kelly, S., Kelly, S., Kelly, D., Parker, J., Hull, C., Warrilow, A. Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals Applied and Environmental Microbiology 77 4 1460 1465
  26. Martel, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Kelly, D., Kelly, S., Kelly, S., Kelly, D., Parker, J., Hull, C., Warrilow, A. A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14alpha-Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin B Antimicrobial Agents and Chemotherapy 54 9 3578 3583
  27. Warrilow, A., Melo, N., Martel, C., Parker, J., Nes, W., Kelly, S., Kelly, D., Kelly, S., Kelly, D., Parker, J., Warrilow, A. Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14alpha-Demethylase (CYP51) Isoenzymes A and B Antimicrobial Agents and Chemotherapy 54 10 4225 4234
  28. Martel, C., Parker, J., Warrilow, A., Rolley, N., Kelly, S., Kelly, D., Kelly, S., Parker, J., Hull, C., Warrilow, A. Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14alpha-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B Antimicrobial Agents and Chemotherapy 54 11 4920 4923
  29. Lamb, D., Lei, L., Zhao, B., Yuan, H., Jackson, C., Warrilow, A., Skaug, T., Dyson, P., Dawson, E., Kelly, S., Hachey, D., Waterman, M., Dyson, P., Kelly, S., Warrilow, A. Streptomyces coelicolor A3(2) CYP102 Protein, a Novel Fatty Acid Hydroxylase Encoded as a Heme Domain without an N-Terminal Redox Partner Applied and Environmental Microbiology 76 6 1975 1980
  30. Martel, C., Warrilow, A., Jackson, C., Mullins, J., Togawa, R., Parker, J., Morris, M., Donnison, I., Kelly, D., Kelly, S., Mullins, J., Kelly, S., Kelly, D., Parker, J., Hull, C., Warrilow, A. Expression, purification and use of the soluble domain of Lactobacillus paracasei β-fructosidase to optimise production of bioethanol from grass fructans Bioresource Technology 101 12 4395 4402
  31. Martel, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Rolley, N., Kelly, D., Kelly, S., Kelly, S., Kelly, D., Parker, J., Hull, C., Warrilow, A. Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans Antimicrobial Agents and Chemotherapy 54 11 4527 4533
  32. Lamb, D., Lei, L., Warrilow, A., Lepesheva, G., Mullins, J., Waterman, M., Kelly, S., Mullins, J., Kelly, S., Warrilow, A. The First Virally Encoded Cytochrome P450 Journal of Virology 83 16 8266 8269
  33. Melo, N., Moran, G., Warrilow, A., Dudley, E., Smith, S., Sullivan, D., Lamb, D., Kelly, D., Coleman, D., Kelly, S., Dudley, E., Kelly, S., Warrilow, A. CYP56 (Dit2p) in Candida albicans: Characterization and Investigation of Its Role in Growth and Antifungal Drug Susceptibility Antimicrobial Agents and Chemotherapy 52 10 3718 3724
  34. Warrilow, A., Ugochukwu, C., Lamb, D., Kelly, D., Kelly, S. Expression and Characterization of CYP51, the Ancient Sterol 14alpha-demethylase Activity for Cytochromes P450 (CYP), in the White-Rot Fungus Phanerochaete chrysosporium Lipids 43 12 1143 1153
  35. Warrilow, A., Jackson, C., Parker, J., Marczylo, T., Kelly, D., Lamb, D., Kelly, S., Kelly, S., Parker, J., Warrilow, A. Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis CYP164A2, a Homolog of ML2088, the Sole Cytochrome P450 Gene of Mycobacterium leprae Antimicrobial Agents and Chemotherapy 53 3 1157 1164