Publications

Journal Articles

  1. Khoja, S., Eltayef, K., Baxter, I., Bull, J., Loveridge, E., Butt, T., Loveridge, J. Fungal volatile organic compounds show promise as potent molluscicides Pest Management Science 75 12 3392 3404
  2. Day, A., Adams, S., Gines, L., Williams, O., Johnson, B., Fallis, I., Loveridge, E., Bahra, G., Oyston, P., Herrera, J., Pope, S., Loveridge, J. Synthetic routes, characterization and photophysical properties of luminescent, surface functionalized nanodiamonds Carbon 152 335 343
  3. Moody, S., Bull, J., Dudley, E., Loveridge, E., Dudley, E., Moody, S., Loveridge, J., Bull, J. The impact of combinatorial stress on the growth dynamics and metabolome of Burkholderia mesoacidophila demonstrates the complexity of tolerance mechanisms Journal of Applied Microbiology 127 5 1521 1531
  4. Madura, F., Rizkallah, P., Legut, M., Holland, C., Fuller, A., Bulek, A., Schauenburg, A., Trimby, A., Hopkins, J., Wells, S., Godkin, A., Miles, J., Sami, M., Li, Y., Liddy, N., Jakobsen, B., Loveridge, E., Cole, D., Sewell, A., Loveridge, J. TCR‐induced alteration of primary MHC peptide anchor residue European Journal of Immunology
  5. Angelastro, A., Dawson, W., Luk, L., Loveridge, E., Allemann, R., Loveridge, J. Chemoenzymatic Assembly of Isotopically Labeled Folates Journal of the American Chemical Society 139 37 13047 13054
  6. Loveridge, E., Jones, C., Bull, M., Moody, S., Kahl, M., Khan, Z., Neilson, L., Tomeva, M., Adams, S., Wood, A., Rodriguez-Martin, D., Pinel, I., Parkhill, J., Mahenthiralingam, E., Crosby, J., Loveridge, J. Reclassification of the Specialized Metabolite Producer Pseudomonas mesoacidophila ATCC 31433 as a Member of the Burkholderia cepacia Complex Journal of Bacteriology 199 13 e00125-17
  7. Hughes, R., Johnson, L., Behiry, E., Loveridge, E., Allemann, R., Loveridge, J. A Rapid Analysis of Variations in Conformational Behavior during Dihydrofolate Reductase Catalysis Biochemistry 56 15 2126 2133
  8. Loveridge, E., Hroch, L., Hughes, R., Williams, T., Davies, R., Angelastro, A., Luk, L., Maglia, G., Allemann, R., Loveridge, J. Reduction of Folate by Dihydrofolate Reductase from Thermotoga maritima Biochemistry 56 13 1879 1886
  9. Ruiz-Pernia, J., Behiry, E., Loveridge, J., Luk, L., Tunon, I., Moliner, V., Allemann, R. Minimization of dynamic effects in the evolution of dihydrofolate reductase Chemical Science 7 5 3248 3255
  10. Loveridge, E., Allemann, R., Loveridge, J. Pinpointing dynamic coupling in enzymes for efficient drug design Future Science OA 2 1
  11. Luk, L., Ruiz-Pernía, J., Adesina, A., Loveridge, E., Tuñón, I., Moliner, V., Allemann, R., Loveridge, J. Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase Angewandte Chemie International Edition 54 31 9016 9020
  12. Luk, L., Loveridge, E., Allemann, R., Loveridge, J. Protein motions and dynamic effects in enzyme catalysis Physical Chemistry Chemical Physics 17 46 30817 30827
  13. Luk, L., Ruiz-Pernía, J., Dawson, W., Loveridge, E., Tuñón, I., Moliner, V., Allemann, R., Loveridge, J. Protein Isotope Effects in Dihydrofolate Reductase FromGeobacillus stearothermophilusShow Entropic–Enthalpic Compensatory Effects on the Rate Constant Journal of the American Chemical Society 136 49 17317 17323
  14. Hull, C., Loveridge, E., Rolley, N., Donnison, I., Kelly, S., Kelly, D., Loveridge, J. Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock Biotechnology for Biofuels 7 1 133
  15. Hull, C., Loveridge, E., Donnison, I., Kelly, D., Kelly, S., Loveridge, J. Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept AMB Express 4 1 64
  16. Behiry, E., Evans, R., Guo, J., Loveridge, E., Allemann, R., Loveridge, J. Loop Interactions during Catalysis by Dihydrofolate Reductase fromMoritella profunda Biochemistry 53 29 4769 4774
  17. Behiry, E., Luk, L., Matthews, S., Loveridge, E., Allemann, R., Loveridge, J. Role of the Occluded Conformation in Bacterial Dihydrofolate Reductases Biochemistry 53 29 4761 4768
  18. Luk, L., Loveridge, E., Allemann, R., Loveridge, J. Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases Journal of the American Chemical Society 136 19 6862 6865
  19. Guo, J., Luk, L., Loveridge, E., Allemann, R., Loveridge, J. Thermal Adaptation of Dihydrofolate Reductase from the Moderate ThermophileGeobacillus stearothermophilus Biochemistry 53 17 2855 2863
  20. Luk, L., Loveridge, E., Allemann, R., Loveridge, J. Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases Journal of the American Chemical Society 136 19 6862 6865
  21. Moody, S., Loveridge, E., Loveridge, J. CYP105-diverse structures, functions and roles in an intriguing family of enzymes inStreptomyces Journal of Applied Microbiology 117 6 1549 1563
  22. Ruiz-Pernia, J., Luk, L., García-Meseguer, R., Martí, S., Loveridge, E., Tuñón, I., Moliner, V., Allemann, R., Loveridge, J. Increased Dynamic Effects in a Catalytically Compromised Variant ofEscherichia coliDihydrofolate Reductase Journal of the American Chemical Society 135 49 18689 18696
  23. Loveridge, E., Matthews, S., Williams, C., Whittaker, S., Guenther, U., Evans, R., Dawson, W., Crump, M., Allemann, R., Loveridge, J. Aliphatic 1H, 13C and 15N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP+ and folate Biomolecular NMR Assignments 7 1 61 64
  24. Guo, J., Loveridge, E., Luk, L., Allemann, R., Loveridge, J. Effect of Dimerization on Dihydrofolate Reductase Catalysis Biochemistry 52 22 3881 3887
  25. Wysoczanski, P., Mart, R., Loveridge, E., Williams, C., Whittaker, S., Crump, M., Allemann, R., Loveridge, J. 1H, 13C and 15N chemical shift assignments of unliganded Bcl-xL and its complex with a photoresponsive Bak-derived peptide Biomolecular NMR Assignments 7 2 187 191
  26. Luk, L., Javier Ruiz-Pernia, J., Dawson, W., Roca, M., Loveridge, E., Glowacki, D., Harvey, J., Mulholland, A., Tunon, I., Moliner, V., Allemann, R., Loveridge, J. Unraveling the role of protein dynamics in dihydrofolate reductase catalysis Proceedings of the National Academy of Sciences 110 41 16344 16349
  27. Guo, J., Loveridge, E., Luk, L., Allemann, R., Loveridge, J. Effect of Dimerization on Dihydrofolate Reductase Catalysis Biochemistry 52 22 3881 3887
  28. Loveridge, E., Behiry, E., Guo, J., Allemann, R., Loveridge, J. Evidence that a ‘dynamic knockout’ in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis Nature Chemistry 4 4 292 297
  29. Wysoczanski, P., Mart, R., Loveridge, E., Williams, C., Whittaker, S., Crump, M., Allemann, R., Loveridge, J. NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-xL Journal of the American Chemical Society 134 18 7644 7647
  30. Wysoczanski, P., Mart, R., Loveridge, E., Williams, C., Whittaker, S., Crump, M., Allemann, R., Loveridge, J. NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-xL Journal of the American Chemical Society 134 18 7644 7647
  31. Loveridge, E., Allemann, R., Loveridge, J. Effect of pH on Hydride Transfer by Escherichia coli Dihydrofolate Reductase ChemBioChem 12 8 1258 1262
  32. Loveridge, E., Dawson, W., Evans, R., Sobolewska, A., Allemann, R., Loveridge, J. Reduced Susceptibility of Moritella profunda Dihydrofolate Reductase to Trimethoprim is Not Due to Glutamate 28 The Protein Journal 30 8 546 548
  33. Loveridge, E., Tey, L., Behiry, E., Dawson, W., Evans, R., Whittaker, S., Guenther, U., Williams, C., Crump, M., Allemann, R., Loveridge, J. The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase Journal of the American Chemical Society 133 50 20561 20570
  34. Evans, R., Behiry, E., Tey, L., Guo, J., Loveridge, E., Allemann, R., Loveridge, J. Catalysis by Dihydrofolate Reductase from the Psychropiezophile Moritella profunda ChemBioChem 11 14 2010 2017
  35. Tey, L., Loveridge, E., Swanwick, R., Flitsch, S., Allemann, R., Loveridge, J. Highly site-selective stability increases by glycosylation of dihydrofolate reductase FEBS Journal 277 9 2171 2179
  36. Loveridge, E., Tey, L., Allemann, R., Loveridge, J. Solvent Effects on Catalysis byEscherichia coliDihydrofolate Reductase Journal of the American Chemical Society 132 3 1137 1143
  37. Loveridge, E., Allemann, R., Loveridge, J. The Temperature Dependence of the Kinetic Isotope Effects of Dihydrofolate Reductase fromThermotoga maritimaIs Influenced by Intersubunit Interactions Biochemistry 49 25 5390 5396
  38. Hay, S., Evans, R., Levy, C., Loveridge, E., Wang, X., Leys, D., Allemann, R., Scrutton, N., Loveridge, J. Are the Catalytic Properties of Enzymes from Piezophilic Organisms Pressure Adapted? ChemBioChem 10 14 2348 2353
  39. Loveridge, E., Behiry, E., Swanwick, R., Allemann, R., Loveridge, J. Different Reaction Mechanisms for Mesophilic and Thermophilic Dihydrofolate Reductases Journal of the American Chemical Society 131 20 6926 6927
  40. Loveridge, E., Rodriguez, R., Swanwick, R., Allemann, R., Loveridge, J. Effect of Dimerization on the Stability and Catalytic Activity of Dihydrofolate Reductase from the HyperthermophileThermotoga maritima Biochemistry 48 25 5922 5933
  41. Allemann, R., Evans, R., Loveridge, E., Loveridge, J. Probing coupled motions in enzymatic hydrogen tunnelling reactions Biochemical Society Transactions 37 2 349 353
  42. Loveridge, E., Maglia, G., Allemann, R., Loveridge, J. The Role of Arginine 28 in Catalysis by Dihydrofolate Reductase from the HyperthermophileThermotoga maritima ChemBioChem 10 16 2624 2627
  43. Kneissl, S., Loveridge, E., Williams, C., Crump, M., Allemann, R., Loveridge, J. Photocontrollable Peptide-Based Switches Target the Anti-Apoptotic Protein Bcl-xL ChemBioChem 9 18 3046 3054
  44. Loveridge, E., Evans, R., Allemann, R., Loveridge, J. Solvent Effects on Environmentally Coupled Hydrogen Tunnelling During Catalysis by Dihydrofolate Reductase from Thermotoga maritima Chemistry - A European Journal 14 34 10782 10788
  45. Simm, A., Loveridge, E., Crosby, J., Avison, M., Walsh, T., Bennett, P., Loveridge, J. Bulgecin A: a novel inhibitor of binuclear metallo-β-lactamases Biochemical Journal 387 3 585 590

Book Chapters

  1. Joel Loveridge, E., Allemann, R., Loveridge, J. Chapter 8. Direct Methods for the Analysis of Quantum-Mechanical Tunnelling: Dihydrofolate Reductase (Ed.), Quantum Tunnelling in Enzyme-Catalysed Reactions 179 198 London Royal Society of Chemistry