Professor Steve Conlan
Personal Chair
Medicine
Telephone: (01792) 295386
Room: Office CNH - 009
Ground Floor
Institute of Life Science 2
Singleton Campus

Steve Conlan is Professor of Molecular and Cell Biology at Swansea University Medical School. He is head of the Reproductive Biology and Gynaecological Oncology research group, and Director of Strategic Partnerships for the Medical School.

Prof Conlan is a Fellow of the Royal Society of Biology (FRSB), and a Trustee of the British Society of Nanomedicine. He is a Senior Affiliate Member of The Methodist Hospital Research Institute, Houston Texas, and Distinguished Professor at Xi'an Jiaotong University, Suzhou Academy, China.

Steve has achieved success in developing infrastructure bids, strategic national and international collaborations, and industrial partnerships.

He was a founding Director of the £22 Million Centre for NanoHealth  [CNH] at Swansea University, an interdisciplinary R&D facility bringing together clinicians, biologists, physicists, chemists, engineers and businesses together under one roof to deliver advances in nanomedicine.

Steve is now Strategic Director of the Celtic Advanced Life Science Innovation Network (CALIN), a €12Million Ireland-Wales INTERREG operation established to build a innovation bridge between Wales and Ireland in life sciences. CALIN partners include Swansea (lead), Bangor, Cardiff, University College Dublin, National University Galway, University College Cork.

He currently leads industry facing R&D projects with industrial partners including Axis Bioservices, Bruker nano, GSK, GE Healthcare, Ig Innovations (part of the Abbott group), Porvair, and ReNeuron.

Prof Conlan’s research focuses on the application of molecular, cellular and nano biology approaches to understanding gynaecological pathologies including cancer and infertility. He has a particular interest in the impact of aberrant transcription and epigenetic processes, and advanced therapeutics (Antibody Drug Conjugates, exosomes, and nanoparticle deliver systems). He is affiliated to the Wales Cancer Research Centre, a virtual network in Wales, where he coordinates activity in developing novel therapeutics for ovarian cancer with colleagues in Swansea and Cardiff.

As Director of Strategic Partnerships, and member of the University’s Internationalisation Strategy Group, he leads strategic collaborative initiatives with Grenoble - France, Houston - US and Suzhou and Wuhan – China.

Prof Conlan holds an honorary consultant position in the Abertawe Bro Morgannwg NHS Board, working with clinical colleagues in Singleton Hospital Swansea and The Princess of Wales Hospital Bridgend.

Areas of Expertise

  • Reproductive Biology and Gynaecological Oncology
  • Molecular and Cell Biology
  • Nanomedicine
  • Translational Biomedical Research

Publications

  1. & Morphophysical dynamics of human endometrial cells during decidualization. Nanomedicine: Nanotechnology, Biology and Medicine
  2. & Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Proceedings of the National Academy of Sciences 111(7), 2500-2505.
  3. & Exosomes as Reconfigurable Therapeutic Systems. Trends in Molecular Medicine 23(7), 636-650.
  4. & Antibody–drug conjugates and other nanomedicines: the frontier of gynaecological cancer treatment. Interface Focus 6(6), 20160054
  5. et. al. Loss of WT1 Expression in the Endometrium of Infertile PCOS Patients: A Hyperandrogenic Effect?. The Journal of Clinical Endocrinology & Metabolism 97(3), 957-966.

See more...

Teaching

  • PM-317 Genetics of Cancer

    This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.

  • PMND00 Nanomedicine Research Dissertation

    This module builds on the knowledge and skills developed in teaching components in part one of their relevant programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study within nanomedicine.

  • PMNMD0 Postgraduate Taught Masters Dissertation

    Students will have the opportunity to join an established research group to work in a modern and well equipped laboratory or alternatively undertake a suitable non-laboratory based project. In this module the student will be able to gain extensive `hands on¿ specialist expertise in a chosen topic which could be targeted to their future career in the field of mass spectrometry. Please note that the topic choice will be made in conjunction with the supervisor, based upon novelty, feasibility and practical considerations on a 'first come first served' basis. The final approval of the topic rests with the module lead.

Supervision

  • Integrating image-based machine learning and in-line biochemical analysis for enhancing successful IVF/ICSI Outcome (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • no change (current)

    Student name:
    PhD
    Other supervisor: Dr Ernest Azzopardi
  • Development of novel Antibody Drug Conjugates for oncology applications (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Untitled (current)

    Student name:
    MSc
    Other supervisor: Dr Ricardo Del Sol Abascal
  • The Identification of Potential of Ovarian Cancer in at Risk Patients With Endometriosis (current)

    Student name:
    MSc
    Other supervisor: Dr Deyarina Gonzalez
  • Companion diagnostic development guides Antibody-Drug Conjugate formulation: Implications for patient stratification and precision medicine (current)

    Student name:
    PhD
    Other supervisor: Dr Ricardo Del Sol Abascal
  • "Design and Evaluation of an Antibody-Drug Conjugate for the treatment of aggressive Prostate Cancer" (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
  • Geochemistry of cancer: Effect of Selenium as a treatment and characterization of a copper biomarker of ovarian cancer (current)

    Student name:
    PhD
    Other supervisor: Dr Lewis Francis
  • Biosensors for enhanced in-vitro fertilisation (IVF) outcomes (current)

    Student name:
    PhD
    Other supervisor: Ms Sofia Rodrigues Teixeira
  • Targeted therapies for oncology applications (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Therapeutic exosomes as novel treatment for ovarian cancer (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • 'Aberrant Epigenetics and the Differentiation of Gynaecological Cancers' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Dr Lewis Francis
  • 'Antibody-drug conjugates for gynaecological cancers.' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • 'The impact of HBO1 in Ovarian Cancer' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Dr Lewis Francis
  • 'The molecular mechanisms for chemo-preventative effects of aspirin on prostate cancer' (awarded 2017)

    Student name:
    MSc
    Other supervisor: Prof Shareen Doak
  • 'Role of chronic urinary infection in the pathophysiology of overactive bladder syndrome' (awarded 2017)

    Student name:
    MD
    Other supervisor: Dr Deyarina Gonzalez
  • 'Investigations into novel diagnostic biomarkers for oesophageal adenocarcinoma' (awarded 2017)

    Student name:
    PhD
    Other supervisor: Prof Gareth Jenkins
  • 'A platform to determine mutation events in the cancer genome and chemical toxicity' (awarded 2017)

    Student name:
    PhD
    Other supervisor: Prof Paul Lewis

Research Groups