Dr William Walker
Senior Lecturer
Medicine
Telephone: (01792) 513482
Room: Academic Office - 227
Second Floor
Institute of Life Science 1
Singleton Campus

Areas of Expertise

  • immunology
  • allergy
  • siRNA
  • preclinical

Publications

  1. Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6. PLoS ONE 9(2), e90338
  2. & Evaluation of nasal epithelium sampling as a tool in the preclinical development of siRNA-based therapeutics for asthma. Journal of Cellular and Molecular Medicine 17(3), 356-364.
  3. & Identification of small interfering RNA targeting signal transducer and activator of transcription-6: characterisation and selection of candidates for pre-clinical development. J. RNAi Gene Silencing 6, 401-10.
  4. & RNA interference of STAT6 rapidly attenuates ongoing interleukin-13-mediated events in lung epithelial cells. Immunology 127, 256-266.
  5. Variation in dinucleotide (GT) repeat sequence in the first exon of the STAT6 gene is associated with atopic asthma and differentially regulates the promoter activity in vitro. Journal of Medical Genetics 41(7), 535-539.

See more...

Teaching

  • PM-304 Biomolecular Research Project

    *

  • PM-347 Human Immunopathology

    The module aims to provide students with a greater understanding of the human immune system and the causes of a range of diseases associated with immune dysfunction including autoimmune diseases, metabolic disorders and neurological conditions.

Supervision

  • Functional characterisation of EFA6R, a possible biomarker for Epithelial Ovarian Cancer (current)

    Student name:
    PhD
    Other supervisor: Dr William Walker
    Other supervisor: Prof Venkat Kanamarlapudi
  • Targeting the interleukin-13 receptor (IL-13R)alpha2 expressing pancreatic cancer by a novel hybrid lytic peptide drug (current)

    Student name:
    PhD
    Other supervisor: Dr William Walker
    Other supervisor: Prof Venkat Kanamarlapudi
  • Contemporary approaches to the diagnosis and management of Pancreatic Ductal Adenocarcinoma, examining the role of Raman Spectroscopy and ELISA in the development of reliable biomarkers to aid early diagnosis (current)

    Student name:
    MD
    Other supervisor: Dr William Walker
    Other supervisor: Prof Venkat Kanamarlapudi