Associate Professor
Swansea University Medical School
Telephone: (01792) 295018
Room: Academic Office - 137
First Floor
Institute of Life Science 1
Singleton Campus

I have been a member of academic staff in Microbiology and Infectious Disease in the College of Medicine at Swansea University since September 2008 . I undertook my PhD in College of Medicine at Cardiff University (1997-2001) prior to two periods of postdoctoral training in Seattle (Hope Heart Institute, 2001-2004) and Edinburgh (MRC Centre for Inflammation Research, 2004-2008). At Swansea my academic role focuses on basic and translational research, support of postgraduate research degrees and undergraduate teaching.

My research interests include:
1. Development of new anti-biofilm therapeutics to target medical device related infections
2. Identifying innate immune barrier responses in epithelial cells to specific lineages of Campylobacter and Staphylococci
3. Linking bacterial genotype with their phenotypic responses in cell co-culture systems
4. Investigating the interactions between bacterial biofilms in primary leukocyte systems

I can be found in the ILS1 building, in room 137.

Publications

  1. & A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk. BMC Biology 16(1)
  2. & The Bacterial Species Campylobacter jejuni Induce Diverse Innate Immune Responses in Human and Avian Intestinal Epithelial Cells. Frontiers in Microbiology 8
  3. & Limitations in the use of PSMγ, agr , RNAIII, and biofilm formation as biomarkers to define invasive Staphylococcus epidermidis from chronic biomedical device-associated infections. International Journal of Medical Microbiology 307(7), 382-387.
  4. et. al. Recombination-Mediated Host Adaptation by Avian Staphylococcus aureus. Genome Biology and Evolution 9(4), 830-842.
  5. & Critical review of the current and future challenges associated with advancedin vitrosystems towards the study of nanoparticle (secondary) genotoxicity. Mutagenesis 32(1), 233-241.

See more...

Teaching

  • PM-004 Fundamentals of Microbiology & Disease

    This module will provide the student with an overview of the fundamentals of microbiology, its causative role in human disease and the intervention of antimicrobials and antibiotics. The role of immunity and its role in human defence against disease will also be introduced in this module, and how this may be modulated in response to pathogens. Lectures will be accompanied by a practical session in microbiological techniques and an essay with academic support. Mae'r modiwl yma yn rhoi trosolwg i fyfyrwyr o hanfodion mewn microbioleg, ei rôl achosol mewn afiechydon dynol ac ymyrraeth gwrthficrobaidd a gwrthfiotig. Caiff rôl imiwnedd a'i rôl mewn amddiffyn dyn yn erbyn afiechydon, a sut mae'n addasu mewn ymateb i bathogenau ei gyflwyno hefyd yn y modiwl yma. Caiff y darlithoedd eu cyfeilio gan sesiynau ymarferol mewn technegau microbiolegol a traethawd efo cefnogaeth academaidd.

  • PM-132 Eukaryotic Cell Biology

    This module will provide a broad introduction to fundamental concepts in Eukaryotic cell biology investigating the origins of the cell, cell structure and specialised cells and cells in disease. There will be a general focus on human cells throughout with reference to other organisms when needed. Students will gain practical experience in identification, differentiation of cells from different human and animal species.

  • PM-132C Bioleg Celloedd Ewcaryotig

    Bydd y modiwl hwn yn darparu cyflwyniad bras i gysyniadau sylfaenol ym maes bioleg celloedd Ewcaryotig, gan ymchwilio i darddiad y gell, strwythur y gell a chelloedd arbenigol a chelloedd mewn clefyd. Bydd ffocws cyffredinol ar gelloedd dynol drwy gydol y modiwl, gan gyfeirio at organebau eraill yn ôl yr angen. Bydd myfyrwyr yn cael profiad ymarferol o nodi celloedd, gwahaniaethu rhwng gwahanol gelloedd dynol a rhywogaethau o anifeiliaid.

  • PM-249 Human Immunology

    The course is designed as an introduction to immunology and the human immune system. The course covers the fundamentals of immunology including functional perturbations associated with disease and experimental approaches to the study of immunology.

  • PM-250 Infectious Disease and Parasitology

    The course will build on the fundamentals of microbiology and introduce new topics in bacteriology, mycology and parasitology. Level 5 Immunology (PM-249) is a pre-requisite. The course covers the fundamentals of infectious diseases, including clinical aspects, treatment / prevention, and experimental approaches to the study of infectious and parasitic organisms. The course will also cover topics including disease outbreaks, beneficial parasites, tropical disease and behaviour-modifying parasites.

  • PM-304 Biomolecular Research Project

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  • PM-347 Human Immunopathology

    The module aims to provide students with a greater understanding of the human immune system and the causes of a range of diseases associated with immune dysfunction including autoimmune diseases, metabolic disorders and neurological conditions.

  • PMLM05 LC/MS Applications IV: Medical and life sciences

    Students will have the opportunity to gain extensive knowledge of the role mass spectrometry plays in biomarker discovery (proteins and small molecules).with its application to clinical diagnosis including the analysis of carbohydrates, glycoproteins and nucleic acids using activity-based proteomics and techniques for affinity pull-down.

Supervision

  • Understanding the Seasonality of Campylobacter Infection in Commercial Broiler Chickens (current)

    Student name:
    PhD
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Prof Thomas Humphrey
  • Use of whole genome sequencing in understanding transmission dynamics of tuberculosis (current)

    Student name:
    PhD
    Other supervisor: Dr Llinos Harris
    Other supervisor: Prof Thomas Humphrey
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Dr Angharad Davies
  • Co-exposure of infectious bacteria with carbon-based nanoparticles in relevant, advanced in vitro systems. (current)

    Student name:
    MSc
    Other supervisor: Dr Martin Clift
    Other supervisor: Dr Thomas Wilkinson
  • Sensing bacterial infection: 25-hydroxycholesterol as a biomarker (current)

    Student name:
    PhD
    Other supervisor: Prof William Griffiths
    Other supervisor: Prof Yuqin Wang
    Other supervisor: Prof Thomas Humphrey
    Other supervisor: Dr Thomas Wilkinson
  • Characterisation of alginate interactions for tailored therapeutic development in Cystic Fibrosis (current)

    Student name:
    PhD
    Other supervisor: Prof Paul Lewis
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Prof Gareth Jenkins
  • Effect of Camplylobacter on the inflammatory response of intestinal cells (current)

    Student name:
    PhD
    Other supervisor: Prof Thomas Humphrey
    Other supervisor: Dr Thomas Wilkinson
  • Molecular mechanism of Arf6 small GTPase inhibition in treating multidrug resistant bacterial infections (current)

    Student name:
    PhD
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Prof Venkat Kanamarlapudi
  • The effects of NX-AS-401 on Methicillin Resistant Staphylococcus aureus. (current)

    Student name:
    PhD
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Dr Rowena Jenkins
  • 'Population genomics of bacterial pathogens' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Dr Ricardo Del Sol Abascal
    Other supervisor: Dr Thomas Wilkinson
  • 'Population genomics approaches to understanding the evolution and ecology of bacterial pathogens' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Dr Ricardo Del Sol Abascal
    Other supervisor: Dr Thomas Wilkinson
  • 'Genomic variation and virulence in Helicobacter pylori: identifying the genes/alleles underlying phenotype variation.' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Samuel Sheppard
    Other supervisor: Prof Thomas Humphrey
    Other supervisor: Dr Jane Mikhail
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Dr Thomas Wilkinson