I am a research officer in the research team of Dr Spyridon Theofilopoulos.

I hold a BSc in Genetics and a Health and Care Research Wales funded PhD in Medical and Health Care Studies both from Swansea University. My PhD focused on the function of innate immune receptors in gestation associated tissues. This has led to a long-standing interest on the role innate immunity in health and disease, particularly relating to the inflammasome and IL-1 family cytokines.

My current research involves identifying the function and mechanism of action of cholesterol metabolites, up- or down-regulated in Parkinson’s disease (PD) patients. Any newly identified neuroprotective agents will be examined to determine if they can prevent or rescue phenotypic features of PD in models of PD.

Further to my research role, I also contribute to teaching at different levels across the medical school.

Areas of Expertise

  • Innate Immunity
  • Inflammation
  • Placental Inflammation & Immunology

Publications

  1. Jones, R., Thornton, C., Bryant, A. Human gestation-associated tissues express functional cytosolic nucleic acid sensing pattern recognition receptors Clinical & Experimental Immunology
  2. Bryant, A. Cytokines and the Innate Immune Response at the Materno-Fetal Interface (Ed.), Recent Advances in Research on the Human Placenta InTech
  3. Jones, R., Thornton, C., Bryant, A. Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development Advances in Neuroimmune Biology 1 2 193 203
  4. Skibinski, D., Jones, R., Thornton, C., Bryant, A., Francis, N., Jones, N. Bioenergetic analysis of human peripheral blood mononuclear cells Clinical & Experimental Immunology 182 1 69 80
  5. Thornton, C., Bryant, A. Functional activity but not gene expression of toll-like receptors is decreased in the preterm versus term human placenta Placenta 36 9 1031 1038

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Teaching

  • PM-003 Introduction to Molecular Biology

    This module will provide the learner with an introduction to molecular biology, classification of species and its applications in medical science. The concept of evolution and sexual reproduction and development will also be covered, and the processes of inheritance and genetic variation, particularly with regard to evolution and natural selection. This module will be supported by a practical session and essay with academic support on a topic relevant to the medical applications of molecular biology.

  • PM-120 Skills for Geneticists I

    This module is designed to develop the skills required for students of genetics and medical genetics. Students will meet with tutors and be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy. Joint sessions will cover generic skills such as internet searching for scientific sources, referencing and plagiarism.

  • PM-132C Bioleg Celloedd Ewcaryotig

    Bydd y modiwl hwn yn darparu cyflwyniad bras i gysyniadau sylfaenol ym maes bioleg celloedd Ewcaryotig, gan ymchwilio i darddiad y gell, strwythur y gell a chelloedd arbenigol a chelloedd mewn clefyd. Bydd ffocws cyffredinol ar gelloedd dynol drwy gydol y modiwl, gan gyfeirio at organebau eraill yn ├┤l yr angen. Bydd myfyrwyr yn cael profiad ymarferol o nodi celloedd, gwahaniaethu rhwng gwahanol gelloedd dynol a rhywogaethau o anifeiliaid.

  • PM-141 Human Physiology II

    This module aims to provide students with further understanding of human physiology through studies on systems physiology including the endocrine, renal, blood, digestive/metabolism and reproductive system. The module will equally describe how malfunction of physiological systems gives rise to disease, using specific examples to enable students to appreciate the relationship between physiology/anatomy and medicine. Fundamental principles of physiology will be illustrated with appropriate clinical examples and during practical assignments.

  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

  • PM-344 Capstone Project

    The aim of this module is to provide a capstone experience to students┬┐ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

  • PM-352 Reproductive Biology and Medicine

    This module is designed to provide students with knowledge of the biochemistry, physiology and pathology of human pregnancy, fetal development, parturition and menopause. Particular focus will be given to fertility treatments and pharmacological interventions of menopause. Lectures will cover a recap of endocrinology of reproduction, and provide details of assisted reproductive technologies. Lectures will be supported by case studies which include current clinical approaches used to treat infertility and menopause.