Lecturer in Applied Medical Sciences and Medical Pharmacology
Medicine
Telephone: (01792) 295056
Room: Academic Office - 110
First Floor
Institute of Life Science 1
Singleton Campus

Kate was awarded her BSc in Biochemistry from the University of Bath in 2010, before joining the In Vitro Toxicology Group at Swansea University in the same year to commence her PhD studies. Funded by the National Centre for the 3Rs (NC3Rs) and supervised by Professor Gareth Jenkins, Kate’s PhD centred on the improvement of existing in vitro genotoxicity tests. This involved the development of chronic dosing regimens and 3D tissue culture models.

Following the completion of her PhD laboratory work in 2014, Kate remained within the In Vitro Toxicology Group as a Postdoctoral Researcher, developing a novel in vitro carcinogenicity tool as a potential replacement for the two-year rodent bioassay. From her research activity, Kate has developed a keen interest in animal replacement science, specifically the potential of novel in vitro alternatives in furthering medical research.

Kate is currently a Lecturer in Applied Medical Sciences and Medical Pharmacology at Swansea University Medical School, commencing this role in 2018. Kate is Deputy Examinations Officer and leads several modules. Kate also contributes to teaching on other degree courses within the Medical School, such as the BSc Genetics and Biochemistry programmes and MSc Genomic Medicine and Nanomedicine programmes. Kate collaborates with and provides training to scientists at other institutions, most notably at the Thailand Institute of Scientific and Technological Research.4

Kate has been awarded several national and international prizes during her career to date, including the international Lush Young Researcher Prize (2016), as well as the Welsh Livery Guild Travel Scholarship and Best New Investigator Platform Presentation at the USA EEMGS Meeting (2014). Kate has also been the recipient of several small grants, including those awarded by the UK Environmental Mutagen Society and the NC3Rs.

Publications

  1. & The Micronucleus (MN) Assay Using Human-derived Cells. In The Micronucleus Assay in Toxicology. (pp. 169-191). Royal Society of Chemistry.
  2. & A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 825, 51-58.
  3. & Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N -methyl- N -nitrosourea. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 819, 38-46.
  4. & A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells. Archives of Toxicology, 1-7.
  5. & Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™). Particle and Fibre Toxicology 13(1)

See more...

Teaching

  • PM-003 Introduction to Molecular Biology

    This module will provide the learner with an introduction to molecular biology, classification of species and its applications in medical science. The concept of evolution and sexual reproduction and development will also be covered, and the processes of inheritance and genetic variation, particularly with regard to evolution and natural selection. This module will be supported by a practical session and essay with academic support on a topic relevant to the medical applications of molecular biology.

  • PM-138 Skills for Medical Sciences

    The aim of this module is to provide the student with basic skills required for laboratory research in the field of applied medical sciences. The module will be both theoretical and applied: the student will be instructed in methods essential for data acquisition and analyses but will also actively participate in the laboratory, using broadly applicable experimental techniques. They will also develop skills that are not experimental techniques themselves, but are nevertheless fundamental to the scientific process, such as `lab math,¿ sourcing information, referencing, ethics and health and safety.

  • PM-138C Sgiliau ar gyfer Gwyddorau Meddygol

    Nod y modiwl hwn yw darparu¿r sgiliau sylfaenol sydd eu hangen ar fyfyrwyr ar gyfer ymchwil labordy ym maes y gwyddorau meddygol cymhwysol. Bydd y modiwl yn cynnwys gwaith damcaniaethol a chymhwysol: caiff y myfyriwr ei hyfforddi mewn dulliau sy¿n hanfodol ar gyfer caffael data a¿i ddadansoddi, ond bydd hefyd yn cymryd rhan weithredol yn y labordy, gan ddefnyddio¿n fras y technegau arbrofol perthnasol. Byddant hefyd yn datblygu sgiliau nad ydynt yn dechnegau arbrofol yn eu hunain, ond sydd er hynny, yn sylfaenol i¿r broses wyddonol, megis, mathemateg y labordy¿, cyrchu gwybodaeth, cyfeirnodi, moeseg ac iechyd a diogelwch.

  • PM-140 Anatomy

    This module will help to discover the anatomy of the human body in a systems based approach (cardiovascular, gastrointestinal, musculo-skeletal, respiratory and nervous systems). Anatomy is a fundamental science and supports many areas of biology and medicine. As such, the topics chosen for this module are those most useful to other areas of biological science, with clinical significance. This module will be delivered through lectures and practical classes with demonstrators leading practical and self-studying activities. Support materials and laboratory space for self-directed learning, including prosections, plastic anatomical models, bones and skeletons, and computer based anatomical models will be available.

  • PM-147 The Dose Makes the Poison: Intro to Toxicology and Dose Response

    We are surrounded by substances that may do our bodies harm ¿ poisons. The harm these poisons causes depends on our exposure - the dose. The science of toxicology, a discipline that crosscuts biology, chemistry, pharmacology, and medicine, is based on the principle that the dose makes the poison. This module will provide you with an introduction to toxicology and how dose-response relationships relate to the physiological effects of toxic substances. You will explore how they produce cellular and chemical changes that cause tissues and organs to malfunction. You will learn how the structure and function of these tissues can be affected to varying degrees and begin to understand how tissue may repair itself and when the damage is permanent or fatal.

  • PM-226 Human and Medical Genetics

    The course is designed to introduce fundamental concepts in the study of human genetics with particular reference to the application of the principles to medicine. The course covers the role of genetics in human health and disease and methods for the detection of genetic variability in human populations.

  • PM-250 Infectious Disease and Parasitology

    The course will build on the fundamentals of microbiology and introduce new topics in bacteriology, mycology and parasitology. Level 5 Immunology (PM-249) is a pre-requisite. The course covers the fundamentals of infectious diseases, including clinical aspects, treatment / prevention, and experimental approaches to the study of infectious and parasitic organisms. The course will also cover topics including disease outbreaks, beneficial parasites, tropical disease and behaviour-modifying parasites.

  • PM-250C Clefydau Heintus a Pharasitoleg

    Bydd y cwrs yn adeiladu ar sylfeini microbioleg ac yn cyflwyno pynciau newydd ym meysydd bacterioleg, mycoleg a pharasitoleg. Mae Imiwnoleg Lefel 5 (PM-249) yn rhagofyniad. Mae'r cwrs yn ymdrin ag egwyddorion sylfaenol clefydau heintus, gan gynnwys agweddau clinigol, triniaeth/atal, ac ymagweddau arbrofol at astudio organebau heintus a pharasitig. Bydd y cwrs hefyd yn ymdrin â phynciau gan gynnwys achosion o glefydau, parasitiaid buddiol, clefydau trofannol a pharasitiaid sy'n effeithio ar ymddygiad.

  • PM-259 Contemporary themes and techniques in medical sciences

    This module aims to give students an overview of current and emerging themes in medical sciences, both from clinical and laboratory perspectives. This will cover topics generating high media interest, such as the zika virus and alternative methods of transplantation as well as new laboratory techniques. In addition, the module will be supported by two practical classes for which students will be required to conduct mini-projects based around the identification of patient samples and how these are presented as research cases. The module will also involve a one-day "conference", during which students will present data while experiencing a research conference atmosphere.

  • PM-259C Themâu a thechnegau cyfoes yn y gwyddorau meddygol

    Nod y modiwl hwn yw rhoi trosolwg i fyfyrwyr o'r themâu presennol a'r rhai sy'n datblygu yn y gwyddorau meddygol, o safbwynt clinigol a'r labordy. Bydd yn ymdrin â phynciau sy'n denu sylw sylweddol yn y cyfryngau, megis y firws Zika a dulliau trawsblannu amgen yn ogystal â thechnegau labordy newydd. Yn ogystal, ategir y modiwl gan ddau ddosbarth ymarferol - disgwylir i fyfyrwyr ymgymryd â phrosiectau bach ar sail dadansoddi samplau cleifion, a sut caiff y rhain eu cyflwyno fel astudiaethau ymchwil. Bydd y modiwl hefyd yn cynnwys 'cynhadledd' undydd pan fydd myfyrwyr yn cyflwyno data ac yn cael profiad o awyrgylch cynhadledd ymchwil.

  • PM-300 Medical Genetics

    The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.

  • PM-304 Biomolecular Research Project

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  • PM-317 Genetics of Cancer

    This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.

  • PM-342 Advances in Pharmacology

    Pharmacology is the science of how drugs act on the body and how the body acts on drugs. Pharmacology investigates the chemical and physical properties of drugs, how those properties confer actions on living tissues and how those actions affect health and disease. The beneficial, therapeutic effects of drugs will be discussed, but also some negative consequences of drug administration, such as toxicity, addiction and microbial drug-resistance.

  • PM-344 Capstone Project

    The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

  • PM-354 Cancer Pharmacology

    Cancer remains a significant cause of mortality in the modern world. Current and emerging chemotherapies, and the rationale, experimental, and clinical evidence of the pathways or molecules targeted will be explored. Causes of treatment-related side effects, and the therapies used to address these, will be discussed along with the mechanisms that lead to anti-cancer drug resistance.

  • PM-401 Science Communication

    This module will encompass a range of communication modes, from presentation of science to the general public to making a pitch for funding to `investors¿ The module will be run as a series of online seminars to prepare, firstly, for a short 3 minute thesis-like presentations to both a professional and non-professional audience. This will be complemented by preparation of short, New Scientist-style articles by each student on the topic of their presentation. Students will be assigned a topic that is appropriate to their degree title. For example, a Medical Geneticist could address recent advances in gene therapy. Subsequently, their task will be to produce a pitch to attract investment to commercialise their research. In the latter half of the module, the focus will be on skills-training for writing a scientific paper, preparing the ground for their project dissertations.

  • PMGM14 Molecular Pathology of Cancer and Application in Cancer Diagnosis, Screening, and Treatment

    This module covers the molecular mechanisms that underlie cancer development, growth and metastasis, and the differences between different cancers. It will explore the different molecular and cellular actions of anti-cancer treatments, the genomic factors affecting response and resistance to treatment, and the research approaches to anti-cancer drug design and development. Broad situations which confer a high cancer risk to a person and/or to other members of the same family will be discussed in the context of how genomic information may be integrated into cancer screening programmes. This module will prepare the students to interrogate the cancer data sets from the 100,000 Genomes Project as well as to interrogate cancer genomic datasets in general.

  • PMGM21 Pharmacogenomics & Stratified Healthcare