My research interest focuses on microbial pathogenesis and antibiotic resistance; with specific interest in staphylococcal biofilm formation and its role in pathogenesis of biomaterial-related infections and nosocomial infections. I am a highly skilled researcher with excellent knowledge in Staphylococcus aureus and S. epidermidis adhesion and biofilm formation mechanisms. This involves studying the effect of relevant genes on the adhesion and biofilm formation of staphylococci to implant surfaces using various molecular biology techniques and whole genome sequencing. I am also competent in using confocal laser scanning microscopy, scanning electron microscopy, transmission electron microscope, and immunolabelling techniques.  I help supervise both undergraduate and postgraduate students working on a variety of staphylococci and Campylobacter pathogenicity projects in collaboration with the Abertawe Bro Morgannwg University Health Board (ABMU), Public Health Wales, and AO Research Institute Davos, Switzerland.

I am/have been a co-applicant on a Coleg Cymraeg Cenedlaethol PhD studentship, an MRC research grant and a InvestorG8 grant. I also manage the Microbiology and Infectious Diseases laboratory. I peer-review for several high impact journals and I am a member of the European Cells & Materials Journal’s International Editorial Review Board. I am a member of the Management Committee of COST Action TD1305, Improved Protection of Medical Devices Against Infection (IPROMEDAI). I am an active member of the Microbiology Society (formerly known as Society for General Microbiology), American Society of Microbiology, and the Society for Applied Microbiology.

Areas of Expertise

  • Staphylococcus
  • microbial pathogenesis
  • biofilm
  • microscopy
  • antimicrobial resistance
  • molecular biology
  • microbiology

Publications

  1. & Biofilm Morphotypes and Population Structure among Staphylococcus epidermidis from Commensal and Clinical Samples. PLOS ONE 11(3), e0151240
  2. & Dormant Cells of Staphylococcus aureus Are Resuscitated by Spent Culture Supernatant. PLoS ONE 9(2), e85998
  3. et. al. Ecological overlap and horizontal gene transfer in Staphylococcus aureus and Staphylococcus epidermidis. Genome Biology and Evolution
  4. & Lucilia sericata Chymotrypsin Disrupts Protein Adhesin-Mediated Staphylococcal Biofilm Formation. Applied and Environmental Microbiology 79(4), 1393-1395.
  5. & Identification of Clinical Isolates of  -Hemolytic Streptococci by 16S rRNA Gene Sequencing, Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Using MALDI Biotyper, and Conventional Phenotypic Methods: a Comparison. Journal of Clinical Microbiology 50(12), 4087-4090.

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Teaching

  • PM-200 Genetic Analysis II

    This module will give assignments designed to build on essay writing and oral presentation skills introduced in level 1. It will also develop critical evaluation, analysis skills for the understanding of peer-reviewed research papers.

  • PM-250 Infectious Disease and Parasitology

    The course will build on the fundamentals of microbiology and introduce new topics in bacteriology, mycology and parasitology. Level 5 Immunology (PM-249) is a pre-requisite. The course covers the fundamentals of infectious diseases, including clinical aspects, treatment / prevention, and experimental approaches to the study of infectious and parasitic organisms. The course will also cover topics including disease outbreaks, beneficial parasites, tropical disease and behaviour-modifying parasites.

  • PM-315 Genetic Analysis III

    The module aims to develop the student¿s ability to critically analyse and synthesise advanced research topics in genetics and molecular biology, and their oral and written scientific presentation skills.

Supervision

  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Angharad Davies
    Other supervisor: Prof Thomas Humphrey
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Dr Llinos Harris