Publications

Journal Articles

  1. & Synthetic routes, characterization and photophysical properties of luminescent, surface functionalized nanodiamonds. Carbon 152, 335-343.
  2. & TCR‐induced alteration of primary MHC peptide anchor residue. European Journal of Immunology
  3. & The impact of combinatorial stress on the growth dynamics and metabolome of Burkholderia mesoacidophila demonstrates the complexity of tolerance mechanisms. Journal of Applied Microbiology
  4. & Chemoenzymatic Assembly of Isotopically Labeled Folates. Journal of the American Chemical Society 139(37), 13047-13054.
  5. & Reclassification of the Specialized Metabolite Producer Pseudomonas mesoacidophila ATCC 31433 as a Member of the Burkholderia cepacia Complex. Journal of Bacteriology 199(13), e00125-17
  6. & A Rapid Analysis of Variations in Conformational Behavior during Dihydrofolate Reductase Catalysis. Biochemistry 56(15), 2126-2133.
  7. & Reduction of Folate by Dihydrofolate Reductase from Thermotoga maritima. Biochemistry 56(13), 1879-1886.
  8. & Minimization of dynamic effects in the evolution of dihydrofolate reductase. Chemical Science 7(5), 3248-3255.
  9. & Pinpointing dynamic coupling in enzymes for efficient drug design. Future Science OA 2(1)
  10. & Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase. Angewandte Chemie International Edition 54(31), 9016-9020.
  11. & Protein motions and dynamic effects in enzyme catalysis. Physical Chemistry Chemical Physics 17(46), 30817-30827.
  12. & Protein Isotope Effects in Dihydrofolate Reductase FromGeobacillus stearothermophilusShow Entropic–Enthalpic Compensatory Effects on the Rate Constant. Journal of the American Chemical Society 136(49), 17317-17323.
  13. & Role of the Occluded Conformation in Bacterial Dihydrofolate Reductases. Biochemistry 53(29), 4761-4768.
  14. & Loop Interactions during Catalysis by Dihydrofolate Reductase fromMoritella profunda. Biochemistry 53(29), 4769-4774.
  15. & Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases. Journal of the American Chemical Society 136(19), 6862-6865.
  16. & Thermal Adaptation of Dihydrofolate Reductase from the Moderate ThermophileGeobacillus stearothermophilus. Biochemistry 53(17), 2855-2863.
  17. & CYP105-diverse structures, functions and roles in an intriguing family of enzymes inStreptomyces. Journal of Applied Microbiology 117(6), 1549-1563.
  18. & Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept. AMB Express 4(1)
  19. & Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock. Biotechnology for Biofuels 7(1)
  20. & Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases. Journal of the American Chemical Society 136(19), 6862-6865.
  21. & Increased Dynamic Effects in a Catalytically Compromised Variant ofEscherichia coliDihydrofolate Reductase. Journal of the American Chemical Society 135(49), 18689-18696.
  22. & Unraveling the role of protein dynamics in dihydrofolate reductase catalysis. Proceedings of the National Academy of Sciences 110(41), 16344-16349.
  23. & Aliphatic 1H, 13C and 15N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP+ and folate. Biomolecular NMR Assignments 7(1), 61-64.
  24. & Effect of Dimerization on Dihydrofolate Reductase Catalysis. Biochemistry 52(22), 3881-3887.
  25. & 1H, 13C and 15N chemical shift assignments of unliganded Bcl-xL and its complex with a photoresponsive Bak-derived peptide. Biomolecular NMR Assignments 7(2), 187-191.
  26. & Effect of Dimerization on Dihydrofolate Reductase Catalysis. Biochemistry 52(22), 3881-3887.
  27. & NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-xL. Journal of the American Chemical Society 134(18), 7644-7647.
  28. & Evidence that a ‘dynamic knockout’ in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis. Nature Chemistry 4(4), 292-297.
  29. & NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-xL. Journal of the American Chemical Society 134(18), 7644-7647.
  30. & Effect of pH on Hydride Transfer by Escherichia coli Dihydrofolate Reductase. ChemBioChem 12(8), 1258-1262.
  31. & Reduced Susceptibility of Moritella profunda Dihydrofolate Reductase to Trimethoprim is Not Due to Glutamate 28. The Protein Journal 30(8), 546-548.
  32. & The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase. Journal of the American Chemical Society 133(50), 20561-20570.
  33. & Catalysis by Dihydrofolate Reductase from the Psychropiezophile Moritella profunda. ChemBioChem 11(14), 2010-2017.
  34. & Highly site-selective stability increases by glycosylation of dihydrofolate reductase. FEBS Journal 277(9), 2171-2179.
  35. & Solvent Effects on Catalysis byEscherichia coliDihydrofolate Reductase. Journal of the American Chemical Society 132(3), 1137-1143.
  36. & The Temperature Dependence of the Kinetic Isotope Effects of Dihydrofolate Reductase fromThermotoga maritimaIs Influenced by Intersubunit Interactions. Biochemistry 49(25), 5390-5396.
  37. & Are the Catalytic Properties of Enzymes from Piezophilic Organisms Pressure Adapted?. ChemBioChem 10(14), 2348-2353.
  38. & Different Reaction Mechanisms for Mesophilic and Thermophilic Dihydrofolate Reductases. Journal of the American Chemical Society 131(20), 6926-6927.
  39. & Effect of Dimerization on the Stability and Catalytic Activity of Dihydrofolate Reductase from the HyperthermophileThermotoga maritima. Biochemistry 48(25), 5922-5933.
  40. & Probing coupled motions in enzymatic hydrogen tunnelling reactions. Biochemical Society Transactions 37(2), 349-353.
  41. & The Role of Arginine 28 in Catalysis by Dihydrofolate Reductase from the HyperthermophileThermotoga maritima. ChemBioChem 10(16), 2624-2627.
  42. & Photocontrollable Peptide-Based Switches Target the Anti-Apoptotic Protein Bcl-xL. ChemBioChem 9(18), 3046-3054.
  43. & Solvent Effects on Environmentally Coupled Hydrogen Tunnelling During Catalysis by Dihydrofolate Reductase from Thermotoga maritima. Chemistry - A European Journal 14(34), 10782-10788.
  44. & Bulgecin A: a novel inhibitor of binuclear metallo-β-lactamases. Biochemical Journal 387(3), 585-590.

Book Chapters

  1. & Chapter 8. Direct Methods for the Analysis of Quantum-Mechanical Tunnelling: Dihydrofolate Reductase. In Rudolf K Allemann, Nigel S Scrutton (Ed.), Quantum Tunnelling in Enzyme-Catalysed Reactions. (pp. 179-198). London: Royal Society of Chemistry.