Steve Conlan is Professor of Molecular and Cell Biology, head of Reproductive Biology and Gynaecological Oncology research, Director of Strategic Partnerships for the College, and Director of the Centre for NanoHealth.

Prof Conlan’s research focuses on the application of molecular, cellular and nano biology approaches to understanding gynaecological pathologies including infertility and cancer due to abnormalities in the endometrium (the lining of the womb) and ovaries. He has a particular interest in the impact of aberrant transcription and epigenetic processes in these diseases. His aim is to work towards biomarkers and points of intervention that can be developed for clinical use.
His interest in NanoHealth centres around the characterisation of cellular interactions at the nanoscale. The group have developed the application of Atomic Force Microscopy (AFM) for biophysical analysis of live cells and tissue, including cancer cells, stem cells and cartilage.
He is a Director of the £22 Million Centre for NanoHealth at Swansea University, which is focused on regenerative medicine, nano-genotoxicology, the development of nano-enabelled devices and characterisation techniques for the detection and monitoring of disease.

Prof Conlan works closely with the life science and healthcare industrial sector, and has active collaborations with SMEs and multinational companies. As Director of Strategic Partnerships, and member of the University’s Internationalisation Strategy Group, he leads strategic collaborative initiatives with Grenoble - France, Houston - US and Suzhou and Wuhan – China. Prof Conlan holds an honorary consultant position in the Abertawe Bro Morgannwg NHS Board, working with clinical colleagues in Singleton Hospital Swansea and The Princess of Wales Hospital Bridgend. He is a Senior Affiliate Member of The Methodist Hospital Research Institute, Houston Texas, and Distinguished Professor at Xi'an Jiaotong University, Suzhou Academy, China.

Areas of Expertise

  • Molecular and Cell Biology
  • Epigenetics
  • Cancer Biology
  • Nanomedicine
  • Gynaecology
  • Gynaecological Oncology
  • Reproductive Biology
  • Translational Biomedical Research
  • Academic Business Partnerships
  • Internationalisation

Publications

  1. & Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Proceedings of the National Academy of Sciences 111(7), 2500-2505.
  2. & Nanoscience and Nanotechnology for Human Health. In Nanoscience and Nanotechnology for Human Health. (pp. 359-374). Wiley.
  3. & Chromophores in operative surgery: Current practice and rationalized development. Journal of Controlled Release 249, 123-130.
  4. Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB. Oncotarget
  5. & A three-dimensional model of primary bovine endometrium using an electrospun scaffold. Biofabrication 7(2), 025010

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Teaching

  • PM-317 Genetics of Cancer

    This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.

Supervision

  • The impact of HBO1 in Ovarian Cancer (current)

    Student name:
    PhD
    Other supervisor: Dr Lewis Francis
  • Antibody-drug conjugates for gynaecological cancers. (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Identification of biomarkers associated with the development of ovarian cancer in at risk patients diagnosed with ovarian endometriosis (current)

    Student name:
    MSc
    Other supervisor: Dr Deyarina Gonzalez
  • Aberrant Epigenetics and the Differentiation of Gynaecological Cancers (current)

    Student name:
    PhD
    Other supervisor: Dr Lewis Francis
  • 'A platform to determine mutation events in the cancer genome and chemical toxicity' (current)

    Student name:
    PhD
    Other supervisor: Prof Paul Lewis
  • 'Role of chronic urinary infection in the pathophysiology of overactive bladder syndrome' (current)

    Student name:
    MD
    Other supervisor: Dr Deyarina Gonzalez
  • 'Investigations into novel diagnostic biomarkers for oesophageal adenocarcinoma' (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
  • Integrating image-based machine learning and in-line biochemical analysis for enhancing successful IVF/ICSI Outcome (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Development of novel Antibody Drug Conjugates for oncology applications (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
  • 'The molecular mechanisms for chemo-preventative effects of aspirin on prostate cancer' (current)

    Student name:
    MSc
    Other supervisor: Prof Shareen Doak
  • A real time pharmacoepidemiological surveillance system for children with asthma (current)

    Student name:
    PhD
    Other supervisor: Ms Sofia Rodrigues Teixeira
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Therapeutic exosomes as new treatment for ovarian cancer (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Graphene-based amylase biosensor for infection diagnosis (current)

    Student name:
    PhD
    Other supervisor: Dr Ernest Azzopardi
  • Companion diagnostic development guides Antibody-Drug Conjugate formulation: Implications for patient stratification and precision medicine (current)

    Student name:
    PhD
    Other supervisor: Dr Ricardo Del Sol Abascal
  • A novel biomarker for infection (awarded 2016)

    Student name:
    MSc
    Other supervisor: Dr Ernest Azzopardi
    Other supervisor: Prof Iain Whitaker
  • '"A liquid Biopsy" assay to monitor cancer biomarkers in free circulating DNA: A pilot study combining PointMan q-PCR technology and Next Generation Sequencing.' (awarded 2016)

    Student name:
    MSc
    Other supervisor: Dr Ricardo Del Sol Abascal
    Other supervisor: Dr Deyarina Gonzalez
  • Characterization of Oesteopontin expression as Biomarker for Endometrial Cancer (awarded 2016)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
    Other supervisor: Prof Anthony Brenton
  • 'In vitro characterisation of articular cartilage-derived stem cells' (awarded 2016)

    Student name:
    PhD
    Other supervisor: Dr Lewis Francis
  • 'The Role of RAGE in Endometrial Cancer' (awarded 2016)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • 'A novel progesterone oral formulation for the treatment of endometrial hyperplasia with reduced adverse signalling compared to synthetic proteins' (awarded 2015)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • 'Investigation of Biochemical Fingerprints in Sputum of Lung Cancer and Chronic Obstructive Pulmonary Disease Patients Using Spectroscopic Methods' (awarded 2015)

    Student name:
    PhD
    Other supervisor: Prof Paul Lewis
  • 'Prediciting response in rectal cancer to chemoradiotherapy: influence of molecular classification' (awarded 2015)

    Student name:
    MD
    Other supervisor: Prof Gareth Jenkins
  • 'Graphene and carbon nanotube biosensors for detection of human chorionic gondatropin' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Prof Owen Guy
  • 'Endometrial mucins and human embryo implantation.' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Dr Christopher Wright
    Other supervisor: Dr Lewis Francis
  • 'Characterisation of Osteopontin and CD44 in endometrium of infertile women ' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Professor John White
    Other supervisor: Dr Lewis Francis
  • 'Optical piconewton sensor based on ZnO nanowires arrays for cell forces measurement' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Mr Thierry Maffeis
  • 'Analysis of intrinsic DNA curvature in the TP53 tumour suppressor gene using atomic force microscopy' (awarded 2013)

    Student name:
    PhD
    Other supervisor: Prof Paul Lewis
  • 'The effect of bacterial pathogen-associated molecular patterns and metabolism on innate immunity in the bovine endometrium' (awarded 2013)

    Student name:
    PhD
    Other supervisor: Prof Martin Sheldon
  • 'Expression of MAGE-11 and AR in human endometrium in fertile and infertile patients' (awarded 2012)

    Student name:
    MD
    Other supervisor: Professor John White
    Other supervisor: Dr John Joels
  • The modulators of Receptor for Advanced Glycation ENd products (RAGE) in the human endometrium (awarded 2012)

    Student name:
    PhD
    Other supervisor: Professor John White
    Other supervisor: Prof Paul Lewis
  • The role of the Wilms tumour suppressor gene (WT1) during human decidualization (awarded 2011)

    Student name:
    PhD
    Other supervisor: Professor John White
  • Characterising human endometrial epithelium with the atomic force microscope (awarded 2010)

    Student name:
    PhD
    Other supervisor: Dr Christopher Wright
  • Mediator Auto-Regulation Controls Differentially Expressed Ssn6-Tup1 Targets (awarded 2008)

    Student name:
    PhD
    Other supervisor: Professor Gerry Thomas
  • Investigation into the Different Methods and Applications of Technology for the Thermal Management of Light Emitting Diodes (awarded 2008)

    Student name:
    MRes
    Other supervisor: Prof Paul Rees
    Other supervisor: Dr Christopher Wright
  • Optimising the refolding conditions of a recombinant protein (awarded 2008)

    Student name:
    MPhil
    Other supervisor: Dr Hugh Jones
  • Nitric Oxide and the VE-Cadherin/catenin complex: Modulation of the adherant junction through post translational modifications (awarded 2007)

    Student name:
    PhD
    Other supervisor: Dr Christopher Smith
  • Untitled (awarded 2006)

    Student name:
    PhD
    Other supervisor: Dr Hugh Jones