Institute of Life Science 1 internal Atrium view up

Professor Shareen Doak

Personal Chair

Biomedical Sciences

+44 (0) 1792 295388

s.h.doak@swansea.ac.uk

Academic Office - 404
Fourth Floor
Institute of Life Science 1
Singleton Campus

Available For Postgraduate Supervision

Research Links

https://orcid.org/0000-0002-6753-1987

About

Shareen Doak is Professor of Genotoxicology and Cancer in Swansea University Medical School. Shareen is co-lead of the In Vitro Toxicology Group. She is a UK and EUROTOX Registered Toxicologist, an invited Fellow of the Royal Society of Biology (FRSB) and an elected Fellow of the Learned Society of Wales (FLSW).
Shareen sits on the UK Government Committee on Mutagenicity (COM) and is Editor-in-Chief for Mutagenesis.
Shareen Coordinates the €13Million H2020 PATROLS project (www.patrols-h2020.eu) and is Director of the €12Million  Celtic Advanced Life Science Innovation Network (CALIN), an Ireland-Wales INTERREG operation established to build a innovation bridge between Wales and Ireland in life sciences.
Shareen’s research interests focus on the genotoxic profiles of engineered nanomaterials, the mechanisms underlying their DNA damaging potential and subsequent consequences upon human health. Her interests extend to the development of advanced 3D culture models and mechanism-based bioassays for safety assessment to reduce the need for animal testing.  While her prostate cancer research focuses on understanding the molecular basis of progression to invasive, aggressive disease; with an ultimate aim of identifying a prognostic biomarker panel for improved clinical management of patients.

Areas Of Expertise

Genetic Toxicology
Nanotoxicology
DNA Damage Mechanisms
Biomarkers / Molecular Biology of Prostate Cancer

Publications

Research Highlights

Suh, M., Park, J., Ko, G., Kim, J., Hwang, D., Rees, L., Conway, G., Doak, S., Kang, H., Lee, N., Hyeon, T., Lee, Y., & Lee, D. (2024). Optimization of micelle-encapsulated extremely small sized iron oxide nanoparticles as a T1 contrast imaging agent: biodistribution and safety profile. Journal of Nanobiotechnology, 22(1)
https://doi.org/10.1186/s12951-024-02699-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67147
Mitchell, S., Meldrum, K., Bateman, J., Tetley, T., Doak, S., & Clift, M. (2024). Development and characterisation of a novel complex triple cell culture model of the human alveolar epithelial barrier. In vitro models, 3(2-3), 125-137.
https://doi.org/10.1007/s44164-024-00075-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67177
Meldrum, K., Evans, S., Burgum, M., Doak, S., & Clift, M. (2024). Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro. Particle and Fibre Toxicology, 21(1)
https://doi.org/10.1186/s12989-024-00584-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66993
Groenewold, M., Bleeker, E., Noorlander, C., Sips, A., Zee, M., Aitken, R., Baker, J., Bakker, M., Bouman, E., Doak, S., Drobne, D., Dumit, V., Florin, M., Fransman, W., Gonzalez, M., Heunisch, E., Isigonis, P., Jeliazkova, N., Jensen, K...., & Scott-Fordsmand, J. (2024). Governance of advanced materials: Shaping a safe and sustainable future. NanoImpact, 35, 100513
https://doi.org/10.1016/j.impact.2024.100513, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66934
Jeliazkova, N., Longhin, E., Yamani, N., Rundén-Pran, E., Moschini, E., Serchi, T., Vrček, I., Burgum, M., Doak, S., Cimpan, M., Rios-Mondragon, I., Cimpan, E., Battistelli, C., Bossa, C., Tsekovska, R., Drobne, D., Novak, S., Repar, N., Ammar, A...., & Dusinska, M. (2024). A template wizard for the cocreation of machine-readable data-reporting to harmonize the evaluation of (nano)materials. Nature Protocols, 19(9), 2642-2684.
https://doi.org/10.1038/s41596-024-00993-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66932
Burgum, M., Ulrich, C., Partosa, N., Evans, S., Gomes, C., Seiffert, S., Landsiedel, R., Honarvar, N., & Doak, S. (2024). Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices. Mutagenesis, 39(3), 205-217.
https://doi.org/10.1093/mutage/geae010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65963
http://dx.doi.org/10.1093/mutage/geae010
Lawrence, R., Munn, K., Naser, H., Thomas, L., Haboubi, H., Williams, L., Doak, S., & Jenkins, G. (2023). The PIG-A gene mutation assay in human biomonitoring and disease. Environmental and Molecular Mutagenesis, 64(8-9), 480-493.
https://doi.org/10.1002/em.22577, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65085
Brown, S., Evans, S., Burgum, M., Meldrum, K., Herridge, J., Akinbola, B., Harris, L., Jenkins, R., Doak, S., Clift, M., & Wilkinson, T. (2024). An In Vitro Model to Assess Early Immune Markers Following Co-Exposure of Epithelial Cells to Carbon Black (Nano)Particles in the Presence of S. aureus: A Role for Stressed Cells in Toxicological Testing. Biomedicines, 12(1), 128
https://doi.org/10.3390/biomedicines12010128, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65427
Chapman, K., Shah, U., Fletcher, J., Johnson, G., Doak, S., & Jenkins, G. (2024). An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens. Mutagenesis, 39(2), 69-77.
https://doi.org/10.1093/mutage/geae004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65653
Naser, H., Munn, K., Lawrence, R., Wright, R., GREWAL, E., Williams, L., Doak, S., & Jenkins, G. (2024). Human plasma can modulate micronucleus frequency in TK6 and OE33 cells in vitro. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 896, 503766
https://doi.org/10.1016/j.mrgentox.2024.503766, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66474
Braakhuis, H., Gremmer, E., Bannuscher, A., Drasler, B., Keshavan, S., Rothen-Rutishauser, B., Birk, B., Verlohner, A., Landsiedel, R., Meldrum, K., Doak, S., Clift, M., Erdem, J., Foss, O., Zienolddiny-Narui, S., Serchi, T., Moschini, E., Weber, P., Burla, S...., & Vandebriel, R. (2023). Transferability and reproducibility of exposed air-liquid interface co-culture lung models. NanoImpact, 31, 100466
https://doi.org/10.1016/j.impact.2023.100466, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63446
http://dx.doi.org/10.1016/j.impact.2023.100466
Doak, S., Andreoli, C., Burgum, M., Chaudhry, Q., Bleeker, E., Bossa, C., Domenech, J., Drobne, D., Fessard, V., Jeliazkova, N., Longhin, E., Rundén-Pran, E., Stepnik, M., Yamani, N., Catalán, J., & Dusinska, M. (2023). Current status and future challenges of genotoxicity OECD test guidelines (TGs) for nanomaterials: a workshop report. Mutagenesis
https://doi.org/10.1093/mutage/gead017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63542
http://dx.doi.org/10.1093/mutage/gead017
Jovic, T., Nicholson, T., Arora, H., Nelson, K., Doak, S., & Whitaker, I. (2023). A comparative analysis of pulp-derived nanocelluloses for 3D bioprinting facial cartilages. Carbohydrate Polymers, 321, 121261
https://doi.org/10.1016/j.carbpol.2023.121261, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64062
http://dx.doi.org/10.1016/j.carbpol.2023.121261
Stannard, L., Doherty, A., Chapman, K., Doak, S., Jenkins, G., & Stannard, L. (2024). Multi-endpoint analysis of cadmium chloride-induced genotoxicity shows role for reactive oxygen species and p53 activation in DNA damage induction, cell cycle irregularities, and cell size aberrations. Mutagenesis, 39(1), 13-23.
https://doi.org/10.1093/mutage/gead025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64199
Coskun, E., Singh, N., Scanlan, L., Jaruga, P., Doak, S., Dizdaroglu, M., & Nelson, B. (2022). Inhibition of human APE1 and MTH1 DNA repair proteins by dextran-coated γ-Fe₂O₃ ultrasmall superparamagnetic iron oxide nanoparticles. Nanomedicine, 17(26), 2011-2021.
https://doi.org/10.2217/nnm-2022-0204, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62772
http://dx.doi.org/10.2217/nnm-2022-0204
Amaral Duarte De Moura, J., Meldrum, K., Doak, S., & Clift, M. (2023). Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook. Seminars in Cell & Developmental Biology, 147, 70-82.
https://doi.org/10.1016/j.semcdb.2022.12.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62217
http://dx.doi.org/10.1016/j.semcdb.2022.12.006
Bannuscher, A., Schmid, O., Drasler, B., Rohrbasser, A., Braakhuis, H., Meldrum, K., Zwart, E., Gremmer, E., Birk, B., Rissel, M., Landsiedel, R., Moschini, E., Evans, S., Kumar, P., Orak, S., Doryab, A., Erdem, J., Serchi, T., Vandebriel, R...., & Rothen-Rutishauser, B. (2022). An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials. NanoImpact, 28, 100439
https://doi.org/10.1016/j.impact.2022.100439, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62077
Meldrum, K., Amaral Duarte De Moura, J., Doak, S., & Clift, M. (2022). Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro. Nanomaterials, 12(19), 3431
https://doi.org/10.3390/nano12193431, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61384
Evans, S., Lawrence, R., Ilett, M., Burgum, M., Meldrum, K., Hondow, N., Jenkins, G., Clift, M., & Doak, S. (2022). Industrial-relevant TiO2 types do not promote cytotoxicity in the A549 or TK6 cell lines regardless of cell specific interaction. Toxicology in Vitro, 83, 105415
https://doi.org/10.1016/j.tiv.2022.105415, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60312
Llewellyn, S., Kermanizadeh, A., Ude, V., Jacobsen, N., Conway, G., Shah, U., Niemeijer, M., Moné, M., Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G., & Doak, S. (2022). Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in Vitro, 85, 105473
https://doi.org/10.1016/j.tiv.2022.105473, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61191
Evans, S., Jenkins, G., Doak, S., & Clift, M. (2019). Cellular Defense Mechanisms Following Nanomaterial Exposure: A Focus on Oxidative Stress and Cytotoxicity. Biological Responses to Nanoscale Particles (pp. 243-254). Springer International Publishing
https://doi.org/10.1007/978-3-030-12461-8_10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50127
Doak, S., Clift, M., Costa, A., Delmaar, C., Gosens, I., Halappanavar, S., Kelly, S., Pejinenburg, W., Rothen‐Rutishauser, B., Schins, R., Stone, V., Tran, L., Vijver, M., Vogel, U., Wohlleben, W., & Cassee, F. (2022). The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability—A PATROLS Perspective on New Approach Methodologies. Small, 18(17), 2200231
https://doi.org/10.1002/smll.202200231, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59702
Groff, K., Evans, S., Doak, S., Pfuhler, S., Corvi, R., Saunders, S., & Stoddart, G. (2021). In vitro and integrated in vivo strategies to reduce animal use in genotoxicity testing. Mutagenesis, 36(6), 389-400.
https://doi.org/10.1093/mutage/geab035, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58118
Verdon, R., Stone, V., Murphy, F., Christopher, E., Johnston, H., Doak, S., Vogel, U., Haase, A., & Kermanizadeh, A. (2022). The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment. Particle and Fibre Toxicology, 19(1)
https://doi.org/10.1186/s12989-022-00476-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59989
Evans, S., Vecchiarelli, P., Clift, M., Doak, S., & Lead, J. (2021). Overview of Nanotoxicology in Humans and the Environment; Developments, Challenges and Impacts. Nanotoxicology in Humans and the Environment (pp. 1-40). Springer International Publishing
https://doi.org/10.1007/978-3-030-79808-6_1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59028
Llewellyn, S., Parak, W., Hühn, J., Burgum, M., Evans, S., Chapman, K., Jenkins, G., Doak, S., & Clift, M. (2022). Deducing the cellular mechanisms associated with the potential genotoxic impact of gold and silver engineered nanoparticles upon different lung epithelial cell lines in vitro. Nanotoxicology, 16(1), 52-72.
https://doi.org/10.1080/17435390.2022.2030823, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59210
Meldrum, K., Evans, S., Vogel, U., Tran, L., Doak, S., & Clift, M. (2022). The influence of exposure approaches to in vitro lung epithelial barrier models to assess engineered nanomaterial hazard. Nanotoxicology, 16(1), 114-134.
https://doi.org/10.1080/17435390.2022.2051627, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59667
Kah, M., Johnston, L., Kookana, R., Bruce, W., Haase, A., Ritz, V., Dinglasan, J., Doak, S., Garelick, H., & Gubala, V. (2021). Comprehensive framework for human health risk assessment of nanopesticides. Nature Nanotechnology, 16(9), 955-964.
https://doi.org/10.1038/s41565-021-00964-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57882
Isigonis, P., Afantitis, A., Antunes, D., Bartonova, A., Beitollahi, A., Bohmer, N., Bouman, E., Chaudhry, Q., Cimpan, M., Cimpan, E., Doak, S., Dupin, D., Fedrigo, D., Fessard, V., Gromelski, M., Gutleb, A., Halappanavar, S., Hoet, P., Jeliazkova, N...., & Dusinska, M. (2020). Risk Governance of Emerging Technologies Demonstrated in Terms of its Applicability to Nanomaterials. Small, 16(36), 2003303
https://doi.org/10.1002/smll.202003303, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57432
Llewellyn, S., Conway, G., Zanoni, I., Jørgensen, A., Shah, U., Seleci, D., Keller, J., Kim, J., Wohlleben, W., Jensen, K., Costa, A., Jenkins, G., Clift, M., & Doak, S. (2021). Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00938-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57237
Llewellyn, S., Kämpfer, A., Keller, J., Vilsmeier, K., Büttner, V., Seleci, D., Schins, R., Doak, S., & Wohlleben, W. (2021). Simulating Nanomaterial Transformation in Cascaded Biological Compartments to Enhance the Physiological Relevance of In Vitro Dosing Regimes: Optional or Required?. Small, 17(15), 2004630
https://doi.org/10.1002/smll.202004630, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56095
Thomson, E., Jessop, Z., Naderi, N., Griffin, M., Dobbs, T., Ibrahim, A., Evans, S., Burnell, S., Doak, S., & Whitaker, I. (2016). Adipose regeneration and implications for breast reconstruction: update and the future. Gland Surgery, 5(2), 227-241.
https://doi.org/10.3978/j.issn.2227-684X.2016.01.01, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56657
https://gs.amegroups.com/article/view/9095
Barosova, H., Meldrum, K., Karakocak, B., Balog, S., Doak, S., Petri-Fink, A., Clift, M., & Rothen-Rutishauser, B. (2021). Inter-laboratory variability of A549 epithelial cells grown under submerged and air-liquid interface conditions. Toxicology in Vitro, 75, 105178
https://doi.org/10.1016/j.tiv.2021.105178, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56826
Clift, M. & Doak, S. (2021). Advanced In Vitro Models for Replacement of Animal Experiments. Small, 17(15), 2101474
https://doi.org/10.1002/smll.202101474, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56827
Llewellyn, S., Niemeijer, M., Nymark, P., Moné, M., Water, B., Conway, G., Jenkins, G., & Doak, S. (2021). In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment. Small, 17(15), 2006055
https://doi.org/10.1002/smll.202006055, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56073
Burgum, M., Clift, M., Evans, S., Hondow, N., Tarat, A., Jenkins, G., & Doak, S. (2021). Few-layer graphene induces both primary and secondary genotoxicity in epithelial barrier models in vitro. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00769-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56078
Conway, G., Shah, U., Llewellyn, S., Cervena, T., Evans, S., Al-Ali, A., Jenkins, G., Clift, M., & Doak, S. (2020). Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations. Mutagenesis, 35(4), 319-329.
https://doi.org/10.1093/mutage/geaa018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54991
Chapman, K., Wilde, E., Chapman, F., Verma, J., Shah, U., Stannard, L., Seager, A., Tonkin, J., Brown, R., Doherty, A., Johnson, G., Doak, S., & Jenkins, G. (2021). Multiple-endpoint in vitro carcinogenicity test in human cell line TK6 distinguishes carcinogens from non-carcinogens and highlights mechanisms of action. Archives of Toxicology, 95(1), 321-336.
https://doi.org/10.1007/s00204-020-02902-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55186
Shah, U., Verma, J., Chapman, K., Wilde, E., Tonkin, J., Brown, R., Johnson, G., Doak, S., & Jenkins, G. (2020). Detection of urethane-induced genotoxicity in vitro using metabolically competent human 2D and 3D spheroid culture models. Mutagenesis, 35(6), 445-452.
https://doi.org/10.1093/mutage/geaa029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55770
Dural, E., Shah, U., Pritchard, D., Chapman, K., Doak, S., Jenkins, G., & Jenkins, G. (2020). The effect of chronic dosing and p53 status on the genotoxicity of pro-oxidant chemicals in vitro. Mutagenesis, 35(6), 479-489.
https://doi.org/10.1093/mutage/geaa024, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55854
Walker, K., Doak, S., Dunstan, P., Dunstan, P., & Doak, S. (2011). Mechanisms of cell–cell adhesion identified by immunofluorescent labelling with quantum dots: A scanning near-field optical microscopy approach. Ultramicroscopy, 111(8), 1200-1205.
https://doi.org/10.1016/j.ultramic.2011.01.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1118
Doak, S., Jenkins, G., Parry, E., Griffiths, A., Shah, V., Baxter, J., Parry, J., Jenkins, G., Doak, S., & Baxter, J. (2003). Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma. British Journal of Cancer, 89(9), 1729-1735.
https://doi.org/10.1038/sj.bjc.6601323, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1363
Doak, S., Jenkins, G., & Doak, S. (2003). Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus. Gut, 52(5), 623-628.
https://doi.org/10.1136/gut.52.5.623, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1388
Baylis, R., BAYLIS, R., DOAK, S., PARRY, J., DUNSTAN, P., Dunstan, P., & Doak, S. (2006). Chromosome morphology after long-term storage investigated by scanning near-field optical microscopy. Journal of Microscopy, 221(3), 177-182.
https://doi.org/10.1111/j.1365-2818.2006.01561.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1549
Walker, K., Morgan, C., Doak, S., & Dunstan, P. (2012). Quantum Dots for Multiplexed Detection and Characterisation of Prostate Cancer Cells Using a Scanning Near-Field Optical Microscope. PLoS ONE, 7(2), e31592
https://doi.org/10.1371/journal.pone.0031592, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa7294
Manshian, B., Jenkins, G., Williams, P., Wright, C., Barron, A., Brown, A., Hondow, N., Dunstan, P., Rickman, R., Brady, K., Doak, S., & Wright, C. (2013). Single-walled carbon nanotubes: differential genotoxic potential associated with physico-chemical properties. Nanotoxicology, 7(2), 144-156.
https://doi.org/10.3109/17435390.2011.647928, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa7295
Johnson, G., Jenkins, G., Thomas, A., & Doak, S. (2010). Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 702(2), 189-192.
https://doi.org/10.1016/j.mrgentox.2009.07.014, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9258
Jenkins, G., Zaïr, Z., Johnson, G., & Doak, S. (2010). Genotoxic thresholds, DNA repair, and susceptibility in human populations. Toxicology, 278(3), 305-310.
https://doi.org/10.1016/j.tox.2009.11.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9893
Zair, Z., Jenkins, G., Doak, S., Singh, R., Brown, K., Johnson, G., Jenkins, G., Doak, S., & Johnson, G. (2011). N-Methylpurine DNA Glycosylase Plays a Pivotal Role in the Threshold Response of Ethyl Methanesulfonate-Induced Chromosome Damage. Toxicological Sciences, 119(2), 346-358.
https://doi.org/10.1093/toxsci/kfq341, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10158
Seager, A., Shah, U., Mikhail, J., Nelson, B., Marquis, B., Doak, S., Johnson, G., Griffiths, S., Carmichael, P., Scott, S., Scott, A., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., & Mikhail, J. (2012). Pro-oxidant Induced DNA Damage in Human Lymphoblastoid Cells: Homeostatic Mechanisms of Genotoxic Tolerance. Toxicological Sciences, 128(2), 387-397.
https://doi.org/10.1093/toxsci/kfs152, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10909
http://toxsci.oxfordjournals.org/content/early/2012/04/26/toxsci.kfs152.abstract
Thomas, A., Jenkins, G., Kaina, B., Bodger, O., Tomaszowski, K., Lewis, P., Doak, S., Johnson, G., Jenkins, G., Lewis, P., Doak, S., Bodger, O., & Johnson, G. (2013). Influence of DNA Repair on Nonlinear Dose-Responses for Mutation. Toxicological Sciences, 132(1), 87-95.
https://doi.org/10.1093/toxsci/kfs341, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13715
Jenkins, G., Doak, S., & Bruesehafer, K. (2014). Chromosome Breakage Induced by the Genotoxic Agents Mitomycin C and Cytosine arabinoside. Toxicological Sciences, 140(1), 94-102.
https://doi.org/10.1093/toxsci/kfu058, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18150
Jenkins, G., Doak, S., & Chapman, K. (2014). Automation and validation of micronucleus detection in the 3D EpiDerm human reconstructed skin. Mutagenesis, 29(3), 165-175.
https://doi.org/10.1093/mutage/geu011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18153
Whiteland, H., Lewis, P., Doak, S., & Morgan, C. (2014). A role for STEAP2 in prostate cancer progression. Clinical & Experimental Metastasis, 1-12.
https://doi.org/10.1007/s10585-014-9679-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18791
Johnson, G., Slob, W., Doak, S., Fellows, M., Gollapudi, B., Heflich, R., Rees, B., Soeteman-Hernández, L., Verma, J., Wills, J., Jenkins, G., & White, P. (2015). New approaches to advance the use of genetic toxicology analyses for human health risk assessment. Toxicology Research, 4(3), 667-676.
https://doi.org/10.1039/C4TX00118D, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19282
http://pubs.rsc.org/en/content/articlelanding/2014/tx/c4tx00118d#!divAbstract
Tehrani, Z., Burwell, G., Azmi, M., Castaing, A., Rickman, R., Almarashi, J., Dunstan, P., Beigi, A., Doak, S., & Guy, O. (2014). Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker. 2D Materials, 1(2), 025004
https://doi.org/10.1088/2053-1583/1/2/025004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19735
Azmi, M., Tehrani, Z., Lewis, R., Walker, K., Jones, D., Daniels, D., Doak, S., & Guy, O. (2014). Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker. Biosensors and Bioelectronics, 52, 216-224.
https://doi.org/10.1016/j.bios.2013.08.030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19740
Seager, A., Shah, U., Brusehafer, K., Wills, J., Manshian, B., Chapman, K., Thomas, A., Scott, A., Doherty, A., Doak, S., Johnson, G., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., Bruesehafer, K., Shah, U., & Chapman, K. (2014). Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells. Mutagenesis, 29(3), 155-164.
https://doi.org/10.1093/mutage/geu008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17804
Doak, S., Jenkins, G., Johnson, G., Quick, E., Parry, E., Parry, J., Jenkins, G., Doak, S., & Johnson, G. (2007). Mechanistic Influences for Mutation Induction Curves after Exposure to DNA-Reactive Carcinogens. Cancer Research, 67(8), 3904-3911.
https://doi.org/10.1158/0008-5472.CAN-06-4061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17856
Chapman, K., Doak, S., Jenkins, G., Jenkins, G., Doak, S., & Chapman, K. (2015). Acute Dosing and p53-Deficiency Promote Cellular Sensitivity to DNA Methylating Agents. Toxicological Sciences, 144(2), 357-365.
https://doi.org/10.1093/toxsci/kfv004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20121
Brüsehafer, K., Manshian, B., Doherty, A., Zaïr, Z., Johnson, G., Doak, S., Jenkins, G., & Bruesehafer, K. (2016). The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency. Mutagenesis, 31(2), 171-180.
https://doi.org/10.1093/mutage/gev069, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23828
Wills, J., Johnson, G., Doak, S., Soeteman-Hernández, L., Slob, W., & White, P. (2016). Empirical analysis of BMD metrics in genetic toxicology part I:in vitroanalyses to provide robust potency rankings and support MOA determinations. Mutagenesis, 31(3), 255-263.
https://doi.org/10.1093/mutage/gev085, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25190
Al-Himdani, S., Jessop, Z., Al-Sabah, A., Combellack, E., Ibrahim, A., Doak, S., Hart, A., Archer, C., Thornton, C., & Whitaker, I. (2017). Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice. Frontiers in Surgery, 4, article 4
https://doi.org/10.3389/fsurg.2017.00004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31747
http://journal.frontiersin.org/article/10.3389/fsurg.2017.00004/full
Pfuhler, S., Benthem, J., Curren, R., Doak, S., Dusinska, M., Hayashi, M., Heflich, R., Kidd, D., Kirkland, D., Luan, Y., Ouedraogo, G., Reisinger, K., Sofuni, T., Acker, F., Yang, Y., & Corvi, R. (2020). Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT). Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 850-851, 503135
https://doi.org/10.1016/j.mrgentox.2020.503135, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53559
Burgum, M., Clift, M., Evans, S., Hondow, N., Miller, M., Bustamante-Lopez, S., Williams, A., Tarat, A., Jenkins, G., & Doak, S. (2021). In Vitro Primary‐Indirect Genotoxicity in Bronchial Epithelial Cells Promoted by Industrially Relevant Few‐Layer Graphene. Small, 17(15), 2002551
https://doi.org/10.1002/smll.202002551, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54412
Llewellyn, S., Conway, G., Shah, U., Evans, S., Jenkins, G., Clift, M., & Doak, S. (2020). Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure. Journal of Visualized Experiments(160)
https://doi.org/10.3791/61141, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54416
Cronin, J., Jones, N., Thornton, C., Jenkins, G., Doak, S., & Clift, M. (2020). Nanomaterials and Innate Immunity: A Perspective of the Current Status in Nanosafety. Chemical Research in Toxicology, 33(5), 1061-1073.
https://doi.org/10.1021/acs.chemrestox.0c00051, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54417
http://dx.doi.org/10.1021/acs.chemrestox.0c00051
Nelson, B., Minelli, C., Doak, S., & Roesslein, M. (2020). Emerging Standards and Analytical Science for Nanoenabled Medical Products. Annual Review of Analytical Chemistry, 13(1), 431-452.
https://doi.org/10.1146/annurev-anchem-091619-102216, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54480
Chapman, F., Sparham, C., Hastie, C., Sanders, D., Egmond, R., Chapman, K., Doak, S., Scott, A., & Jenkins, G. (2020). Comparison of passive-dosed and solvent spiked exposures of pro-carcinogen, benzo[a]pyrene, to human lymphoblastoid cell line, MCL-5. Toxicology in Vitro, 67, 104905
https://doi.org/10.1016/j.tiv.2020.104905, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54540
Nelson, B., Wright, C., Ibuki, Y., Moreno-Villanueva, M., Karlsson, H., Hendriks, G., Sims, C., Singh, N., & Doak, S. (2017). Emerging metrology for high-throughput nanomaterial genotoxicology. Mutagenesis, 32(1), 215-232.
https://doi.org/10.1093/mutage/gew037, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54572
Ede, J., Lobaskin, V., Vogel, U., Lynch, I., Halappanavar, S., Doak, S., Roberts, M., & Shatkin, J. (2020). Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials. Nanomaterials, 10(6), 1229
https://doi.org/10.3390/nano10061229, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54573
Clift, M., Jenkins, G., & Doak, S. (2020). An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health. Small, 16(36), 2002002
https://doi.org/10.1002/smll.202002002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54913
Morgan, C., Lewis, P., Hopkins, L., Burnell, S., Kynaston, H., & Doak, S. (2015). Increased expression of ARF GTPases in prostate cancer tissue. SpringerPlus, 4(1)
https://doi.org/10.1186/s40064-015-1136-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34906
Burden, N., Aschberger, K., Chaudhry, Q., Clift, M., Fowler, P., Johnston, H., Landsiedel, R., Rowland, J., Stone, V., & Doak, S. (2017). Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities?. Regulatory Toxicology and Pharmacology, 91, 257-266.
https://doi.org/10.1016/j.yrtph.2017.10.021, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36250
Morgan, C., Swithenbank, L., Whiteland, H., & Doak, S. (2018). Increased ARF6 activation correlates with HGF stimulation in non-invasive prostate cancer cells. Journal of Cancer Metastasis and Treatment, 4(8), 46
https://doi.org/10.20517/2394-4722.2018.19, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43606
Bodger, O., Burnell, S., Spencer-Harty, S., Howarth, S., Bodger, O., Kynaston, H., Morgan, C., & Doak, S. (2019). Utilisation of the STEAP protein family in a diagnostic setting may provide a more comprehensive prognosis of prostate cancer. PLOS ONE, 14(8), e0220456
https://doi.org/10.1371/journal.pone.0220456, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51465
Evans, S., Gollapudi, B., Moore, M., & Doak, S. (2019). Horizon scanning for novel and emerging in vitro mammalian cell mutagenicity test systems. Mutation Research/Genetic Toxicology and Environmental Mutagenesis
https://doi.org/10.1016/j.mrgentox.2019.02.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49201
Evans, S., Clift, M., Singh, N., Wills, J., Hondow, N., Wilkinson, T., Burgum, M., Brown, A., Jenkins, G., & Doak, S. (2019). In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials. Particle and Fibre Toxicology, 16(1)
https://doi.org/10.1186/s12989-019-0291-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48861
Burnell, S., Spencer-Harty, S., Howarth, S., Bodger, O., Kynaston, H., Morgan, C., & Doak, S. (2018). STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells. Scientific Reports, 8(1)
https://doi.org/10.1038/s41598-018-24655-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39502
Wills, J., Summers, H., Hondow, N., Sooresh, A., Meissner, K., White, P., Rees, P., Brown, A., & Doak, S. (2017). Characterizing Nanoparticles in Biological Matrices: Tipping Points in Agglomeration State and Cellular Delivery In Vitro. ACS Nano, 11(12), 11986-12000.
https://doi.org/10.1021/acsnano.7b03708, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36707
http://dx.doi.org/10.1021/acsnano.7b03708
Chapman, K., Hoffmann, G., Doak, S., & Jenkins, G. (2017). Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N -methyl- N -nitrosourea. Mutation Research/Genetic Toxicology and Environmental Mutagenesis
https://doi.org/10.1016/j.mrgentox.2017.05.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33260
Joris, F., Valdepérez, D., Pelaz, B., Wang, T., Doak, S., Manshian, B., Soenen, S., Parak, W., De Smedt, S., & Raemdonck, K. (2017). Choose your cell model wisely: The in vitro nanoneurotoxicity of differentially coated iron oxide nanoparticles for neural cell labeling. Acta Biomaterialia
https://doi.org/10.1016/j.actbio.2017.03.053, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33262
Wills, J., Hondow, N., Thomas, A., Chapman, K., Fish, D., Maffeis, T., Penny, M., Brown, R., Jenkins, G., Brown, A., White, P., & Doak, S. (2016). Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™). Particle and Fibre Toxicology, 13(1)
https://doi.org/10.1186/s12989-016-0161-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29852
Peynshaert, K., Soenen, S., Manshian, B., Doak, S., Braeckmans, K., Smedt, S., & Remaut, K. (2016). Coating of Quantum Dots strongly defines their effect on lysosomal health and autophagy. Acta Biomaterialia, 48
https://doi.org/10.1016/j.actbio.2016.10.022, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30608
Doak, S. (2016). Opinion of the Scientific Committee on consumer safety (SCCS) - Opinion on the use of 2,2′-methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) (nano) – S79 – In cosmetic products. Regulatory Toxicology and Pharmacology, 76, 215-216.
https://doi.org/10.1016/j.yrtph.2016.01.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26473
Al-Ali, A., Singh, N., Manshian, B., Wilkinson, T., Wills, J., Jenkins, G., Doak, S., & Wilkinson, T. (2015). Quantum dot induced cellular perturbations involving varying toxicity pathways. Toxicol. Res.
https://doi.org/10.1039/C4TX00175C, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20114
Manshian, B., Soenen, S., Al-Ali, A., Brown, A., Hondow, N., Wills, J., Jenkins, G., Doak, S., Jenkins, G., & Doak, S. (2015). Cell Type-Dependent Changes in CdSe/ZnS Quantum Dot Uptake and Toxic Endpoints. Toxicological Sciences
https://doi.org/10.1093/toxsci/kfv002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20117
Manshian, B., Soenen, S., Brown, A., Hondow, N., Wills, J., Jenkins, G., Doak, S., Jenkins, G., & Doak, S. (2015). Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries. Mutagenesis, gev061
https://doi.org/10.1093/mutage/gev061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26170
http://europepmc.org/abstract/med/26275419
Soenen+José-Maria, S. & Doak, S. (2014). The effect of nanoparticle degradation on poly(methacrylic acid)-coated quantum dot toxicity: The importance of particle functionality assessment in toxicology. Acta Biomaterialia, 10(2), 732-741.
https://doi.org/10.1016/j.actbio.2013.09.041, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17886
Soenen+Lynn, S. & Doak, S. (2014). Unraveling the effects of siRNA carrier systems on cell physiology: a multiparametric approach demonstrated on dextran nanogels. Nanomedicine, 9(1), 61-76.
https://doi.org/10.2217/nnm.12.208, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17888
Pfuhler+Rosalie, S. & Doak, S. (2013). Genotoxicity of nanomaterials: Refining strategies and tests for hazard identification. Environmental and Molecular Mutagenesis, 54(4), 229-239.
https://doi.org/10.1002/em.21770, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17889
Soenen+Bella, S. & Doak, S. (2013). Fluorescent non-porous silica nanoparticles for long-term cell monitoring: Cytotoxicity and particle functionality. Acta Biomaterialia, 9(11), 9183-9193.
https://doi.org/10.1016/j.actbio.2013.04.026, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17887
Morgan, C., Jenkins, S., Kynaston, H., & Doak, S. (2013). The Role of Adhesion Molecules as Biomarkers for the Aggressive Prostate Cancer Phenotype. PLoS ONE, 8(12), e81666
https://doi.org/10.1371/journal.pone.0081666, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16740
Whiteland, H., Spencer-Harty, S., Thomas, D., Davies, C., Morgan, C., Kynaston, H., Bose, P., Fenn, N., Lewis, P., Bodger, O., Jenkins, S., & Doak, S. (2013). Putative prognostic epithelial-to-mesenchymal transition biomarkers for aggressive prostate cancer. Experimental and Molecular Pathology, 95(2), 220-226.
https://doi.org/10.1016/j.yexmp.2013.07.010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16741
Soenen, S., Manshian, B., Montenegro, J., Amin, F., Meermann, B., Thiron, T., Cornelissen, M., Vanhaecke, F., Doak, S., Parak, W., Smedt, S., & Braeckmans, K. (2012). Cytotoxic Effects of Gold Nanoparticles: A Multiparametric Study. ACS Nano, 6(7), 5767
https://doi.org/10.1021/nn301714n, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11792
Doak, S., Manshian, B., Jenkins, G., Singh, N., Jenkins, G., & Doak, S. (2012). In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 745(1-2), 104
https://doi.org/10.1016/j.mrgentox.2011.09.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10472
Doak, S., Manshian, B., Jenkins, G., & Doak, S. (2012). In vitro genotoxicity testing strategy for nanomaterials and the adptation of curent OECD guidelines.. Mutation Research - Gen tox, 745(1-2), 104-11.
https://doi.org/10.1016/j.mrgentox.2011.09.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10081
Doak, S., Liu, Y., & Chen, C. (2012). Genotoxicity and Cancer. Adverse Effects of Engineered Nanomaterials (pp. 243Elsevier
https://doi.org/10.1016/B978-0-12-386940-1.00014-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10476
Singh, N., Jenkins, G., Nelson, B., Marquis, B., Maffeis, T., Brown, A., Williams, P., Wright, C., Doak, S., & Wright, C. (2012). The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles. Biomaterials, 33(1), 163
https://doi.org/10.1016/j.biomaterials.2011.09.087, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14121

All Research

Journal Articles

Jovic, T., Thomson, E., Jones, N., Thornton, C., Doak, S., & Whitaker, I. (2024). Nasoseptal chondroprogenitors isolated through fibronectin-adherence confer no biological advantage for cartilage tissue engineering compared to nasoseptal chondrocytes.. Frontiers in Bioengineering and Biotechnology, 12
https://doi.org/10.3389/fbioe.2024.1421111, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68056
Moura, J., Barlow, H., Doak, S., Hawkins, K., Muller, I., & Clift, M. (2024). Exploring the Role of Fibrin Gels in Enhancing Cell Migration for Vasculature Formation. Journal of Functional Biomaterials, 15(9), 265
https://doi.org/10.3390/jfb15090265, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67608
Jeliazkova, N., Longhin, E., Yamani, N., Rundén-Pran, E., Moschini, E., Serchi, T., Vrček, I., Burgum, M., Doak, S., Cimpan, M., Rios-Mondragon, I., Cimpan, E., Battistelli, C., Bossa, C., Tsekovska, R., Drobne, D., Novak, S., Repar, N., Ammar, A...., & Dusinska, M. (2024). A template wizard for the cocreation of machine-readable data-reporting to harmonize the evaluation of (nano)materials. Nature Protocols, 19(9), 2642-2684.
https://doi.org/10.1038/s41596-024-00993-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66932
Hristozov, D., Badetti, E., Bigini, P., Brunelli, A., Dekkers, S., Diomede, L., Doak, S., Fransman, W., Gajewicz-Skretna, A., Giubilato, E., Gómez-Cuadrado, L., Grafström, R., Gutleb, A., Halappanavar, S., Hischier, R., Hunt, N., Katsumiti, A., Kermanizadeh, A., Marcomini, A...., & Zabeo, A. (2024). Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives. NanoImpact, 35, 100523
https://doi.org/10.1016/j.impact.2024.100523, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67277
Suh, M., Park, J., Ko, G., Kim, J., Hwang, D., Rees, L., Conway, G., Doak, S., Kang, H., Lee, N., Hyeon, T., Lee, Y., & Lee, D. (2024). Optimization of micelle-encapsulated extremely small sized iron oxide nanoparticles as a T1 contrast imaging agent: biodistribution and safety profile. Journal of Nanobiotechnology, 22(1)
https://doi.org/10.1186/s12951-024-02699-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67147
Groenewold, M., Bleeker, E., Noorlander, C., Sips, A., Zee, M., Aitken, R., Baker, J., Bakker, M., Bouman, E., Doak, S., Drobne, D., Dumit, V., Florin, M., Fransman, W., Gonzalez, M., Heunisch, E., Isigonis, P., Jeliazkova, N., Jensen, K...., & Scott-Fordsmand, J. (2024). Governance of advanced materials: Shaping a safe and sustainable future. NanoImpact, 35, 100513
https://doi.org/10.1016/j.impact.2024.100513, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66934
Mitchell, S., Meldrum, K., Bateman, J., Tetley, T., Doak, S., & Clift, M. (2024). Development and characterisation of a novel complex triple cell culture model of the human alveolar epithelial barrier. In vitro models, 3(2-3), 125-137.
https://doi.org/10.1007/s44164-024-00075-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67177
Naser, H., Munn, K., Lawrence, R., Wright, R., GREWAL, E., Williams, L., Doak, S., & Jenkins, G. (2024). Human plasma can modulate micronucleus frequency in TK6 and OE33 cells in vitro. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 896, 503766
https://doi.org/10.1016/j.mrgentox.2024.503766, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66474
Meldrum, K., Evans, S., Burgum, M., Doak, S., & Clift, M. (2024). Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro. Particle and Fibre Toxicology, 21(1)
https://doi.org/10.1186/s12989-024-00584-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66993
Burgum, M., Ulrich, C., Partosa, N., Evans, S., Gomes, C., Seiffert, S., Landsiedel, R., Honarvar, N., & Doak, S. (2024). Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices. Mutagenesis, 39(3), 205-217.
https://doi.org/10.1093/mutage/geae010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65963
http://dx.doi.org/10.1093/mutage/geae010
Jovic, T., Zhao, F., Jia, H., Doak, S., & Whitaker, I. (2024). Orbital shaking conditions augment human nasoseptal cartilage formation in 3D culture. Frontiers in Bioengineering and Biotechnology, 12
https://doi.org/10.3389/fbioe.2024.1360089, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68089
http://dx.doi.org/10.3389/fbioe.2024.1360089
Chapman, K., Shah, U., Fletcher, J., Johnson, G., Doak, S., & Jenkins, G. (2024). An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens. Mutagenesis, 39(2), 69-77.
https://doi.org/10.1093/mutage/geae004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65653
Brown, S., Evans, S., Burgum, M., Meldrum, K., Herridge, J., Akinbola, B., Harris, L., Jenkins, R., Doak, S., Clift, M., & Wilkinson, T. (2024). An In Vitro Model to Assess Early Immune Markers Following Co-Exposure of Epithelial Cells to Carbon Black (Nano)Particles in the Presence of S. aureus: A Role for Stressed Cells in Toxicological Testing. Biomedicines, 12(1), 128
https://doi.org/10.3390/biomedicines12010128, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65427
Stannard, L., Doherty, A., Chapman, K., Doak, S., Jenkins, G., & Stannard, L. (2024). Multi-endpoint analysis of cadmium chloride-induced genotoxicity shows role for reactive oxygen species and p53 activation in DNA damage induction, cell cycle irregularities, and cell size aberrations. Mutagenesis, 39(1), 13-23.
https://doi.org/10.1093/mutage/gead025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64199
Lawrence, R., Munn, K., Naser, H., Thomas, L., Haboubi, H., Williams, L., Doak, S., & Jenkins, G. (2023). The PIG-A gene mutation assay in human biomonitoring and disease. Environmental and Molecular Mutagenesis, 64(8-9), 480-493.
https://doi.org/10.1002/em.22577, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65085
Jovic, T., Nicholson, T., Arora, H., Nelson, K., Doak, S., & Whitaker, I. (2023). A comparative analysis of pulp-derived nanocelluloses for 3D bioprinting facial cartilages. Carbohydrate Polymers, 321, 121261
https://doi.org/10.1016/j.carbpol.2023.121261, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64062
http://dx.doi.org/10.1016/j.carbpol.2023.121261
Amaral Duarte De Moura, J., Meldrum, K., Doak, S., & Clift, M. (2023). Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook. Seminars in Cell & Developmental Biology, 147, 70-82.
https://doi.org/10.1016/j.semcdb.2022.12.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62217
http://dx.doi.org/10.1016/j.semcdb.2022.12.006
Braakhuis, H., Gremmer, E., Bannuscher, A., Drasler, B., Keshavan, S., Rothen-Rutishauser, B., Birk, B., Verlohner, A., Landsiedel, R., Meldrum, K., Doak, S., Clift, M., Erdem, J., Foss, O., Zienolddiny-Narui, S., Serchi, T., Moschini, E., Weber, P., Burla, S...., & Vandebriel, R. (2023). Transferability and reproducibility of exposed air-liquid interface co-culture lung models. NanoImpact, 31, 100466
https://doi.org/10.1016/j.impact.2023.100466, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63446
http://dx.doi.org/10.1016/j.impact.2023.100466
Doak, S., Andreoli, C., Burgum, M., Chaudhry, Q., Bleeker, E., Bossa, C., Domenech, J., Drobne, D., Fessard, V., Jeliazkova, N., Longhin, E., Rundén-Pran, E., Stepnik, M., Yamani, N., Catalán, J., & Dusinska, M. (2023). Current status and future challenges of genotoxicity OECD test guidelines (TGs) for nanomaterials: a workshop report. Mutagenesis
https://doi.org/10.1093/mutage/gead017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63542
http://dx.doi.org/10.1093/mutage/gead017
Llewellyn, S., Kermanizadeh, A., Ude, V., Jacobsen, N., Conway, G., Shah, U., Niemeijer, M., Moné, M., Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G., & Doak, S. (2022). Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in Vitro, 85, 105473
https://doi.org/10.1016/j.tiv.2022.105473, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61191
Coskun, E., Singh, N., Scanlan, L., Jaruga, P., Doak, S., Dizdaroglu, M., & Nelson, B. (2022). Inhibition of human APE1 and MTH1 DNA repair proteins by dextran-coated γ-Fe₂O₃ ultrasmall superparamagnetic iron oxide nanoparticles. Nanomedicine, 17(26), 2011-2021.
https://doi.org/10.2217/nnm-2022-0204, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62772
http://dx.doi.org/10.2217/nnm-2022-0204
Bannuscher, A., Schmid, O., Drasler, B., Rohrbasser, A., Braakhuis, H., Meldrum, K., Zwart, E., Gremmer, E., Birk, B., Rissel, M., Landsiedel, R., Moschini, E., Evans, S., Kumar, P., Orak, S., Doryab, A., Erdem, J., Serchi, T., Vandebriel, R...., & Rothen-Rutishauser, B. (2022). An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials. NanoImpact, 28, 100439
https://doi.org/10.1016/j.impact.2022.100439, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62077
Meldrum, K., Amaral Duarte De Moura, J., Doak, S., & Clift, M. (2022). Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro. Nanomaterials, 12(19), 3431
https://doi.org/10.3390/nano12193431, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61384
Evans, S., Lawrence, R., Ilett, M., Burgum, M., Meldrum, K., Hondow, N., Jenkins, G., Clift, M., & Doak, S. (2022). Industrial-relevant TiO2 types do not promote cytotoxicity in the A549 or TK6 cell lines regardless of cell specific interaction. Toxicology in Vitro, 83, 105415
https://doi.org/10.1016/j.tiv.2022.105415, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60312
Verdon, R., Stone, V., Murphy, F., Christopher, E., Johnston, H., Doak, S., Vogel, U., Haase, A., & Kermanizadeh, A. (2022). The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment. Particle and Fibre Toxicology, 19(1)
https://doi.org/10.1186/s12989-022-00476-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59989
Doak, S., Clift, M., Costa, A., Delmaar, C., Gosens, I., Halappanavar, S., Kelly, S., Pejinenburg, W., Rothen‐Rutishauser, B., Schins, R., Stone, V., Tran, L., Vijver, M., Vogel, U., Wohlleben, W., & Cassee, F. (2022). The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability—A PATROLS Perspective on New Approach Methodologies. Small, 18(17), 2200231
https://doi.org/10.1002/smll.202200231, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59702
Meldrum, K., Evans, S., Vogel, U., Tran, L., Doak, S., & Clift, M. (2022). The influence of exposure approaches to in vitro lung epithelial barrier models to assess engineered nanomaterial hazard. Nanotoxicology, 16(1), 114-134.
https://doi.org/10.1080/17435390.2022.2051627, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59667
Llewellyn, S., Parak, W., Hühn, J., Burgum, M., Evans, S., Chapman, K., Jenkins, G., Doak, S., & Clift, M. (2022). Deducing the cellular mechanisms associated with the potential genotoxic impact of gold and silver engineered nanoparticles upon different lung epithelial cell lines in vitro. Nanotoxicology, 16(1), 52-72.
https://doi.org/10.1080/17435390.2022.2030823, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59210
Groff, K., Evans, S., Doak, S., Pfuhler, S., Corvi, R., Saunders, S., & Stoddart, G. (2021). In vitro and integrated in vivo strategies to reduce animal use in genotoxicity testing. Mutagenesis, 36(6), 389-400.
https://doi.org/10.1093/mutage/geab035, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58118
Kah, M., Johnston, L., Kookana, R., Bruce, W., Haase, A., Ritz, V., Dinglasan, J., Doak, S., Garelick, H., & Gubala, V. (2021). Comprehensive framework for human health risk assessment of nanopesticides. Nature Nanotechnology, 16(9), 955-964.
https://doi.org/10.1038/s41565-021-00964-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57882
Barosova, H., Meldrum, K., Karakocak, B., Balog, S., Doak, S., Petri-Fink, A., Clift, M., & Rothen-Rutishauser, B. (2021). Inter-laboratory variability of A549 epithelial cells grown under submerged and air-liquid interface conditions. Toxicology in Vitro, 75, 105178
https://doi.org/10.1016/j.tiv.2021.105178, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56826
Llewellyn, S., Conway, G., Zanoni, I., Jørgensen, A., Shah, U., Seleci, D., Keller, J., Kim, J., Wohlleben, W., Jensen, K., Costa, A., Jenkins, G., Clift, M., & Doak, S. (2021). Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00938-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57237
Llewellyn, S., Kämpfer, A., Keller, J., Vilsmeier, K., Büttner, V., Seleci, D., Schins, R., Doak, S., & Wohlleben, W. (2021). Simulating Nanomaterial Transformation in Cascaded Biological Compartments to Enhance the Physiological Relevance of In Vitro Dosing Regimes: Optional or Required?. Small, 17(15), 2004630
https://doi.org/10.1002/smll.202004630, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56095
Clift, M. & Doak, S. (2021). Advanced In Vitro Models for Replacement of Animal Experiments. Small, 17(15), 2101474
https://doi.org/10.1002/smll.202101474, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56827
Llewellyn, S., Niemeijer, M., Nymark, P., Moné, M., Water, B., Conway, G., Jenkins, G., & Doak, S. (2021). In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment. Small, 17(15), 2006055
https://doi.org/10.1002/smll.202006055, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56073
Burgum, M., Clift, M., Evans, S., Hondow, N., Miller, M., Bustamante-Lopez, S., Williams, A., Tarat, A., Jenkins, G., & Doak, S. (2021). In Vitro Primary‐Indirect Genotoxicity in Bronchial Epithelial Cells Promoted by Industrially Relevant Few‐Layer Graphene. Small, 17(15), 2002551
https://doi.org/10.1002/smll.202002551, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54412
Burgum, M., Clift, M., Evans, S., Hondow, N., Tarat, A., Jenkins, G., & Doak, S. (2021). Few-layer graphene induces both primary and secondary genotoxicity in epithelial barrier models in vitro. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00769-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56078
Chapman, K., Wilde, E., Chapman, F., Verma, J., Shah, U., Stannard, L., Seager, A., Tonkin, J., Brown, R., Doherty, A., Johnson, G., Doak, S., & Jenkins, G. (2021). Multiple-endpoint in vitro carcinogenicity test in human cell line TK6 distinguishes carcinogens from non-carcinogens and highlights mechanisms of action. Archives of Toxicology, 95(1), 321-336.
https://doi.org/10.1007/s00204-020-02902-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55186
Shah, U., Verma, J., Chapman, K., Wilde, E., Tonkin, J., Brown, R., Johnson, G., Doak, S., & Jenkins, G. (2020). Detection of urethane-induced genotoxicity in vitro using metabolically competent human 2D and 3D spheroid culture models. Mutagenesis, 35(6), 445-452.
https://doi.org/10.1093/mutage/geaa029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55770
Dural, E., Shah, U., Pritchard, D., Chapman, K., Doak, S., Jenkins, G., & Jenkins, G. (2020). The effect of chronic dosing and p53 status on the genotoxicity of pro-oxidant chemicals in vitro. Mutagenesis, 35(6), 479-489.
https://doi.org/10.1093/mutage/geaa024, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55854
Conway, G., Shah, U., Llewellyn, S., Cervena, T., Evans, S., Al-Ali, A., Jenkins, G., Clift, M., & Doak, S. (2020). Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations. Mutagenesis, 35(4), 319-329.
https://doi.org/10.1093/mutage/geaa018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54991
Isigonis, P., Afantitis, A., Antunes, D., Bartonova, A., Beitollahi, A., Bohmer, N., Bouman, E., Chaudhry, Q., Cimpan, M., Cimpan, E., Doak, S., Dupin, D., Fedrigo, D., Fessard, V., Gromelski, M., Gutleb, A., Halappanavar, S., Hoet, P., Jeliazkova, N...., & Dusinska, M. (2020). Risk Governance of Emerging Technologies Demonstrated in Terms of its Applicability to Nanomaterials. Small, 16(36), 2003303
https://doi.org/10.1002/smll.202003303, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57432
Clift, M., Jenkins, G., & Doak, S. (2020). An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health. Small, 16(36), 2002002
https://doi.org/10.1002/smll.202002002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54913
Chapman, F., Sparham, C., Hastie, C., Sanders, D., Egmond, R., Chapman, K., Doak, S., Scott, A., & Jenkins, G. (2020). Comparison of passive-dosed and solvent spiked exposures of pro-carcinogen, benzo[a]pyrene, to human lymphoblastoid cell line, MCL-5. Toxicology in Vitro, 67, 104905
https://doi.org/10.1016/j.tiv.2020.104905, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54540
Ede, J., Lobaskin, V., Vogel, U., Lynch, I., Halappanavar, S., Doak, S., Roberts, M., & Shatkin, J. (2020). Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials. Nanomaterials, 10(6), 1229
https://doi.org/10.3390/nano10061229, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54573
Nelson, B., Minelli, C., Doak, S., & Roesslein, M. (2020). Emerging Standards and Analytical Science for Nanoenabled Medical Products. Annual Review of Analytical Chemistry, 13(1), 431-452.
https://doi.org/10.1146/annurev-anchem-091619-102216, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54480
Llewellyn, S., Conway, G., Shah, U., Evans, S., Jenkins, G., Clift, M., & Doak, S. (2020). Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure. Journal of Visualized Experiments(160)
https://doi.org/10.3791/61141, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54416
Cronin, J., Jones, N., Thornton, C., Jenkins, G., Doak, S., & Clift, M. (2020). Nanomaterials and Innate Immunity: A Perspective of the Current Status in Nanosafety. Chemical Research in Toxicology, 33(5), 1061-1073.
https://doi.org/10.1021/acs.chemrestox.0c00051, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54417
http://dx.doi.org/10.1021/acs.chemrestox.0c00051
Pfuhler, S., Benthem, J., Curren, R., Doak, S., Dusinska, M., Hayashi, M., Heflich, R., Kidd, D., Kirkland, D., Luan, Y., Ouedraogo, G., Reisinger, K., Sofuni, T., Acker, F., Yang, Y., & Corvi, R. (2020). Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT). Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 850-851, 503135
https://doi.org/10.1016/j.mrgentox.2020.503135, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53559
Evans, S., Gollapudi, B., Moore, M., & Doak, S. (2019). Horizon scanning for novel and emerging in vitro mammalian cell mutagenicity test systems. Mutation Research/Genetic Toxicology and Environmental Mutagenesis
https://doi.org/10.1016/j.mrgentox.2019.02.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49201
Bodger, O., Burnell, S., Spencer-Harty, S., Howarth, S., Bodger, O., Kynaston, H., Morgan, C., & Doak, S. (2019). Utilisation of the STEAP protein family in a diagnostic setting may provide a more comprehensive prognosis of prostate cancer. PLOS ONE, 14(8), e0220456
https://doi.org/10.1371/journal.pone.0220456, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51465
Evans, S., Clift, M., Singh, N., Wills, J., Hondow, N., Wilkinson, T., Burgum, M., Brown, A., Jenkins, G., & Doak, S. (2019). In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials. Particle and Fibre Toxicology, 16(1)
https://doi.org/10.1186/s12989-019-0291-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48861
Morgan, C., Swithenbank, L., Whiteland, H., & Doak, S. (2018). Increased ARF6 activation correlates with HGF stimulation in non-invasive prostate cancer cells. Journal of Cancer Metastasis and Treatment, 4(8), 46
https://doi.org/10.20517/2394-4722.2018.19, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43606
Burnell, S., Spencer-Harty, S., Howarth, S., Bodger, O., Kynaston, H., Morgan, C., & Doak, S. (2018). STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells. Scientific Reports, 8(1)
https://doi.org/10.1038/s41598-018-24655-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39502
Chapman, K., Hoffmann, G., Doak, S., & Jenkins, G. (2017). Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N -methyl- N -nitrosourea. Mutation Research/Genetic Toxicology and Environmental Mutagenesis
https://doi.org/10.1016/j.mrgentox.2017.05.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33260
Joris, F., Valdepérez, D., Pelaz, B., Wang, T., Doak, S., Manshian, B., Soenen, S., Parak, W., De Smedt, S., & Raemdonck, K. (2017). Choose your cell model wisely: The in vitro nanoneurotoxicity of differentially coated iron oxide nanoparticles for neural cell labeling. Acta Biomaterialia
https://doi.org/10.1016/j.actbio.2017.03.053, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33262
Wills, J., Summers, H., Hondow, N., Sooresh, A., Meissner, K., White, P., Rees, P., Brown, A., & Doak, S. (2017). Characterizing Nanoparticles in Biological Matrices: Tipping Points in Agglomeration State and Cellular Delivery In Vitro. ACS Nano, 11(12), 11986-12000.
https://doi.org/10.1021/acsnano.7b03708, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36707
http://dx.doi.org/10.1021/acsnano.7b03708
Burden, N., Aschberger, K., Chaudhry, Q., Clift, M., Fowler, P., Johnston, H., Landsiedel, R., Rowland, J., Stone, V., & Doak, S. (2017). Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities?. Regulatory Toxicology and Pharmacology, 91, 257-266.
https://doi.org/10.1016/j.yrtph.2017.10.021, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36250
Al-Himdani, S., Jessop, Z., Al-Sabah, A., Combellack, E., Ibrahim, A., Doak, S., Hart, A., Archer, C., Thornton, C., & Whitaker, I. (2017). Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice. Frontiers in Surgery, 4, article 4
https://doi.org/10.3389/fsurg.2017.00004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31747
http://journal.frontiersin.org/article/10.3389/fsurg.2017.00004/full
Nelson, B., Wright, C., Ibuki, Y., Moreno-Villanueva, M., Karlsson, H., Hendriks, G., Sims, C., Singh, N., & Doak, S. (2017). Emerging metrology for high-throughput nanomaterial genotoxicology. Mutagenesis, 32(1), 215-232.
https://doi.org/10.1093/mutage/gew037, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54572
Brüsehafer, K., Manshian, B., Doherty, A., Zaïr, Z., Johnson, G., Doak, S., Jenkins, G., & Bruesehafer, K. (2016). The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency. Mutagenesis, 31(2), 171-180.
https://doi.org/10.1093/mutage/gev069, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23828
Peynshaert, K., Soenen, S., Manshian, B., Doak, S., Braeckmans, K., Smedt, S., & Remaut, K. (2016). Coating of Quantum Dots strongly defines their effect on lysosomal health and autophagy. Acta Biomaterialia, 48
https://doi.org/10.1016/j.actbio.2016.10.022, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30608
Doak, S. (2016). Opinion of the Scientific Committee on consumer safety (SCCS) - Opinion on the use of 2,2′-methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) (nano) – S79 – In cosmetic products. Regulatory Toxicology and Pharmacology, 76, 215-216.
https://doi.org/10.1016/j.yrtph.2016.01.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26473
Wills, J., Hondow, N., Thomas, A., Chapman, K., Fish, D., Maffeis, T., Penny, M., Brown, R., Jenkins, G., Brown, A., White, P., & Doak, S. (2016). Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™). Particle and Fibre Toxicology, 13(1)
https://doi.org/10.1186/s12989-016-0161-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29852
Wills, J., Johnson, G., Doak, S., Soeteman-Hernández, L., Slob, W., & White, P. (2016). Empirical analysis of BMD metrics in genetic toxicology part I:in vitroanalyses to provide robust potency rankings and support MOA determinations. Mutagenesis, 31(3), 255-263.
https://doi.org/10.1093/mutage/gev085, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25190
Thomson, E., Jessop, Z., Naderi, N., Griffin, M., Dobbs, T., Ibrahim, A., Evans, S., Burnell, S., Doak, S., & Whitaker, I. (2016). Adipose regeneration and implications for breast reconstruction: update and the future. Gland Surgery, 5(2), 227-241.
https://doi.org/10.3978/j.issn.2227-684X.2016.01.01, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56657
https://gs.amegroups.com/article/view/9095
Al-Ali, A., Singh, N., Manshian, B., Wilkinson, T., Wills, J., Jenkins, G., Doak, S., & Wilkinson, T. (2015). Quantum dot induced cellular perturbations involving varying toxicity pathways. Toxicol. Res.
https://doi.org/10.1039/C4TX00175C, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20114
Manshian, B., Soenen, S., Al-Ali, A., Brown, A., Hondow, N., Wills, J., Jenkins, G., Doak, S., Jenkins, G., & Doak, S. (2015). Cell Type-Dependent Changes in CdSe/ZnS Quantum Dot Uptake and Toxic Endpoints. Toxicological Sciences
https://doi.org/10.1093/toxsci/kfv002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20117
Johnson, G., Slob, W., Doak, S., Fellows, M., Gollapudi, B., Heflich, R., Rees, B., Soeteman-Hernández, L., Verma, J., Wills, J., Jenkins, G., & White, P. (2015). New approaches to advance the use of genetic toxicology analyses for human health risk assessment. Toxicology Research, 4(3), 667-676.
https://doi.org/10.1039/C4TX00118D, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19282
http://pubs.rsc.org/en/content/articlelanding/2014/tx/c4tx00118d#!divAbstract
Morgan, C., Lewis, P., Hopkins, L., Burnell, S., Kynaston, H., & Doak, S. (2015). Increased expression of ARF GTPases in prostate cancer tissue. SpringerPlus, 4(1)
https://doi.org/10.1186/s40064-015-1136-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34906
Chapman, K., Doak, S., Jenkins, G., Jenkins, G., Doak, S., & Chapman, K. (2015). Acute Dosing and p53-Deficiency Promote Cellular Sensitivity to DNA Methylating Agents. Toxicological Sciences, 144(2), 357-365.
https://doi.org/10.1093/toxsci/kfv004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20121
Manshian, B., Soenen, S., Brown, A., Hondow, N., Wills, J., Jenkins, G., Doak, S., Jenkins, G., & Doak, S. (2015). Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries. Mutagenesis, gev061
https://doi.org/10.1093/mutage/gev061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26170
http://europepmc.org/abstract/med/26275419
Soenen+José-Maria, S. & Doak, S. (2014). The effect of nanoparticle degradation on poly(methacrylic acid)-coated quantum dot toxicity: The importance of particle functionality assessment in toxicology. Acta Biomaterialia, 10(2), 732-741.
https://doi.org/10.1016/j.actbio.2013.09.041, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17886
Soenen+Lynn, S. & Doak, S. (2014). Unraveling the effects of siRNA carrier systems on cell physiology: a multiparametric approach demonstrated on dextran nanogels. Nanomedicine, 9(1), 61-76.
https://doi.org/10.2217/nnm.12.208, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17888
Whiteland, H., Lewis, P., Doak, S., & Morgan, C. (2014). A role for STEAP2 in prostate cancer progression. Clinical & Experimental Metastasis, 1-12.
https://doi.org/10.1007/s10585-014-9679-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18791
Tehrani, Z., Burwell, G., Azmi, M., Castaing, A., Rickman, R., Almarashi, J., Dunstan, P., Beigi, A., Doak, S., & Guy, O. (2014). Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker. 2D Materials, 1(2), 025004
https://doi.org/10.1088/2053-1583/1/2/025004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19735
Jenkins, G., Doak, S., & Bruesehafer, K. (2014). Chromosome Breakage Induced by the Genotoxic Agents Mitomycin C and Cytosine arabinoside. Toxicological Sciences, 140(1), 94-102.
https://doi.org/10.1093/toxsci/kfu058, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18150
Seager, A., Shah, U., Brusehafer, K., Wills, J., Manshian, B., Chapman, K., Thomas, A., Scott, A., Doherty, A., Doak, S., Johnson, G., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., Bruesehafer, K., Shah, U., & Chapman, K. (2014). Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells. Mutagenesis, 29(3), 155-164.
https://doi.org/10.1093/mutage/geu008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17804
Jenkins, G., Doak, S., & Chapman, K. (2014). Automation and validation of micronucleus detection in the 3D EpiDerm human reconstructed skin. Mutagenesis, 29(3), 165-175.
https://doi.org/10.1093/mutage/geu011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18153
Azmi, M., Tehrani, Z., Lewis, R., Walker, K., Jones, D., Daniels, D., Doak, S., & Guy, O. (2014). Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker. Biosensors and Bioelectronics, 52, 216-224.
https://doi.org/10.1016/j.bios.2013.08.030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19740
Manshian, B., Jenkins, G., Williams, P., Wright, C., Barron, A., Brown, A., Hondow, N., Dunstan, P., Rickman, R., Brady, K., Doak, S., & Wright, C. (2013). Single-walled carbon nanotubes: differential genotoxic potential associated with physico-chemical properties. Nanotoxicology, 7(2), 144-156.
https://doi.org/10.3109/17435390.2011.647928, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa7295
Pfuhler+Rosalie, S. & Doak, S. (2013). Genotoxicity of nanomaterials: Refining strategies and tests for hazard identification. Environmental and Molecular Mutagenesis, 54(4), 229-239.
https://doi.org/10.1002/em.21770, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17889
Soenen+Bella, S. & Doak, S. (2013). Fluorescent non-porous silica nanoparticles for long-term cell monitoring: Cytotoxicity and particle functionality. Acta Biomaterialia, 9(11), 9183-9193.
https://doi.org/10.1016/j.actbio.2013.04.026, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17887
Morgan, C., Jenkins, S., Kynaston, H., & Doak, S. (2013). The Role of Adhesion Molecules as Biomarkers for the Aggressive Prostate Cancer Phenotype. PLoS ONE, 8(12), e81666
https://doi.org/10.1371/journal.pone.0081666, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16740
Whiteland, H., Spencer-Harty, S., Thomas, D., Davies, C., Morgan, C., Kynaston, H., Bose, P., Fenn, N., Lewis, P., Bodger, O., Jenkins, S., & Doak, S. (2013). Putative prognostic epithelial-to-mesenchymal transition biomarkers for aggressive prostate cancer. Experimental and Molecular Pathology, 95(2), 220-226.
https://doi.org/10.1016/j.yexmp.2013.07.010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16741
Thomas, A., Jenkins, G., Kaina, B., Bodger, O., Tomaszowski, K., Lewis, P., Doak, S., Johnson, G., Jenkins, G., Lewis, P., Doak, S., Bodger, O., & Johnson, G. (2013). Influence of DNA Repair on Nonlinear Dose-Responses for Mutation. Toxicological Sciences, 132(1), 87-95.
https://doi.org/10.1093/toxsci/kfs341, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13715
Walker, K., Morgan, C., Doak, S., & Dunstan, P. (2012). Quantum Dots for Multiplexed Detection and Characterisation of Prostate Cancer Cells Using a Scanning Near-Field Optical Microscope. PLoS ONE, 7(2), e31592
https://doi.org/10.1371/journal.pone.0031592, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa7294
Seager, A., Shah, U., Mikhail, J., Nelson, B., Marquis, B., Doak, S., Johnson, G., Griffiths, S., Carmichael, P., Scott, S., Scott, A., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., & Mikhail, J. (2012). Pro-oxidant Induced DNA Damage in Human Lymphoblastoid Cells: Homeostatic Mechanisms of Genotoxic Tolerance. Toxicological Sciences, 128(2), 387-397.
https://doi.org/10.1093/toxsci/kfs152, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10909
http://toxsci.oxfordjournals.org/content/early/2012/04/26/toxsci.kfs152.abstract
Soenen, S., Manshian, B., Montenegro, J., Amin, F., Meermann, B., Thiron, T., Cornelissen, M., Vanhaecke, F., Doak, S., Parak, W., Smedt, S., & Braeckmans, K. (2012). Cytotoxic Effects of Gold Nanoparticles: A Multiparametric Study. ACS Nano, 6(7), 5767
https://doi.org/10.1021/nn301714n, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11792
Doak, S., Manshian, B., Jenkins, G., Singh, N., Jenkins, G., & Doak, S. (2012). In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 745(1-2), 104
https://doi.org/10.1016/j.mrgentox.2011.09.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10472
Doak, S., Manshian, B., Jenkins, G., & Doak, S. (2012). In vitro genotoxicity testing strategy for nanomaterials and the adptation of curent OECD guidelines.. Mutation Research - Gen tox, 745(1-2), 104-11.
https://doi.org/10.1016/j.mrgentox.2011.09.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10081
Singh, N., Jenkins, G., Nelson, B., Marquis, B., Maffeis, T., Brown, A., Williams, P., Wright, C., Doak, S., & Wright, C. (2012). The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles. Biomaterials, 33(1), 163
https://doi.org/10.1016/j.biomaterials.2011.09.087, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14121
Guy, O., Burwell, G., Tehrani, Z., Castaing, A., Walker, K., Doak, S., & Doak, S. (2012). Graphene Nano-Biosensors for Detection of Cancer Risk. Materials Science Forum, 711, 246-252.
https://doi.org/10.4028/www.scientific.net/MSF.711.246, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10471
Walker, K., Doak, S., Dunstan, P., Dunstan, P., & Doak, S. (2011). Mechanisms of cell–cell adhesion identified by immunofluorescent labelling with quantum dots: A scanning near-field optical microscopy approach. Ultramicroscopy, 111(8), 1200-1205.
https://doi.org/10.1016/j.ultramic.2011.01.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1118
Doak, S. & Zaïr, Z. (2011). Real-Time Reverse-Transcription Polymerase Chain Reaction: Technical Considerations for Gene Expression Analysis. , 817, 251-270.
https://doi.org/10.1007/978-1-61779-421-6_13, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10475
Hondow, N., Harrington, J., Brydson, R., Doak, S., Singh, N., Manshian, B., & Brown, A. (2011). STEM mode in the SEM: A practical tool for nanotoxicology. Nanotoxicology, 5(2), 215
https://doi.org/10.3109/17435390.2010.535622, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9846
Griffiths, S., Singh, N., Jenkins, G., Wright, C., Jenkins, G., Williams, P., Doak, S., & Orbaek White, A. (2011). Dextran coated ultrafine superparamagnetic iron oxide nanoparticles: compatibility with common fluorometric and colorimetric dyes.. Analytical Chemistry, 83(10), 3778-3785.
https://doi.org/10.1021/ac200103x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10082
Zair, Z., Jenkins, G., Doak, S., Singh, R., Brown, K., Johnson, G., Jenkins, G., Doak, S., & Johnson, G. (2011). N-Methylpurine DNA Glycosylase Plays a Pivotal Role in the Threshold Response of Ethyl Methanesulfonate-Induced Chromosome Damage. Toxicological Sciences, 119(2), 346-358.
https://doi.org/10.1093/toxsci/kfq341, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10158
Jenkins, G., Zaïr, Z., Johnson, G., & Doak, S. (2010). Genotoxic thresholds, DNA repair, and susceptibility in human populations. Toxicology, 278(3), 305-310.
https://doi.org/10.1016/j.tox.2009.11.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9893
Johnson, G., Jenkins, G., Thomas, A., & Doak, S. (2010). Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 702(2), 189-192.
https://doi.org/10.1016/j.mrgentox.2009.07.014, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9258
Singh, N., Manshian, B., Jenkins, G., Griffiths, S., Williams, P., Maffeis, T., Wright, C., Doak, S., & Wright, C. (2009). NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials. Biomaterials, 30(23-24), 3891-3914.
https://doi.org/10.1016/j.biomaterials.2009.04.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10709
Doak, S., Griffiths, S., Manshian, B., Singh, N., Williams, P., Brown, A., Jenkins, G., Jenkins, G., Williams, P., & Doak, S. (2009). Confounding experimental considerations in nanogenotoxicology. Mutagenesis, 24(4), 285
https://doi.org/10.1093/mutage/gep010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9847
Doak, S., Brusehafer, K., Dudley, E., Jenkins, G., Dudley, E., Doak, S., Johnson, G., & Bruesehafer, K. (2008). No-observed effect levels are associated with up-regulation of MGMT following MMS Exposure. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS ??, 648(1-2), 9-14.
https://doi.org/10.1016/j.mrfmmm.2008.09.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10127
Doak, S., Rogers, D., Jones, B., Wright, C., Doak, S., & Francis, L. (2008). High resolution imaging using a novel atomic force microscope and confocal laser scanning microscope hybrid instrument: essential sample preparation aspects. Histochemistry & cell biology, 130(5), 909-916.
https://doi.org/10.1007/s00418-008-0489-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10128
Doak, S., Jenkins, S., Hurle, R., Varma, M., Hawizy, A., Kynaston, H., & Parry, J. (2007). Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer. Cancer Genetics and Cytogenetics, 176(2), 161-165.
https://doi.org/10.1016/j.cancergencyto.2007.03.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16739
Doak, S., Jenkins, G., Johnson, G., Quick, E., Parry, E., Parry, J., Jenkins, G., Doak, S., & Johnson, G. (2007). Mechanistic Influences for Mutation Induction Curves after Exposure to DNA-Reactive Carcinogens. Cancer Research, 67(8), 3904-3911.
https://doi.org/10.1158/0008-5472.CAN-06-4061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17856
Baylis, R., BAYLIS, R., DOAK, S., PARRY, J., DUNSTAN, P., Dunstan, P., & Doak, S. (2006). Chromosome morphology after long-term storage investigated by scanning near-field optical microscopy. Journal of Microscopy, 221(3), 177-182.
https://doi.org/10.1111/j.1365-2818.2006.01561.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1549
Ivil, K., Doak, S., Jenkins, S., Parry, E., Kynaston, H., Parry, J., Stephenson, T., & Doak, S. (2006). Fluorescence in-situ hybridisation on biopsies from clam ileocystoplasties and on a clam cancer. British Journal of Cancer, 94(6), 891
https://doi.org/10.1038/sj.bjc.6603035, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1409
Doak, S., Jenkins, G., & Doak, S. (2004). Differential expression of the MAD2, BUB1 and HSP27 genes in Barrett's oesophagus—their association with aneuploidy and neoplastic progression. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 547(1-2), 133
https://doi.org/10.1016/j.mrfmmm.2003.12.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1408
Doak, S., Jenkins, G., Parry, E., Griffiths, A., Shah, V., Baxter, J., Parry, J., Jenkins, G., Doak, S., & Baxter, J. (2003). Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma. British Journal of Cancer, 89(9), 1729-1735.
https://doi.org/10.1038/sj.bjc.6601323, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1363
Doak, S., Jenkins, G., & Doak, S. (2003). Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus. Gut, 52(5), 623-628.
https://doi.org/10.1136/gut.52.5.623, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1388

Book Chapters

Evans, S., Vecchiarelli, P., Clift, M., Doak, S., & Lead, J. (2021). Overview of Nanotoxicology in Humans and the Environment; Developments, Challenges and Impacts. Nanotoxicology in Humans and the Environment (pp. 1-40). Springer International Publishing
https://doi.org/10.1007/978-3-030-79808-6_1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59028
Evans, S., Jenkins, G., Doak, S., & Clift, M. (2019). Cellular Defense Mechanisms Following Nanomaterial Exposure: A Focus on Oxidative Stress and Cytotoxicity. Biological Responses to Nanoscale Particles (pp. 243-254). Springer International Publishing
https://doi.org/10.1007/978-3-030-12461-8_10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50127
Doak, S., Liu, Y., & Chen, C. (2012). Genotoxicity and Cancer. Adverse Effects of Engineered Nanomaterials (pp. 243Elsevier
https://doi.org/10.1016/B978-0-12-386940-1.00014-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10476
Jenkins, G., Johnson, G., Parry, J., & Doak, S. (2011). Genotoxic Thresholds. Genotoxic Impurities (pp. 169John Wiley & Sons, Ltd
https://doi.org/10.1002/9780470929377.ch7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10474

Supervision

Investigating Genotoxic and Metabolic Effects of Dietary Carcinogens in Gastrointestinal and Hepatic Cell Models for a Novel 3R-Compliant In Vitro Safety Assessment (current)

PhD

Other supervisor: Prof Gareth Jenkins
Mechanistic investigation of the causes of tumour induced lymphocyte DNA damage. (current)

PhD

Other supervisor: Prof Gareth Jenkins
Developing quantitative Adverse Outcome Pathways (qAOPs) for genotoxicity using 3D liver models (current)

PhD

Other supervisor: Prof Gareth Jenkins
Selective Inhibition of extracellular vesicle subtypes associated with aggressive prostate cancer (current)

PhD

Other supervisor: Dr Jason Webber
Deducing the impact of engineered nanomaterials upon human health using advanced lung cell systems combined with state-of-the-art analytical approaches (current)

PhD

Other supervisor: Prof Martin Clift
Development of an advanced multi-cellular and dynamic flow model of the human alveolar airway (awarded 2022)

PhD

Other supervisor: Prof Martin Clift
Using DNA damage in circulating blood cells as a biomarker for oesophageal adenocarcinoma risk (current)

PhD

Other supervisor: Prof Gareth Jenkins
Disentangling the Effects of Nitrogen Dioxide and Particulates in Air Pollution on Human Health: A Mechanistic Toxicological Approach (current)

PhD

Other supervisor: Prof Martin Clift
Establishing the Effects of ADSCs on the Tumorigenic Characteristics of Breast Cancer (awarded 2022)

PhD

Other supervisor: Prof Iain Whitaker
Novel Multiple Endpoint Approaches for Assessing Genotoxicity and Carcinogenicity Potential In Vitro (awarded 2024)

PhD

Other supervisor: Prof Gareth Jenkins
Development of a novel composite bioink for cartilage tissue engineering (awarded 2023)

PhD

Other supervisor: Prof Iain Whitaker
Developing an in vitro repeat-dose approach to detect non-genotoxic carcinogens (NGCs) (awarded 2024)

PhD

Other supervisor: Prof Gareth Jenkins
The impact of epithelial cell passage number upon key toxicological endpoint analyses (awarded 2024)

MSc

Other supervisor: Prof Martin Clift
Elucidating the Impact of Inhaled Micro-, Nanoplastics from Surgical Face Masks In Vitro (awarded 2024)

MSc

Other supervisor: Prof Martin Clift

Taught Modules

PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-351 Nanotoxicology

Nanomaterials are comprised of very small particles that provide many of the products we use increased strength, chemical reactivity or conductivity. They can also be the by-product of e.g. industrial processes or they can occur naturally, as with soot from forest fires or volcanic ash. The particles range in size from approximately 1 to 100 nanometres; that is 1 / 1,000,000,000th of a metre. Due to their small size they can readily enter our bodies through a number of exposure routes, of which inhalation, ingestion or absorption through the skin, as well as injection into the circulation are dominant. These particles have unique properties compared to their larger counterparts and we are only beginning to understand what their health effects may be. The purpose of this module is to give an introduction into the field of nanoscience, nanotechnology and the potential risks posed by this new Industrial Age to humans.
PM-M28 Nano(geno)toxicology

The field of nanotechnology is ever increasing in size, and the number of nano-sized (1-100nm) particles being produced on a daily basis is at the tonnage level. Although nanotechnology-based applications are considered to be advantageous for a plethora of human activities, the potential risks posed by human exposure to nanoparticles is a constantly developing field of research. The purpose of this module therefore is to introduce to the student to particle toxicology and how it can impact upon human health. Further to this, the students will undertake a specific practical component to complement that of the theoretical content of the module. To this extent, the students will undertake a week-long, 'mini-project', covering the major areas of nanoparticle toxicology. From this approach, it is intended that the student will experience the key practical approaches taken in the field.

Professor Shareen Doak

Research Links

About

Areas Of Expertise

Publications

Research Highlights

All Research

Journal Articles

Book Chapters

Supervision

Investigating Genotoxic and Metabolic Effects of Dietary Carcinogens in Gastrointestinal and Hepatic Cell Models for a Novel 3R-Compliant In Vitro Safety Assessment (current)

Mechanistic investigation of the causes of tumour induced lymphocyte DNA damage. (current)

Developing quantitative Adverse Outcome Pathways (qAOPs) for genotoxicity using 3D liver models (current)

Selective Inhibition of extracellular vesicle subtypes associated with aggressive prostate cancer (current)

Deducing the impact of engineered nanomaterials upon human health using advanced lung cell systems combined with state-of-the-art analytical approaches (current)

Development of an advanced multi-cellular and dynamic flow model of the human alveolar airway (awarded 2022)

Using DNA damage in circulating blood cells as a biomarker for oesophageal adenocarcinoma risk (current)

Disentangling the Effects of Nitrogen Dioxide and Particulates in Air Pollution on Human Health: A Mechanistic Toxicological Approach (current)

Establishing the Effects of ADSCs on the Tumorigenic Characteristics of Breast Cancer (awarded 2022)

Novel Multiple Endpoint Approaches for Assessing Genotoxicity and Carcinogenicity Potential In Vitro (awarded 2024)

Development of a novel composite bioink for cartilage tissue engineering (awarded 2023)

Developing an in vitro repeat-dose approach to detect non-genotoxic carcinogens (NGCs) (awarded 2024)

The impact of epithelial cell passage number upon key toxicological endpoint analyses (awarded 2024)

Elucidating the Impact of Inhaled Micro-, Nanoplastics from Surgical Face Masks In Vitro (awarded 2024)

Taught Modules

PM-344 Capstone Project

PM-351 Nanotoxicology

PM-M28 Nano(geno)toxicology

Key Grants and Projects

PATROLS 2018

CALIN 2016

RiskGONE 2019

NanoInformaTIX 2019

Professor Shareen Doak

Telephone number

Email address

Research Links

About

Areas Of Expertise

Research Highlights

All Research

Investigating Genotoxic and Metabolic Effects of Dietary Carcinogens in Gastrointestinal and Hepatic Cell Models for a Novel 3R-Compliant In Vitro Safety Assessment (current)

Mechanistic investigation of the causes of tumour induced lymphocyte DNA damage. (current)

Developing quantitative Adverse Outcome Pathways (qAOPs) for genotoxicity using 3D liver models (current)

Selective Inhibition of extracellular vesicle subtypes associated with aggressive prostate cancer (current)

Deducing the impact of engineered nanomaterials upon human health using advanced lung cell systems combined with state-of-the-art analytical approaches (current)

Development of an advanced multi-cellular and dynamic flow model of the human alveolar airway (awarded 2022)

Using DNA damage in circulating blood cells as a biomarker for oesophageal adenocarcinoma risk (current)

Disentangling the Effects of Nitrogen Dioxide and Particulates in Air Pollution on Human Health: A Mechanistic Toxicological Approach (current)

Establishing the Effects of ADSCs on the Tumorigenic Characteristics of Breast Cancer (awarded 2022)

Novel Multiple Endpoint Approaches for Assessing Genotoxicity and Carcinogenicity Potential In Vitro (awarded 2024)

Development of a novel composite bioink for cartilage tissue engineering (awarded 2023)

Developing an in vitro repeat-dose approach to detect non-genotoxic carcinogens (NGCs) (awarded 2024)

The impact of epithelial cell passage number upon key toxicological endpoint analyses (awarded 2024)

Elucidating the Impact of Inhaled Micro-, Nanoplastics from Surgical Face Masks In Vitro (awarded 2024)

PM-344 Capstone Project

PM-351 Nanotoxicology

PM-M28 Nano(geno)toxicology