Professor Jenkins’s research falls within the “Biomarkers and Genes” theme of the Medical School.

His research group investigate the molecular basis of cancer in the gastrointestinal tract, particularly the pre-malignant condition; Barrett’s Oesophagus. Group aims are to develop early detection systems for cancer. His blood based cancer detection approach (based on Pig A gene mutations in red blood cells) recently received a lot of media interest. His group investigate DNA damage levels in Barrett’s patients and NF-kB signalling induced in oesophageal tissues. The research is aimed at better understanding early carcinogenesis and to identify diagnostic markers for clinical utility. Professor Jenkins also collaborates with others in the areas of colorectal cancer biology and pancreatic cancer.

He is also an internationally recognised researcher in the field of Genetic Toxicology (DNA damage), being at the forefront of research efforts to improve in vitro (cell-based) assessment of genotoxic risks from chemical exposure. Current work centres on mechanistic studies of genotoxic thresholds, 3-D tissue models for genotoxicity and coupling genotoxic assessment with disruption of other cell biological processes (cell cycle, cell signalling, cell morphology).

Professor Jenkins was appointed to the UK Government’s Committee on Mutagenicity (COM) in 2009, was appointed a “Research Leader” by Health and Care Research Wales in 2012 and was appointed Senior Editor of Mutagenesis in 2016. He has received over £3million in grant income, written over 70 peer-reviewed papers and edited a book on the toxicology of Bile acids. Professor Jenkins is the head of research at the Medical School. He has an Honorary position at Abertawe Bro Morgannwg University (ABMU) Health Board.

Areas of Expertise

  • DNA mutation
  • Cancer Biomarkers
  • Oesophageal cancer
  • Safety Assessment
  • Genetic Toxicology

Publications

  1. & A Newly Developed Nested PCR Assay for the Detection of Helicobacter pylori in the Oral Cavity. Journal of Clinical Gastroenterology, 1
  2. & The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF- B activation in oesophageal cells, with a mechanism of action involving ROS. Mutagenesis 23(5), 399-405.
  3. & No-observed effect levels are associated with up-regulation of MGMT following MMS exposure. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 648(1-2), 9-14.
  4. & Non-linear dose–response of DNA-reactive genotoxins: Recommendations for data analysis. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 678(2), 95-100.
  5. & Confounding experimental considerations in nanogenotoxicology. Mutagenesis 24(4), 285-293.

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Teaching

  • PM-304 Biomolecular Research Project

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  • PM-317 Genetics of Cancer

    This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.

  • PM-M16 Nano(geno)toxicology

    Nano(geno)toxicology is a new discipline that has recently evolved with the development of the nanotechnology industry. This subject encompasses general toxicology associated with nanomaterials and also specifically focuses on the sub-discipline of genotoxicology. This course will therefore focus on, (I) the parameters of engineered nanomaterials that govern their interaction and influence on biological systems; (II) techniques that are central elements in assessing the safety evaluation of nanomaterials; (III) portals of entry into the body, their potential fate and the mechanisms that underlie cellular damage by nanomaterials.

  • PM-M28 Nano(geno)toxicology

    Nano(geno)toxicology is a new discipline that has recently evolved with the development of the nanotechnology industry. This subject encompasses general toxicology associated with nanomaterials and also specifically focuses on the sub-discipline of genotoxicology. This course will therefore focus on, (I) the parameters of engineered nanomaterials that govern their interaction and influence on biological systems; (II) techniques that are central elements in assessing the safety evaluation of nanomaterials; (III) portals of entry into the body, their potential fate and the mechanisms that underlie cellular damage by nanomaterials.

Supervision

  • Blood-based test for pancreatic cancer (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • Blood based chemotherapy response monitoring (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • Development of a blood based biomarker for early GI tract cancer (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • Development and characterisation of prostate cancer spheroids for drug evaluation (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • Characterization of alginate-mucin glycan interaction for tailored therapeutic development in cystic fibrosis (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Prof Paul Lewis
  • In vitro assessment of genotoxicity and cell cycle abnormalities to better understand carcinogenic risk (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • The effect of chronic dosing regimes on genotoxic hazard identification (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • Defining the mechanisms driving genomic variation and virulence in Helicobacter pylori and identifying the genes/alleles responsible. (current)

    Student name:
    PhD
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Prof Thomas Humphrey
    Other supervisor: Prof Gareth Jenkins
  • Mechanistic Investigation of the Epigenetic Aberrations Underlying Colorectal Cancer and its Resistance to Therapy (current)

    Student name:
    MD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • Development of a novel in vitro liver 3D model to assess potential (geno)toxicity of nanomaterials (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • 'Investigations into novel diagnostic biomarkers for oesophageal adenocarcinoma' (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Steve Conlan
  • An investigation of the clinical and patient reported outcomes following surgically treated pancreatic cancer in Wales? (current)

    Student name:
    MD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Hayley Hutchings
  • 'The role of pelvic exenteration in the management of locally advanced primary rectal cancer.' (awarded 2017)

    Student name:
    MD
    Other supervisor: Prof Paul Lewis
    Other supervisor: Prof Gareth Jenkins
  • 'Generic and epigenetic factors in colon and rectal cancer' (awarded 2017)

    Student name:
    MD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • 'Cytotoxic and Genotoxic Evaluation of Nano-Graphene Sheets as a Function of Surface Chemistry' (awarded 2016)

    Student name:
    MSc
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • 'Differentiating In vitro genotoxic carcinogens, non-genotoxic carcinogens and misleading positive non-carcinogens' (awarded 2016)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • 'A study of in vitro genotoxicity test system' (awarded 2015)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • 'Prediciting response in rectal cancer to chemoradiotherapy: influence of molecular classification' (awarded 2015)

    Student name:
    MD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Steve Conlan
  • 'Development of the high throughput mammalian Pig-A gene mutation assay in vitro' (awarded 2015)

    Student name:
    PhD
    Other supervisor: Dr George Johnson
    Other supervisor: Prof Gareth Jenkins
  • ''''Studies into the molecular mechanisms of the metaplasia-dysplasia-cancer progression in Barrett''s Oesophagus'''' (awarded 2015)

    Student name:
    MD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Paul Lewis
  • '''Aneuploidy in pancreatic intraepithelial neoplasia''' (awarded 2015)

    Student name:
    MD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Bilal Al-Sarireh
    Other supervisor: Prof Shareen Doak
  • ''Genotoxic Responses At Low Doses For Chemicals Requiring Matabolic Activation Using Different Human Cell Lines'' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • 'Cellular uptake and genotoxicity of quantum dots as a function of surface chemistry' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • ''Investigations into the causes of aneuploidy in pre-malignant stages of intestinal-ype gastric cancer'' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • 'Development and optimisation of methods to support in-vitro nanogenotoxicolgy' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • 'Role of p53 in low dose response relationships of genotoxins' (awarded 2013)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • The role of NF-KB Helicobacter Pylori-Induced Ciastric Carcinogenesis (awarded 2012)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Professor Dietrich Mack
  • Fluorescence In situ hybridisation (FISH) analysis of chromosome 1 and gene expression levels of MAD2 and BUB1 levels in premalignant stages of gastric cancer. (awarded 2012)

    Student name:
    MD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof John Williams
  • Identification of dead regions within the Cochlea using Threshold Equalising noise test (TEN) in patients who had chemotherapy with platinum based drugs (awarded 2011)

    Student name:
    MPhil
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Mr Simon Browning
  • Gastro-duodenal Oesophagael Reflux Induced NFkB Signalling in Oesophagel Adenocarcinoma (awarded 2011)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Dr Liz Parry
  • The use of curcumin in Barrett's Oesophagus and an assessment of its toxicity in the oesophageal cancer cell line (awarded 2011)

    Student name:
    MD
    Other supervisor: Prof John Baxter
    Other supervisor: Prof Gareth Jenkins
  • An assessment of the genotoxicity and cell survival abnormalities in Barrett's oesophagus. (awarded 2010)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Professor James Parry
  • REPRIMO G> 824 AND P53R2 C>G 4696 SINGLE NUCLEOTIDE POLYMORPHISMS AND COLORECTAL CANCER - A CASE-CONTROL DISEASE - ASSOCIATION STUDY. (awarded 2008)

    Student name:
    MPhil
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Professor James Parry
  • Gene Expression Analysis of Gastric Cancer and Pre-Malignant Gastric Disease. (awarded 2008)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Professor James Parry
  • Genotoxicity assessment of andrographolide (awarded 2008)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • Molecular Analysis of Inflammation, Oxidative Stress, and Gastric Carcinogenesis. (awarded 2007)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Professor James Parry
  • the Role of Nuclear Factor KappaB Activation in Barretts Oesophagus (awarded 2007)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Dr Liz Parry