Professor Venkat Kanamarlapudi

Publications

Journal Articles

  1. & The Bacterial Species Campylobacter jejuni Induce Diverse Innate Immune Responses in Human and Avian Intestinal Epithelial Cells. Frontiers in Microbiology 8, 1840
  2. & Shear Stress-Induced Total Blood Trauma in Multiple Species. Artificial Organs
  3. & EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment. Journal of Cell Science, jcs.207423
  4. & Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation. PLOS ONE 11(4), e0154229
  5. & Luteinizing hormone/chorionic gonadotrophin receptor overexpressed in granulosa cells from polycystic ovary syndrome ovaries is functionally active. Reproductive BioMedicine Online
  6. & Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunology
  7. & Distinct Regions in the C-Terminus Required for GLP-1R Cell Surface Expression, Activity and Internalisation. Molecular and Cellular Endocrinology 413, 66-77.
  8. & Exclusion of Integrins from CNS Axons Is Regulated by Arf6 Activation and the AIS. Journal of Neuroscience 35(21), 8359-8375.
  9. & The regions within the N-terminus critical for human glucagon like peptide-1 receptor (hGLP-1R) cell Surface expression. Scientific Reports 4, 7410
  10. & Growth factors mediated differentiation of mesenchymal stem cells to cardiac polymicrotissue using hanging drop and bioreactor. Cell Biology International 39(4), 502-507.
  11. & Agonist-induced internalisation of the glucagon-like peptide-1 receptor is mediated by the Gαq pathway. Biochemical Pharmacology 93(1), 72-84.
  12. Exchange factor EFA6R requires C-terminal targeting to the plasma membrane to promote cytoskeletal rearrangement through the activation of ARF6. Journal of Biological Chemistry 289(48), 33378-33390.
  13. & Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2. Biochemical Pharmacology 92(4), 651-660.
  14. & ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes. BIOCHEMICAL PHARMACOLOGY 90(4), 406-413.
  15. et. al. The Effect of Shear Stress on the Size, Structure, and Function of Human von Willebrand Factor. Artificial Organs 38(9), 741-750.
  16. et. al. The temporal expression of estrogen receptor alpha-36 and runx2 in human bone marrow derived mesenchymal stromal cells during osteogenesis. Biochemical and Biophysical Research Communications
  17. Type 2 Diabetes Mellitus and Glucagon Like Peptide-1 Receptor Signalling. Clinical & Experimental Pharmacology 03(04)
  18. & Lactoferrin inhibits dexamethasone-induced chondrocyte impairment from osteoarthritic cartilage through up-regulation of extracellular signal-regulated kinase 1/2 and suppression of FASL, FAS, and Caspase 3. Biochemical and Biophysical Research Communications 441(1), 249-255.
  19. & ARF6 Directs Axon Transport and Traffic of Integrins and Regulates Axon Growth in Adult DRG Neurons. The Journal of Neuroscience 32(30), 10352-10364.
  20. & ADP-Ribosylation Factor 6 Expression and Activation Are Reduced in Myometrium in Complicated Pregnancies. PLoS ONE 7(5), e37954
  21. & ARF6 Activated by the LHCG Receptor through the Cytohesin Family of Guanine Nucleotide Exchange Factors Mediates the Receptor Internalization and Signaling. Journal of Biological Chemistry 287(24), 20443
  22. & ARF6-Dependent Regulation of P2Y Receptor Traffic and Function in Human Platelets. PLoS ONE 7(8), e43532
  23. & A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation. Human Mutation 30(1), 61-68.
  24. & Single-Channel Characterization of the Rabbit Recombinant RyR2 Reveals a Novel Inactivation Property of Physiological Concentrations of ATP. Journal of Membrane Biology 222(2), 65-77.
  25. & PI-3-kinase-dependent membrane recruitment of centaurin- 2 is essential for its effect on ARF6-mediated actin cytoskeleton reorganisation. Journal of Cell Science 120(5), 792-801.
  26. Bouschet, Tristan, Martin, Stephane, Kanamarlapudi, Venkateswarlu, Mundell, Stuart, Henley, Jeremy M. The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network. Journal of Cell Science 120(15), 2489-2497.
  27. Kanumilli, S., Tringham, E. W., Payne, C. E., Dupere, J. R. B., Venkateswarlu, K., Usowicz, M. M. Alternative splicing generates a smaller assortment of CaV2.1 transcripts in cerebellar Purkinje cells than in the cerebellum. Physiological Genomics 24(2), 86-96.
  28. Kanamarlapudi V Centaurin-α1 and KIF13B kinesin motor protein interaction in ARF6 signalling. Biochemical Society Transactions 33(6), 1279
  29. Lawrence, J., Mundell, S. J., Yun, H. R., Kelly, E., Venkateswarlu, K. Centaurin- 1, an ADP-Ribosylation Factor 6 GTPase Activating Protein, Inhibits  2-Adrenoceptor Internalization. Molecular Pharmacology 67(6), 1822-1828.
  30. Kanamarlapudi, V. Centaurin-alpha(1) and KIF13B kinesin motor protein interaction in ARF6 signalling. Biochemical Society Transactions 33
  31. Gunn-Moore, F. J., Welsh, G. I., Herron, L. R., Brannigan, F., Venkateswarlu, K., Gillespie, S., Brandwein-Gensler, M., Madan, R., Tavare, J. M., Brophy, P. J., Prystowsky, M. B., Guild, S. A novel 4.1 ezrin radixin moesin (FERM)-containing protein, ‘Willin’. FEBS Letters 579(22), 5089-5094.
  32. Centaurin- 1 interacts directly with kinesin motor protein KIF13B. Journal of Cell Science 118(11), 2471-2484.
  33. Centaurin- 1 Is an in Vivo Phosphatidylinositol 3,4,5-Trisphosphate-dependent GTPase-activating Protein for ARF6 That Is Involved in Actin Cytoskeleton Organization. Journal of Biological Chemistry 279(8), 6205-6208.
  34. Interaction Protein for Cytohesin Exchange Factors 1 (IPCEF1) Binds Cytohesin 2 and Modifies Its Activity. Journal of Biological Chemistry 278(44), 43460-43469.
  35. Kanumilli, S., Toms, N. J., Venkateswarlu, K., Mellor, H., Roberts, P. J. Functional coupling of rat metabotropic glutamate 1a receptors to phospholipase D in CHO cells: involvement of extracellular Ca2+, protein kinase C, tyrosine kinase and Rho-A. Neuropharmacology 42(1), 1-8.
  36. Bobe, R., Wilde, J. I., Maschberger, P., Venkateswarlu, K., Cullen, P. J., Siess, W., Watson, S. P. Phosphatidylinositol 3-kinase-dependent translocation of phospholipase Cgamma2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation. Blood 97(3), 678-684.
  37. Lamb, D. C., Kaderbhai, N. N., Venkateswarlu, K., Kelly, D. E., Kelly, S. L., Kaderbhai, M. A. Human Sterol 14α-Demethylase Activity Is Enhanced by the Membrane-Bound State of Cytochrome b5. Archives of Biochemistry and Biophysics 395(1), 78-84.
  38. Dubois, T., Kerai, P., Zemlickova, E., Howell, S., Jackson, T. R., Venkateswarlu, K., Cullen, P. J., Theibert, A. B., Larose, L., Roach, P. J., Aitken, A. Casein Kinase I Associates with Members of the Centaurin-alpha Family of Phosphatidylinositol 3,4,5-Trisphosphate-binding Proteins. Journal of Biological Chemistry 276(22), 18757-18764.
  39. Lamb, D. C., Warrilow, A. G. S., Venkateswarlu, K., Kelly, D. E., Kelly, S. L. Activities and Kinetic Mechanisms of Native and Soluble NADPH–Cytochrome P450 Reductase. Biochemical and Biophysical Research Communications 286(1), 48-54.
  40. Venkateswarlu, K., Cullen, P. J. Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase. Biochemical Journal 345(3), 719
  41. Cullen, P. J., Venkateswarlu, K. Potential regulation of ADP-ribosylation factor 6 signalling by phosphatidylinositol 3,4,5-trisphosphaee. Biochemical Society Transactions 27
  42. Venkateswarlu, K., Cullen, P. J. Molecular Cloning and Functional Characterization of a Human Homologue of Centaurin-α. Biochemical and Biophysical Research Communications 262(1), 237-244.
  43. Lockyer, P. J., Wennstrom, S., Kupzig, S., Venkateswarlu, K., Downward, J., Cullen, P. J. Identification of the Ras GTPase-activating protein GAP1m as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo. Current Biology 9(5), 265-269.
  44. Venkateswarlu, K., Oatey, P. B., Tavare, J. M., Jackson, T. R., Cullen, P. J. Identification of centaurin-α1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1. Biochemical Journal 340(2), 359
  45. Lamb, D. C., Kelly, D. E., Venkateswarlu, K., Manning, N. J., Bligh, H. F. J., Schunck, W. H., Kelly, S. L. Generation of a Complete, Soluble, and Catalytically Active Sterol 14α-Demethylase−Reductase Complex†. Biochemistry 38(27), 8733-8738.
  46. Venkateswarlu, K., Gunn-Moore, F., Tavare, J. M., Cullen, P. J. EGF- and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain. Journal of Cell Science 112
  47. Oatey, P. B., Venkateswarlu, K., Williams, A. G., Fletcher, L. M., Foulstone, E. J., Cullen, P. J., Tavare, J. M. Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin- and PDGF-stimulated 3T3-L1 adipocytes. Biochemical Journal 344(2), 511
  48. Venkateswarlu, K., Lamb, D. C., Kelly, D. E., Manning, N. J., Kelly, S. L. The N-Terminal Membrane Domain of Yeast NADPH-Cytochrome P450 (CYP) Oxidoreductase Is Not Required for Catalytic Activity in Sterol Biosynthesis or in Reconstitution of CYP Activity. Journal of Biological Chemistry 273(8), 4492-4496.
  49. Venkateswarlu, K., Gunn-Moore, F., Oatey, P. B., Tavare, J. M., Cullen, P. J. Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP ribosylation factor exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain. Biochemical Journal 335
  50. Venkateswarlu, K., Kelly, D. E., Manning, N. J., Kelly, S. L. NADPH cytochrome P-450 oxidoreductase and susceptibility to ketoconazole. Antimicrobial Agents and Chemotherapy 42
  51. Venkateswarlu, K., Oatey, P. B., Tavare, J. M., Cullen, P. J. Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase. Current Biology 8(8), 463-466.
  52. Venkateswarlu, K., Kelly, S. L. Stereoselective interaction of SCH 39304, a triazole, with sterol 14alpha-demethylase of Aspergillus fumigatus. Journal of Antimicrobial Chemotherapy 39(5), 597-601.
  53. Denning, D. W., Venkateswarlu, K., Oakley, K. L., Anderson, M. J., Manning, N. J., Stevens, D. A., Warnock, D. W., Kelly, S. L. Itraconazole resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy 41
  54. Venkateswarlu, K., Denning, D. W., Kelly, S. L. Inhibition and interaction of cytochrome P450 of Candida krusei with azole antifungal drugs. Journal of Medical and Veterinary Mycology 35
  55. Venkateswarlu, K., Denning, D. W., Kelly, S. L. In-vitro activity of D0870, a new triazole antifungal drug, in comparison with fluconazole and itraconazole against Aspergillus fumigatus and Candida krusei. Journal of Antimicrobial Chemotherapy 39(6), 731-736.
  56. Venkateswarlu, K., Taylor, M., Manning, N. J., Rinaldi, M. G., Kelly, S. L. Fluconazole tolerance in clinical isolates of Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy 41
  57. Lockyer, P. J., Bottomley, J. R., Reynolds, J. S., McNulty, T. J., Venkateswarlu, K., Potter, B. V. L., Dempsey, C. E., Cullen, P. J. Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting. Current Biology 7(12), 1007-1010.
  58. Venkateswarlu, K., Kelly, D. E., Kelly, S. L. Characterization of Saccharomyces cerevisiae CYP51 and a CYP51 fusion protein with NADPH cytochrome P-450 oxidoreductase expressed in Escherichia coli. Antimicrobial Agents and Chemotherapy 41
  59. Venkateswarlu, K., Denning, D. W., Manning, N. J., Kelly, S. L. Reduced accumulation of drug in Candida krusei accounts for itraconazole resistance. Antimicrobial Agents and Chemotherapy 40
  60. Venkateswarlu, K., Marsh, R. M., Faber, B., Kelly, S. L. Investigation of Cytochrome P450 Mediated Benzo(a)pyrene Hydroxylation in Aspergillus fumigatus. Journal of Chemical Technology & Biotechnology 66(2), 139-144.
  61. Masaphy, S., Levanon, D., Henis, Y., Venkateswarlu, K., Kelly, S. L. Evidence for cytochrome P-450 and P-450-mediated benzo(a) pyrene hydroxylation in the white rot fungusPhanerochaete chrysosporium. FEMS Microbiology Letters 135(1), 51-55.
  62. Venkateswarlu, K., Denning, D. W., Manning, N. J., Kelly, S. L. Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays. Antimicrobial Agents and Chemotherapy 40
  63. Venkateswarlu, K., Kelly, S. L. Biochemical characterisation of ketoconazole inhibitory action onAspergillus fumigatus. FEMS Immunology & Medical Microbiology 16(1), 11-20.
  64. Venkateswarlu, K., Denning, D. W., Manning, N. J., Kelly, S. L. Resistance to fluconazole inCandida albicansfrom AIDS patients correlated with reduced intracellular accumulation of drug. FEMS Microbiology Letters 131(3), 337-341.
  65. Masaphy, S., Levanon, D., Henis, Y., Venkateswarlu, K., Kelly, S. L. Microsomal and cytosolic cytochrome P450 mediated benzo(a)pyrene hydroxylation in Pleurotus pulmonarius. Biotechnology Letters 17(9), 969-974.
  66. Fang, G., Venkateswarlu, K., Kelly, D. E., Kelly, S. L. STUDIES ON YEAST HOST STRAINS FOR HETEROLOGOUS P450 EXPRESSION. Biotechnology Letters 16
  67. Padidam, M., Venkateswarlu, K., Johri, M. M. Ammonium represses NADPH-nitrate reductase in the moss Funaria hygrometrica. Plant Science 75(2), 185-194.

Book Chapters

  1. Venkateswarlu, K. GTPases Regulating Membrane Dynamics. In Analysis of the Interaction Between Cytohesin 2 and IPCEF1. (pp. 252-266).

Other Research Outputs

  1. & SCREENING METHOD FOR REGULATORY ENZYMES EMPLOYING TRIBRID (TRI-HYBRID) SYSTEM.