1. Rybak, Jeffrey M.., Ge, Wenbo., Wiederhold, Nathan P.., Parker, Josie E.., Kelly, Steven L.., Rogers, P. David. & Fortwendel, Jarrod R.. (2019). Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus. mBio 10(2)

   https://cronfa.swan.ac.uk/Record/cronfa49873 doi:10.1128/mBio.00437-19
2. Warrilow, Andrew G.., Nishimoto, Andrew T.., Parker, Josie E.., Price, Claire L.., Flowers, Stephanie A.., Kelly, Diane E.., Rogers, P. David. & Kelly, Steven L.. (2019). The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions. Antimicrobial Agents and Chemotherapy

   https://cronfa.swan.ac.uk/Record/cronfa48946 doi:10.1128/AAC.02586-18
3. Griffiths, William J.., Crick, Peter J.., Meljon, Anna., Theofilopoulos, Spyridon., Abdel-Khalik, Jonas., Yutuc, Eylan., Parker, Josie E.., Kelly, Diane E.., Kelly, Steven L.., Arenas, Ernest. & Wang, Yuqin. (2019). Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864(2), 191-211.

   https://cronfa.swan.ac.uk/Record/cronfa46175 doi:10.1016/j.bbalip.2018.11.006
4. Ahmad, Suhail., Joseph, Leena., Parker, Josie E.., Asadzadeh, Mohammad., Kelly, Steven L.., Meis, Jacques F.. & Khan, Ziauddin. (2018). ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait. Antimicrobial Agents and Chemotherapy 63(2), e01900-18

   https://cronfa.swan.ac.uk/Record/cronfa46174 doi:10.1128/AAC.01900-18
5. Zhou, Wenxu., Warrilow, Andrew G.S.., Thomas, Crista D.., Ramos, Emilio., Parker, Josie E.., Price, Claire L.., Vanderloop, Boden H.., Fisher, Paxtyn M.., Loftis, Michael D.., Kelly, Diane E.., Kelly, Steven L.. & Nes, W. David. (2018). Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1863(10), 1164-1178.

   https://cronfa.swan.ac.uk/Record/cronfa41148 doi:10.1016/j.bbalip.2018.07.004
6. Luna-Tapia, Arturo., Willems, Hubertine M. E.., Parker, Josie E.., Tournu, Hélène., Barker, Katherine S.., Nishimoto, Andrew T.., Rogers, P. David., Kelly, Steven L.., Peters, Brian M.. & Palmer, Glen E.. (2018). Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity. mBio 9(3), e00225-18

   https://cronfa.swan.ac.uk/Record/cronfa40413 doi:10.1128/mBio.00225-18
7. Colley, Thomas., Sehra, Gurpreet., Chowdhary, Anuradha., Alanio, Alexandre., Kelly, Steven L.., Kizawa, Yasuo., Armstrong-James, Darius., Fisher, Matthew C.., Warrilow, Andrew G.S.., Parker, Josie E.., Kelly, Diane E.., Kimura, Genki., Nishimoto, Yuki., Sunose, Mihiro., Onions, Stuart., Crepin, Damien., Lagasse, Franz., Crittall, Matthew., Shannon, Jonathan., et. al. (2018). In Vitro and In Vivo Efficacy of a Novel and Long Acting Fungicidal Azole, PC1244 on Aspergillus fumigatus Infection. Antimicrobial Agents and Chemotherapy, AAC.01941-17

   https://cronfa.swan.ac.uk/Record/cronfa39297 doi:10.1128/AAC.01941-17
8. Butts, A., DeJarnette, C., Peters, T., Parker, J., Kerns, M., Eberle, K., Kelly, S. & Palmer, G. (2017). Target Abundance-Based Fitness Screening (TAFiS) Facilitates Rapid Identification of Target-Specific and Physiologically Active Chemical Probes. mSphere 2(5), e00379-17

   https://cronfa.swan.ac.uk/Record/cronfa36657 doi:10.1128/mSphere.00379-17
9. Rybak, J., Dickens, C., Parker, J., Caudle, K., Manigaba, K., Whaley, S., Nishimoto, A., Luna-Tapia, A., Roy, S., Zhang, Q., Barker, K., Palmer, G., Sutter, T., Homayouni, R., Wiederhold, N., Kelly, S. & Rogers, P. (2017). Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of Candida parapsilosis. Antimicrobial Agents and Chemotherapy, AAC.00651-17

   https://cronfa.swan.ac.uk/Record/cronfa34719 doi:10.1128/AAC.00651-17
10. Warrilow, A., Parker, J., Price, C., Garvey, E., Hoekstra, W., Schotzinger, R., Wiederhold, N., Nes, W., Kelly, D. & Kelly, S. (2017). The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51. Antimicrobial Agents and Chemotherapy 61(7), e00333-17

    https://cronfa.swan.ac.uk/Record/cronfa34720 doi:10.1128/AAC.00333-17
11. Colley, T., Alanio, A., Kelly, S., Sehra, G., Kizawa, Y., Warrilow, A., Parker, J., Kelly, D., Kimura, G., Anderson-Dring, L., Nakaoki, T., Sunose, M., Onions, S., Crepin, D., Lagasse, F., Crittall, M., Shannon, J., Cooke, M., Bretagne, S., et. al. (2017). In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection. Antimicrobial Agents and Chemotherapy 61(5), e02280-16

    https://cronfa.swan.ac.uk/Record/cronfa33103 doi:10.1128/AAC.02280-16
12. McCourt, P., Liu, H., Parker, J., Gallo-Ebert, C., Donigan, M., Bata, A., Giordano, C., Kelly, S. & Nickels, J. (2016). Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence. G3: Genes|Genomes|Genetics

    https://cronfa.swan.ac.uk/Record/cronfa32088 doi:10.1534/g3.116.033969
13. Warrilow, A., Parker, J., Price, C., Nes, W., Garvey, E., Hoekstra, W., Schotzinger, R., Kelly, D. & Kelly, S. (2016). The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. Antimicrobial Agents and Chemotherapy 60(8), 4530-4538.

    https://cronfa.swan.ac.uk/Record/cronfa29213 doi:10.1128/AAC.00349-16
14. Warrilow, A., Price, C., Parker, J., Rolley, N., Smyrniotis, C., Hughes, D., Thoss, V., Nes, W., Kelly, D., Holman, T. & Kelly, S. (2016). Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Scientific Reports 6, 27690

    https://cronfa.swan.ac.uk/Record/cronfa29214 doi:10.1038/srep27690
15. Berkow, E., Manigaba, K., Parker, J., Barker, K., Kelly, S. & Rogers, P. (2015). Multidrug transporters and alterations in sterol biosynthesis contribute to azole antifungal resistance inCandida parapsilosis. Antimicrobial Agents and Chemotherapy, AAC.01358-15

    https://cronfa.swan.ac.uk/Record/cronfa22523 doi:10.1128/AAC.01358-15
16. Derbyshire, M., Michaelson, L., Parker, J., Kelly, S., Thacker, U., Powers, S., Bailey, A., Hammond-Kosack, K., Courbot, M. & Rudd, J. (2015). Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence. Fungal Genetics and Biology

    https://cronfa.swan.ac.uk/Record/cronfa22091 doi:10.1016/j.fgb.2015.05.008
17. Lamb, D., Warrilow, A., Rolley, N., Parker, J., Nes, W., Smith, S., Kelly, D. & Kelly, S. (2015). Azole antifungal agents to treat the human pathogensAcanthamoeba castellanii and Acanthamoeba polyphagathrough inhibition of sterol 14α-demethylase (CYP51). Antimicrobial Agents and Chemotherapy, AAC.00476-15

    https://cronfa.swan.ac.uk/Record/cronfa21904 doi:10.1128/AAC.00476-15
18. Price, C., Parker, J., Warrilow, A., Kelly, D. & Kelly, S. (2015). Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. Pest Management Science 71(8), 1054-1058.

    https://cronfa.swan.ac.uk/Record/cronfa21903 doi:10.1002/ps.4029
19. (2015). In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy 59(12), 7771-7778.

    https://cronfa.swan.ac.uk/Record/cronfa29212 doi:10.1128/AAC.01806-15
20. Price, C., Warrilow, A., Parker, J., Mullins, J., Nes, W., Kelly, D., Kelly, S. & Schottel, J. (2015). Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Applied and Environmental Microbiology 81(10), 3379-3386.

    https://cronfa.swan.ac.uk/Record/cronfa21902 doi:10.1128/AEM.03965-14
21. Warrilow, A., Hull, C., Rolley, N., Parker, J., Nes, W., Smith, S., et. al. (2014). Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51). Applied and Environmental Microbiology 80(19), 6154-6166.

    https://cronfa.swan.ac.uk/Record/cronfa19341 doi:10.1128/AEM.01195-14
22. Parker, J., Warrilow, A., Price, C., Mullins, J., Kelly, D. & Kelly, S. (2014). Resistance to antifungals that target CYP51. Journal of Chemical Biology 7(4), 143-161.

    https://cronfa.swan.ac.uk/Record/cronfa19342 doi:10.1007/s12154-014-0121-1
23. Warrilow, A., Hull, C., Parker, J., Garvey, E., Hoekstra, W., Moore, W., et. al. (2014). The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme. Antimicrobial Agents and Chemotherapy 58(12), 7121-7127.

    https://cronfa.swan.ac.uk/Record/cronfa19343 doi:10.1128/AAC.03707-14
24. Warrilow, A. Parker, J. Kelly, D. & Kelly, S. (2013). Azole Affinity of Sterol 14 -Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens. Antimicrobial Agents and Chemotherapy 57(3)-1360.

    https://cronfa.swan.ac.uk/Record/cronfa14419 doi:10.1128/AAC.02067-12
25. Parker, J. Warrilow, A. Cools, H. Fraaije, B. Lucas, J. Rigdova, K. Griffiths, W. Kelly, D. & Kelly, S. (2013). Prothioconazole and Prothioconazole-Desthio Activities against Candida albicans Sterol 14- -Demethylase. Applied and Environmental Microbiology 79(5)-1645.

    https://cronfa.swan.ac.uk/Record/cronfa14420 doi:10.1128/AEM.03246-12
26. Fan, J. Urban, M. Parker, J. Brewer, H. Kelly, S. Hammond-Kosack, K. Fraaije, B. Liu, X. & Cools, H. (2013). Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function. New Phytologist-n/a.

    https://cronfa.swan.ac.uk/Record/cronfa14421 doi:10.1111/NPH.12193
27. Eddouzi, J. Parker, J. Vale-Silva, L. Coste, A. Ischer, F. Kelly, S. Manai, M. & Sanglard, D. (2013). Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals. Antimicrobial Agents and Chemotherapy 57(7)-3193.

    https://cronfa.swan.ac.uk/Record/cronfa15734 doi:10.1128/AAC.00555-13
28. Nie, D. Hoobler, E. Rai, G. Warrilow, A. Perry, S. Smyrniotis, C. Jadhav, A. Simeonov, A. Parker, J. Kelly, D. Maloney, D. Kelly, S. & Holman, T. (2013). Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy. PLoS ONE 8(6)

    https://cronfa.swan.ac.uk/Record/cronfa15735 doi:10.1371/journal.pone.0065928
29. Vale-Silva, L. Coste, A. Ischer, F. Parker, J. Kelly, S. Pinto, E. & Sanglard, D. (2012). Azole resistance by loss of function of the sterol  5,6-desaturase gene (ERG3) in Candida albicans does not necessarily decrease virulence. Antimicrobial Agents and Chemotherapy

    https://cronfa.swan.ac.uk/Record/cronfa6836 doi:10.1128/AAC.05720-11
30. Warrilow, A. Mullins, J. Hull, C. Parker, J. Lamb, D. Kelly, D. & Kelly, S. (2012). S279 Point Mutations in Candida albicans Sterol 14-  Demethylase (CYP51) Reduces in vitro Inhibition by Fluconazole.. Antimicrobial Agents and Chemotherapy

    https://cronfa.swan.ac.uk/Record/cronfa6838 doi:10.1128/AAC.05389-11

See more...

• PM-130 Biochemistry Skills Development

  This module is designed to develop the skills required for students of biochemistry and medical biochemistry. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy. Joint session cover generic skills such as internet searching for scientific sources, referencing and plagiarism

• PM-246 Biochemistry Skills Development II

  This module is designed to develop the skills required for students of biochemistry. Students meet with tutors and will be given a series of assignments designed to develop skills in key areas including essay writing, presentation and analysis of research papers.

• PM-250 Infectious Disease and Parasitology

  The course will build on the fundamentals of microbiology and introduce new topics in bacteriology, mycology and parasitology. Level 5 Immunology (PM-249) is a pre-requisite. The course covers the fundamentals of infectious diseases, including clinical aspects, treatment / prevention, and experimental approaches to the study of infectious and parasitic organisms. The course will also cover topics including disease outbreaks, beneficial parasites, tropical disease and behaviour-modifying parasites.

• PM-300 Medical Genetics

  The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.

• PM-304 Biomolecular Research Project

  *

• PM-334 Biochemistry Literature Review and Communication

  Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

• PM-357 Biomedical Laboratory Techniques

  The module will provide practical and in depth theory of applications and equipment available to MSci students in the biomedical research laboratories based at the Medical School. The module will provide guidelines and rationale for experimental design, and data and statistical analysis.

• PM-357C Technegau Labordy Biofeddygol

  Bydd y modiwl yn darparu damcaniaeth ymarferol a manwl o¿r cymwysiadau ac offer sydd ar gael i fyfyrwyr MSci yn y labordai ymchwil biofeddygol sydd wedi'u lleoli yn yr Ysgol Feddygaeth. Bydd y modiwl yn darparu canllawiau a rhesymeg ar gyfer cynlluniau arbrofol, a dadansoddiad data ac ystadegau.

• PM-402 Advanced Research Project B

  The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an 9-month period. The project will fall into one of the current medically-related research themes: Biomarkers and Genes; Microbes and Immunity; Devices. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title. For example, a Genetics student could be assigned a project investigating gene function in an insect vector of a tropical disease, using the technique of RNA interference. The advanced research project is divided between 2 modules, PM-400 and PM-402. PM-402 comprises the final written dissertation.

• PMGM19 Pharmacogenomics and Stratified Healthcare

  Pharmacogenomics and stratified health care ensure that healthcare professionals offer the 'right treatment, for the right person, at the right time¿ is a fast-developing area but far from a new concept. Pythagoras may have been the first to note pharmacogenomic responses when he noted that ingestion of fava beans results in haemolytic anaemic in some, but not all, people. Personalised medicine is the buzzword of the moment, with advances in pharmacogenomic testing enabling more effective, targeted therapies to patients in the field of asthma, analgesia, haematology, oncology and beyond. Continued understanding of the genomic basis of drug response will reduce drug-related adverse effects, save costs, and ensure a better therapeutic outcome. This module will provide a comprehensive overview of the analytical strategies and techniques used in pharmacogenomics and explore some of the challenges and limitations in this field (e.g. availability of patient material for studies of adverse drug reactions which tend to be rare, allelic heterogeneity between different ethnic groups, patient compliance etc.). These genomic variations act as biomarkers and so are the predictive tools for optimising drug response and preventing adverse drug reactions. The module will also provide an overview of the different type of pharmacogenomic biomarkers currently in use or emerging.