Foundation Applied Medical Sciences Skills Development 1
The module will provide the student with a diversity of study, laboratory and scientific skills in relation to the undertaking of undergraduate practical sessions in a safe manner. This will involve the development of skills including basic biologically relevant mathematics, appropriate data handling, working safely and key laboratory skills. Students will also be provided with an introduction to laboratory methods such as accurate pipetting and standard curve construction. In addition, students will receive lectures on developing study skills in literature searching, referencing & plagiarism and communication of information.
Skills for Medical Sciences
The aim of this module is to provide the student with basic skills required for laboratory research in the field of applied medical sciences. The module will be both theoretical and applied: the student will be instructed in methods essential for data acquisition and analyses but will also actively participate in the laboratory, using broadly applicable experimental techniques. They will also develop skills that are not experimental techniques themselves, but are nevertheless fundamental to the scientific process, such as `lab math,¿ sourcing information, referencing, ethics and health and safety.
Sgiliau ar gyfer Gwyddorau Meddygol
Nod y modiwl hwn yw darparu¿r sgiliau sylfaenol sydd eu hangen ar fyfyrwyr ar gyfer ymchwil labordy ym maes y gwyddorau meddygol cymhwysol. Bydd y modiwl yn cynnwys gwaith damcaniaethol a chymhwysol: caiff y myfyriwr ei hyfforddi mewn dulliau sy¿n hanfodol ar gyfer caffael data a¿i ddadansoddi, ond bydd hefyd yn cymryd rhan weithredol yn y labordy, gan ddefnyddio¿n fras y technegau arbrofol perthnasol. Byddant hefyd yn datblygu sgiliau nad ydynt yn dechnegau arbrofol yn eu hunain, ond sydd er hynny, yn sylfaenol i¿r broses wyddonol, megis, mathemateg y labordy¿, cyrchu gwybodaeth, cyfeirnodi, moeseg ac iechyd a diogelwch.
The Dose Makes the Poison: Intro to Toxicology and Dose Response
We are surrounded by substances that may do our bodies harm ¿ poisons. The harm these poisons causes depends on our exposure - the dose. The science of toxicology, a discipline that crosscuts biology, chemistry, pharmacology, and medicine, is based on the principle that the dose makes the poison.
This module will provide you with an introduction to toxicology and how dose-response relationships relate to the physiological effects of toxic substances. You will explore how they produce cellular and chemical changes that cause tissues and organs to malfunction. You will learn how the structure and function of these tissues can be affected to varying degrees and begin to understand how tissue may repair itself and when the damage is permanent or fatal.
Metabolic Regulation: Enzymes & Signal Transduction
This module reviews the basic elements of enzyme kinetics, including their mechanism and inhibition. The control of enzyme function by allosteric mechanisms is considered together with an appreciation of the significance of sigmoid kinetics. An overview of coenzymes and (metal) co-factors in enzyme function is given together with a description of the role played by vitamins in co-enzyme production. The module concludes with an overview of enzymes from extremophiles and their applications.
Infectious Disease and Parasitology
The course will build on the fundamentals of microbiology and introduce new topics in bacteriology, mycology and parasitology. Level 5 Immunology (PM-249) is a pre-requisite. The course covers the fundamentals of infectious diseases, including clinical aspects, treatment / prevention, and experimental approaches to the study of infectious and parasitic organisms. The course will also cover topics including disease outbreaks, beneficial parasites, tropical disease and behaviour-modifying parasites.
Clefydau Heintus a Pharasitoleg
Bydd y cwrs yn adeiladu ar sylfeini microbioleg ac yn cyflwyno pynciau newydd ym meysydd bacterioleg, mycoleg a pharasitoleg. Mae Imiwnoleg Lefel 5 (PM-249) yn rhagofyniad. Mae'r cwrs yn ymdrin ag egwyddorion sylfaenol clefydau heintus, gan gynnwys agweddau clinigol, triniaeth/atal, ac ymagweddau arbrofol at astudio organebau heintus a pharasitig. Bydd y cwrs hefyd yn ymdrin â phynciau gan gynnwys achosion o glefydau, parasitiaid buddiol, clefydau trofannol a pharasitiaid sy'n effeithio ar ymddygiad.
Meddygon, Cleifion a Nodau Meddygaeth
Genes on Drugs: Pharmacogenomics
Genes affect how the body reacts to drugs as well as how they are absorbed, metabolized and eliminated.
You will learn how variation in genes encoding proteins involved in these processes affect how drugs work ¿ or don¿t ¿ therapeutically. By understanding these factors, you will gain insight into the emerging field of personalized medicine and learn how individualized drug design and selection can improve therapeutic efficacy, safety and sustainability.
Advances in Toxicology: Pick Your Poison
BSc Medical Pharmacology module, follow on from PM-147 Introduction to Toxicology.
This module will provide students with the opportunity to expand their toxicology knowledge and apply it to analytical experience. This module will encompass medical toxicology, applied toxicology, and clinical poison information.
Content will be analytical, forensic and clinical toxicology.
The module provides an understanding of the subcellular organelles, the regulation of their biosynthesis and how
impairment of this process leads to disease.
Advances in Pharmacology
Pharmacology is the science of how drugs act on the body and how the body acts on drugs. Pharmacology investigates the chemical and physical properties of drugs, how those properties confer actions on living tissues and how those actions affect health and disease. The beneficial, therapeutic effects of drugs will be discussed, but also some negative consequences of drug administration, such as toxicity, addiction and microbial drug-resistance.
The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.
Cancer remains a significant cause of mortality in the modern world. Current and emerging chemotherapies, and the rationale, experimental, and clinical evidence of the pathways or molecules targeted will be explored. Causes of treatment-related side effects, and the therapies used to address these, will be discussed along with the mechanisms that lead to anti-cancer drug resistance.
Genomics of Common and Rare Inherited Disease
This module will provide an introduction to the clinical presentation and manifestations of rare inherited and common diseases, and considers the patient and family perspective with respect to the role and impact of genomics. It reviews traditional and current strategies and techniques used to identify genes responsible for both common multifactorial and rare inherited diseases.
Critical Literature Review
This module will allow students to carry out a critical and in-depth evaluation of previous research based on a specific subject related to genomics
Pharmacogenomics & Stratified Healthcare
Pharmacogenomics and stratified health care ensure that healthcare professionals offer the 'right treatment, for the right person, at the right time¿ is a fast-developing area. `Personalised medicine¿ is the buzzword of the moment, with advances in pharmacogenomic testing enabling more effective, targeted therapies to patients in the field of asthma, analgesia, oncology and beyond.
Continued understanding of the genomic basis of drug response will reduce drug-related adverse effects, save costs, and ensure a better therapeutic outcome. This module will provide a comprehensive overview of the analytical strategies and techniques used in pharmacogenomics and explore some of the challenges and limitations in this field. The module will also provide an overview of the different type of pharmacogenomic biomarkers currently in use or emerging and the current feasibility of delivering `personalised medicine¿ in the clinic.