Steve Conlan is Professor of Molecular and Cell Biology, head of Reproductive Biology and Gynaecological Oncology research, Director of Strategic Partnerships for the College, and Director of the Centre for NanoHealth.

Prof Conlan’s research focuses on the application of molecular, cellular and nano biology approaches to understanding gynaecological pathologies including infertility and cancer due to abnormalities in the endometrium (the lining of the womb) and ovaries. He has a particular interest in the impact of aberrant transcription and epigenetic processes in these diseases. His aim is to work towards biomarkers and points of intervention that can be developed for clinical use.
His interest in NanoHealth centres around the characterisation of cellular interactions at the nanoscale. The group have developed the application of Atomic Force Microscopy (AFM) for biophysical analysis of live cells and tissue, including cancer cells, stem cells and cartilage.
He is a Director of the £22 Million Centre for NanoHealth at Swansea University, which is focused on regenerative medicine, nano-genotoxicology, the development of nano-enabelled devices and characterisation techniques for the detection and monitoring of disease.

Prof Conlan works closely with the life science and healthcare industrial sector, and has active collaborations with SMEs and multinational companies. As Director of Strategic Partnerships, and member of the University’s Internationalisation Strategy Group, he leads strategic collaborative initiatives with Grenoble - France, Houston - US and Suzhou and Wuhan – China. Prof Conlan holds an honorary consultant position in the Abertawe Bro Morgannwg NHS Board, working with clinical colleagues in Singleton Hospital Swansea and The Princess of Wales Hospital Bridgend. He is a Senior Affiliate Member of The Methodist Hospital Research Institute, Houston Texas, and Distinguished Professor at Xi'an Jiaotong University, Suzhou Academy, China.

Areas of Expertise

  • Molecular and Cell Biology
  • Epigenetics
  • Cancer Biology
  • Nanomedicine
  • Gynaecology
  • Gynaecological Oncology
  • Reproductive Biology
  • Translational Biomedical Research
  • Academic Business Partnerships
  • Internationalisation

Publications

  1. & Exosomes as Reconfigurable Therapeutic Systems. Trends in Molecular Medicine 23(7), 636-650.
  2. & Antibody–drug conjugates and other nanomedicines: the frontier of gynaecological cancer treatment. Interface Focus 6(6), 20160054
  3. & Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Proceedings of the National Academy of Sciences 111(7), 2500-2505.
  4. & Nanoscience and Nanotechnology for Human Health. In Nanoscience and Nanotechnology for Human Health. (pp. 359-374). Wiley.
  5. & Chromophores in operative surgery: Current practice and rationalized development. Journal of Controlled Release 249, 123-130.

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Teaching

  • PM-317 Genetics of Cancer

    This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.

  • PMND00 Nanomedicine Research Dissertation

    This module builds on the knowledge and skills developed in teaching components in part one of their relevant programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study within nanomedicine.

Supervision

  • Development of novel Antibody Drug Conjugates for oncology applications (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Integrating image-based machine learning and in-line biochemical analysis for enhancing successful IVF/ICSI Outcome (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Antibody-drug conjugates for gynaecological cancers. (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • 'Aberrant Epigenetics and the Differentiation of Gynaecological Cancers' (current)

    Student name:
    PhD
    Other supervisor: Dr Lewis Francis
  • 'The molecular mechanisms for chemo-preventative effects of aspirin on prostate cancer' (current)

    Student name:
    MSc
    Other supervisor: Prof Shareen Doak
  • Identification of biomarkers associated with the development of ovarian cancer in at risk patients diagnosed with ovarian endometriosis (current)

    Student name:
    MSc
    Other supervisor: Dr Deyarina Gonzalez
  • 'Role of chronic urinary infection in the pathophysiology of overactive bladder syndrome' (current)

    Student name:
    MD
    Other supervisor: Dr Deyarina Gonzalez
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Lewis Francis
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Graphene-based amylase biosensor for infection diagnosis (current)

    Student name:
    PhD
    Other supervisor: Dr Ernest Azzopardi
  • Targeted therapies for oncology applications (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • The impact of HBO1 in Ovarian Cancer (current)

    Student name:
    PhD
    Other supervisor: Dr Lewis Francis
  • Companion diagnostic development guides Antibody-Drug Conjugate formulation: Implications for patient stratification and precision medicine (current)

    Student name:
    PhD
    Other supervisor: Dr Ricardo Del Sol Abascal
  • Graphene EGFET sensors for enhanced in-vitro fertilisation (IVF) outcomes and gynaecological cancer detection (current)

    Student name:
    PhD
    Other supervisor: Ms Sofia Rodrigues Teixeira
  • 'Investigations into novel diagnostic biomarkers for oesophageal adenocarcinoma' (awarded 2017)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
  • 'A platform to determine mutation events in the cancer genome and chemical toxicity' (awarded 2017)

    Student name:
    PhD
    Other supervisor: Prof Paul Lewis