Dr Anna Seager

Research Highlights

1. Shah, U., Seager, A., Fowler, P., Doak, S., Johnson, G., Scott, S., Scott, A., & Jenkins, G. (2016). A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 808, 8-19.

   https://doi.org/10.1016/j.mrgentox.2016.06.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29535
2. Patni, S., Wynen, L., Seager, A., Morgan, G., White, J., & Thornton, C. (2009). Expression and Activity of Toll-Like Receptors 1–9 in the Human Term Placenta and Changes Associated with Labor at Term. Biology of Reproduction, 80(2), 243-248.

   https://doi.org/10.1095/biolreprod.108.069252, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10151
3. Macfarlane, T., Seager, A., Moller, M., Morgan, G., & Thornton, C. (2010). Thymic stromal lymphopoietin is present in human breast milk. Pediatric Allergy and Immunology, 21(2p2), e454-e456.

   https://doi.org/10.1111/j.1399-3038.2009.00916.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10152
4. Seager, A., Shah, U., Mikhail, J., Nelson, B., Marquis, B., Doak, S., Johnson, G., Griffiths, S., Carmichael, P., Scott, S., Scott, A., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., & Mikhail, J. (2012). Pro-oxidant Induced DNA Damage in Human Lymphoblastoid Cells: Homeostatic Mechanisms of Genotoxic Tolerance. Toxicological Sciences, 128(2), 387-397.

   https://doi.org/10.1093/toxsci/kfs152, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10909

   http://toxsci.oxfordjournals.org/content/early/2012/04/26/toxsci.kfs152.abstract
5. Seager, A., Shah, U., Brusehafer, K., Wills, J., Manshian, B., Chapman, K., Thomas, A., Scott, A., Doherty, A., Doak, S., Johnson, G., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., Bruesehafer, K., Shah, U., & Chapman, K. (2014). Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells. Mutagenesis, 29(3), 155-164.

   https://doi.org/10.1093/mutage/geu008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17804
6. Chapman, K., Wilde, E., Chapman, F., Verma, J., Shah, U., Stannard, L., Seager, A., Tonkin, J., Brown, R., Doherty, A., Johnson, G., Doak, S., & Jenkins, G. (2021). Multiple-endpoint in vitro carcinogenicity test in human cell line TK6 distinguishes carcinogens from non-carcinogens and highlights mechanisms of action. Archives of Toxicology, 95(1), 321-336.

   https://doi.org/10.1007/s00204-020-02902-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55186

All Research

• PM-147 Introduction to Toxicology: The Dose Makes the Poison

  We are surrounded by substances that may do our bodies harm i.e. poisons. The harm these poisons causes depends on our exposure - the dose. The science of toxicology, a discipline that crosscuts biology, chemistry, pharmacology, and medicine, is based on the principle that the dose makes the poison. This module will provide you with an introduction to toxicology and how dose-response relationships relate to the physiological effects of toxic substances. You will explore how they produce cellular and chemical changes that cause tissues and organs to malfunction. You will learn how the structure and function of these tissues can be affected to varying degrees and begin to understand how tissue may repair itself and when the damage is reversible, permanent or fatal. You will also learn how we use toxic substances to our advantage in both the laboratory and within the clinic.

• PM-259 Contemporary themes and techniques in medical sciences

  This module aims to give students an overview of current and emerging themes in medical sciences, both from clinical and laboratory perspectives. This will cover topics generating high media interest, such as the COVID virus and alternative methods of transplantation as well as new laboratory techniques. In addition, the module will be supported by two practical classes for which students will be required to conduct mini-projects based around the identification of patient samples and how these are presented as research cases.

• PM-259C Themâu a thechnegau cyfoes yn y gwyddorau meddygol

  Nod y modiwl hwn yw rhoi trosolwg i fyfyrwyr o'r themâu presennol a'r rhai sy'n datblygu yn y gwyddorau meddygol, o safbwynt clinigol a'r labordy. Bydd yn ymdrin â phynciau sy'n denu sylw sylweddol yn y cyfryngau, megis y firws Zika a dulliau trawsblannu amgen yn ogystal â thechnegau labordy newydd. Yn ogystal, ategir y modiwl gan ddau ddosbarth ymarferol - disgwylir i fyfyrwyr ymgymryd â phrosiectau bach ar sail dadansoddi samplau cleifion, a sut caiff y rhain eu cyflwyno fel astudiaethau ymchwil. Bydd y modiwl hefyd yn cynnwys 'cynhadledd' undydd pan fydd myfyrwyr yn cyflwyno data ac yn cael profiad o awyrgylch cynhadledd ymchwil.

• PM-317 Genetics of Cancer

  This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.

• PM-354 Cancer Pharmacology

  Cancer remains a significant cause of mortality in the modern world. Current and emerging chemotherapies, and the rationale, experimental, and clinical evidence of the pathways or molecules targeted will be explored. Causes of treatment-related side effects, and the therapies used to address these, will be discussed along with the mechanisms that lead to anti-cancer drug resistance.

• PMRM00 Introduction to the practice of Medical Physicists & Clinical Engineers in Health Care

  Provides a broad-based overview of the Medical Physics & Clinical Engineering discipline.