Professor Venkat Kanamarlapudi

Publications

Journal Articles

  1. Chiou, T., Long, P., Schumann-Gillett, A., Kanamarlapudi, V., Haas, S., Harvey, K., O’Mara, M., De Blas, A., Kalscheuer, V., Harvey, R. Mutation p.R356Q in the Collybistin Phosphoinositide Binding Site Is Associated With Mild Intellectual Disability Frontiers in Molecular Neuroscience 12
  2. Eva, R., Koseki, H., Kanamarlapudi, V., Fawcett, J. EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment Journal of Cell Science 130 21 3663 3675
  3. John, D., Williams, L., Kanamarlapudi, V., Humphrey, T., Wilkinson, T. The Bacterial Species Campylobacter jejuni Induce Diverse Innate Immune Responses in Human and Avian Intestinal Epithelial Cells Frontiers in Microbiology 8
  4. Chan, C., Pieper, I., Robinson, C., Friedmann, Y., Kanamarlapudi, V., Thornton, C. Shear Stress-Induced Total Blood Trauma in Multiple Species Artificial Organs
  5. Cronin, J., Kanamarlapudi, V., Thornton, C., Sheldon, I., Thornton, C., Cronin, J., Kanamarlapudi, V., Sheldon, M. Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells Mucosal Immunology 9 4 1125 1136
  6. Ahmad, R., Thompson, A., Stephens, J., Bain, S., Kanamarlapudi, V. Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation PLOS ONE 11 4 e0154229
  7. Venkateswarlu, K., Uma, D., Andrés, L., Kanamarlapudi, V. Luteinizing hormone/chorionic gonadotrophin receptor overexpressed in granulosa cells from polycystic ovary syndrome ovaries is functionally active Reproductive BioMedicine Online
  8. Thompson, A., Kanamarlapudi, V. Distinct Regions in the C-Terminus Required for GLP-1R Cell Surface Expression, Activity and Internalisation Molecular and Cellular Endocrinology 413 66 77
  9. Franssen, E., Zhao, R., Koseki, H., Kanamarlapudi, V., Hoogenraad, C., Eva, R., Fawcett, J., Kanamarlapudi, V. Exclusion of Integrins from CNS Axons Is Regulated by Arf6 Activation and the AIS Journal of Neuroscience 35 21 8359 8375
  10. Thompson, A., Kanamarlapudi, V. Agonist-induced internalisation of the glucagon-like peptide-1 receptor is mediated by the Gαq pathway Biochemical Pharmacology 93 1 72 84
  11. Thompson, A., Kanamarlapudi, V. The regions within the N-terminus critical for human glucagon like peptide-1 receptor (hGLP-1R) cell Surface expression Scientific Reports 4 7410
  12. Davies, J., Tamaddon-Jahromi, S., Jannoo, R., Kanamarlapudi, V. Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2 Biochemical Pharmacology 92 4 651 660
  13. Konstantinou, D., Lei, M., Xia, Z., Kanamarlapudi, V. Growth factors mediated differentiation of mesenchymal stem cells to cardiac polymicrotissue using hanging drop and bioreactor Cell Biology International 39 4 502 507
  14. Kanamarlapudi, V., Kanamarlapudi, V. Exchange factor EFA6R requires C-terminal targeting to the plasma membrane to promote cytoskeletal rearrangement through the activation of ARF6 Journal of Biological Chemistry 289 48 33378 33390
  15. Xia, Z., Francis, W., Kanamarlapudi, V., Owens, S. The temporal expression of estrogen receptor alpha-36 and runx2 in human bone marrow derived mesenchymal stromal cells during osteogenesis Biochem Biophys Res Commun
  16. Davies, J., Bain, S., Kanamarlapudi, V. ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes BIOCHEMICAL PHARMACOLOGY 90 4 406 413
  17. Chan, C., Pieper, I., Fleming, S., Friedmann, Y., Foster, G., Hawkins, K., Thornton, C., Kanamarlapudi, V. The Effect of Shear Stress on the Size, Structure, and Function of Human von Willebrand Factor Artificial Organs 38 9 741 750
  18. Aiysha Thompson, K., Kanamarlapudi, V. Type 2 Diabetes Mellitus and Glucagon Like Peptide-1 Receptor Signalling Clinical & Experimental Pharmacology 03 04
  19. Tu, Y., Xue, H., Francis, W., Davies, A., Pallister, I., Kanamarlapudi, V., Xia, Z. Lactoferrin inhibits dexamethasone-induced chondrocyte impairment from osteoarthritic cartilage through up-regulation of extracellular signal-regulated kinase 1/2 and suppression of FASL, FAS, and Caspase 3 Biochemical and Biophysical Research Communications 441 1 249 255
  20. Kanamarlapudi, V., Owens, S., Saha, K., Pope, R., Mundell, S., Owens, S. ARF6-Dependent Regulation of P2Y Receptor Traffic and Function in Human Platelets PLoS ONE 7 8 e43532
  21. Eva, R., Crisp, S., Marland, J., Norman, J., Kanamarlapudi, V., ffrench-Constant, C., Fawcett, J. ARF6 Directs Axon Transport and Traffic of Integrins and Regulates Axon Growth in Adult DRG Neurons The Journal of Neuroscience 32 30 10352 10364
  22. Kanamarlapudi, V., Owens, S., Lartey, J., Bernal, A., Owens, S. ADP-Ribosylation Factor 6 Expression and Activation Are Reduced in Myometrium in Complicated Pregnancies PLoS ONE 7 5 e37954
  23. Kanamarlapudi, V., Thompson, A., Kelly, E., Bernal, A. ARF6 Activated by the LHCG Receptor through the Cytohesin Family of Guanine Nucleotide Exchange Factors Mediates the Receptor Internalization and Signaling Journal of Biological Chemistry 287 24 20443
  24. Kalscheuer, V., Musante, L., Fang, C., Hoffmann, K., Fuchs, C., Carta, E., Deas, E., Venkateswarlu, K., Menzel, C., Ullmann, R., Tommerup, N., Dalprà, L., Tzschach, A., Selicorni, A., Lüscher, B., Ropers, H., Harvey, K., Harvey, R., Kanamarlapudi, V. A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation Human Mutation 30 1 61 68
  25. Stewart, R., Song, L., Carter, S., Sigalas, C., Zaccai, N., Kanamarlapudi, V., Bhat, M., Takeshima, H., Sitsapesan, R. Single-Channel Characterization of the Rabbit Recombinant RyR2 Reveals a Novel Inactivation Property of Physiological Concentrations of ATP Journal of Membrane Biology 222 2 65 77
  26. Venkateswarlu, K., Brandom, K., Yun, H., Kanamarlapudi, V. PI-3-kinase-dependent membrane recruitment of centaurin- 2 is essential for its effect on ARF6-mediated actin cytoskeleton reorganisation Journal of Cell Science 120 5 792 801
  27. Bouschet, T., Martin, S., Kanamarlapudi, V., Mundell, S., Henley, J. The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network Journal of Cell Science 120 15 2489 2497
  28. Kanumilli, S., Tringham, E., Payne, C., Dupere, J., Venkateswarlu, K., Usowicz, M., Kanamarlapudi, V. Alternative splicing generates a smaller assortment of CaV2.1 transcripts in cerebellar Purkinje cells than in the cerebellum Physiological Genomics 24 2 86 96
  29. Kanamarlapudi, V., Kanamarlapudi, V. Centaurin-α1 and KIF13B kinesin motor protein interaction in ARF6 signalling Biochemical Society Transactions 33 6 1279
  30. Lawrence, J., Mundell, S., Yun, H., Kelly, E., Venkateswarlu, K., Kanamarlapudi, V. Centaurin- 1, an ADP-Ribosylation Factor 6 GTPase Activating Protein, Inhibits  2-Adrenoceptor Internalization Molecular Pharmacology 67 6 1822 1828
  31. Kanamarlapudi, V., Kanamarlapudi, V. Centaurin-alpha(1) and KIF13B kinesin motor protein interaction in ARF6 signalling Biochemical Society Transactions 33
  32. Gunn-Moore, F., Welsh, G., Herron, L., Brannigan, F., Venkateswarlu, K., Gillespie, S., Brandwein-Gensler, M., Madan, R., Tavare, J., Brophy, P., Prystowsky, M., Guild, S., Kanamarlapudi, V. A novel 4.1 ezrin radixin moesin (FERM)-containing protein, ‘Willin’ FEBS Letters 579 22 5089 5094
  33. Venkateswarlu, K., Kanamarlapudi, V. Centaurin- 1 interacts directly with kinesin motor protein KIF13B Journal of Cell Science 118 11 2471 2484
  34. Lockyer, P., Bottomley, J., Reynolds, J., McNulty, T., Venkateswarlu, K., Potter, B., Dempsey, C., Cullen, P., Kanamarlapudi, V. Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1 IP4BP and GAP1 m result from the GAP1 IP4BP PH domain directing plasma membrane targeting Current Biology 7 12 1007 1010
  35. Venkateswarlu, K., Kanamarlapudi, V. Centaurin- 1 Is an in Vivo Phosphatidylinositol 3,4,5-Trisphosphate-dependent GTPase-activating Protein for ARF6 That Is Involved in Actin Cytoskeleton Organization Journal of Biological Chemistry 279 8 6205 6208
  36. Venkateswarlu, K., Kanamarlapudi, V. Interaction Protein for Cytohesin Exchange Factors 1 (IPCEF1) Binds Cytohesin 2 and Modifies Its Activity Journal of Biological Chemistry 278 44 43460 43469
  37. Kanumilli, S., Toms, N., Venkateswarlu, K., Mellor, H., Roberts, P., Kanamarlapudi, V. Functional coupling of rat metabotropic glutamate 1a receptors to phospholipase D in CHO cells: involvement of extracellular Ca2+, protein kinase C, tyrosine kinase and Rho-A Neuropharmacology 42 1 1 8
  38. Bobe, R., Wilde, J., Maschberger, P., Venkateswarlu, K., Cullen, P., Siess, W., Watson, S., Kanamarlapudi, V. Phosphatidylinositol 3-kinase-dependent translocation of phospholipase Cgamma2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation Blood 97 3 678 684
  39. Lamb, D., Kaderbhai, N., Venkateswarlu, K., Kelly, D., Kelly, S., Kaderbhai, M., Kanamarlapudi, V. Human Sterol 14α-Demethylase Activity Is Enhanced by the Membrane-Bound State of Cytochrome b5 Archives of Biochemistry and Biophysics 395 1 78 84
  40. Dubois, T., Kerai, P., Zemlickova, E., Howell, S., Jackson, T., Venkateswarlu, K., Cullen, P., Theibert, A., Larose, L., Roach, P., Aitken, A., Kanamarlapudi, V. Casein Kinase I Associates with Members of the Centaurin-alpha Family of Phosphatidylinositol 3,4,5-Trisphosphate-binding Proteins Journal of Biological Chemistry 276 22 18757 18764
  41. Lamb, D., Warrilow, A., Venkateswarlu, K., Kelly, D., Kelly, S., Kanamarlapudi, V. Activities and Kinetic Mechanisms of Native and Soluble NADPH–Cytochrome P450 Reductase Biochemical and Biophysical Research Communications 286 1 48 54
  42. Venkateswarlu, K., Cullen, P., Kanamarlapudi, V. Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase Biochemical Journal 345 3 719
  43. Cullen, P., Venkateswarlu, K., Kanamarlapudi, V. Potential regulation of ADP-ribosylation factor 6 signalling by phosphatidylinositol 3,4,5-trisphosphate Biochemical Society Transactions 27 4 683 689
  44. Kanamarlapudi, V. Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1. The Biochemical Journal 340 359 363
  45. Cullen, P., Venkateswarlu, K., Kanamarlapudi, V. Potential regulation of ADP-ribosylation factor 6 signalling by phosphatidylinositol 3,4,5-trisphosphaee Biochemical Society Transactions 27
  46. Venkateswarlu, K., Cullen, P., Kanamarlapudi, V. Molecular Cloning and Functional Characterization of a Human Homologue of Centaurin-α Biochemical and Biophysical Research Communications 262 1 237 244
  47. Lockyer, P., Wennstrom, S., Kupzig, S., Venkateswarlu, K., Downward, J., Cullen, P., Kanamarlapudi, V. Identification of the Ras GTPase-activating protein GAP1m as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo Current Biology 9 5 265 269
  48. Venkateswarlu, K., Oatey, P., Tavare, J., Jackson, T., Cullen, P., Kanamarlapudi, V. Identification of centaurin-α1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1 Biochemical Journal 340 2 359
  49. Lamb, D., Kelly, D., Venkateswarlu, K., Manning, N., Bligh, H., Schunck, W., Kelly, S., Kanamarlapudi, V. Generation of a Complete, Soluble, and Catalytically Active Sterol 14α-Demethylase−Reductase Complex† Biochemistry 38 27 8733 8738
  50. Venkateswarlu, K., Gunn-Moore, F., Tavare, J., Cullen, P., Kanamarlapudi, V. EGF- and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain Journal of Cell Science 112
  51. Oatey, P., Venkateswarlu, K., Williams, A., Fletcher, L., Foulstone, E., Cullen, P., Tavare, J., Kanamarlapudi, V. Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin- and PDGF-stimulated 3T3-L1 adipocytes Biochemical Journal 344 2 511
  52. Venkateswarlu, K., Lamb, D., Kelly, D., Manning, N., Kelly, S., Kanamarlapudi, V. The N-Terminal Membrane Domain of Yeast NADPH-Cytochrome P450 (CYP) Oxidoreductase Is Not Required for Catalytic Activity in Sterol Biosynthesis or in Reconstitution of CYP Activity Journal of Biological Chemistry 273 8 4492 4496
  53. Venkateswarlu, K., Gunn-Moore, F., Oatey, P., Tavare, J., Cullen, P., Kanamarlapudi, V. Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP ribosylation factor exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain Biochemical Journal 335
  54. Venkateswarlu, K., Kelly, D., Manning, N., Kelly, S., Kanamarlapudi, V. NADPH cytochrome P-450 oxidoreductase and susceptibility to ketoconazole Antimicrobial Agents and Chemotherapy 42
  55. Venkateswarlu, K., Oatey, P., Tavare, J., Cullen, P., Kanamarlapudi, V. Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase Current Biology 8 8 463 466
  56. VENKATESWARLU, K., GUNN-MOORE, F., OATEY, P., TAVARÉ, J., CULLEN, P., Kanamarlapudi, V. Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain Biochemical Journal 335 1 139 146
  57. Cullen, P., Lockyer, P., Reynolds, J., Venkateswarlu, K., Kanamarlapudi, V. GAP1IP4BP; a protein linking inositol 1,3,4,5-tetrakisphosphate with Ras and Ca2+homeostasis Biochemical Society Transactions 25 3 507S.3 507S
  58. Venkateswarlu, K., Kelly, S., Kanamarlapudi, V. Stereoselective interaction of SCH 39304, a triazole, with sterol 14alpha-demethylase of Aspergillus fumigatus Journal of Antimicrobial Chemotherapy 39 5 597 601
  59. Denning, D., Venkateswarlu, K., Oakley, K., Anderson, M., Manning, N., Stevens, D., Warnock, D., Kelly, S., Kanamarlapudi, V. Itraconazole resistance in Aspergillus fumigatus Antimicrobial Agents and Chemotherapy 41
  60. Venkateswarlu, K., Denning, D., Kelly, S., Kanamarlapudi, V. Inhibition and interaction of cytochrome P450 of Candida krusei with azole antifungal drugs Journal of Medical and Veterinary Mycology 35
  61. Venkateswarlu, K., Denning, D., Kelly, S., Kanamarlapudi, V. In-vitro activity of D0870, a new triazole antifungal drug, in comparison with fluconazole and itraconazole against Aspergillus fumigatus and Candida krusei Journal of Antimicrobial Chemotherapy 39 6 731 736
  62. Venkateswarlu, K., Taylor, M., Manning, N., Rinaldi, M., Kelly, S., Kanamarlapudi, V. Fluconazole tolerance in clinical isolates of Cryptococcus neoformans Antimicrobial Agents and Chemotherapy 41
  63. Lockyer, P., Bottomley, J., Reynolds, J., McNulty, T., Venkateswarlu, K., Potter, B., Dempsey, C., Cullen, P., Kanamarlapudi, V. Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting Current Biology 7 12 1007 1010
  64. Venkateswarlu, K., Kelly, D., Kelly, S., Kanamarlapudi, V. Characterization of Saccharomyces cerevisiae CYP51 and a CYP51 fusion protein with NADPH cytochrome P-450 oxidoreductase expressed in Escherichia coli Antimicrobial Agents and Chemotherapy 41
  65. Masaphy, S., Kanamarlapudi, V. Evidence for cytochrome P-450 and P-450-mediated benzo(a) pyrene hydroxylation in the white rot fungus Phanerochaete chrysosporium FEMS Microbiology Letters 135 1 51 55
  66. Venkateswarlu, K., Kelly, S., Kanamarlapudi, V. Biochemical characterisation of ketoconazole inhibitory action onAspergillus fumigatus FEMS Immunology & Medical Microbiology 16 1 11 20
  67. Venkateswarlu, K., Denning, D., Manning, N., Kelly, S., Kanamarlapudi, V. Reduced accumulation of drug in Candida krusei accounts for itraconazole resistance Antimicrobial Agents and Chemotherapy 40
  68. Venkateswarlu, K., Marsh, R., Faber, B., Kelly, S., Kanamarlapudi, V. Investigation of Cytochrome P450 Mediated Benzo(a)pyrene Hydroxylation in Aspergillus fumigatus Journal of Chemical Technology & Biotechnology 66 2 139 144
  69. Masaphy, S., Levanon, D., Henis, Y., Venkateswarlu, K., Kelly, S., Kanamarlapudi, V. Evidence for cytochrome P-450 and P-450-mediated benzo(a) pyrene hydroxylation in the white rot fungusPhanerochaete chrysosporium FEMS Microbiology Letters 135 1 51 55
  70. Venkateswarlu, K., Denning, D., Manning, N., Kelly, S., Kanamarlapudi, V. Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays Antimicrobial Agents and Chemotherapy 40
  71. Venkateswarlu, K., Kelly, S., Kanamarlapudi, V. Biochemical characterisation of ketoconazole inhibitory action onAspergillus fumigatus FEMS Immunology & Medical Microbiology 16 1 11 20
  72. Venkateswarlu, K., Kanamarlapudi, V. Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug FEMS Microbiology Letters 131 3 337 341
  73. Venkateswarlu, K., Denning, D., Manning, N., Kelly, S., Kanamarlapudi, V. Resistance to fluconazole inCandida albicansfrom AIDS patients correlated with reduced intracellular accumulation of drug FEMS Microbiology Letters 131 3 337 341
  74. Masaphy, S., Levanon, D., Henis, Y., Venkateswarlu, K., Kelly, S., Kanamarlapudi, V. Microsomal and cytosolic cytochrome P450 mediated benzo(a)pyrene hydroxylation in Pleurotus pulmonarius Biotechnology Letters 17 9 969 974
  75. Fang, G., Venkateswarlu, K., Kelly, D., Kelly, S., Kanamarlapudi, V. STUDIES ON YEAST HOST STRAINS FOR HETEROLOGOUS P450 EXPRESSION Biotechnology Letters 16
  76. Padidam, M., Venkateswarlu, K., Johri, M., Kanamarlapudi, V. Ammonium represses NADPH-nitrate reductase in the moss Funaria hygrometrica Plant Science 75 2 185 194

Book Chapters

  1. Venkateswarlu, K., Kanamarlapudi, V. GTPases Regulating Membrane Dynamics (Ed.), Analysis of the Interaction Between Cytohesin 2 and IPCEF1 252 266

Other Research Outputs

  1. VENKATESWARLU, K., POOLE, A., Kanamarlapudi, V. SCREENING METHOD FOR REGULATORY ENZYMES EMPLOYING TRIBRID (TRI-HYBRID) SYSTEM