Professor Gareth Jenkins
Personal Chair
Medicine
Telephone: (01792) 602512
Room: Academic Office - 405
Fourth Floor
Institute of Life Science 1
Singleton Campus

Professor Jenkins’s research falls within the “Biomarkers and Genes” theme of the Medical School.

His research group investigate the molecular basis of cancer in the gastrointestinal tract, particularly the pre-malignant condition; Barrett’s Oesophagus. Group aims are to develop early detection systems for cancer. His blood based cancer detection approach (based on Pig A gene mutations in red blood cells) recently received a lot of media interest. His group investigate DNA damage levels in Barrett’s patients and NF-kB signalling induced in oesophageal tissues. The research is aimed at better understanding early carcinogenesis and to identify diagnostic markers for clinical utility. Professor Jenkins also collaborates with others in the areas of colorectal cancer biology and pancreatic cancer.

He is also an internationally recognised researcher in the field of Genetic Toxicology (DNA damage), being at the forefront of research efforts to improve in vitro (cell-based) assessment of genotoxic risks from chemical exposure. Current work centres on mechanistic studies of genotoxic thresholds, 3-D tissue models for genotoxicity and coupling genotoxic assessment with disruption of other cell biological processes (cell cycle, cell signalling, cell morphology).

Professor Jenkins was appointed to the UK Government’s Committee on Mutagenicity (COM) in 2009, was appointed a “Research Leader” by Health and Care Research Wales in 2012 and was appointed Senior Editor of Mutagenesis in 2016. He has received over £3million in grant income, written over 70 peer-reviewed papers and edited a book on the toxicology of Bile acids. Professor Jenkins is the head of research at the Medical School. He has an Honorary position at Abertawe Bro Morgannwg University (ABMU) Health Board.

Areas of Expertise

  • DNA mutation
  • Cancer Biomarkers
  • Oesophageal cancer
  • Safety Assessment
  • Genetic Toxicology

Publications

  1. & The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile. Journal of Nanobiotechnology 15(1)
  2. & Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N -methyl- N -nitrosourea. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 819, 38-46.
  3. & A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells. Archives of Toxicology
  4. & Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells.. Archives of Toxicology 91
  5. & Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease. The Journal of Steroid Biochemistry and Molecular Biology 174, 290-295.

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Teaching

  • PM-304 Biomolecular Research Project

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  • PM-317 Genetics of Cancer

    This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.

  • PM-344 Capstone Project

    The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

  • PM-M28 Nano(geno)toxicology

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  • PMGM14 Molecular Pathology of Cancer and Application in Cancer Diagnosis, Screening, and Treatment

    This module covers the molecular mechanisms that underlie cancer development, growth and metastasis, and the differences between different cancers. It will explore the different molecular and cellular actions of anti-cancer treatments, the genomic factors affecting response and resistance to treatment, and the research approaches to anti-cancer drug design and development. Broad situations which confer a high cancer risk to a person and/or to other members of the same family will be discussed in the context of how genomic information may be integrated into cancer screening programmes. This module will prepare the students to interrogate the cancer data sets from the 100,000 Genomes Project as well as to interrogate cancer genomic datasets in general.

Supervision

  • Medicines information on websites: a new proposed automatic approach of information quality assessment. (current)

    Student name:
    PhD
    Other supervisor: Dr Kerina Jones
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof David Skibinski
    Other supervisor: Prof David Skibinski
  • Untitled (current)

    Student name:
    MD
    Other supervisor: Prof Peter Dunstan
    Other supervisor: Prof Gareth Jenkins
  • Characterisation of alginate interactions for tailored therapeutic development in Cystic Fibrosis (current)

    Student name:
    PhD
    Other supervisor: Prof Paul Lewis
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Prof Gareth Jenkins
  • Development of a novel in vitro liver 3D model to assess potential (geno)toxicity of nanomaterials (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • 'Implementation of the Electronic Health Record systems in the Primary Healthcare Centres in Saudi Arabia' (current)

    Student name:
    PhD
    Other supervisor: Prof Hayley Hutchings
    Other supervisor: Prof Hayley Hutchings
    Other supervisor: Prof Gareth Jenkins
  • Optimisation and Application of Passive Dosing Exposures in In Vitro Genotoxicity Tests (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • Development of a blood based biomarker for early GI tract cancer (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • Sodium Salicylate Effects On Prostate Cancer Aggressiveness And Development And Development Of Prostate Cancer Spheroids For Drug Evaluation (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • Developing an in vitro repeat-dose approach to detect non-genotoxic carcinogens. (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • The impact of a centralised pancreatic cancer services in Wales. (current)

    Student name:
    MD
    Other supervisor: Prof Hayley Hutchings
    Other supervisor: Prof Gareth Jenkins
  • Blood-based test for pancreatic cancer (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • A Mechanistic Investigation of the Relationship between Extramural Vascular Invasion (EMVI) and CpG Island Methylation Phenotype (CIMP) in Rectal Cancer (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • Blood based chemotherapy response monitoring (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • Characterising The Role Of Tumourigenic Markers In Prostate Cancer Invasion Through 3D Tumour-Bone Stromal Cell Models (current)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof Shareen Doak
  • 'Genomic variation and virulence in Helicobacter pylori: identifying the genes/alleles underlying phenotype variation.' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Samuel Sheppard
    Other supervisor: Prof Thomas Humphrey
    Other supervisor: Dr Jane Mikhail
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Dr Thomas Wilkinson
  • 'In vitro assessment of genotoxicity and cell cycle abnormalities to better understand carcinogenic risk' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Prof Gareth Jenkins
  • 'Investigations into novel diagnostic biomarkers for oesophageal adenocarcinoma' (awarded 2017)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
    Other supervisor: Prof Gareth Jenkins