Dr Andrew Warrilow
Research Officer
Medicine
Telephone: (01792) 295828
Room: Academic Office - 527
Fifth Floor
Institute of Life Science 1
Singleton Campus

Areas of Expertise

  • Sterol 14-alpha demethylases (CYP51)
  • NADPH-Cytochrome P450 reductases
  • Azole antifungals (pharmazoles and agriazoles)
  • Enzymology
  • Protein Biochemistry
  • Protein Purification
  • Centre for Cytochrome P450 Biodiversity Homepage ( http://www.p450swansea.co.uk/ )
  • Co-investigator on BEACON ( http://www.beaconwales.org )

Publications

  1. & Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens. International Journal of Antimicrobial Agents
  2. & On the occurrence of cytochrome P450 in viruses. Proceedings of the National Academy of Sciences, 201901080
  3. & The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions. Antimicrobial Agents and Chemotherapy 63(5)
  4. & Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1863(10), 1164-1178.
  5. et. al. In Vitro and In Vivo Efficacy of a Novel and Long Acting Fungicidal Azole, PC1244 on Aspergillus fumigatus Infection. Antimicrobial Agents and Chemotherapy, AAC.01941-17

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Teaching

  • PM-357 Biomedical Laboratory Techniques

    The module will provide practical and in depth theory of applications and equipment available to MSci students in the biomedical research laboratories based at the Medical School. The module will provide guidelines and rationale for experimental design, and data and statistical analysis.

  • PM-357C Technegau Labordy Biofeddygol

    Bydd y modiwl yn darparu damcaniaeth ymarferol a manwl o¿r cymwysiadau ac offer sydd ar gael i fyfyrwyr MSci yn y labordai ymchwil biofeddygol sydd wedi'u lleoli yn yr Ysgol Feddygaeth. Bydd y modiwl yn darparu canllawiau a rhesymeg ar gyfer cynlluniau arbrofol, a dadansoddiad data ac ystadegau.