Publications

Journal Articles

  1. Stéphanou, A., Ballet, P., Powathil, G. Hybrid data-based modelling in oncology: successes, challenges and hopes Mathematical Modelling of Natural Phenomena 15 21
  2. Hamis, S., Kohandel, M., Dubois, L., Yaromina, A., Lambin, P., Powathil, G. Combining Hypoxia-Activated Prodrugs and Radiotherapy in silico: Impact of Treatment Scheduling and the Intra-Tumoural Oxygen Landscape bioRxiv
  3. Hamis, S., Stratiev, ., Powathil, G. Uncertainty and Sensitivity Analyses Methods for Agent-Based Mathematical Models: An Introductory Review arxIV arXiv:1911.08429
  4. Hamis, S., Yates, J., Chaplain, M., Powathil, G. Targeting Cellular DNA Damage Responses: Predicting in vivo treatment responses using an in vitro-calibrated agent-based mathematical model. bioRxiv
  5. Meaney, C., G Powathil, G., Yaromina, A., J Dubois, L., Lambin, P., Kohande, M., Powathil, G. Role of hypoxia-activated prodrugs in combination with radiation therapy: An in silico approach Mathematical Biosciences and Engineering 16 6 6257 6273
  6. Hamis, S., Powathil, G., Chaplain, M. Blackboard to Bedside: A Mathematical Modeling Bottom-Up Approach Toward Personalized Cancer Treatments JCO Clinical Cancer Informatics 3 1 11
  7. Mothersill, C., Abend, M., Bréchignac, F., Copplestone, D., Geras’kin, S., Goodman, J., Horemans, N., Jeggo, P., McBride, W., Mousseau, T., O’Hare, A., Papineni, R., Powathil, G., Schofield, P., Seymour, C., Sutcliffe, J., Austin, B. The tubercular badger and the uncertain curve:- The need for a multiple stressor approach in environmental radiation protection Environmental Research 168 130 140
  8. Hamis, S., Nithiarasu, P., Powathil, G. What does not kill a tumour may make it stronger: In silico insights into chemotherapeutic drug resistance Journal of Theoretical Biology 454 253 267
  9. Kim, Y., Kang, H., Powathil, G., Kim, H., Trucu, D., Lee, W., Lawler, S., Chaplain, M. Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma PLOS ONE 13 10 e0204865
  10. Bowness, R., Chaplain, M., Powathil, G., Gillespie, S. Modelling the effects of bacterial cell state and spatial location on tuberculosis treatment: Insights from a hybrid multiscale cellular automaton model Journal of Theoretical Biology 446 87 100
  11. Mothersill, C., Abend, M., Bréchignac, F., Iliakis, G., Impens, N., Kadhim, M., Møller, A., Oughton, D., Powathil, G., Saenen, E., Seymour, C., Sutcliffe, J., Tang, F., Schofield, P. When a duck is not a duck; a new interdisciplinary synthesis for environmental radiation protection Environmental Research 162 318 324
  12. Brüningk, S., Powathil, G., Ziegenhein, P., Ijaz, J., Rivens, I., Nill, S., Chaplain, M., Oelfke, U., ter Haar, G., Powathil, G. Combining radiation with hyperthermia: a multiscale model informed by in vitro experiments Journal of The Royal Society Interface 15 138 20170681
  13. Powathil, G., Munro, A., Chaplain, M., Swat, M. Bystander effects and their implications for clinical radiation therapy: Insights from multiscale in silico experiments Journal of Theoretical Biology 401 1 14
  14. Borasi, G., Nahum, A., Paulides, M., Powathil, G., Russo, G., Fariselli, L., Lamia, D., Cirincione, R., Forte, G., Borrazzo, C., Caccia, B., di Castro, E., Pozzi, S., Gilardi, M. Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma Journal of Therapeutic Ultrasound 4 1
  15. Chaplain, M., Powathil, G. Multiscale modelling of cancer progression and treatment control: The role of intracellular heterogeneities in chemotherapy treatment Biophysical Reviews and Letters
  16. Kim, Y., Powathil, G., Kang, H., Trucu, D., Kim, H., Lawler, S., Chaplain, M. Strategies of Eradicating Glioma Cells: A Multi-Scale Mathematical Model with MiR-451-AMPK-mTOR Control PLOS ONE 10 1 e0114370
  17. Powathil, G., Swat, M., Chaplain, M. Systems oncology: Towards patient-specific treatment regimes informed by multiscale mathematical modelling Seminars in Cancer Biology
  18. Powathil, G., Chaplain, M., Swat, M. Investigating the development of chemotherapeutic drug resistance in cancer: A multiscale computational study (preprint) arXiv.org
  19. Powathil, G., Adamson, D., Chaplain, M. Towards Predicting the Response of a Solid Tumour to Chemotherapy and Radiotherapy Treatments: Clinical Insights from a Computational Model PLoS Computational Biology 9 7 e1003120
  20. Powathil, G., Gordon, K., Hill, L., Chaplain, M. Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: Biological insights from a hybrid multiscale cellular automaton model Journal of Theoretical Biology 308 1 19
  21. Powathil, G., Kohandel, M., Milosevic, M., Sivaloganathan, S. Modeling the Spatial Distribution of Chronic Tumor Hypoxia: Implications for Experimental and Clinical Studies Computational and Mathematical Methods in Medicine 2012 1 11
  22. Powathil, G., Kohandel, M., Sivaloganathan, S., Oza, A., Milosevic, M., Powathil, G. Mathematical modeling of brain tumors: effects of radiotherapy and chemotherapy Physics in Medicine and Biology 52 11 3291 3306

Book Chapters

  1. Powathil, G., Chaplain, M. A Hybrid Multiscale Approach in Cancer Modelling and Treatment Prediction (Ed.), Mathematical Oncology 2013 237 263 Birkhauser

Conference Contributions

  1. Powathil, G., Thompson, A., Chaplain, M., Powathil, G. The role of cellular heterogeneity on the therapeutic response of breast cancer: Clinical insights from a hybrid multiscale computational model Cancer Research 72 24 Supplement P5-05-02 P5-05-02

Other Research Outputs

  1. Powathil, G. Modelling of brain tumours: Effects of microenvironment and associated therapeutic strategies
  2. Powathil, G. A heat and mass transfer model for bread baking: an investigation using numerical schemes