Publications

Journal Articles

  1. Castle, D., Wynford-Thomas, R., Loveless, S., Bentley, E., Howell, O., Tallantyre, E. Using biomarkers to predict clinical outcomes in multiple sclerosis Practical Neurology 19 4 342 349
  2. Ratcliff, M., Rees, D., McGrady, S., Buntwal, L., Hornsby, A., Bayliss, J., Kent, B., Bussey, T., Saksida, L., Beynon, A., Howell, O., Morgan, A., Sun, Y., Andrews, Z., Wells, T., Davies, J. Calorie restriction activates new adult born olfactory‐bulb neurones in a ghrelin‐dependent manner but acyl‐ghrelin does not enhance subventricular zone neurogenesis Journal of Neuroendocrinology 31 7
  3. Bevan, R., Evans, R., Griffiths, L., Watkins, L., Rees, M., Magliozzi, R., Allen, I., McDonnell, G., Kee, R., Naughton, M., Fitzgerald, D., Reynolds, R., Neal, J., Howell, O. Meningeal inflammation and cortical demyelination in acute multiple sclerosis Annals of Neurology
  4. Zeis, T., Howell, O., Reynolds, R., Schaeren-Wiemers, N., Howell, O. Molecular pathology of Multiple Sclerosis lesions reveals a heterogeneous expression pattern of genes involved in oligodendrogliogenesis Experimental Neurology
  5. Magliozzi, R., Howell, O., Nicholas, R., Cruciani, C., Castellaro, M., Romualdi, C., Rossi, S., Pitteri, M., Benedetti, M., Gajofatto, A., Pizzini, F., Montemezzi, S., Rasia, S., Capra, R., Bertoldo, A., Facchiano, F., Monaco, S., Reynolds, R., Calabrese, M., Howell, O. Inflammatory intrathecal profiles and cortical damage in multiple sclerosis Annals of Neurology
  6. Zelek, W., Watkins, L., Howell, O., Evans, R., Loveless, S., Robertson, N., Beenes, M., Willems, L., Brandwijk, R., Morgan, B. Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59 Multiple Sclerosis Journal
  7. Loveless, S., Neal, J., Howell, O., Harding, K., Sarkies, P., Evans, R., Bevan, R., Hakobyan, S., Harris, C., Robertson, N., Morgan, B. Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis Brain Pathology
  8. Watkins, L., Neal, J., Loveless, S., Michailidou, I., Ramaglia, V., Rees, M., Reynolds, R., Robertson, N., Morgan, B., Howell, O. Complement is activated in progressive multiple sclerosis cortical grey matter lesions Journal of Neuroinflammation 13 1
  9. Howell, O., Schulz-Trieglaff, E., Carassiti, D., Gentleman, S., Nicholas, R., Roncaroli, F., Reynolds, R. Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space Neuropathology and Applied Neurobiology 41 6 798 813
  10. Ingram, G., Loveless, S., Howell, O., Hakobyan, S., Dancey, B., Harris, C., Robertson, N., Neal, J., Morgan, B. Complement activation in multiple sclerosis plaques: an immunohistochemical analysis Acta Neuropathologica Communications 2 1 53
  11. Gardner, C., Magliozzi, R., Durrenberger, P., Howell, O., Rundle, J., Reynolds, R., Howell, O. Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats Brain
  12. Chung, S., Bode, A., Cushion, T., Thomas, R., Hunt, C., Wood, S., Pickrell, W., Drew, C., Yamashita, S., Shiang, R., Leiz, S., Longhardt, A., Raile, V., Weschke, B., Puri, R., Verma, I., Harvey, R., Ratnasinghe, D., Parker, M., Rittey, C., Masri, A., Lingappa, L., Howell, O., Vanbellinghen, J., Mullins, J., Lynch, J., Rees, M., Mullins, J., Rees, M., Chung, S., Thomas, R., Cushion, T., Howell, O., Pickrell, O. GLRB is the third major gene of effect in hyperekplexia Human Molecular Genetics 22 5 927 940
  13. Choi, S., Howell, O., Carassiti, D., Magliozzi, R., Gveric, D., Muraro, P., Nicholas, R., Roncaroli, F., Reynolds, R., Howell, O. Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis Brain 135 10 2925 2937
  14. Howell, O., Reeves, C., Nicholas, R., Carassiti, D., Radotra, B., Gentleman, S., Serafini, B., Aloisi, F., Roncaroli, F., Magliozzi, R., Reynolds, R., Howell, O. Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis Brain 134 9 2755 2771
  15. Reynolds, R., Roncaroli, F., Nicholas, R., Radotra, B., Gveric, D., Howell, O. The neuropathological basis of clinical progression in multiple sclerosis Acta Neuropathologica 122 2 155 170
  16. Campbell, G., Ziabreva, I., Reeve, A., Krishnan, K., Reynolds, R., Howell, O., Lassmann, H., Turnbull, D., Mahad, D., Howell, O. Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis Annals of Neurology 69 3 481 492
  17. Lovato, L., Willis, S., Rodig, S., Caron, T., Almendinger, S., Howell, O., Reynolds, R., O'Connor, K., Hafler, D., Howell, O. Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis Brain 134 2 534 541
  18. Owen, D., Howell, O., Tang, S., Wells, L., Bennacef, I., Bergstrom, M., Gunn, R., Rabiner, E., Wilkins, M., Reynolds, R., Matthews, P., Parker, C. Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation Journal of Cerebral Blood Flow & Metabolism 30 9 1608 1618
  19. Magliozzi, R., Howell, O., Reeves, C., Roncaroli, F., Nicholas, R., Serafini, B., Aloisi, F., Reynolds, R. A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis Annals of Neurology 68 4 477 493
  20. Kim, J., Shen, S., Dietz, K., He, Y., Howell, O., Reynolds, R., Casaccia, P. HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage Nature Neuroscience 13 2 180 189
  21. Howell, O., Rundle, J., Garg, A., Komada, M., Brophy, P., Reynolds, R. Activated Microglia Mediate Axoglial Disruption That Contributes to Axonal Injury in Multiple Sclerosis Journal of Neuropathology and Experimental Neurology 69 10 1017 1033
  22. Aloisi, F., Serafini, B., Magliozzi, R., Howell, O., Reynolds, R., Howell, O. Detection of Epstein-Barr virus and B-cell follicles in the multiple sclerosis brain: what you find depends on how and where you look Brain 133 12 e157 e157
  23. Laskowski, A., Howell, O., Sosuov, A., McKhann, G., Gray, W. NPY mediates basal and seizure-induced proliferation in the subcallosal zone NeuroReport 18 10 1005 1008
  24. Howell, O., al, e. Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus Neurobiol Disease 26 174
  25. Magliozzi, R., Howell, O., Vora, A., Serafini, B., Nicholas, R., Puopolo, M., Reynolds, R., Aloisi, F., Howell, O. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology Brain 130 4 1089 1104
  26. Howell, O., Palser, A., Polito, A., Melrose, S., Zonta, B., Scheiermann, C., Vora, A., Brophy, P., Reynolds, R., Howell, O. Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis Brain 129 12 3173 3185
  27. Reynolds, D., Rosahl, T., al, e., Howell, O. Sedation and Anesthesia Mediated by Distinct GABAA Receptor Isoforms J Neurosci 23 8607 8617
  28. Reynolds, D., Rosahl, T., Cirone, J., O'Meara, G., Haythornthwaite, A., Newman, R., Myers, J., Sur, C., Howell, O., Rutter, A., Atack, J., Macaulay, A., Hadingham, K., Hutson, P., Belelli, D., Lambert, J., Dawson, G., McKernan, R., Whiting, P., Wafford, K. Sedation and Anesthesia Mediated by Distinct GABAAReceptor Isoforms The Journal of Neuroscience 23 24 8608 8617
  29. Collinson, N., al, e., Howell, O. Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor J Neurosci 22 5572
  30. Collinson, N., Kuenzi, F., Jarolimek, W., Maubach, K., Cothliff, R., Sur, C., Smith, A., Otu, F., Howell, O., Atack, J., McKernan, R., Seabrook, G., Dawson, G., Whiting, P., Rosahl, T. Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor The Journal of Neuroscience 22 13 5572 5580
  31. Sur, C., al, e., Howell, O. Loss of the Major GABAA Receptor Subtype in the Brain Is Not Lethal in Mice J Neurosci 21 3409 3418
  32. Sur, C., Wafford, K., Reynolds, D., Hadingham, K., Bromidge, F., Macaulay, A., Collinson, N., O'Meara, G., Howell, O., Newman, R., Myers, J., Atack, J., Dawson, G., McKernan, R., Whiting, P., Rosahl, T. Loss of the Major GABAAReceptor Subtype in the Brain Is Not Lethal in Mice The Journal of Neuroscience 21 10 3409 3418
  33. Howell, O., al, e. Density and pharmacology of α5 subunit-containing GABAA receptors are preserved in hippocampus of Alzheimer’s disease patients Neuroscience 98 669 675
  34. McKernan, R., Rosahl, T., Reynolds, D., Sur, C., al, e., Howell, O. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor alpha1 subtype Nature Neuroscience 3 587 592
  35. Chadha, A., al, e., Howell, O. Changes in [3H]zolpidem and [3H]Ro 15-1788 binding in rat globus pallidus and substantia nigra pars reticulata following a nigrostriatal tract lesion. Brain Res 862 280
  36. Chadha, A., Howell, O., Atack, J., Sur, C., Duty, S. Changes in [3H]zolpidem and [3H]Ro 15-1788 binding in rat globus pallidus and substantia nigra pars reticulata following a nigrostriatal tract lesion Brain Research 862 1-2 280 283
  37. Howell, O., Atack, J., Dewar, D., McKernan, R., Sur, C., Howell, O. Density and pharmacology of α5 subunit-containing GABAA receptors are preserved in hippocampus of Alzheimer’s disease patients Neuroscience 98 4 669 675
  38. Sur, C., al, e., Howell, O. Autoradiographic localization of α5 subunit-containing GABAA receptors in rat brain Brain Res 822 265
  39. Sur, C., Fresu, L., Howell, O., McKernan, R., Atack, J. Autoradiographic localization of α5 subunit-containing GABAA receptors in rat brain Brain Research 822 1-2 265 270