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I am a British Heart Foundation sponsored research scientist. I'm one of those awkward people who uses their middle name, so most will know me as Lowri. My research focusses on the massice intracellular cardiac ion channel, the ryanodine receptor (RyR2) and its role in health and disease - in particular the generation of cardiac arrhythmia. My role in the Molecular Cardiology Group is to use mutagenesis and expression techniques to make recombinant ion channel proteins and assess their gating behaviour (i.e. the way in which they open and close) using single channel recording in lipid bilayers. I'm also looking at in how these molecular events translate into calcium release dysfunction at the cellular level. As a result, I have an interest in the use of human induced pluripotent stem cell derived cariac myocytes as a model for arrhythmic disease.

Areas of Expertise

  • Single ion channel gating
  • Cardiac channelopathies
  • Molecular biology
  • Calcium imaging

Publications

  1. Handhle, A., Ormonde, C., Thomas, N., Bralesford, C., Williams, A., Lai, F., Zissimopoulos, S., Thomas, N., Zisimopoulos, S. Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain Journal of Cell Science jcs.191643
  2. Seidel, M., Thomas, N., Williams, A., Lai, F., Zissimopoulos, S., Thomas, N., Zisimopoulos, S., Williams, A. Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors Cardiovascular Research 105 1 118 128
  3. Euden, J., Mason, S., Viero, C., Thomas, N., Williams, A., Thomas, N., Williams, A. Investigations of the Contribution of a Putative Glycine Hinge to Ryanodine Receptor Channel Gating Journal of Biological Chemistry 288 23 16671 16679
  4. Thomas, N., Williams, A., Thomas, N. Pharmacology of ryanodine receptors and Ca2+-induced Ca2+ release Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 1 4 383 397
  5. Viero, C., Thomas, N., Euden, J., Mason, S., George, C., Williams, A., Thomas, N., Williams, A. Calcium Signaling Techniques and Methodologies to Study the Ryanodine Receptor at the Molecular, Subcellular and Cellular Level Chapter 8 183 215

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Career History

Start Date End Date Position Held Location
2017 Present Researcher Swansea University Medical School
2007 2017 Researcher Cardiff University

Key Grants and Projects

  • "Functional assessment of cardiac ryanodine receptor calcium release channel populations: a direct demonstration of coupled gating?" 2016 - 2018

    , with Dr Bevan Cumbes (Swansea University), Dr Oliver Castell (Cardiff University)

  • "Predicting anti-arrhythmic drug afficacy from the divergent molecular basis of RyR2 dysfunction in genetic arrythmia syndromes" 2015 - 2020

    , with Dr Saptarshi Mukherjee

Research Groups

  • Molecular Cardiology Group

    The Molecular Cardiology Group is part of the British Heart Foundation project based at Swansea University Medical School.