Professor / Evolutionary Biology
Medicine
Telephone: (01792) 295390
Room: Open Plan Office - 203
Second Floor
Institute of Life Science 1
Singleton Campus

My Current Main Research Interests:

Causes of genetic diversity in natural populations

Proteomics and transcriptomics with emphasis on data analysis methods

Causes and consequences of paternal inheritance of mitochondrial DNA

Evolutionary genetic modelling of plankton populations

Comparative protein modelling and applications in evolutionary biology and medicine

See my LinkedIn and ResearchGate pages (links under my photo) for further information about me.

Areas of Expertise

  • In Research:
  • Genetics and Evolution
  • Molecular Population Genetics
  • Biological Statistics and Modelling
  • Genomics and Bioinformatics

Publications

  1. & RNA-seq data from mature male gonads of marine mussels Mytilus edulis and M. galloprovincialis. Data in Brief 21, 167-175.
  2. & RNA-seq coupled to proteomic analysis reveals high sperm proteome variation between two closely related marine mussel species. Journal of Proteomics
  3. & Structure-Related Differences between Cytochrome Oxidase I Proteins in a Stable Heteroplasmic Mitochondrial System. Genome Biology and Evolution 9(12), 3265-3281.
  4. & Effects of growth rate, cell size, motion, and elemental stoichiometry on nutrient transport kinetics. PLOS Computational Biology 14(4), e1006118
  5. & Acclimation, adaptation, traits and trade-offs in plankton functional type models: reconciling terminology for biology and modelling. Journal of Plankton Research 37(4), 683-691.
  6. & Bioenergetic analysis of human peripheral blood mononuclear cells. Clinical & Experimental Immunology 182(1), 69-80.
  7. & Genetic Variation Underlying Protein Expression in Eggs of the Marine Mussel Mytilus edulis. Molecular & Cellular Proteomics 8, 132-144.
  8. & Multiple Hypothesis Testing in Proteomics: A Strategy for Experimental Work. Molecular & Cellular Proteomics 10(3), M110.004374-M110.004374.
  9. & Proteomic Analysis of Eggs fromMytilus edulisFemales Differing in Mitochondrial DNA Transmission Mode. Molecular & Cellular Proteomics 12(11), 3068-3080.
  10. & The consequences of sample pooling in proteomics: An empirical study. ELECTROPHORESIS 30(17), 2967-2975.
  11. & Identification and characterisation of highly expressed proteins in sperm cells of the marine mussel Mytilus edulis. PROTEOMICS 12(12), 1949-1956.
  12. & Bayesian phylogenetics of Bryozoa. MOLECULAR PHYLOGENETICS AND EVOLUTION 52, 904-910.
  13. & Non-linear dose-response of DNA-reactive genotoxins: Recommendations for data analysis. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 678, 95-100.
  14. & Scottish Mytilus trossulus mussels retain ancestral mitochondrial DNA: Complete sequences of male and female mtDNA genomes. GENE 456, 45-53.
  15. & The Evolution of an Osmotically Inducible dps in the Genus Streptomyces. PLoS ONE 8(4)

See more...

Teaching

  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

  • PMGM11 Introduction to Human Genetics and Genomics

    The Introduction to Human Genetics and Genomics module is a subject-specific module in the MSc Genomic Medicine programme. This unit will provide essential and contemporary knowledge relating to genetic science and genetic disease. The module will prepare participants to understand disease genetics, how genomic medicine can be utilised to elucidate disease mechanisms and biology in the context of genomic medicine. It will provide core knowledge underpinning later modules in bioinformatics and statistics. This module will serve as a foundation for those wishing to advance their careers within the NHS in genomic medicine.

Supervision

  • Medicines information on websites: a new proposed automatic approach of information quality assessment. (current)

    Student name:
    PhD
    Other supervisor: Dr Kerina Jones
    Other supervisor: Prof Gareth Jenkins
    Other supervisor: Prof David Skibinski
    Other supervisor: Prof David Skibinski

Administrative Responsibilities

  • Deputy Head - College of Medicine

    2010 - 2013

  • Programme Director BSc Degrees in Biochemistry and Genetics

    2006 - 2013