Professor Gareth Jenkins
Personal Chair
Biomedical Sciences
Telephone: (01792) 602512
Room: Academic Office - 405
Fourth Floor
Institute of Life Science 1
Singleton Campus

Professor Jenkins’s research falls within the “Biomarkers and Genes” theme of the Medical School.

His research group investigate the molecular basis of cancer in the gastrointestinal tract, particularly the pre-malignant condition; Barrett’s Oesophagus. Group aims are to develop early detection systems for cancer. His blood based cancer detection approach (based on Pig A gene mutations in red blood cells) recently received a lot of media interest. His group investigate DNA damage levels in Barrett’s patients and NF-kB signalling induced in oesophageal tissues. The research is aimed at better understanding early carcinogenesis and to identify diagnostic markers for clinical utility. Professor Jenkins also collaborates with others in the areas of colorectal cancer biology and pancreatic cancer.

He is also an internationally recognised researcher in the field of Genetic Toxicology (DNA damage), being at the forefront of research efforts to improve in vitro (cell-based) assessment of genotoxic risks from chemical exposure. Current work centres on mechanistic studies of genotoxic thresholds, 3-D tissue models for genotoxicity and coupling genotoxic assessment with disruption of other cell biological processes (cell cycle, cell signalling, cell morphology).

Professor Jenkins was appointed to the UK Government’s Committee on Mutagenicity (COM) in 2009, was appointed a “Research Leader” by Health and Care Research Wales in 2012 and was appointed Senior Editor of Mutagenesis in 2016. He has received over £3million in grant income, written over 70 peer-reviewed papers and edited a book on the toxicology of Bile acids. Professor Jenkins is the head of research at the Medical School. He has an Honorary position at Abertawe Bro Morgannwg University (ABMU) Health Board.

Areas of Expertise

  • DNA mutation
  • Cancer Biomarkers
  • Oesophageal cancer
  • Safety Assessment
  • Genetic Toxicology

Publications

  1. Williams, L., Manson, J., Al-Mossawi, N., Bodger, O., Griffiths, P., Thornton, C., Jenkins, G., Rees, B., Lawrence, R., Haboubi, H. Developing a blood-based gene mutation assay as a novel biomarker for oesophageal adenocarcinoma Scientific Reports 9 1
  2. Jenkins, G., Cronin, J. Bile Acids Chapter 6. Bile Acids and Oesophageal Adenocarcinoma (OA)
  3. Jenkins, G., Parry, J. A novel method for the construction of an internal standard molecule for quantitative PCR Technical Tips Online 2 1 177 180
  4. Suzen, S., Jenkins, G., Parry, J. Application of the restriction site mutation technique to N‐methyl‐N‐nitrosourea‐induced mutations in the rat Teratogenesis, Carcinogenesis, and Mutagenesis 18 4 171 182
  5. Takahashi, N., Parry, J., Jenkins, G. A study of ENU‐induced mutagenesis in the mouse using the restriction site mutation (RSM) assay Teratogenesis, Carcinogenesis, and Mutagenesis 19 4 281 292

See more...

Teaching

  • PM-317 Genetics of Cancer

    This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.

  • PM-M28 Nano(geno)toxicology

    The field of nanotechnology is ever increasing in size, and the number of nano-sized (1-100nm) particles being produced on a daily basis is at the tonnage level. Although nanotechnology-based applications are considered to be advantageous for a plethora of human activities, the potential risks posed by human exposure to nanoparticles is a constantly developing field of research. The purpose of this module therefore is to introduce to the student to particle toxicology and how it can impact upon human health. Further to this, the students will undertake a specific practical component to complement that of the theoretical content of the module. To this extent, the students will undertake a week-long, 'mini-project', covering the major areas of nanoparticle toxicology. From this approach, it is intended that the student will experience the key points of the field.

  • PMGM14 Molecular Pathology of Cancer and Application in Cancer Diagnosis, Screening, and Treatment

    This module covers the molecular mechanisms that underlie cancer development, growth and metastasis, and the differences between different cancers. It will explore the different molecular and cellular actions of anti-cancer treatments, the genomic factors affecting response and resistance to treatment, and the research approaches to anti-cancer drug design and development. Broad situations which confer a high cancer risk to a person and/or to other members of the same family will be discussed in the context of how genomic information may be integrated into cancer screening programmes. This module will prepare the students to interrogate the cancer data sets from the 100,000 Genomes Project as well as to interrogate cancer genomic datasets in general.

Supervision

  • Raman Spectroscopy as a surrogate endpoint marker for chemotherapy response in colorectal cancer. (current)

    Student name:
    MD
    Other supervisor: Prof Peter Dunstan
    Other supervisor: Prof Gareth Jenkins
  • Blood based chemotherapy response monitoring (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • Development of a blood-based biomarker for early detection of oesophageal adenocarcinoma (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • The development and evaluation of a computer-based tool for assessing web-based information on medicines. (current)

    Student name:
    PhD
    Other supervisor: Prof Kerina Jones
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof David Skibinski
    Other supervisor: Prof David Skibinski
  • Characterisation of alginate-mucin interactions for tailored therapeutic development in Cystic Fibrosis (current)

    Student name:
    PhD
    Other supervisor: Prof Paul Lewis
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Prof Gareth Jenkins
  • Characterising The Role Of Tumourigenic Markers In Prostate Cancer Invasion Through 3D Tumour-Bone Stromal Cell Models (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • Blood-based test for pancreatic cancer (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • A Mechanistic Investigation of the Relationship between Extramural Vascular Invasion (EMVI) and CpG Island Methylation Phenotype (CIMP) in Rectal Cancer (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • Automated High Content Imaging for Carcinogenicity Testing In Vitro. (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • Development of a novel in vitro liver 3D model to assess potential (geno)toxicity of nanomaterials (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • Developing an in vitro repeat-dose approach to detect non-genotoxic carcinogens. (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • The impact of a centralised pancreatic cancer services in Wales. (current)

    Student name:
    MD
    Other supervisor: Prof Hayley Hutchings
    Other supervisor: Prof Gareth Jenkins
  • Implementing a Large-scale Electronic Health Record System in the Primary Healthcare Centres in Saudi Arabia (awarded 2019)

    Student name:
    PhD
    Other supervisor: Prof Hayley Hutchings
    Other supervisor: Prof Hayley Hutchings
    Other supervisor: Prof Gareth Jenkins
  • Sodium Salicylate Effects On Prostate Cancer Aggressiveness And Development Of Prostate Cancer Spheroids For Drug Evaluation (awarded 2019)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • 'Genomic variation and virulence in Helicobacter pylori: identifying the genes/alleles underlying phenotype variation.' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Samuel Sheppard
    Other supervisor: Prof Thomas Humphrey
    Other supervisor: Dr Jane Mikhail
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Dr Thomas Wilkinson
  • 'In vitro assessment of genotoxicity and cell cycle abnormalities to better understand carcinogenic risk' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • Optimisation and Application of Passive Dosing Exposures in In Vitro Genotoxicity Tests (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • 'Investigations into novel diagnostic biomarkers for oesophageal adenocarcinoma' (awarded 2017)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
    Other supervisor: Prof Gareth Jenkins