Publications

Journal Articles

  1. Griffiths, W., Wang, Y. Oxysterols as Lipid Mediators: Their Biosynthetic Genes, Enzymes and Metabolites Prostaglandins & Other Lipid Mediators 106381
  2. Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., Griffiths, W. Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism Proceedings of the National Academy of Sciences 201917421
  3. Hudson, N., Reverter, A., Griffiths, W., Yutuc, E., Wang, Y., Jeanes, A., McWilliam, S., Pethick, D., Greenwood, P. Gene expression identifies metabolic and functional differences between intramuscular and subcutaneous adipocytes in cattle BMC Genomics 21 1
  4. Griffiths, W., Wang, Y. Sterolomics in biology, biochemistry, medicine TrAC Trends in Analytical Chemistry 120 115280
  5. Meljon, A., Crick, P., Yutuc, E., Yau, J., Seckl, J., Theofilopoulos, S., Arenas, E., Wang, Y., Griffiths, W. Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5 Biomolecules 9 4 149
  6. Theofilopoulos, S., Oliveira, W., Yang, S., Yutuc, E., Saeed, A., Abdel-Khalik, J., Ullgren, A., Cedazo-Minguez, A., Björkhem, I., Wang, Y., Griffiths, W., Arenas, E. 24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo Journal of Biological Chemistry 294 11 4169 4176
  7. Griffiths, W., Crick, P., Meljon, A., Theofilopoulos, S., Abdel-Khalik, J., Yutuc, E., Parker, J., Kelly, D., Kelly, S., Arenas, E., Wang, Y. Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864 2 191 211
  8. Abdel-Khalik, J., Crick, P., Yutuc, E., DeBarber, A., Duell, P., Steiner, R., Laina, I., Wang, Y., Griffiths, W. Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma Biochimie
  9. Griffiths, W., Gilmore, i., Yutuc, E., Abdel-Khalik, J., Crick, P., Hearn, T., Dickson, A., Bigger, B., Wu, T., Goenka, A., Ghosh, A., Jones, S., Wang, Y. Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation Journal of Lipid Research 59 6 1058 1070
  10. Kurowska-Stolarska, M., Hasoo, M., Welsh, D., Stewart, L., McIntyre, D., Morton, B., Johnstone, S., Miller, A., Asquith, D., Millar, N., Millar, A., Feghali-Bostwick, C., Hirani, N., Crick, P., Wang, Y., Griffiths, W., McInnes, I., McSharry, C. The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis Journal of Allergy and Clinical Immunology 139 6 1946 1956
  11. Rees, D., Crick, P., Jenkins, G., Wang, Y., Griffiths, W., Brown, T., Al-Sarireh, B. Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease The Journal of Steroid Biochemistry and Molecular Biology 174 290 295
  12. Abdel-Khalik, J., Yutuc, E., Crick, P., Gustafsson, J., Warner, M., Roman, G., Talbot, K., Gray, E., Griffiths, W., Turner, M., Wang, Y. Defective cholesterol metabolism in amyotrophic lateral sclerosis Journal of Lipid Research jlr.P071639
  13. Crick, P., Griffiths, W., Zhang, J., Beibel, M., Abdel-Khalik, J., Kuhle, J., Sailer, A., Wang, Y. Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients Molecular Neurobiology
  14. Robertson, K., Hsieh, W., Forster, T., Blanc, M., Lu, H., Crick, P., Yutuc, E., Watterson, S., Martin, K., Griffiths, S., Enright, A., Yamamoto, M., Pradeepa, M., Lennox, K., Behlke, M., Talbot, S., Haas, J., Dölken, L., Griffiths, W., Wang, Y., Angulo, A., Ghazal, P. An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway PLOS Biology 14 3 e1002364
  15. Griffiths, W., Abdel-Khalik, J., Crick, P., Ogundare, M., Shackleton, C., Tuschl, K., Kwok, M., Bigger, B., Morris, A., Honda, A., Xu, L., Porter, N., Björkhem, I., Clayton, P., Wang, Y. Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients The Journal of Steroid Biochemistry and Molecular Biology
  16. Griffiths, W., Abdel-Khalik, J., Hearn, T., Yutuc, E., Morgan, A., Wang, Y., Griffiths, W., Wang, Y., Morgan, A., Yutuc, E. Current trends in oxysterol research Biochemical Society Transactions 44 2 652 658
  17. Iuliano, L., Crick, P., Zerbinati, C., Tritapepe, L., Abdel-Khalik, J., Poirot, M., Wang, Y., Griffiths, W. Cholesterol metabolites exported from human brain Steroids
  18. Crick, P., Beckers, L., Baes, M., Van Veldhoven, P., Wang, Y., Griffiths, W. The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid Steroids
  19. Crick, P., Bentley, T., Wang, Y., Griffiths, W. Revised sample preparation for the analysis of oxysterols by enzyme-assisted derivatisation for sterol analysis (EADSA) Analytical and Bioanalytical Chemistry 407 17 5235 5239
  20. , ., Griffiths, W., Wang, Y. Liver disease in infancy caused by oxysterol 7α-hydroxylase deficiency: successful treatment with chenodeoxycholic acid Journal of Inherited Metabolic Disease
  21. , ., Griffiths, W., Wang, Y. A new derivative for oxosteroid analysis by mass spectrometry Biochemical and Biophysical Research Communications
  22. , ., Griffiths, W., Wang, Y. Evaluation of novel derivatisation reagents for the analysis of oxysterols Biochemical and Biophysical Research Communications
  23. , ., Griffiths, W., Wang, Y. Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse Biochemical and Biophysical Research Communications
  24. , ., Griffiths, W., Wang, Y. Studies on the analysis of 25-hydroxyvitamin D3 by isotope-dilution liquid chromatography–tandem mass spectrometry using enzyme-assisted derivatisation Biochemical and Biophysical Research Communications
  25. , ., Griffiths, W., Wang, Y. Role of α-Methylacyl-CoA Racemase (Amacr) and peroxisomal Multifunctional Enzyme 1 (Mfe-1) in bile acid synthesis in mice Biochemical Journal
  26. Bjorkhem+U., I., Griffiths, W., Wang, Y. On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO The Journal of Lipid Research
  27. Wang, Y., Karu, K., Meljon, A., Turton, J., Yau, J., Seckl, J., Wang, Y., Griffiths, W. 24S,25-Epoxycholesterol in mouse and rat brain Biochemical and Biophysical Research Communications
  28. Saeed, A., Genove, G., Li, T., Luetjohann, D., Olin, M., Mast, N., Pikuleva, I., Crick, P., Wang, Y., Griffiths, W., Betsholtz, C., Bjorkhem, I., Griffiths, W., Wang, Y. Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain Journal of Biological Chemistry
  29. Crick, P., William Bentley, T., Abdel-Khalik, J., Matthews, I., Clayton, P., Morris, A., Bigger, B., Zerbinati, C., Tritapepe, L., Iuliano, L., Wang, Y., Griffiths, W., Griffiths, W., Wang, Y. Quantitative Charge-Tags for Sterol and Oxysterol Analysis Clinical Chemistry
  30. Theofilopoulos, S., Griffiths, W., Crick, P., Yang, S., Meljon, A., Ogundare, M., Kitambi, S., Lockhart, A., Tuschl, K., Clayton, P., Morris, A., Martinez, A., Reddy, M., Martinuzzi, A., Bassi, M., Honda, A., Mizuochi, T., Kimura, A., Nittono, H., Michele, G., Carbone, R., Criscuolo, C., Yau, J., Seckl, J., Schüle, R., Schöls, L., Sailer, A., Kuhle, J., Fraidakis, M., Gustafsson, J., Steffensen, K., Björkhem, I., Ernfors, P., Sjövall, J., Arenas, E., Wang, Y. Cholestenoic acids regulate motor neuron survival via liver X receptors Journal of Clinical Investigation 124 11 4829 4842
  31. Blanc, M., Hsieh, W., Robertson, K., Kropp, K., Forster, T., Shui, G., Lacaze, P., Watterson, S., Griffiths, S., Spann, N., Meljon, A., Talbot, S., Krishnan, K., Covey, D., Wenk, M., Craigon, M., Ruzsics, Z., Haas, J., Angulo, A., Griffiths, W., Glass, C., Wang, Y., Ghazal, P., Griffiths, W. The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response Immunity 38 1 106 118
  32. Griffiths, W., Crick, P., Wang, Y. Methods for oxysterol analysis: Past, present and future Biochemical Pharmacology
  33. Meljon, A., Watson, G., Wang, Y., Shackleton, C., Griffiths, W. Analysis by Liquid Chromatography - Mass Spectrometry of Sterols and Oxysterols in Brain of the Newborn Dhcr7Δ3-5/T93M Mouse: A Model of Smith-Lemli-Opitz Syndrome Biochemical Pharmacology
  34. Saini, R., Kataeva, O., Schmidt, A., Wang, Y., Meljon, A., Griffiths, W., Knölker, H. Synthesis and biological activity of (24E)- and (24Z)-26-hydroxydesmosterol Bioorganic & Medicinal Chemistry
  35. Theofilopoulos, S., Wang, Y., Kitambi, S., Sacchetti, P., Sousa, K., Bodin, K., Kirk, J., Saltó, C., Gustafsson, M., Toledo, E., Karu, K., Gustafsson, J., Steffensen, K., Ernfors, P., Sjövall, J., Griffiths, W., Arenas, E. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis Nature Chemical Biology 9 2 126 133
  36. Griffiths, W., Crick, P., Wang, Y., Ogundare, M., Tuschl, K., Morris, A., Bigger, B., Clayton, P., Wang, Y. Analytical strategies for characterization of oxysterol lipidomes: Liver X receptor ligands in plasma Free Radical Biology and Medicine
  37. Chen, Y., Ogundare, M., Williams, C., Wang, Y., Wang, Y., Sewell, G., Smith, P., Rahman, F., O'Shea, N., Segal, A., Griffiths, W. Shotgun cholanomics of ileal fluid Biochimie
  38. Meljon, A., Theofilopoulos, S., Shackleton, C., Watson, G., Javitt, N., Knolker, H., Saini, R., Arenas, E., Wang, Y., Griffiths, W., Griffiths, W., Wang, Y., Theofilopoulos, S. Analysis of bioactive oxysterols in newborn mouse brain by LC/MS Journal of Lipid Research 53 11 2469 2483
  39. Björkhem, I., Diczfalusy, U., Olsson, T., Russell, D., McDonald, J., Wang, Y., Griffiths, W. Detecting oxysterols in the human circulation Nature Immunology 12 7 577 577
  40. Karu, K., Turton, J., Wang, Y., Griffiths, W. Nano-liquid chromatography–tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation Chemistry and Physics of Lipids 164 6 411 424
  41. Griffiths, W., Wang, Y., Griffiths, W., Wang, Y. Are 15-oxygenated sterols present in the human circulation? The Journal of Lipid Research 52 1 4 5
  42. Griffiths, W., Ogundare, M., Williams, C., Wang, Y. On the future of “omics”: lipidomics Journal of Inherited Metabolic Disease 34 3 583 592
  43. Ogundare, M., Theofilopoulos, S., Lockhart, A., Wang, Y. Cerebrospinal fluid steroidomics: Are bioactive bile acids present in brain Journal of Biological Chemistry 285 4666 79
  44. Griffiths, W., Wang, Y., Brenton, A., Hall, L., Arenas, E., Lockhart, A., Theofilopoulos, S., Sjövall, J., Ogundare, M. Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain? Journal of Biological Chemistry 285 7 4666 4679
  45. Griffiths, W., Wang, Y., Wang, Y. The Importance of Steroidomics in the Study of Neurodegenerative Disease and Ageing Combinatorial Chemistry & High Throughput Screening 12 2 212 228
  46. Griffiths, W., Wang, Y. Mass spectrometry: from proteomics to metabolomics and lipidomics Chemical Society Reviews 38 7 1882
  47. Griffiths, W., Wang, Y. Analysis of neurosterols by GC–MS and LC–MS/MS Journal of Chromatography B 877 26 2778 2805
  48. Siebert, C., Davidson, B., Fuller, B., Wang, Y. Multiple-Approaches to the Identification and Quantification of Cytochromes P450 in Human Liver Tissue by Mass Spectrometry. J Proteome Res 8 1672 81
  49. Wang, Y., Sousa, K., Bodin, K., Griffiths, W., Wang, Y. Targeted lipidomic analysis of oxysterols in the embryonic central nervous system Molecular BioSystems 5 529 41
  50. Griffiths, W., Wang, Y. Sterol lipidomics in health and disease: Methodologies and applications European Journal of Lipid Science and Technology 111 1 14 38
  51. Seibert, C., Davidson, B., Fuller, B., Patterson, L., Griffiths, W., Wang, Y. Multiple-Approaches to the Identification and Quantification of Cytochromes P450 in Human Liver Tissue by Mass Spectrometry Journal of Proteome Research 8 4 1672 1681
  52. Ogundare, M., Theofilopoulos, S., Lockhart, A., Hall, L., Arenas, E., Sjövall, J., Brenton, A., Wang, Y., Griffiths, W., Brenton, A., Gregory, S. Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain? Journal of Biological Chemistry 285 7 4666 4679
  53. Griffiths, W., Arenas, E., Sjövall, J., Karu, K., Theofilopoulos, S., Hornshaw, M., Sacchetti, P., Bodin, K., Sousa, K., Woffendin, G., Wang, Y. Targeted lipidomic analysis of oxysterols in the embryonic central nervous system Molecular BioSystems 5 5 529
  54. Wang, Y., Griffiths, W. Capillary liquid chromatography combined with tandem mass spectrometry for the study of neurosteroids and oxysterols in brain Neurochemistry International 52 4-5 506 521
  55. Wang, Y., Muneton, S., Sjövall, J., Jovanovic, J., Griffiths, W. The Effect of 24S-Hydroxycholesterol on Cholesterol Homeostasis in Neurons: Quantitative Changes to the Cortical Neuron Proteome Journal of Proteome Research 7 4 1606 1614
  56. Griffiths, W., Hornshaw, M., Woffendin, G., Baker, S., Lockhart, A., Heidelberger, S., Gustafsson, M., Sjövall, J., Wang, Y. Discovering Oxysterols in Plasma: A Window on the Metabolome Journal of Proteome Research 7 8 3602 3612
  57. Wang, Y., Karu, K., Griffiths, W., Griffiths, W., Wang, Y. Analysis of neurosterols and neurosteroids by mass spectrometry Biochimie 89 2 182 191
  58. Griffiths, W., Karu, K., Hornshaw, M., Woffendin, G., Wang, Y., Griffiths, W., Wang, Y. Metabolomics and metabolite profiling: past heroes and future developments European Journal of Mass Spectrometry 13 1 45
  59. Karu, K., Hornshaw, M., Woffendin, G., Bodin, K., Hamberg, M., Alvelius, G., Sjovall, J., Turton, J., Wang, Y., Griffiths, W., Griffiths, W., Wang, Y. Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols The Journal of Lipid Research 48 4 976 987
  60. Lane, C., Wang, Y., Betts, R., Griffiths, W., Patterson, L., Griffiths, W., Wang, Y. Comparative Cytochrome P450 Proteomics in the Livers of Immunodeficient Mice Using 18O Stable Isotope Labeling Molecular & Cellular Proteomics 6 6 953 962
  61. Wang, Y., Griffiths, W. Modern Methods of Bile Acid Analysis by Mass Spectrometry: A View into the Metabolome Current Analytical Chemistry 3 2 103 126
  62. Khan, M., Wang, Y., Heidelberger, S., Alvelius, G., Liu, S., Sjövall, J., Griffiths, W., Griffiths, W., Wang, Y. Analysis of derivatised steroids by matrix-assisted laser desorption/ionisation and post-source decay mass spectrometry Steroids 71 1 42 53
  63. Wang, Y., Al-Gazzar, A., Seibert, C., Sharif, A., Lane, C., Griffiths, W., Griffiths, W., Wang, Y. Proteomic analysis of cytochromes P450: a mass spectrometry approach Biochemical Society Transactions 34 6 1246 1251
  64. Wang, Y., Hornshaw, M., Alvelius, G., Bodin, K., Liu, S., Sjövall, J., Griffiths, W. Matrix-Assisted Laser Desorption/Ionization High-Energy Collision-Induced Dissociation of Steroids:  Analysis of Oxysterols in Rat Brain Analytical Chemistry 78 1 164 173
  65. Griffiths, W., Wang, Y., Alvelius, G., Liu, S., Bodin, K., Sjövall, J. Analysis of oxysterols by electrospray tandem mass spectrometry Journal of the American Society for Mass Spectrometry 17 3 341 362
  66. Heap, C., Wang, Y., Pinheiro, T., Reading, S., Jennings, K., Dimmock, N., Wang, Y. Analysis of a 17-amino acid residue, virus-neutralizing microantibody Journal of General Virology 86 6 1791 1800
  67. Wang, Y., Walter, G., Herting, E., Agerberth, B., Johansson, J., Wang, Y. Antibacterial Activities of the Cathelicidins Prophenin (Residues 62 to 79) and LL-37 in the Presence of a Lung Surfactant Preparation Antimicrobial Agents and Chemotherapy 48 6 2097 2100
  68. Wang, Y., Griffiths, W., Jörnvall, H., Agerberth, B., Johansson, J., Griffiths, W., Wang, Y. Antibacterial peptides in stimulated human granulocytes European Journal of Biochemistry 269 2 512 518
  69. Wang, Y., Johansson, J., Griffiths, W., Griffiths, W., Wang, Y. Characterisation of variant forms of prophenin: mechanistic aspects of the fragmentation of proline-rich peptides Rapid Communications in Mass Spectrometry 14 23 2182 2202
  70. Wang, Y., Griffiths, W., Curstedt, T., Johansson, J., Griffiths, W., Wang, Y. Porcine pulmonary surfactant preparations contain the antibacterial peptide prophenin and a C-terminal 18-residue fragment thereof FEBS Letters 460 2 257 262
  71. Wang, Y., Agerberth, B., Löthgren, A., Almstedt, A., Johansson, J., Wang, Y. Apolipoprotein A-I Binds and Inhibits the Human Antibacterial/Cytotoxic Peptide LL-37 Journal of Biological Chemistry 273 50 33115 33118
  72. Stark, M., Wang, Y., Danielsson, O., Jörnvall, H., Johansson, J. Determination of Proteins, Phosphatidylethanolamine, and Phosphatidylserine in Organic Solvent Extracts of Tissue Material by Analysis of Phenylthiocarbamyl Derivatives Analytical Biochemistry 265 1 97 102

Books

  1. Griffiths, W., Wang, Y. Lipidomics Cambridge Royal Society of Chemistry

Book Chapters

  1. Dudley, E., Yousef, M., Wang, Y., Griffiths, W., Wang, Y. Targeted metabolomics and mass spectrometry (Ed.), 83
  2. Griffiths, W., Wang, Y. CHAPTER 10. New Scans and Resources in Lipidomics (Ed.), New Developments in Mass Spectrometry 263 282 Cambridge Royal Society of Chemistry
  3. Wang, Y., Griffiths, W. CHAPTER 6. Derivatisation for Direct Infusion– and Liquid Chromatography–Mass Spectrometry (Ed.), New Developments in Mass Spectrometry 122 147 Cambridge Royal Society of Chemistry
  4. Griffiths, W., Yutuc, E., Davies, D., Dickson, A., Angelini, R., Assad, D., Frache, G., Wang, Y. CHAPTER 1. Lipidomics Basics (Ed.), New Developments in Mass Spectrometry 1 24 Cambridge Royal Society of Chemistry

Other Research Outputs

  1. Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., Griffiths, W. Imaging Sterols and Oxysterols in Mouse Brain Reveals Distinct Spatial Cholesterol Metabolism Cold Spring Harbor Laboratory