Research:

Systems Cytometry
Nanoparticle metrology and toxicology
Nanoparticle fluorophores

Publications

  1. & Spatially-resolved profiling of carbon nanotube uptake across cell lines. Nanoscale 9(20), 6800-6807.
  2. & Profiling movement quality and gait characteristics according to body-mass index in children (9–11 y). Human Movement Science 49, 291-300.
  3. & Carbon nanotubes' surface chemistry determines their potency as vaccine nanocarriers in vitro and in vivo. Journal of Controlled Release 225, 205-216.
  4. & Quantifying the cellular uptake of semiconductor quantum dot nanoparticles by analytical electron microscopy. Journal of Microscopy, n/a-n/a.
  5. & Label-free cell cycle analysis for high-throughput imaging flow cytometry. Nature Communications 7, 10256

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Teaching

  • EGA219 Cell Biology and cell mechanics for engineers

    This course provides an introduction to the biology and mechanical properties of cells from an engineering prospective. The basic processes of cell function - energy production, growth, division, genetic duplication will be covered and related to the interaction of cells within large populations and the growth of tissue. The fundamental principles will be related to specific areas of interest to medical engineers - technology developments, the risk of infection from medical implants and the use of stem cells for tissue engineering.

  • EGA226 Physiological systems

    This course will consider human physiology from an Engineering standpoint, concentrating on the system architecture of major physiological components within the body, e.g. cardiovascular, nervous, muscular and respiratory systems. Emphasis will be place on the system level output and the control mechanisms required to maintain body homeostasis. A major practical element will run alongside the presentation of taught material. The Simulink programming environment will be used to i. model the behaviour and control of generalised systems and ii. simulate the function of specific biological systems relating to human physiology. Course elements: o introduction to basic systems - definition, components and architecture, emergent phenomenon o introduction to control theory - feedback, error monitoring, proportional control, dynamic systems o translation of systems control theory and models to human physiology o detailed modelling and simulation of specific physiological systems

  • PM-M16 Nano(geno)toxicology

    Nano(geno)toxicology is a new discipline that has recently evolved with the development of the nanotechnology industry. This subject encompasses general toxicology associated with nanomaterials and also specifically focuses on the sub-discipline of genotoxicology. This course will therefore focus on, (I) the parameters of engineered nanomaterials that govern their interaction and influence on biological systems; (II) techniques that are central elements in assessing the safety evaluation of nanomaterials; (III) portals of entry into the body, their potential fate and the mechanisms that underlie cellular damage by nanomaterials.

Supervision

  • 'Group-based analysis of human exercise, performance and health' (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Stratton
  • in vivo and in vitro sensing for disease diagnostics (current)

    Student name:
    PhD
    Other supervisor: Prof Kenith Meissner
  • Lab on chip system for blood clotting analyses (current)

    Student name:
    PhD
    Other supervisor: Prof Owen Guy
  • Development of POC diagnostic sensors and integrated microfluidics (current)

    Student name:
    PhD
    Other supervisor: Prof Owen Guy
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Neil Bezodis