The course is designed to introduce fundamental concepts in the study of human genetics with particular reference to the application of the principles to medicine. The course covers the role of genetics in human health and disease and methods for the detection of genetic variability in human populations.
The control systems governing gene expression in prokaryotic cells are explored and the molecular basis for gene regulation introduced. Practical skills in obtaining and analysing data on a bacterial system are developed. The module then assesses the structure of the bacterial genome and how genetic analysis can be used to investigate structure and function of individual components of that genome. Specific examples explored in depth are the genetics of recombination and DNA repair. The technologies used for functional genomic analysis of fully sequenced bacteria are described with reference to analysis of human pathogens. Finally, the module includes examples of synthetic biology applied to bacteria.
The module provides an understanding of the principles of animal development, introducing critical genes and their products that play roles in regulating metazoan development. Classical embryology will be integrated with contemporary molecular investigations into developmental mechanisms.
The module aims to explain the biological basis of biotechnology and protein engineering: their limitations, industrial and medical importance. Students will develop their skills in gathering and interpreting relevant information.
The module aims to develop the student¿s ability to critically analyse and synthesise advanced research topics in genetics and molecular biology, and their oral and written scientific presentation skills.