Professor Paul Dyson
Professor
Biomedical Sciences
Telephone: (01792) 295667
Room: Academic Office - 111
First Floor
Institute of Life Science 1
Singleton Campus

Areas of Expertise

  • Molecular microbiology
  • Gene expression analysis
  • Cell biology
  • Bacterial symbionts of insects
  • Tumour-targetting bacteria

Publications

  1. Zhang, B., Wu, X., Tai, X., Sun, L., Wu, M., Zhang, W., Chen, X., Zhang, G., Chen, T., Liu, G., Dyson, P. Variation in Actinobacterial Community Composition and Potential Function in Different Soil Ecosystems Belonging to the Arid Heihe River Basin of Northwest China Frontiers in Microbiology 10
  2. Zhang, B., Tang, S., Yang, R., Chen, X., Zhang, D., Zhang, W., Li, S., Chen, T., Liu, G., Dyson, P. Streptomyces dangxiongensis sp. nov., isolated from soil of Qinghai-Tibet Plateau International Journal of Systematic and Evolutionary Microbiology
  3. Ansari, M., Walker, M., Dyson, P., Walker (neeWhitten), M. Fungi as Biocontrol Agents of Culicoides Biting Midges, the Putative Vectors of Bluetongue Disease Vector-Borne and Zoonotic Diseases
  4. Sherratt, D., Arthur, A., Dyson, P. Site-specific recombination Nature 294 5842 608 610
  5. Dyson, P. Transposon-encoded site-specific recombination: nature of the Tn3 DNA sequences which constitute the recombination site res.

See more...

Teaching

  • PM-226 Human and Medical Genetics

    The course is designed to introduce fundamental concepts in the study of human genetics with particular reference to the application of the principles to medicine. The course covers the role of genetics in human health and disease and methods for the detection of genetic variability in human populations.

  • PM-251 Microbial Molecular Genetics

    The control systems governing gene expression in prokaryotic cells are explored and the molecular basis for gene regulation introduced. Practical skills in obtaining and analysing data on a bacterial system are developed. The module then assesses the structure of the bacterial genome and how genetic analysis can be used to investigate structure and function of individual components of that genome. Specific examples explored in depth are the genetics of recombination and DNA repair. The technologies used for functional genomic analysis of fully sequenced bacteria are described with reference to analysis of human pathogens. Finally, the module includes examples of synthetic biology applied to bacteria.

  • PM-304 Biomolecular Research Project

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  • PM-308 Animal Development

    The module provides an understanding of the principles of animal development, introducing critical genes and their products that play roles in regulating metazoan development. Classical embryology will be integrated with contemporary molecular investigations into developmental mechanisms.

  • PM-314 Biotechnology & Protein Engineering

    The module aims to explain the biological basis of biotechnology and protein engineering: their limitations, industrial and medical importance. Students will develop their skills in gathering and interpreting relevant information.

  • PM-315 Skills For Geneticists III

    The module aims to develop the student¿s ability to critically analyse and synthesise advanced research topics in genetics and molecular biology, and their oral and written scientific presentation skills.

  • PM-315C Sgiliau ar gyfer Genetegwyr III

    Amcan y modiwl yw datblygu gallu'r myfyriwr i ddadansoddi'n feirniadol a syntheseiddio pynciau ymchwil uwch ym maes geneteg a bioleg foleciwlaidd, ac i feithrin eu sgiliau cyflwyno gwyddonol llafar ac ysgrifenedig.

  • PM-400 Advanced Research Project A

    The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an 9-month period. The project will fall into one of the current medically-related research themes: Biomarkers and Genes; Microbes and Immunity; Devices. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title. For example, a Genetics student could be assigned a project investigating gene function in an insect vector of a tropical disease, using the technique of RNA interference. The advanced research project is divided between 2 modules, PM-400 and PM-402. PM-400 includes the following components: (1) Preparation of a research poster, (2) A 15-minute audio recording giving a presentation of the research area, (3) Lab performance and (4) Oral defence of the project in an open viva (20-minute presentation followed by 10-minutes of questions).

  • PM-400C Prosiect Ymchwil Uwch A

    Mae'r prosiect ymchwil uwch yn elfen allweddol o'r flwyddyn astudio olaf. Mae'n rhoi cyfle i fyfyrwyr gael profiad o ymgymryd ag ymchwil arloesol yn y Sefydliad Gwyddor Bywyd a'r Ganolfan NanoIechyd am naw mis. Bydd y prosiect yn canolbwyntio ar un o'r themâu ymchwil canlynol sy'n berthnasol i'r gwyddorau meddygol: Biofarcwyr a Genynnau; Microbau ac Imiwnedd; Dyfeisiau. Bydd myfyrwyr yn defnyddio amrywiaeth o dechnegau dadansoddi uwch i ymchwilio i bwnc penodol. Yn ogystal, byddant yn cael profiad o lunio cynnig ymchwil a chyflwyno eu data mewn amrywiaeth o fformatau. Dynodir themâu ymchwil sy'n briodol i deitl gradd penodol. Er enghraifft, os yw myfyriwr yn astudio Geneteg, gellir dynodi prosiect yn ymchwilio i weithrediad gennyn mewn fector pryfed clefyd trofannol, gan ddefnyddio techneg ymyrraeth RNA. Rhennir y prosiect ymchwil uwch rhwng dau fodiwl, PM-400 a PM-402. Mae PM-400 yn cynnwys y cydrannau canlynol: (1) Llunio poster ymchwil; (2) Recordiad sain 15 munud sy'n cyflwyno'r maes ymchwil; (3) Perfformiad yn y labordy a (4) Amddiffyn y prosiect mewn arholiad llafar agored (cyflwyniad 20 munud i'w ddilyn gan 10 munud o gwestiynau).

  • PM-402 Advanced Research Project B

    The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an 9-month period. The project will fall into one of the current medically-related research themes: Biomarkers and Genes; Microbes and Immunity; Devices. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title. For example, a Genetics student could be assigned a project investigating gene function in an insect vector of a tropical disease, using the technique of RNA interference. The advanced research project is divided between 2 modules, PM-400 and PM-402. PM-402 comprises the final written dissertation.

Supervision

  • Effect of c-MYC Knockdown on PD-L1 Expression in Colorectal Cancer (current)

    Student name:
    MSc
    Other supervisor: Dr Nicholas Jones
  • Using symbiotic Asaia spp. to produce interfering RNA’s within mosquito hosts in order to interrupt offspring blood feeding ability. (current)

    Student name:
    MSc
    Other supervisor: Dr Miranda Walker (Neewhitten)
  • A Genome Sequence view of the Microbiome in Two Insect Species: Relevance to the Prey and Predator Relationship (current)

    Student name:
    PhD
    Other supervisor: Dr Ricardo Del Sol Abascal
  • Investigation of Candida albicans diversity in an infertile cohort using next generation genetic analysis (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
  • Microbiome Characterization Guides the Development of Novel Pest Control Strategies: Lessons Derived From F. occidentalis Microbial Symbionts (current)

    Student name:
    PhD
    Other supervisor: Dr Ricardo Del Sol Abascal
  • Bacterial Targeting and Manipulation of Tumour Cell Metabolism (current)

    Student name:
    PhD
    Other supervisor: Dr Claire Morgan
  • “DEVELOPING BACTERIAL MEDIATED RNAi AS A THERAPY FOR PANCREATIC CANCER” (awarded 2019)

    Student name:
    MSc
    Other supervisor: Dr Claire Morgan
  • 'Post Transcriptional gene silencing of Trypanosoma brucei brucei through endocytosis of dsRNA' (awarded 2018)

    Student name:
    MSc
    Other supervisor: Dr Miranda Walker (Neewhitten)