Publications

Journal Articles

  1. Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., Griffiths, W. Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism Proceedings of the National Academy of Sciences 201917421
  2. Magliozzi, R., Howell, O., Durrenberger, P., Aricò, E., James, R., Cruciani, C., Reeves, C., Roncaroli, F., Nicholas, R., Reynolds, R. Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis Journal of Neuroinflammation 16 1
  3. Castle, D., Wynford-Thomas, R., Loveless, S., Bentley, E., Howell, O., Tallantyre, E. Using biomarkers to predict clinical outcomes in multiple sclerosis Practical Neurology 19 4 342 349
  4. Ratcliff, M., Rees, D., McGrady, S., Buntwal, L., Hornsby, A., Bayliss, J., Kent, B., Bussey, T., Saksida, L., Beynon, A., Howell, O., Morgan, A., Sun, Y., Andrews, Z., Wells, T., Davies, J. Calorie restriction activates new adult born olfactory‐bulb neurones in a ghrelin‐dependent manner but acyl‐ghrelin does not enhance subventricular zone neurogenesis Journal of Neuroendocrinology 31 7
  5. Zelek, W., Watkins, L., Howell, O., Evans, R., Loveless, S., Robertson, N., Beenes, M., Willems, L., Brandwijk, R., Morgan, B. Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59 Multiple Sclerosis Journal
  6. Bevan, R., Evans, R., Griffiths, L., Watkins, L., Rees, M., Magliozzi, R., Allen, I., McDonnell, G., Kee, R., Naughton, M., Fitzgerald, D., Reynolds, R., Neal, J., Howell, O. Meningeal inflammation and cortical demyelination in acute multiple sclerosis Annals of Neurology
  7. Zeis, T., Howell, O., Reynolds, R., Schaeren-Wiemers, N., Howell, O. Molecular pathology of Multiple Sclerosis lesions reveals a heterogeneous expression pattern of genes involved in oligodendrogliogenesis Experimental Neurology
  8. Magliozzi, R., Howell, O., Nicholas, R., Cruciani, C., Castellaro, M., Romualdi, C., Rossi, S., Pitteri, M., Benedetti, M., Gajofatto, A., Pizzini, F., Montemezzi, S., Rasia, S., Capra, R., Bertoldo, A., Facchiano, F., Monaco, S., Reynolds, R., Calabrese, M., Howell, O. Inflammatory intrathecal profiles and cortical damage in multiple sclerosis Annals of Neurology
  9. Loveless, S., Neal, J., Howell, O., Harding, K., Sarkies, P., Evans, R., Bevan, R., Hakobyan, S., Harris, C., Robertson, N., Morgan, B. Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis Brain Pathology
  10. Watkins, L., Neal, J., Loveless, S., Michailidou, I., Ramaglia, V., Rees, M., Reynolds, R., Robertson, N., Morgan, B., Howell, O. Complement is activated in progressive multiple sclerosis cortical grey matter lesions Journal of Neuroinflammation 13 1
  11. Howell, O., Schulz-Trieglaff, E., Carassiti, D., Gentleman, S., Nicholas, R., Roncaroli, F., Reynolds, R. Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space Neuropathology and Applied Neurobiology 41 6 798 813
  12. Ingram, G., Loveless, S., Howell, O., Hakobyan, S., Dancey, B., Harris, C., Robertson, N., Neal, J., Morgan, B. Complement activation in multiple sclerosis plaques: an immunohistochemical analysis Acta Neuropathologica Communications 2 1 53
  13. Chung, S., Bode, A., Cushion, T., Thomas, R., Hunt, C., Wood, S., Pickrell, W., Drew, C., Yamashita, S., Shiang, R., Leiz, S., Longhardt, A., Raile, V., Weschke, B., Puri, R., Verma, I., Harvey, R., Ratnasinghe, D., Parker, M., Rittey, C., Masri, A., Lingappa, L., Howell, O., Vanbellinghen, J., Mullins, J., Lynch, J., Rees, M., Mullins, J., Rees, M., Chung, S., Thomas, R., Cushion, T., Howell, O., Pickrell, O. GLRB is the third major gene of effect in hyperekplexia Human Molecular Genetics 22 5 927 940
  14. Gardner, C., Magliozzi, R., Durrenberger, P., Howell, O., Rundle, J., Reynolds, R., Howell, O. Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats Brain
  15. Choi, S., Howell, O., Carassiti, D., Magliozzi, R., Gveric, D., Muraro, P., Nicholas, R., Roncaroli, F., Reynolds, R., Howell, O. Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis Brain 135 10 2925 2937
  16. Howell, O., Reeves, C., Nicholas, R., Carassiti, D., Radotra, B., Gentleman, S., Serafini, B., Aloisi, F., Roncaroli, F., Magliozzi, R., Reynolds, R., Howell, O. Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis Brain 134 9 2755 2771
  17. Reynolds, R., Roncaroli, F., Nicholas, R., Radotra, B., Gveric, D., Howell, O. The neuropathological basis of clinical progression in multiple sclerosis Acta Neuropathologica 122 2 155 170
  18. Campbell, G., Ziabreva, I., Reeve, A., Krishnan, K., Reynolds, R., Howell, O., Lassmann, H., Turnbull, D., Mahad, D., Howell, O. Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis Annals of Neurology 69 3 481 492
  19. Lovato, L., Willis, S., Rodig, S., Caron, T., Almendinger, S., Howell, O., Reynolds, R., O'Connor, K., Hafler, D., Howell, O. Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis Brain 134 2 534 541
  20. Owen, D., Howell, O., Tang, S., Wells, L., Bennacef, I., Bergstrom, M., Gunn, R., Rabiner, E., Wilkins, M., Reynolds, R., Matthews, P., Parker, C. Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation Journal of Cerebral Blood Flow & Metabolism 30 9 1608 1618
  21. Magliozzi, R., Howell, O., Reeves, C., Roncaroli, F., Nicholas, R., Serafini, B., Aloisi, F., Reynolds, R. A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis Annals of Neurology 68 4 477 493
  22. Kim, J., Shen, S., Dietz, K., He, Y., Howell, O., Reynolds, R., Casaccia, P. HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage Nature Neuroscience 13 2 180 189
  23. Howell, O., Rundle, J., Garg, A., Komada, M., Brophy, P., Reynolds, R. Activated Microglia Mediate Axoglial Disruption That Contributes to Axonal Injury in Multiple Sclerosis Journal of Neuropathology and Experimental Neurology 69 10 1017 1033
  24. Aloisi, F., Serafini, B., Magliozzi, R., Howell, O., Reynolds, R., Howell, O. Detection of Epstein-Barr virus and B-cell follicles in the multiple sclerosis brain: what you find depends on how and where you look Brain 133 12 e157 e157
  25. Laskowski, A., Howell, O., Sosuov, A., McKhann, G., Gray, W. NPY mediates basal and seizure-induced proliferation in the subcallosal zone NeuroReport 18 10 1005 1008
  26. Howell, O., al, e. Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus Neurobiol Disease 26 174
  27. Magliozzi, R., Howell, O., Vora, A., Serafini, B., Nicholas, R., Puopolo, M., Reynolds, R., Aloisi, F., Howell, O. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology Brain 130 4 1089 1104
  28. Howell, O., Palser, A., Polito, A., Melrose, S., Zonta, B., Scheiermann, C., Vora, A., Brophy, P., Reynolds, R., Howell, O. Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis Brain 129 12 3173 3185
  29. Reynolds, D., Rosahl, T., al, e., Howell, O. Sedation and Anesthesia Mediated by Distinct GABAA Receptor Isoforms J Neurosci 23 8607 8617
  30. Reynolds, D., Rosahl, T., Cirone, J., O'Meara, G., Haythornthwaite, A., Newman, R., Myers, J., Sur, C., Howell, O., Rutter, A., Atack, J., Macaulay, A., Hadingham, K., Hutson, P., Belelli, D., Lambert, J., Dawson, G., McKernan, R., Whiting, P., Wafford, K. Sedation and Anesthesia Mediated by Distinct GABAAReceptor Isoforms The Journal of Neuroscience 23 24 8608 8617
  31. Collinson, N., al, e., Howell, O. Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor J Neurosci 22 5572
  32. Collinson, N., Kuenzi, F., Jarolimek, W., Maubach, K., Cothliff, R., Sur, C., Smith, A., Otu, F., Howell, O., Atack, J., McKernan, R., Seabrook, G., Dawson, G., Whiting, P., Rosahl, T. Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor The Journal of Neuroscience 22 13 5572 5580
  33. Sur, C., al, e., Howell, O. Loss of the Major GABAA Receptor Subtype in the Brain Is Not Lethal in Mice J Neurosci 21 3409 3418
  34. Sur, C., Wafford, K., Reynolds, D., Hadingham, K., Bromidge, F., Macaulay, A., Collinson, N., O'Meara, G., Howell, O., Newman, R., Myers, J., Atack, J., Dawson, G., McKernan, R., Whiting, P., Rosahl, T. Loss of the Major GABAAReceptor Subtype in the Brain Is Not Lethal in Mice The Journal of Neuroscience 21 10 3409 3418
  35. Howell, O., al, e. Density and pharmacology of α5 subunit-containing GABAA receptors are preserved in hippocampus of Alzheimer’s disease patients Neuroscience 98 669 675
  36. McKernan, R., Rosahl, T., Reynolds, D., Sur, C., al, e., Howell, O. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor alpha1 subtype Nature Neuroscience 3 587 592
  37. Chadha, A., al, e., Howell, O. Changes in [3H]zolpidem and [3H]Ro 15-1788 binding in rat globus pallidus and substantia nigra pars reticulata following a nigrostriatal tract lesion. Brain Res 862 280
  38. Chadha, A., Howell, O., Atack, J., Sur, C., Duty, S. Changes in [3H]zolpidem and [3H]Ro 15-1788 binding in rat globus pallidus and substantia nigra pars reticulata following a nigrostriatal tract lesion Brain Research 862 1-2 280 283
  39. Howell, O., Atack, J., Dewar, D., McKernan, R., Sur, C., Howell, O. Density and pharmacology of α5 subunit-containing GABAA receptors are preserved in hippocampus of Alzheimer’s disease patients Neuroscience 98 4 669 675
  40. Sur, C., al, e., Howell, O. Autoradiographic localization of α5 subunit-containing GABAA receptors in rat brain Brain Res 822 265
  41. Sur, C., Fresu, L., Howell, O., McKernan, R., Atack, J. Autoradiographic localization of α5 subunit-containing GABAA receptors in rat brain Brain Research 822 1-2 265 270