Publications

Journal Articles

1. Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., Griffiths, W. 2020 Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism Proceedings of the National Academy of Sciences 201917421

   https://cronfa.swan.ac.uk/Record/cronfa53792 doi: 10.1073/pnas.1917421117
2. Magliozzi, R., Howell, O., Durrenberger, P., Aricò, E., James, R., Cruciani, C., Reeves, C., Roncaroli, F., Nicholas, R., Reynolds, R. 2019 Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis Journal of Neuroinflammation 16 1

   https://cronfa.swan.ac.uk/Record/cronfa53064 doi: 10.1186/s12974-019-1650-x
3. Castle, D., Wynford-Thomas, R., Loveless, S., Bentley, E., Howell, O., Tallantyre, E. 2019 Using biomarkers to predict clinical outcomes in multiple sclerosis Practical Neurology 19 4 342 349

   https://cronfa.swan.ac.uk/Record/cronfa51666 doi: 10.1136/practneurol-2018-002000
4. Ratcliff, M., Rees, D., McGrady, S., Buntwal, L., Hornsby, A., Bayliss, J., Kent, B., Bussey, T., Saksida, L., Beynon, A., Howell, O., Morgan, A., Sun, Y., Andrews, Z., Wells, T., Davies, J. 2019 Calorie restriction activates new adult born olfactory‐bulb neurones in a ghrelin‐dependent manner but acyl‐ghrelin does not enhance subventricular zone neurogenesis Journal of Neuroendocrinology 31 7

   https://cronfa.swan.ac.uk/Record/cronfa51124 doi: 10.1111/jne.12755
5. Zelek, W., Watkins, L., Howell, O., Evans, R., Loveless, S., Robertson, N., Beenes, M., Willems, L., Brandwijk, R., Morgan, B. 2018 Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59 Multiple Sclerosis Journal

   https://cronfa.swan.ac.uk/Record/cronfa38531 doi: 10.1177/1352458518758927
6. Bevan, R., Evans, R., Griffiths, L., Watkins, L., Rees, M., Magliozzi, R., Allen, I., McDonnell, G., Kee, R., Naughton, M., Fitzgerald, D., Reynolds, R., Neal, J., Howell, O. 2018 Meningeal inflammation and cortical demyelination in acute multiple sclerosis Annals of Neurology

   https://cronfa.swan.ac.uk/Record/cronfa45060 doi: 10.1002/ana.25365

   https://onlinelibrary.wiley.com/doi/10.1002/ana.25365
7. Zeis, T., Howell, O., Reynolds, R., Schaeren-Wiemers, N., Howell, O. 2018 Molecular pathology of Multiple Sclerosis lesions reveals a heterogeneous expression pattern of genes involved in oligodendrogliogenesis Experimental Neurology

   https://cronfa.swan.ac.uk/Record/cronfa39260 doi: 10.1016/j.expneurol.2018.03.012
8. Magliozzi, R., Howell, O., Nicholas, R., Cruciani, C., Castellaro, M., Romualdi, C., Rossi, S., Pitteri, M., Benedetti, M., Gajofatto, A., Pizzini, F., Montemezzi, S., Rasia, S., Capra, R., Bertoldo, A., Facchiano, F., Monaco, S., Reynolds, R., Calabrese, M., Howell, O. 2018 Inflammatory intrathecal profiles and cortical damage in multiple sclerosis Annals of Neurology

   https://cronfa.swan.ac.uk/Record/cronfa39104 doi: 10.1002/ana.25197
9. Loveless, S., Neal, J., Howell, O., Harding, K., Sarkies, P., Evans, R., Bevan, R., Hakobyan, S., Harris, C., Robertson, N., Morgan, B. 2017 Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis Brain Pathology

   https://cronfa.swan.ac.uk/Record/cronfa34829 doi: 10.1111/bpa.12546
10. Watkins, L., Neal, J., Loveless, S., Michailidou, I., Ramaglia, V., Rees, M., Reynolds, R., Robertson, N., Morgan, B., Howell, O. 2016 Complement is activated in progressive multiple sclerosis cortical grey matter lesions Journal of Neuroinflammation 13 1

    https://cronfa.swan.ac.uk/Record/cronfa29210 doi: 10.1186/s12974-016-0611-x
11. Howell, O., Schulz-Trieglaff, E., Carassiti, D., Gentleman, S., Nicholas, R., Roncaroli, F., Reynolds, R. 2015 Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space Neuropathology and Applied Neurobiology 41 6 798 813

    https://cronfa.swan.ac.uk/Record/cronfa20148 doi: 10.1111/nan.12199
12. Ingram, G., Loveless, S., Howell, O., Hakobyan, S., Dancey, B., Harris, C., Robertson, N., Neal, J., Morgan, B. 2014 Complement activation in multiple sclerosis plaques: an immunohistochemical analysis Acta Neuropathologica Communications 2 1 53

    https://cronfa.swan.ac.uk/Record/cronfa19298 doi: 10.1186/2051-5960-2-53

    http://www.actaneurocomms.org/content/2/1/53
13. Chung, S., Bode, A., Cushion, T., Thomas, R., Hunt, C., Wood, S., Pickrell, W., Drew, C., Yamashita, S., Shiang, R., Leiz, S., Longhardt, A., Raile, V., Weschke, B., Puri, R., Verma, I., Harvey, R., Ratnasinghe, D., Parker, M., Rittey, C., Masri, A., Lingappa, L., Howell, O., Vanbellinghen, J., Mullins, J., Lynch, J., Rees, M., Mullins, J., Rees, M., Chung, S., Thomas, R., Cushion, T., Howell, O., Pickrell, O. 2013 GLRB is the third major gene of effect in hyperekplexia Human Molecular Genetics 22 5 927 940

    https://cronfa.swan.ac.uk/Record/cronfa13840 doi: 10.1093/hmg/dds498
14. Gardner, C., Magliozzi, R., Durrenberger, P., Howell, O., Rundle, J., Reynolds, R., Howell, O. 2013 Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats Brain

    https://cronfa.swan.ac.uk/Record/cronfa16583 doi: 10.1093/brain/awt279
15. Choi, S., Howell, O., Carassiti, D., Magliozzi, R., Gveric, D., Muraro, P., Nicholas, R., Roncaroli, F., Reynolds, R., Howell, O. 2012 Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis Brain 135 10 2925 2937

    https://cronfa.swan.ac.uk/Record/cronfa14213 doi: 10.1093/brain/aws189

    http://www.scopus.com/record/display.url?eid=2-s2.0-84867707040&origin=resultslist&sort=plf-f&src=s&st1=howell&st2=o.w&nlo=1&nlr=20&nls=&sid=942755C5CBB33656BBE96DCBEAC4A9AE.iqs8TDG0Wy6BURhzD3nFA%3a122&sot=anl&sdt=aut&sl=33&s=AU-ID%28%22Howell%2c+O.+W.%22+6602393502%29&relpos=2&relpos=2&searchTerm=AU-ID%28\%26quot%3BHowell%2C+O.+W.\%26quot%3B+6602393502%29
16. Howell, O., Reeves, C., Nicholas, R., Carassiti, D., Radotra, B., Gentleman, S., Serafini, B., Aloisi, F., Roncaroli, F., Magliozzi, R., Reynolds, R., Howell, O. 2011 Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis Brain 134 9 2755 2771

    https://cronfa.swan.ac.uk/Record/cronfa14214 doi: 10.1093/brain/awr182

    http://www.scopus.com/record/display.url?eid=2-s2.0-80052927697&origin=resultslist&sort=plf-f&src=s&st1=howell&st2=o.w&nlo=1&nlr=20&nls=&sid=942755C5CBB33656BBE96DCBEAC4A9AE.iqs8TDG0Wy6BURhzD3nFA%3a122&sot=anl&sdt=aut&sl=33&s=AU-ID%28%22Howell%2c+O.+W.%22+6602393502%29&relpos=3&relpos=3&searchTerm=AU-ID%28\%26quot%3BHowell%2C+O.+W.\%26quot%3B+6602393502%29
17. Reynolds, R., Roncaroli, F., Nicholas, R., Radotra, B., Gveric, D., Howell, O. 2011 The neuropathological basis of clinical progression in multiple sclerosis Acta Neuropathologica 122 2 155 170

    https://cronfa.swan.ac.uk/Record/cronfa16584 doi: 10.1007/s00401-011-0840-0
18. Campbell, G., Ziabreva, I., Reeve, A., Krishnan, K., Reynolds, R., Howell, O., Lassmann, H., Turnbull, D., Mahad, D., Howell, O. 2011 Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis Annals of Neurology 69 3 481 492

    https://cronfa.swan.ac.uk/Record/cronfa14218 doi: 10.1002/ana.22109

    http://www.scopus.com/record/display.url?eid=2-s2.0-79953291261&origin=resultslist&sort=plf-f&src=s&st1=howell&st2=o.w&nlo=1&nlr=20&nls=&sid=942755C5CBB33656BBE96DCBEAC4A9AE.iqs8TDG0Wy6BURhzD3nFA%3a122&sot=anl&sdt=aut&sl=33&s=AU-ID%28%22Howell%2c+O.+W.%22+6602393502%29&relpos=5&relpos=5&searchTerm=AU-ID%28\%26quot%3BHowell%2C+O.+W.\%26quot%3B+6602393502%29
19. Lovato, L., Willis, S., Rodig, S., Caron, T., Almendinger, S., Howell, O., Reynolds, R., O'Connor, K., Hafler, D., Howell, O. 2011 Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis Brain 134 2 534 541

    https://cronfa.swan.ac.uk/Record/cronfa14219 doi: 10.1093/brain/awq350

    http://www.scopus.com/record/display.url?eid=2-s2.0-79551695835&origin=resultslist&sort=plf-f&src=s&st1=howell&st2=o.w&nlo=1&nlr=20&nls=&sid=942755C5CBB33656BBE96DCBEAC4A9AE.iqs8TDG0Wy6BURhzD3nFA%3a122&sot=anl&sdt=aut&sl=33&s=AU-ID%28%22Howell%2c+O.+W.%22+6602393502%29&relpos=6&relpos=6&searchTerm=AU-ID%28\%26quot%3BHowell%2C+O.+W.\%26quot%3B+6602393502%29
20. Owen, D., Howell, O., Tang, S., Wells, L., Bennacef, I., Bergstrom, M., Gunn, R., Rabiner, E., Wilkins, M., Reynolds, R., Matthews, P., Parker, C. 2010 Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation Journal of Cerebral Blood Flow & Metabolism 30 9 1608 1618

    https://cronfa.swan.ac.uk/Record/cronfa14220 doi: 10.1038/jcbfm.2010.63

    http://www.scopus.com/record/display.url?eid=2-s2.0-77956263860&origin=resultslist&sort=plf-f&src=s&st1=howell&st2=o.w&nlo=1&nlr=20&nls=&sid=942755C5CBB33656BBE96DCBEAC4A9AE.iqs8TDG0Wy6BURhzD3nFA%3a122&sot=anl&sdt=aut&sl=33&s=AU-ID%28%22Howell%2c+O.+W.%22+6602393502%29&relpos=10&relpos=10&searchTerm=AU-ID%28\%26quot%3BHowell%2C+O.+W.\%26quot%3B+6602393502%29
21. Magliozzi, R., Howell, O., Reeves, C., Roncaroli, F., Nicholas, R., Serafini, B., Aloisi, F., Reynolds, R. 2010 A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis Annals of Neurology 68 4 477 493

    https://cronfa.swan.ac.uk/Record/cronfa14215 doi: 10.1002/ana.22230

    http://www.scopus.com/record/display.url?eid=2-s2.0-78249280011&origin=resultslist&sort=plf-f&src=s&st1=howell&st2=o.w&nlo=1&nlr=20&nls=&sid=942755C5CBB33656BBE96DCBEAC4A9AE.iqs8TDG0Wy6BURhzD3nFA%3a122&sot=anl&sdt=aut&sl=33&s=AU-ID%28%22Howell%2c+O.+W.%22+6602393502%29&relpos=9&relpos=9&searchTerm=AU-ID%28\%26quot%3BHowell%2C+O.+W.\%26quot%3B+6602393502%29
22. Kim, J., Shen, S., Dietz, K., He, Y., Howell, O., Reynolds, R., Casaccia, P. 2010 HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage Nature Neuroscience 13 2 180 189

    https://cronfa.swan.ac.uk/Record/cronfa14216 doi: 10.1038/nn.2471

    http://www.scopus.com/record/display.url?eid=2-s2.0-75549089982&origin=resultslist&sort=plf-f&src=s&st1=howell&st2=o.w&nlo=1&nlr=20&nls=&sid=942755C5CBB33656BBE96DCBEAC4A9AE.iqs8TDG0Wy6BURhzD3nFA%3a122&sot=anl&sdt=aut&sl=33&s=AU-ID%28%22Howell%2c+O.+W.%22+6602393502%29&relpos=12&relpos=12&searchTerm=AU-ID%28\%26quot%3BHowell%2C+O.+W.\%26quot%3B+6602393502%29
23. Howell, O., Rundle, J., Garg, A., Komada, M., Brophy, P., Reynolds, R. 2010 Activated Microglia Mediate Axoglial Disruption That Contributes to Axonal Injury in Multiple Sclerosis Journal of Neuropathology and Experimental Neurology 69 10 1017 1033

    https://cronfa.swan.ac.uk/Record/cronfa14217 doi: 10.1097/NEN.0b013e3181f3a5b1

    http://www.scopus.com/record/display.url?eid=2-s2.0-77957931759&origin=resultslist&sort=plf-f&src=s&st1=howell&st2=o.w&nlo=1&nlr=20&nls=&sid=942755C5CBB33656BBE96DCBEAC4A9AE.iqs8TDG0Wy6BURhzD3nFA%3a122&sot=anl&sdt=aut&sl=33&s=AU-ID%28%22Howell%2c+O.+W.%22+6602393502%29&relpos=8&relpos=8&searchTerm=AU-ID%28\%26quot%3BHowell%2C+O.+W.\%26quot%3B+6602393502%29
24. Aloisi, F., Serafini, B., Magliozzi, R., Howell, O., Reynolds, R., Howell, O. 2010 Detection of Epstein-Barr virus and B-cell follicles in the multiple sclerosis brain: what you find depends on how and where you look Brain 133 12 e157 e157

    https://cronfa.swan.ac.uk/Record/cronfa16586 doi: 10.1093/brain/awq223
25. Laskowski, A., Howell, O., Sosuov, A., McKhann, G., Gray, W. 2007 NPY mediates basal and seizure-induced proliferation in the subcallosal zone NeuroReport 18 10 1005 1008

    https://cronfa.swan.ac.uk/Record/cronfa16598 doi: 10.1097/WNR.0b013e32815277ab
26. Howell, O., al, e. 2007 Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus Neurobiol Disease 26 174

    https://cronfa.swan.ac.uk/Record/cronfa16599
27. Magliozzi, R., Howell, O., Vora, A., Serafini, B., Nicholas, R., Puopolo, M., Reynolds, R., Aloisi, F., Howell, O. 2006 Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology Brain 130 4 1089 1104

    https://cronfa.swan.ac.uk/Record/cronfa16585 doi: 10.1093/brain/awm038
28. Howell, O., Palser, A., Polito, A., Melrose, S., Zonta, B., Scheiermann, C., Vora, A., Brophy, P., Reynolds, R., Howell, O. 2006 Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis Brain 129 12 3173 3185

    https://cronfa.swan.ac.uk/Record/cronfa16590 doi: 10.1093/brain/awl290
29. Reynolds, D., Rosahl, T., al, e., Howell, O. 2003 Sedation and Anesthesia Mediated by Distinct GABAA Receptor Isoforms J Neurosci 23 8607 8617

    https://cronfa.swan.ac.uk/Record/cronfa16592
30. Reynolds, D., Rosahl, T., Cirone, J., O'Meara, G., Haythornthwaite, A., Newman, R., Myers, J., Sur, C., Howell, O., Rutter, A., Atack, J., Macaulay, A., Hadingham, K., Hutson, P., Belelli, D., Lambert, J., Dawson, G., McKernan, R., Whiting, P., Wafford, K. 2003 Sedation and Anesthesia Mediated by Distinct GABAAReceptor Isoforms The Journal of Neuroscience 23 24 8608 8617

    https://cronfa.swan.ac.uk/Record/cronfa51667 doi: 10.1523/JNEUROSCI.23-24-08608.2003
31. Collinson, N., al, e., Howell, O. 2002 Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor J Neurosci 22 5572

    https://cronfa.swan.ac.uk/Record/cronfa16596
32. Collinson, N., Kuenzi, F., Jarolimek, W., Maubach, K., Cothliff, R., Sur, C., Smith, A., Otu, F., Howell, O., Atack, J., McKernan, R., Seabrook, G., Dawson, G., Whiting, P., Rosahl, T. 2002 Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor The Journal of Neuroscience 22 13 5572 5580

    https://cronfa.swan.ac.uk/Record/cronfa51668 doi: 10.1523/JNEUROSCI.22-13-05572.2002
33. Sur, C., al, e., Howell, O. 2001 Loss of the Major GABAA Receptor Subtype in the Brain Is Not Lethal in Mice J Neurosci 21 3409 3418

    https://cronfa.swan.ac.uk/Record/cronfa16593
34. Sur, C., Wafford, K., Reynolds, D., Hadingham, K., Bromidge, F., Macaulay, A., Collinson, N., O'Meara, G., Howell, O., Newman, R., Myers, J., Atack, J., Dawson, G., McKernan, R., Whiting, P., Rosahl, T. 2001 Loss of the Major GABAAReceptor Subtype in the Brain Is Not Lethal in Mice The Journal of Neuroscience 21 10 3409 3418

    https://cronfa.swan.ac.uk/Record/cronfa51669 doi: 10.1523/JNEUROSCI.21-10-03409.2001
35. Howell, O., al, e. 2000 Density and pharmacology of α5 subunit-containing GABAA receptors are preserved in hippocampus of Alzheimer’s disease patients Neuroscience 98 669 675

    https://cronfa.swan.ac.uk/Record/cronfa16594
36. McKernan, R., Rosahl, T., Reynolds, D., Sur, C., al, e., Howell, O. 2000 Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor alpha1 subtype Nature Neuroscience 3 587 592

    https://cronfa.swan.ac.uk/Record/cronfa16591 doi: 10.1038/75761
37. Chadha, A., al, e., Howell, O. 2000 Changes in [3H]zolpidem and [3H]Ro 15-1788 binding in rat globus pallidus and substantia nigra pars reticulata following a nigrostriatal tract lesion. Brain Res 862 280

    https://cronfa.swan.ac.uk/Record/cronfa16597
38. Chadha, A., Howell, O., Atack, J., Sur, C., Duty, S. 2000 Changes in [3H]zolpidem and [3H]Ro 15-1788 binding in rat globus pallidus and substantia nigra pars reticulata following a nigrostriatal tract lesion Brain Research 862 1-2 280 283

    https://cronfa.swan.ac.uk/Record/cronfa51670 doi: 10.1016/S0006-8993(00)02081-3
39. Howell, O., Atack, J., Dewar, D., McKernan, R., Sur, C., Howell, O. 2000 Density and pharmacology of α5 subunit-containing GABAA receptors are preserved in hippocampus of Alzheimer’s disease patients Neuroscience 98 4 669 675

    https://cronfa.swan.ac.uk/Record/cronfa51671 doi: 10.1016/S0306-4522(00)00163-9
40. Sur, C., al, e., Howell, O. 1999 Autoradiographic localization of α5 subunit-containing GABAA receptors in rat brain Brain Res 822 265

    https://cronfa.swan.ac.uk/Record/cronfa16595
41. Sur, C., Fresu, L., Howell, O., McKernan, R., Atack, J. 1999 Autoradiographic localization of α5 subunit-containing GABAA receptors in rat brain Brain Research 822 1-2 265 270

    https://cronfa.swan.ac.uk/Record/cronfa51672 doi: 10.1016/S0006-8993(99)01152-X