Areas of Expertise

  • Molecular microbiology
  • Gene expression analysis
  • Cell biology
  • Bacterial symbionts of insects
  • Tumour-targetting bacteria

Publications

  1. & High-level heterologous production and Functional Secretion by recombinant Pichia pastoris of the shortest proline-rich antibacterial honeybee peptide Apidaecin. Scientific Reports 7(1)
  2. & A trehalose biosynthetic enzyme doubles as an osmotic stress sensor to regulate bacterial morphogenesis. PLOS Genetics 13(10), e1007062
  3. & Comparative Genomics of Facultative Bacterial Symbionts Isolated from European Orius Species Reveals an Ancestral Symbiotic Association. Frontiers in Microbiology
  4. & Gene silencing in non-model insects: Overcoming hurdles using symbiotic bacteria for trauma-free sustainable delivery of RNA interference. BioEssays 39(3), 1600247
  5. & Targeting the Osmotic Stress Response for Strain Improvement of an Industrial Producer of Secondary Metabolites. J. Microbiol. Biotechnol. 25(11), 1787-1795.

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Teaching

  • PM-226 Human and Medical Genetics

    The course is designed to introduce fundamental concepts in the study of human genetics with particular reference to the application of the principles to medicine. The course covers the role of genetics in human health and disease and methods for the detection of genetic variability in human populations.

  • PM-251 Microbial Molecular Genetics

    The control systems governing gene expression in prokaryotic cells are explored and the molecular basis for gene regulation introduced. Practical skills in obtaining and analysing data on a bacterial system are developed. The module then assesses the structure of the bacterial genome and how genetic analysis can be used to investigate structure and function of individual components of that genome. Specific examples explored in depth are the genetics of recombination and DNA repair. The technologies used for functional genomic analysis of fully sequenced bacteria are described with reference to analysis of human pathogens. Finally, the module includes examples of synthetic biology applied to bacteria.

  • PM-304 Biomolecular Research Project

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  • PM-308 Animal Development

    The module provides an understanding of the principles of animal development, introducing critical genes and their products that play roles in regulating metazoan development. Classical embryology will be integrated with contemporary molecular investigations into developmental mechanisms.

  • PM-314 Biotechnology & Protein Engineering

    The module aims to explain the biological basis of biotechnology and protein engineering: their limitations, industrial and medical importance. Students will develop their skills in gathering and interpreting relevant information.

  • PM-315 Genetic Analysis III

    The module aims to develop the student¿s ability to critically analyse and synthesise advanced research topics in genetics and molecular biology, and their oral and written scientific presentation skills.

Supervision

  • 'Post Transcriptional gene silencing of Trypanosoma brucei brucei through endocytosis of dsRNA' (current)

    Student name:
    MSc
    Other supervisor: Dr Miranda Walker (Nee Whitten)
  • Untitled (current)

    Student name:
    MSc
    Other supervisor: Dr Claire Morgan
  • Investigation of Candida diversity in an infertile cohort using next generation genetic analysis (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
  • Molecular characterization of Frankliniella occidentails gut symbionts: Implications to the design of novel bio-pesticides (current)

    Student name:
    PhD
    Other supervisor: Dr Ricardo Del Sol Abascal
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Ricardo Del Sol Abascal