Publications

  1. Structure-Related Differences between Cytochrome Oxidase I Proteins in a Stable Heteroplasmic Mitochondrial System.
  2. & Demethylase Inhibitor Fungicide Resistance in Pyrenophora teres f. sp. teres Associated with Target Site Modification and Inducible Overexpression of Cyp51. Frontiers in Microbiology 7
  3. & Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes. Human Molecular Genetics 24(18), 5313-5325.
  4. & Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition. Neuropsychopharmacology 41(4), 1080-1092.
  5. & Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Applied and Environmental Microbiology 81(10), 3379-3386.

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Teaching

  • PM-239F Doctor as Scholar and Scientist 1

    This module provides medical students with the foundation of scientific knowledge, which is required for the practice of medicine. Focusing on the principle of the Doctor as Scientist and Scholar (Tomorrow's Doctors, GMC 2009), this module enables students to develop their scientific knowledge within a clinical context.

  • PM-257 Neuroscience

    In order to help students understand the biological basis for behavioural neuroscience and neurological disorders, this module seeks to integrate the multidisciplinary sciences ¿ for example, anatomy, physiology and biochemistry - that have combined to build the emerging field of neuroscience. The aim is to gain a mechanistic and holistic knowledge of the nervous system that builds from the molecular, cellular and developmental, to the systems level. In addition to exploring normal function, this module will introduce common disorders of the central and peripheral nervous systems in an integrated way. Students will be guided in exploring the scientific evidence around what is known and unknown and will be introduced to current research findings in the scientific literature.

  • PM-304 Biomolecular Research Project

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  • PM-345 Bioinformatics: From sequence to Function

    The ever increasing availability of genome sequences and protein structure data demands that molecular biologists are proficient at performing extensive data analyses to guide and support traditional laboratory-based research. This Module will provide the theoretical basis and practical training on computational tools currently used to assemble and interrogate genome sequences, infer gene and protein functions, and to examine protein structure data.

  • PM-349D Doctor as Scholar and Scientist 2

    This module further develops the student's scientific knowledge, building on the foundations laid in Year 1. Focusing on the principle of the Doctor as Scientist and Scholar (Tomorrow's Doctors, GMC 2009), this module enables students to enhance their scientific knowledge and understanding of its importance to clinical practice within a clinical context.

  • PM-358I Doctor as Scholar and Scientist 3

    This module enables medical students to integrate their scientific knowledge and clinical skills in order to apply it within the context of clinical practice, thus enhancing their ability to practice medicine. This module builds on the knowledge learned in the previous years, focusing on the notion of the Doctor as a Scientist and Scholar (Tomorrow's Doctors, GMC 2009).

  • PM-367C Doctor as Scholar and Scientist 4

    This module enables medical students to consolidate their scientific knowledge within the context of clinical practice, and prepares them for the Foundation Year training programme. This module builds on the knowledge learned in the previous years, focusing on the notion of the Doctor as Scientist and Scholar (Tomorrow's Doctors, GMC 2009).

Supervision

  • As detailed - Data mining patterns of receptor-drug interactions across vast biological and chemical space (current)

    Student name:
    PhD
    Other supervisor: Dr Heledd Iago
    Other supervisor: Dr Jonathan Mullins
  • Characterisation of genetic variants and their role in neurological disorders (current)

    Student name:
    PhD
    Other supervisor: Dr Jonathan Mullins
    Other supervisor: Prof Mark Rees
    Other supervisor: Dr Seo-Kyung Chung
  • Development of automated in silico pharmacological profiling tools (current)

    Student name:
    PhD
    Other supervisor: Dr Heledd Iago
    Other supervisor: Dr Jonathan Mullins
  • Development of a comprehensive 3D structural database of human proteomic variation and pan-proteomic interaction with the most widely prescribed drugs. (current)

    Student name:
    PhD
    Other supervisor: Dr Heledd Iago
    Other supervisor: Dr Jonathan Mullins
  • An in silico platform for the drug screening of human CYP2D6 variants (current)

    Student name:
    PhD
    Other supervisor: Dr Heledd Iago
    Other supervisor: Dr Jonathan Mullins
  • Inhibiting IL-17 Production by Blocking Endogenous RORγt Agonists for the Treatment of Autoimmune Diseases (current)

    Student name:
    PhD
    Other supervisor: Dr Jonathan Mullins
    Other supervisor: Prof William Griffiths
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Yuqin Wang