Areas of Expertise

  • Sterol 14-alpha demethylases (CYP51)
  • NADPH-Cytochrome P450 reductases
  • Azole antifungals (pharmazoles and agriazoles)
  • Enzymology
  • Protein Biochemistry
  • Protein Purification
  • Centre for Cytochrome P450 Biodiversity Homepage ( http://www.p450swansea.co.uk/ )
  • Co-investigator on BEACON ( http://www.beaconwales.org )

Publications

  1. et. al. In vitro and in vivo antifungal profile of a novel and long acting inhaled azole, PC945, on Aspergillus fumigatus infection. Antimicrobial Agents and Chemotherapy, AAC.02280-16
  2. & The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through its Inhibition of T. rubrum CYP51. Antimicrobial Agents and Chemotherapy, AAC.00333-17
  3. & Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Scientific Reports 6, 27690
  4. & The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. Antimicrobial Agents and Chemotherapy 60(8), 4530-4538.
  5. & The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme. Antimicrobial Agents and Chemotherapy 58(12), 7121-7127.

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